Thyrotropin-releasing hormone (TRH) depolarizes a subset of inspiratory neurons in the newborn mouse brain stem in vitro

Journal of Neurophysiology

Volumn 75, Issue 2, 1996, Pages 811-819

  Rekling, Jens C ^a,b   Champagnat, Jean ^a   Denavit Saubié, Monique ^a  

^a CNRS   (France)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTIRELIN; TETRODOTOXIN;

ANIMAL TISSUE; ARTICLE; BRAIN STEM; DEPOLARIZATION; HYPOGLOSSAL NERVE; MOTONEURON; MOUSE; NERVE CELL MEMBRANE POTENTIAL; NEWBORN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RESPIRATORY NERVE CELL;

EID: 0029961570     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1996.75.2.811     Document Type: Article

References (28)

1. BAYLISS, D. A., VIANA, F., AND BERGER, A. J. Mechanisms underlying excitatory effects of thyrotropin-releasing hormone on rat hypoglossal motoneurons in vitro. J. Neurophysiol. 68: 1733-1745, 1992.
2. BAYLISS, D. A., VIANA, F., AND BERGER. A. J. Effects of thyrotropin-releasing hormone on rat motoneurons are mediated by G proteins. Brain Res. 668: 220-229, 1994a.
3. BAYLISS, D. A., VIANA, F., KANTER, R. K., SZYMECZEK-SEAY, C. L., BERGER, A. J., AND MILLHORN, D. E. Early postnatal development of thyrotropin-releasing hormone (TRH) expression, TRH binding, and TRH responses in neurons of rat brainstem. J. Neurosci. 14: 821-833, 1994b.
4. BORKE, R. C., NAU, M. E., AND RINGLER, JR., R. L. Brain stem affrents of hypoglossal neurons in the rat. Brain Res. 269: 47-55, 1983.
5. CLARKE, K. A. AND KIRBY, K. Stimulation of locomotion in neonate rats by TRH analogue CG3703. Neuropeptides 26: 71-75, 1994.
6. DI PASQUALE, E., MORIN, D., MONTEAU, R., AND HILAIRE, G. Serotonergic modulation of the respiratory rhythm generator at birth: an in vitro study in the rat. Neurosci. Lett. 143: 91-95, 1992.
7. DOBBINS, E. G. AND FELDMAN, J. L. Differential innervation of protruder and retractor muscles of the tongue in rat. J. Comp. Neurol. 357: 376-394, 1995.
8. ERRCHIDI, S., MONTEAU, R., AND HILAIRE, G. Noradrenergic modulation of the medullary respiratory rhythm generator in the newborn rat: an in vitro study. J. Physiol. Lond. 443: 477-498, 1991.
9. FELDMAN, J. L. AND SMITH, J. C. Cellular mechanisms underlying modulation of breathing pattern in mammals. Ann. NY Acad. Sci. 563: 114-130, 1989.
10. FUNK, G. D., SMITH, J. C., AND FELDMAN, J. L. Development of thyrotropin-releasing hormone and norepinephrine potentiation of inspiratory-related hypoglossal motoneruon discharge in neonatal and juvenile mice in vitro. J Neurophysiol. 72: 2538-2541, 1994.
11. HAWKINS, E. F. AND ENGEL, W. K. Kinetic analysis of thyrotropin-releasing hormone binding in the central nervous system: evidence for receptor desensitization. Neurosci. Lett. 79: 157-162, 1987.
12. HEDNER, J., HEDNER, T., JONASON, J., AND LUNDBERO, D, Central respiratory stimulant effect by thyrotropin releasing hormone in the rat. Neurosci. Lett. 25: 317-320, 1981.
13. HOLTMAN, J. R., BULLER, A. L., HAMOSH, P., AND GILLIS R. A. Central respiratory stimulation produced by thyrotropin-releasing hormone in the cat. Peptides 7: 207-212, 1986.
14. HOMMA, I., OOUCHI, M., AND ICHIKAWA, S. Facilitation of inspiration by intra-cerebroventricular injection of thyrotropin-releasing hormone in rabbits. Neurosci. Lett. 44: 265-269, 1984.
15. JOHNSON, S. M. AND GETTING, P. A. Excitatory effects of thyrotropin-releasing hormone on neurons within the nucleus ambiguus of adult guinea pigs. Brain Res. 590: 1-5, 1992.
16. LEHNERT, H., NINK, M., MANN, K., RÖSCHKE, J., AND HELLHAMMER, D. H. Extrapituitary effects of corticotropin-releasing hormone and thyrotropin-releasing hormone. Neuropsychobiology 28: 54-61, 1993.
17. METCALF, G. AND JACKSON, I. M. D. Thyrotropin-Releasing Hormone: Biomedical Significance. Annals of the New York Academy of Sciences. New York: NY Acad. Sci., 1989, vol. 553.
18. MURAKOSHI, T., SUZUE, T., AND TAMAI, S. A pharmacological study on respiratory rhythm in the isolated brainstem-spinal cord preparation of the newborn rat. Br. J. Pharmacol. 86: 95-104, 1985.
19. NINK, M., KRAUSE, U., LEHNERT, H., HEUBERGER, W., HUBER, I., SCHULZ, R., HOMMEL, G., AND BEYER, J. Thyrotropin-releasing hormone has stimulatory effects on ventilation in humans. Acta. Physiol. Scand. 141: 309-318, 1991.
20. PAAKKARI, I., NURMINEN, M.-L., AND SIRÉN, A.-L. Cardioventilator effects of TRH in anaesthetized rats: role of the brain stem. Eur. J. Pharmacol. 122: 131-134, 1986.
21. REKLING, J. C. Excitatory effects of thyrotropin-releasing hormone (TRH) in hypoglossal motoneurons. Brain Res. 510: 175-179, 1990.
22. REKLING, J. C., CHAMPAGNAT, J., AND DENAVIT-SAUBIÉ, M. Thyrotropin-releasing hormone (TRH) depolarizes respiratory related neurons in a thick slice preparation of the newborn mouse brainstem. Soc. Neurosci. Abstr. 2: 1589, 1994.
23. REKLING, J. C., CHAMPAGNAT, J., AND DENAVIT-SAUBIÉ, M. Electroresponsive properties and membrane potential trajectories of three types of inspiratory neurons in the newborn mouse brain stem in vitro. J. Neurophysiol. 75: 795-810, 1996.
24. SHARIF, N. A. Diverse roles of thyrotropin-releasing hormone in brain, pituitary and spinal function. Trends Pharmacol. Sci. 6: 119-122, 1985.
25. TAKAHASHI, T. Thyrotropin-releasing hormone mimics descending slow synaptic potentials in rat spinal motoneurons. Proc. R. Soc. Lond. B Biol Sci. 225: 391-398, 1985.
26. VONHOF, S., SIRÉN, A.-L., AND FEUERSTEIN, G. Z. Central ventilatory effects of thyrotropin-releasing hormone in the conscious rat. Neuropeptides 18: 93-98, 1991.
27. YAMAMOTO, Y., LAGERCRANTZ, H., AND VON EULER, C. Effects of substance P and TRH on ventilation and pattern of breathing in newborn rabbits Acta Physiol. Scand. 113: 541-543, 1981.
28. YAMAMOTO, Y., ONIMARU, H., AND HOMMA, I. Effect of substance P on respiratory rhythm and pre-inspiratory neurons in the ventrolateral structure of rostral medulla oblongata: an in vitro study. Brain Res. 599: 272-274, 1992.