Combating oxidative stress in epilepsy: Design, synthesis, quantum chemical studies and anticonvulsant evaluation of 1-(substituted benzylidene/ethylidene) -4-(naphthalen-1-yl)semicarbazides

European Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2010, Pages 2817-2826

  Azam, Faizul ^a   El Gnidi, Bashir A ^a   Alkskas, Ismail A ^a  

^a Misurata University   (Libyan Arab Jamahiriya)

Author keywords

Epilepsy; Neuroprotection; Oxidative stress; Semicarbazides

Indexed keywords

2 (2' CHLOROBENZYLIDENE) N (NAPHTHALEN 1 YL)HYDRAZINECARBOXAMIDE; 2 (2' HYDROXYBENZYLIDENE) N (NAPHTHALEN 1 YL)HYDRAZINECARBOXAMIDE; 2 (2',4' DICHLOROBENZYLIDENE) N (NAPHTHALEN 1 YL)HYDRAZINECARBOXAMIDE; 2 (2',5' DIMETHOXYBENZYLIDENE) N (NAPHTHALEN 1 YL)HYDRAZINECARBOXAMIDE; 2 (3' METHOXYBENZYLIDENE) N (NAPHTHALEN 1 YL)HYDRAZINECARBOXAMIDE; 2 (3',4' DIMETHOXYBENZYLIDENE) N (NAPHTHALEN 1 YL)HYDRAZINECARBOXAMIDE; 2 (4 HYDROXY 3 METHOXYBENZYLIDENE) N (NAPHTHALEN 1 YL) HYDRAZINECARBOXAMIDE; 2 (4' BROMOBENZYLIDENE) N (NAPHTHALEN 1 YL)HYDRAZINECARBOXAMIDE; 2 (4' CHLOROBENZYLIDENE) N (NAPHTHALEN 1 YL)HYDRAZINECARBOXAMIDE; 2 (4' FLUOROBENZYLIDENE) N (NAPHTHALEN 1 YL)HYDRAZINECARBOXAMIDE; 2 (4' HYDROXYBENZYLIDENE) N (NAPHTHALEN 1 YL)HYDRAZINECARBOXAMIDE; 2 (4' METHOXYBENZYLIDENE) N (NAPHTHALEN 1 YL)HYDRAZINECARBOXAMIDE; 2 [1' (2'',4'' DICHLOROPHENYL)ETHYLIDENE) N (NAPHTHALEN 1 YL)HYDRAZINECARBOXAMIDE; 2 [1' (4'' CHLOROPHENYL)ETHYLIDENE] N (NAPHTHALEN 1 YL)HYDRAZINECARBOXAMIDE; 2 [4 (DIMETHYLAMINO)BENZYLIDENE] N (NAPHTHALEN 1 YL)HYDRAZINECARBOXAMIDE; 2 BENZYLIDENE N (NAPHTHALEN 1 YL)HYDRAZINECARBOXAMIDE; ANTICONVULSIVE AGENT; ANTIOXIDANT; CARBAMAZEPINE; ETHOSUXIMIDE; GLUTATHIONE; N (NAPHTHALEN 1 YL) 2 (1 4 TOLYLETHYLIDENE)HYDRAZINECARBOXAMIDE; N (NAPHTHALEN 1 YL) 2 (1 PHENYLETHYLIDENE)HYDRAZINECARBOXAMIDE; N (NAPHTHALEN 1 YL) 2 (2' NITROBENZYLIDENE)HYDRAZINECARBOXAMIDE; N (NAPHTHALEN 1 YL) 2 (3',4',5' TRIMETHOXYBENZYLIDENE)HYDRAZINECARBOXAMIDE; N (NAPHTHALEN 1 YL) 2 (4' NITROBENZYLIDENE)HYDRAZINECARBOXAMIDE; PHENYTOIN; SEMICARBAZIDE DERIVATIVE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EPILEPSY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; QUANTUM CHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICONVULSANTS; ANTIOXIDANTS; BENZYLIDENE COMPOUNDS; DRUG DESIGN; ELECTRONS; EPILEPSY; MALE; MICE; OXIDATIVE STRESS; QUANTUM THEORY; SEMICARBAZIDES;

EID: 77954349602     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.063     Document Type: Article

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