Structural and biochemical insights into the dicing mechanism of mouse Dicer: A conserved lysine is critical for dsRNA cleavage

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 7, 2008, Pages 2391-2396

  Du, Zhihua ^a   Lee, John K ^b   Tjhen, Richard ^a,b   Stroud, Robert M ^a,b   James, Thomas L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

dsRNA processing; RNA interference; RNase III; X ray crystallography

Indexed keywords

DICER; DOUBLE STRANDED RNA; LYSINE; RIBONUCLEASE III;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; ENZYMATIC ASSAY; ENZYME STRUCTURE; PRIORITY JOURNAL; PROTEIN DOMAIN; RNA CLEAVAGE; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); GIARDIA;

AMINO ACID SEQUENCE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; LYSINE; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RIBONUCLEASE III; RNA, DOUBLE-STRANDED; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 40649086065     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0711506105     Document Type: Article

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