Adenosine modulates inspiratory neurons and the respiratory pattern in the brainstem of neonatal rats

Pediatric Research

Volumn 42, Issue 1, 1997, Pages 46-53

  Herlenius, Eric ^a,b   Lagercrantz, Hugo ^a   Yamamoto, Yuji ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A1 RECEPTOR ANTAGONIST; DIPYRIDAMOLE; PHENYLISOPROPYLADENOSINE; THEOPHYLLINE;

ANIMAL TISSUE; ARTICLE; BRAIN STEM; BREATHING PATTERN; CONTROLLED STUDY; MEDULLA OBLONGATA; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; RESPIRATION CONTROL; RESPIRATION DEPRESSION; RESPIRATORY DISTRESS SYNDROME;

EID: 0031010205     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199707000-00008     Document Type: Article

References (51)

1. Berne RM 1986 Adenosine: an important physiological regulator. Trends Neurosci 1:163-167
2. Collis MG, Hourani SM 1993 Adenosine receptor subtypes. Trends Pharmacol Sci 14:360-366
3. Bissonette JM, Hohimer R, Chao CR, Knopp SJ, Notoroberto NF 1990 Theophylline stimulates fetal breathing movements during hypoxia. Pediatr Res 28:83-86
4. Koos BJ, Matsuda K 1990 Fetal breathing, sleep state, and cardiovascular responses to adenosine in sheep. J Appl Physiol 68:489-495
5. Runold M, Lagercrantz H, Fredholm BB 1986 Ventilatory effect of an adenosine analogue in unanesthetized rabbits during development. J Appl Physiol 61:255-259
6. Runold M, Lagercrantz H, Prabhakar NR, Fredholm BB 1989 Role of adenosine in hypoxic ventilatory depression. J Appl Physiol 67:541-546
7. Eldridge FL, Millhorn DE, Kiley JP 1984 Respiratory effects of a long-acting analog of adenosine. Brain Res 301:273-280
8. Yamamoto M, Nishimura M, Kobayashi S, Akiyama Y, Miyamoto K, Kawakami Y 1994 Role of endogenous adenosine in hypoxic ventilatory response in humans: a study with dipyridamole. J Appl Physiol 76:196-203
9. Winn HR, Rubio R, Berne RM 1981 Brain adenosine concentration during hypoxia in rats. Am J Physiol 241:235-242
10. Hedner T, Hedner J, Jonason J, Wessberg P 1984 Effects of theophylline on adenosine-induced respiratory depression in the preterm rabbit. Eur J Respir Dis 65:153-156
11. Lagercrantz H 1992 What does the preterm infant breathe for? Controversies on apnea of prematurity. Acta Paediatr 81:733-736
12. Rigatto H, Brady JP, Chir B 1972 Periodic breathing and apnea in preterm infants. II. Hypoxia as a primary event. Pediatrics 50:219-28
13. Miller MJ, Martin RJ 1992 Pathophysiology of apnea of prematurity. In: Polin, RF (ed) Fetal and Neonatal Physiology. WB Saunders, Philadelphia, pp 872-885
14. Neylon M, Marshall JM 1991 The role of adenosine in the respiratory and cardiovascular response to systemic hypoxia in the rat. J Physiol 440:529-545
15. Moss IR, Runold M, Dahlin I, Fredholm BB, Nyberg F, Lagercrantz H 1987 Respiratory and neuroendocrine responses of piglets to hypoxia during postnatal development. Acta Physiol Scandinav 131:533-541
16. Lopes JM, Davis GM, Mullahoo K, Aranda JV 1994 Role of adenosine in the hypoxic ventilatory response of the newborn piglet. Pediatr Pulmonol 17:50-55
17. Lagercrantz H, Yamamoto Y, Fredholm BB, Prabhakar NR. Euler C 1984 Adenosine analogues depress ventilation in rabbit neonates. Theophylline stimulation of respiration via adenosine receptors? Pediatr Res 18:387-390
18. Hedner J, Hedner T, Wessberg P, Jonason J, Mueller RA, 1985. Central respiratory effects of adenosine analogues, theophylline and enprofylline. In: Andersson, KE, Persson CGA (eds) Anti-Asthma Xanthines and Adenosine. Excerpta Medica, Copenhagen, pp 467-471
19. Darmall RJ 1985 Aminophylline reduces hypoxic ventilatory depression: possible role of adenosine. Pediatr Res 19:706-710
20. Katchman AN, Hershkowitz N 1993 Adenosine antagonists prevent hypoxia-induced depression of excitatory but not inhibitory synaptic currents. Neurosci Lett 159:123-126
21. Mynlieff M, Beam KG 1994 Adenosine acting at an Al receptor decreases N-type calcium current in mouse motoneurons. J Neurosci 14:3628-3634
22. Lagercrantz H, Runold M, Yamamoto Y, Fredholm BB 1986 Adenosine: a putative mediator of the hypoxic ventilatory response of the neonate. In: Euler H, Lagercrantz H (eds) Neurobiology of the Control of Breathing. Raven Press, New York, pp 133-139
23. Dong XW, Feldman JL 1995 Modulation of inspiratory drive to phrenic motoneurons by presynaptic adenosine Al receptors. J Neurosci 15:3458-3467
24. Suzue T 1984 Respiratory rhythm generation in the in vitro brainstem-spinal cord preparation of the neonatal rat. J Physiol 354:173-183
25. Smith JC, Greer JJ, Liu GS, Feldman JL 1990 Neural mechanisms generating respiratory pattern in mammalian brain stem-spinal cord in vitro. I. Spatiotemporal patterns of motor and medullary neuron activity. J Neurophysiol 64:1149-1169
26. Smith JC, Ellenberger HH, Ballanyi K, Richter DW, Feldman JL 1991 Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science 254:726-729
27. Schwarzacher SW, Smith JC, Richter DW 1995 Pre-Bötzinger complex in the cat. J Neurophysiol 73:1452-1461
28. Arata A, Onimaru H, Homma I 1990 Respiration-related neurons in the ventral medulla of newborn rats in vitro. Brain Res Bull 24:599-604
29. Yamamoto Y, Onimaru H, Homma I 1992 Effect of substance P on respiratory rhythm and pre-inspiratory neurons in the ventrolateral structure of rostral medulla oblongata: an in vitro study. Brain Res 599:272-276
30. Möser GH, Schrader J, Deussen A 1989 Turnover of adenosine in plasma of human and dog blood. Am J Physiol 256:799-806
31. Stone T 1991 Adenosine in the Nervous System. Academic Press, London
32. Eldridge FL, Millhorn DE, Kiley JP 1985 Antagonism by theophylline of respiratory inhibition induced by adenosine. J Appl Physiol 59:1428-1433
33. Thomas T, Elnazir BK, Marshall JM 1994 Differentiation of the peripherally mediated from the centrally mediated influences of adenosine in the rat during systemic hypoxia. Exp Physiol 79:809-822
34. Schmidt C, Bellingham MC, Richter DW 1995 Adenosinergic modulation of respiratory neurones and hypoxic responses in the anaesthetized cat. J Physiol 483:769-781
35. Fredholm BB, Dunwiddie TV 1988 How does adenosine inhibit transmitter release? Pharmacol Sci 9:130-134
36. Fredholm BB, Dunér-Engström M, Fastbom J, Jonzen B, Lindgren E, Nordstedt C, Pedata F, van der Ploeg I 1987 Interactions between the neuromodulator adenosine and the classic transmitters. In: Gerlach E, Becker BF (eds) Topics and Perspectives in Adenosine Research. Springer-Verlag, Berlin, pp 509-520
37. 1 adenosine receptor agonist on the neurochemical, behavioral and histological consequences of ischemia. Brain Res 641:217-224
38. Trussel LO, Jackson MB 1987 Dependence of an adenosine-activated potassium current on a GTP-binding protein in mammalian central neurons. J Neurosci 7:3306-3316
39. Feldman JL, Windhorst U, Anders K, Richter DW 1992 Synaptic interaction between medullary respiratory neurones during apneusis induced by NMDA-receptor blockade in cat. J Physiol 450:303-323
40. Connelly CA, Otto SM, Feldman JL 1992 Blockade of NMDA receptor-channels by MK-801 alters breathing in adult rats. Brain Res 596:99-110
41. Kawai A, Okada Y, Mückenhoff K, Scheid P 1995 Theophylline and hypoxic ventilatory response in the rat isolated brainstem-spinal cord. Respir Physiol 100:25-32
42. Lloyd HG, Lindström K, Fredholm BB 1993 Intracellular formation and release of adenosine from rat hippocampal slices evoked by electrical stimulation or energy depletion. Neurochem Int 23:173-185
43. Cross K, Warner P 1951 The effect of inhalation of high and low oxygen concentration on the respiration of the newborn infant. J Physiol 114:283-295
44. Haddad GG, Mellins RB 1984 Hypoxia and respiratory control in early life. Annu Rev Physiol 46:629-643
45. Bergstrand H, 1985. Xanthines as phosphodiesterase inhibitors. In K.-E. Andersson, K-E, Persson CGA (eds) Anti-Asthma Xanthines and Adenosine. Excerpta Medica, Copenhagen, pp 16-22
46. Arata A, Onimaru H, Homma I 1993 Effects of cAMP on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rat. Brain Res 605:193-199
47. Bryan AC, Bryan MH 1978 Control of respiration in the newborn. Clin Perinatol 5:269-281
48. Elnazir B, Marshall JM, Kumar P 1996 Postnatal development of the pattern of respiratory and cardiovascular response to systemic hypoxia in the piglet: the roles of adenosine. J Physiol 492:573-585
49. Hedner T, Hedner J, Bergman B, Mueller RA, Jonason J 1985 Characterization of adenosine-induced respiratory depression in the preterm rabbit. Biol Neonate 47:323-332
50. von Euler C 1991 Neuronal organization and rhythm generation. In: Crystal RG, West JB (eds) The Lung. Raven Press, New York, pp 1-12
51. Blanchi AL, Denavit-Saubié M, Champagnat J 1995 Central control of breathing in mammals: neuronal circuitry, membrane properties, and neurotransmitters. Physiol Rev 75:1-45