Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A2B receptor antagonists

European Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2010, Pages 2884-2892

  Nieto, Mara Isabel ^b   Balo, Mara Carmen ^a   Brea, Jos ^a   Caamao, Olga ^a   Fernndez, Franco ^a   Garca Mera, Xerardo ^a   Lpez, Carmen ^a   Loza, Mara Isabel ^a   Rodrguez Borges, Jos Enrique ^c   Vidal, Bernat ^d  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIVERSITY OF A CORUÑA   (Spain)

^c UNIVERSITY OF PORTO   (Portugal)

^d Laboratorios Almirall SA ^*  (Spain)

Author keywords

A 1, A2A, A2B, and A3 binding affinities; Adenosine receptor antagonist; Substituted 9 deazaxanthines; Synthesis

Indexed keywords

2 [4 (1,5 DIMETHYL 2,4 DIOXO 3 PROPYL 2,3,4,5 TETRAHYDRO 1H PYRROLO[3,2 D]PYRIMIDIN 6 YL)PHENYLOXY] N (4 FLUOROPHENYL)ACETAMIDE; 2 [4 (2,4 DIOXO 1 PROPYL 2,3,4,5 TETRAHYDRO 1H PYRROLO[3,2 D]PYRIMIDIN 6 YL)PHENYLOXY] N (4 BROMOPHENYL)ACETAMIDE; 2 [4 (2,4 DIOXO 1 PROPYL 2,3,4,5 TETRAHYDRO 1H PYRROLO[3,2 D]PYRIMIDIN 6 YL)PHENYLOXY] N (4 FLUOROPHENYL)]ACETAMIDE; 2 [4 (2,4 DIOXO 1 PROPYL 2,3,4,5 TETRAHYDRO 1H PYRROLO[3,2 D]PYRIMIDIN 6 YL)PHENYLOXY] N PHENYL]ACETAMIDE; 2 [4 (2,4 DIOXO 3 PROPYL 2,3,4,5 TETRAHYDRO 1H PYRROLO[3,2 D]PYRIMIDIN 6 YL)PHENYLOXY] N (4 BROMOPHENYL)]ACETAMIDE; 2 [4 (2,4 DIOXO 3 PROPYL 2,3,4,5 TETRAHYDRO 1H PYRROLO[3,2 D]PYRIMIDIN 6 YL)PHENYLOXY] N (4 FLUOROPHENYL)]ACETAMIDE; 2 [4 (5 METHYL 2,4 DIOXO 1,3 DIPROPYL 2,3,4,5 TETRAHYDRO 1H PYRROLO[3,2 D]PYRIMIDIN 6 YL)PHENYLOXY] N (4 FLUOROPHENYL)ACETAMIDE; 6 [4 (1,2,3,4 TETRAHYDROISOQUINOLIN 2 YL)CARBONYLMETHOXYPHENYL] 1 PROPYL 1,5 DIHYDRO 3H PYRROLO[3,2 D]PYRIMIDINE 2,4 DIONE; 6 [4 (1,2,3,4 TETRAYIDROISOQUINOLIN 2 YL)]CARBONYLMETHOXYPHENYL] 5 METHYL 1,3 DIPROPYL 1,5 DIHYDRO 3H PYRROLO[3,2 D]PYRIMIDINE 2,4 DIONE; 6 [4 (4 PHENYLPIPERAZIN 1 YL)CARBONYLMETHOXYPHENYL] 1 PROPYL 1,5 DIHYDRO 3H PIRROLO[3,2 D]PYRIMIDINE 2,4 DIONE; 6 [4 (4 PHENYLPIPERAZIN 1 YL)CARBONYLMETHOXYPHENYL] 5 METHYL 1,3 DIPROPYL 1,5 DIHYDRO 3H PYRROLO[3,2 D]PYRIMIDINE 2,4 DIONE; 6 [4 [3 (4 BROMOPHENYL) [1,2,4]OXADIAZOL 5 YL] (2-METHOXY)CARBONYLMETHOXYPHENYL] 1,3 DIMETHYL 1,5 DIHYDRO 3H PYRROLO[3,2-D]PYRIMIDINE 2,4 DIONE; 6 [4 [3 (4 BROMOPHENYL) [1,2,4]OXADIAZOL 5 YL]CARBONYLMETHOXYPHENYL] 3 PROPYL 1,5 DIHYDRO 3H PYRROLO[3,2 D]PYRIMIDINE 2,4 DIONE; ADENOSINE A2B RECEPTOR; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HELA CELLS; HUMANS; LIGANDS; RECEPTOR, ADENOSINE A2B; XANTHINES;

EID: 77954314994     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.03.011     Document Type: Article

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