Adenosine A2A-receptor blockade abolishes the roll-off respiratory response to hypoxia in awake lambs

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 288, Issue 5 57-5, 2005, Pages

  Koos, Brian J ^a   Kawasaki, Yoshikazu ^a   Kim, Young Han ^a   Bohorquez, Fanor ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Brain; Caffeine; Newborn; Respiration; Thermoregulation

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A2A RECEPTOR; AMINOPHYLLINE; CAFFEINE; 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE; CARBON DIOXIDE; OXYGEN; TRIAZINE DERIVATIVE; TRIAZOLE DERIVATIVE; XANTHINE DERIVATIVE;

ADOLESCENT; ANIMAL EXPERIMENT; ARTERIAL OXYGEN TENSION; ARTICLE; BREATHING REFLEX; CARDIOPULMONARY HEMODYNAMICS; CATHETERIZATION; CONTROLLED STUDY; FACE MASK; HEART RATE; HYPOXEMIA; HYPOXIA; LAMB; LUNG MINUTE VOLUME; LUNG VENTILATION; MEAN ARTERIAL PRESSURE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; RECTUM TEMPERATURE; RESPIRATION DEPRESSION; TACHYCARDIA; THERMOREGULATION; WAKEFULNESS; ANIMAL; ANOXIA; BLOOD; BLOOD PRESSURE; BODY TEMPERATURE; BREATHING; DRUG ANTAGONISM; DRUG EFFECT; PATHOPHYSIOLOGY; PH; PHYSIOLOGY; SHEEP; TIDAL VOLUME; TIME;

ANIMALS; ANIMALS, NEWBORN; ANOXIA; BLOOD PRESSURE; BODY TEMPERATURE; CARBON DIOXIDE; HEART RATE; HYDROGEN-ION CONCENTRATION; OXYGEN; RECEPTOR, ADENOSINE A2A; RESPIRATION; SHEEP; TIDAL VOLUME; TIME FACTORS; TRIAZINES; TRIAZOLES; XANTHINES;

EID: 17844404797     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00723.2004     Document Type: Article

References (41)

1. Alvaro R, Alvarez J, Kwiatkowsi K, Cates D, and Rigatto H. Small preterm infants (≤ 1500 g) have only a sustained decrease in ventilation in response to hypoxia. Pediatr Res 32: 403-406, 1992.
2. Barros RCH and Branco LGS. Role of central adenosine in the respiratory and thermoregulatory responses to hypoxia. Neuroreport 11: 193-197, 2000.
3. Bissonnette JM. Mechanisms regulating hypoxic respiratory depression during fetal and postnatal life. Am J Physiol Regul Integr Comp Physiol 278: R1391-R1400, 2000.
4. Bissonnette JM, Hohimer AR, Chao CR, Knopp SJ, and Notoroberto NF. Theophylline stimulates fetal breathing movements during hypoxia. Pediatr Res 28: 83-86, 1990.
5. Blanco CE, Dawes GS, Hanson MA, and McCooke HB. The response to hypoxia of arterial chemoreceptors in fetal sheep and new-born lambs. J Physiol 351: 25-37, 1984.
6. Blood AB, Hunter CJ, and Power GG. Adenosine mediates decreased cerebral metabolic rate and increased cerebral blood flow during acute moderate hypoxia in the near-term fetal sheep. J Physiol 553: 935-945, 2003.
7. Bureau M, Zinman R, Foulon P, and Begin R. Diphasic ventilatory response to hypoxia in newborn lambs. J Appl Physiol 56: 84-90, 1984.
8. Chau A and Koos BJ. Metabolic and cardiorespiratory responses to hypoxia in fetal sheep: adenosine receptor blockade. Am J Physiol Regul Integr Comp Physiol 276: R1805-R1811, 1999.
9. Daly MDEB. Interactions between respiration and circulation. In: Handbook of Physiology. The Respiratory System. Control of Breathing. Bethesda, MD: Am. Physiol. Soc., 1985, sect. 3, vol. II, pt. 2, chapt. 16, p. 529-594.
10. Darnall RA. Aminophylline reduces hypoxic ventilatory depression: possible role of adenosine. Pediatr Res 19: 706-710, 1985.
11. Dawes GS. The central control of fetal breathing and skeletal muscle movements. J Physiol 346: 1-8, 1984.
12. Dempsey JA and Skatrud JB. A sleep-induced apneic threshold and its consequences. Am Rev Respir Dis 133: 1163-1170, 1986.
13. Easton PA and Anthonisen NR. Ventilatory response to sustained hypoxia after pretreatment with aminophylline. J Appl Physiol 64: 1445-1450, 1988.
14. Gershan WM, Forster HV, Lowry TF, and Garber AK. Effect of theophylline on ventilatory roll-off during hypoxia in goats. Respir Physiol 103: 157-164, 1996.
15. Gleeson K and Zwillich CW. Adenosine infusion and periodic breathing during sleep. J Appl Physiol 72: 1004-1009, 1992.
16. Guieu R, Peragut JC, Roussel P, Hassani H, Sampieri F, Bechis G, Gola R, and Rochat H. Adenosine and neuropathic pain. Pain 68: 271-274, 1996.
17. Haidmayer R and Kenner T. Physiological approaches to respiratory control mechanisms in infants: assessing the risk for SIDS. In: The Sudden Infant Death Syndrome. Cardiac and Respiratory Mechanisms and Interventions, edited by Schwartz PJ, Southall DP, and Valdes-Dapena M. New York: New York Academy of Sciences, 1988, p. 376-389.
18. Johnston BM and Gluckman PD. Peripheral chemoreceptors respond to hypoxia in pontine-lesioned fetal lambs in utero. J Appl Physiol 75: 1027-1034, 1993.
19. Koos BJ, Chao A, and Doany W. Adenosine stimulates breathing in fetal sheep with brainstem section. J Appl Physiol 72: 94-99, 1992.
20. 2A receptor agonist in sheep. Am J Physiol Regul Integr Comp Physiol 274: R152-R159, 1998.
21. Koos BJ, Chau A, and Ogunyemi D. Adenosine mediates metabolic and cardiovascular responses to hypoxia in fetal sheep. J Physiol 488: 761-766, 1995.
22. Koos BJ, Kawasaki Y, Hari A, Bohorquez F, Jan C, Roostaeian J, Wilson CL, and Kruger L. Electrical stimulation of the posteromedial thalamus modulates breathing in unanesthetized fetal sheep. J Appl Physiol 96: 115-123, 2004.
23. 2A receptors mediate cardiovascular responses to hypoxia in fetal sheep. Am J Physiol Heart Circ Physiol 280: H83-H89, 2001.
24. 2A receptors modulate sleep state and breathing in fetal sheep. J Appl Physiol 91: 343-350, 2001.
25. 2A receptors mediate hypoxic inhibition of fetal breathing in sheep. Am J Obstet Gynecol 186: 663-668, 2002.
26. Koos BJ and Matsuda K. Fetal sleep state, breathing and cardiovascular responses to adenosine in sheep. J Appl Physiol 68: 489-495, 1990.
27. Lin MT, Chandra A, and Liu GG. The effects of theophylline and caffeine on thermoregulatory functions of rats at different ambient temperatures. J Pharm Pharmacol 32: 204-208, 1980.
28. Long WQ and Anthonisen NR. Aminophylline partially blocks ventilatory depression with hypoxia in the awake cat. Can J Physiol Pharmacol 72: 673-678, 1994.
29. 1 adenosine receptors modulate activity of the neonatal mouse via the cAMP-mediated signaling pathway. J Neurophysiol 81: 247-255, 1999.
30. Mortola JP. Implications of hypoxic hypometabolism during mammalian ontogenesis. Respir Physiol Neurobiol 141: 345-356, 2004.
31. Moss TJ and Harding R. Ventilatory and arousal responses of sleeping lambs to respiratory challenges: effect of prenatal maternal anemia. J Appl Physiol 88: 641-648, 2000.
32. Purves MJ. The effects of hypoxia in the new-born lamb before and after denervation of the carotid chemoreceptors. J Physiol 185: 60-77, 1966.
33. Richter DW, Lalley PM, Pierrefiche O, Haji A, Bischoff AM, Wilken B, and Hanefeld F. Intracellular signal pathways controlling respiratory neurons. Respir Physiol 110: 113-123, 1997.
34. Rigatto H. Control of ventilation in the newborn. Annu Rev Physiol 46: 661-74, 1984.
35. Runold M, Lagercrantz H, Prabhakar NR, and Fredholm BB. Role of adenosine in hypoxic ventilatory depression. J Appl Physiol 67: 541-546, 1989.
36. Schmidt C, Bellingham MC, and Richter DW. Adenosinergic modulation of respiratory neurons and hypoxic responses in the anesthetized cat. J Physiol 483: 769-781, 1995.
37. Sidi D, Kuipers JRG, Teitel D, Heymann MA, and Rudolph AM. Developmental changes in oxygenation and circulatory responses to hypoxemia in lambs. Am J Physiol Heart Circ Physiol 245: H674-H682, 1983.
38. Symonds ME, Andrews DC, and Johnson P. The influence of acute hypoxia and carotid body denervation on thermoregulation during non-rapid eye movement sleep in the developing Iamb. Exp Physiol 84: 1115-1126, 1999.
39. Thomas T and Marshall JM. Interdependence of respiratory and cardiovascular changes induced by hypoxia in the rat: the roles of adenosine. J Physiol 480: 627-636, 1994.
40. Vizek M, Pickett CK, and Weil JV. Biphasic ventilatory response of adult cats to sustained hypoxia has central origin. J Appl Physiol 63: 1658-1664, 1987.
41. Wilken B, Ramirez JM, Hanefeld F, and Richter DW. Aminophylline modulation of the mouse respiratory network changes during postnatal maturation. J Appl Physiol 89: 2015-2022, 2000.