Adenosinergic modulation of respiratory neurones in the neonatal rat brainstem in vitro

Journal of Physiology

Volumn 518, Issue 1, 1999, Pages 159-172

  Herlenius, Eric ^a   Lagercrantz, Hugo ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR STIMULATING AGENT; PHENYLISOPROPYLADENOSINE; PRESYNAPTIC RECEPTOR; TETRODOTOXIN;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CONTROLLED STUDY; HYPERPOLARIZATION; NERVE CELL MEMBRANE POTENTIAL; NERVE CONDUCTION; NEWBORN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; RESPIRATORY NERVE CELL; SYNAPTIC TRANSMISSION; THALAMUS VENTRAL NUCLEUS; ADENOSINERGIC MODULATION; ANIMAL CELL; ANIMAL EXPERIMENT; IN VITRO STUDY; INPUT RESISTANCE; MEMBRANE STEADY POTENTIAL; NERVOUS SYSTEM PARAMETERS; NEUROMODULATION; POSTSYNAPTIC INHIBITION; RESPIRATORY RHYTHM; RHYTHM; ROSTRAL VENTROLATERAL MEDULLA; SYNAPTIC INHIBITION; WHOLE CELL PATCH CLAMP; WISTAR RAT;

ADENOSINE; AIRWAY RESISTANCE; ANIMALS; ANIMALS, NEWBORN; BRAIN STEM; ELECTROPHYSIOLOGY; MEMBRANE POTENTIALS; MOTOR NEURONS; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P1; RESPIRATORY MECHANICS; RESPIRATORY SYSTEM; SYNAPTIC TRANSMISSION; XANTHINES;

EID: 0033166705     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1999.0159r.x     Document Type: Article

References (49)

1. ARATA, A., ONIMARU, H. & HOMMA, I. (1998). Possible synaptic connections of expiratory neurons in the rostral ventrolateral medulla of newborn rat brainstem-spinal cord preparation in vitro. NeuroReport 9, 743-746.
2. BALLANYI, K., VOLKER, A. & RICHTER, D. W. (1994). Anoxia induced functional inactivation of neonatal respiratory neurones in vitro. NeuroReport 6, 165-168.
3. BAYLISS, D. A., UMEMIYA, M. & BERGER, A. J. (1995). Inhibition of N-and P-type calcium channels and the afterhyperpolarization in rat motoneurones. Journal of Physiology 485, 635-647.
4. BIANCHI, A. L., DENAVIT-SAUBIÉ, M. & CHAMPAGNAT, J. (1995). Central control of breathing in mammals: neuronal circuitry, membrane properties, and neurotransmitters. Physiological Reviews 75, 1-45.
5. BISSONNETTE, J. M., HOHIMER, A. R. & KNOPP, S. J. (1991). The effect of centrally administered adenosine on fetal breathing movements. Respiratory Physiology 84, 273-285.
6. BLANTON, M. G., LO TURCO, J. J. & KRIEGSTEIN, A. J. (1989). Whole-cell recordings from neurons in slices of reptilian and mammalian cerebral cortex. Journal of Neuroscience Methods 30, 203-210.
7. BRUNDEGE, J. M. & DUNWIDDIE, T. V. (1997). Role of adenosine as a modulator of synaptic activity in the central nervous system. Advances in Pharmacology 39, 353-391.
8. DONG, X. W. & FELDMAN, J. L. (1995). Modulation of inspiratory drive to phrenic motoneurons by presynaptic adenosine A1 receptors. Journal of Neuroscience 15, 3458-3467.
9. EZURE, K. (1990). Synaptic connections between respiratory neurons and considerations on the genesis of respiratory rhythm. Progress in Neurobiology 35, 429-450.
10. FELDMAN, J. L., SMITH, J. C., ELLENBERGER, H. H., CONNELLY, C. A., LIU, G. S., GREER, J. J., LINDSAY, A. D. & OTTO, M. R. (1990). Neurogenesis of respiratory rhythm and pattern: emerging concepts. American Journal of Physiology 259, R879-886.
11. FELDMAN, J. L., SMITH, J. C. & LIU, G. (1991). Respiratory pattern generation in mammals: in vitro en bloc analyses. Current Opinion in Neurobiology 1, 590-594.
12. FREDHOLM, B. B. (1995). Adenosine receptors in the central nervous system. News in Physiological Sciences 10, 122-128.
13. HERLENIUS, E. (1998). Respiratory activity in medulla oblongata and its modulation by adenosine and opioids. PhD Thesis, pp. 152, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden, http://diss.kib.ki.se/1998/91-628-3240-9/
14. HERLENIUS, E., LAGERCRANTZ, H. & YAMAMOTO, Y. (1997). Adenosine modulates inspiratory neurons and the respiratory pattern in the brainstem of neonatal rats. Pediatric Research 42, 46-53.
15. IRESTEDT, L., DAHLIN, I., HERTZBERG, T., SOLLEVI, A. & LAGERCRANTZ, H. (1989). Adenosine concentration in umbilical cord blood of newborn infants after vaginal delivery and cesarean section. Pediatric Research 26, 106-108.
16. + channels of expiratory neurones in the brainstem preparation of the newborn rat. NeuroReport 8, 3673-3678.
17. KATCHMAN, A. N. & HERSHKOWITZ, N. (1993). Adenosine antagonists prevent hypoxia-induced depression of excitatory but not inhibitory synaptic currents. Neuroscience Letters 159, 123-126.
18. KAWAI, A., BALLANTYNE, D., MUCKENHOFF, K. & SCHEID, P. (1996). Chemosensitive medullary neurones in the brainstem-spinal cord preparation of the neonatal rat. Journal of Physiology 492, 277-292.
19. KAWAI, A., OKADA, Y., MUCKENHOFF, K. & SCHEID, P. (1995). Theophylline and hypoxic ventilatory response in the rat isolated brainstem-spinal cord. Respiratory Physiology 100, 25-32.
20. LAGERCRANTZ, H., YAMAMOTO, Y., FREDHOLM, B. B., PRABHAKAR, N. R. & EULER, C. (1984). Adenosine analogues depress ventilation in rabbit neonates. Theophylline stimulation of respiration via adenosine receptors? Pediatric Research 18, 387-390.
21. MIRONOV, S. L., LANGOHR, K., HALLER, M. & RICHTER, D. W. (1998). Hypoxia activates ATP-dependent potassium channels in inspiratory neurones of neonatal mice. Journal of Physiology 509, 755-766.
22. MYNLIEFF, M. & BEAM, K. G. (1994). Adenosine acting at an A1 receptor decreases N-type calcium current in mouse motoneurons. Journal of Neuroscience 14, 3628-3634.
23. NEYLON, M. & MARSHALL, J. M. (1991). The role of adenosine in the respiratory and cardiovascular response to systemic hypoxia in the rat. Journal of Physiology 440, 529-545.
24. ONIMARU, H., ARATA, A. & HOMMA, I. (1988). Primary respiratory rhythm generator in the medulla of brainstem-spinal cord preparation from newborn rat. Brain Research 445, 314-324.
25. ONIMARU, H., ARATA, A. & HOMMA, I. (1990). Inhibitory synaptic inputs to the respiratory rhythm generator in the medulla isolated from newborn rats. Pflügers Archiv 417, 425-432.
26. ONIMARU, H., ARATA, A. & HOMMA, I. (1987). Neuronal mechanisms of respiratory rhythm generation: an approach using in vitro preparation. Japanese Journal of Physiology 47, 385-403.
27. ONIMARU, H., BALLANYI, K. & RICHTER, D. (1996). Calcium-dependent responses in neurons of the isolated respiratory network of newborn rats. Journal of Physiology 491, 677-695.
28. ONIMARU, H. & HOMMA, I. (1992). Whole cell recordings from respiratory neurons in the medulla of brainstem-spinal cord preparations isolated from newborn rats. Pflügers Archiv 420, 399-406.
29. ONIMARU, H., HOMMA, I. & IWATSUKI, K. (1992). Excitation of inspiratory neurons by preinspiratory neurons in rat medulla in vitro. Brain Research Bulletin 29, 879-882.
30. PATON, J. F. & RICHTER, D. W. (1995). Maturational changes in the respiratory rhythm generator of the mouse. Pflügers Archiv 430, 115-124.
31. PIERREFICHE, O., BISCHOFF, A. M., RICHTER, D. W. & SPYER, K. M. (1997). Hypoxic response of hypoglossal motoneurones in the in vivo cat. Journal of Physiology 505, 785-795.
32. RAMIREZ, J. M., QUELLMALZ, U. J. A., WILKEN, B. & RICHTER, D. W. (1998). The hypoxic response of neurones within the in vitro mammalian respiratory network. Journal of Physiology 507, 571-582.
33. REKLING, J. C. & FELDMAN, J. L. (1998). PreBötzinger complex and pacemaker neurons - hypothesized site and kernel for respiratory rhythm generation. Annual Review of Physiology 60, 385-405.
34. RICHTER, D. W. (1982). Generation and maintenance of the respiratory rhythm. Journal of Experimental Biology 100, 93-107.
35. RICHTER, D. W., BISCHOFF, A., ANDERS, K., BELLINGHAM, M. & WINDHORST, U. (1991). Response of the medullary respiratory network of the cat to hypoxia. Journal of Physiology 443, 231-256.
36. RICHTER, D. W., BISCHOFF, A., ANDERS, K., BELLINGHAM, M. & WINDHORST, U. (1993). Modulation of respiratory patterns during hypoxia. In Respiratory Control: Central and Peripheral Mechanisms, ed. SPECK, D. F., DEKIN, M. S., REVELETTE, W. R. & FRAZIER, D. T., pp. 21-28. The University Press of Kentucky, Lexington, USA.
37. RIVKEES, S. A. (1995). The ontogeny of cardiac and neural A1 adenosine receptor expression in rats. Developmental Brain Research 89, 202-213.
38. RUNOLD, M., LAGEBCRANTZ, H. & FREDHOLM, B. B. (1986). Ventilatory effect of an adenosine analogue in unanesthetized rabbits during development. Journal of Applied Physiology 61, 255-259.
39. RUNOLD, M., LAGERCRANTZ, H., PRABHAKAR, N. R. & FREDHOLM, B. B. (1989). Role of adenosine in hypoxic ventilatory depression. Journal of Applied Physiology 67, 541-546.
40. RYBAK, I. A., PATON, J. F. R. & SCHWABER, J. S. (1997). Modelling neural mechanisms for genesis of respiratory rhythm and pattern. 2. Network models of the central respiratory pattern generator. Journal of Neurophysiology 77, 2007-2026.
41. SCHMIDT, C., BELLINGHAM, M. C. & RICHTER, D. W. (1995). Adenosinergic modulation of respiratory neurones and hypoxic responses in the anaesthetized cat. Journal of Physiology 483, 769-781.
42. SHAO, X. M. & FELDMAN, J. L. (1997). Respiratory rhythm generation and synaptic inhibition of expiratory neurons in pre-Bötzinger complex - differential roles of glycinergic and GABAergic neural transmission. Journal of Neurophysiology 77, 1853-1860.
43. SMITH, J. C., ELLENBERGER, H. H., BALLANYI, K., RICHTER, D. W. & FELDMAN, J. L. (1991). Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science 254, 726-729.
44. SMITH, J. C., FELDMAN, J. L. & SCHMIDT, B. J. (1988). Neural mechanisms generating locomotion studied in mammalian brainstem-spinal cord in vitro. FASEB Journal 2, 2283-2288.
45. SMITH, J. C., GREER, J. J., LIU, G. S. & FELDMAN, J. L. (1990). Neural mechanisms generating respiratory pattern in mammalian brainstem-spinal cord in vitro. I. Spatiotemporal patterns of motor and medullary neuron activity. Journal of Neurophysiology 64, 1149-1169.
46. SUZUE, T. (1984). Respiratory rhythm generation in the in vitro brainstem-spinal cord preparation of the neonatal rat. Journal of Physiology 354, 173-183.
47. THOMPSON, S. M., HAAS, H. L. & GAHWILER, B. H. (1992). Comparison of the actions of adenosine at pre- and postsynaptic receptors in the rat hippocampus in vitro. Journal of Physiology 451, 347-363.
48. WINN, H. R., RUBIO, R. & BERNE, R. M. (1981). Brain adenosine concentration during hypoxia in rats. American Journal of Physiology 241, 235-242.
49. VON EULER, C. (1980). Central pattern generation during breathing. Trends in Neurosciences 3, 275-277.