Synthesis and pharmacological evaluation of novel 1- and 8-substituted-3-furfuryl xanthines as adenosine receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 18, 2009, Pages 6755-6760

  Balo, María Carmen ^a   Brea, José ^a   Caamaño, Olga ^a   Fernández, Franco ^a   García Mera, Xerardo ^a   López, Carmen ^a   Loza, María Isabel ^a   Nieto, María Isabel ^b   Rodríguez Borges, José Enrique ^c  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIVERSITY OF A CORUÑA   (Spain)

^c UNIVERSITY OF PORTO   (Portugal)

Author keywords

3 Furfuryl xanthines; A2B, A2A and A3 Binding affinities; Adenosine receptor antagonist; Synthesis

Indexed keywords

3 FURFURYL 7 METHYLXANTHINE DERIVATIVE; 3 FURFURYL XANTHINE DERIVATIVE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS;

ANIMALS; CELL LINE; HUMANS; PROTEIN BINDING; RATS; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A; RECEPTOR, ADENOSINE A2B; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHINES;

RATTUS;

EID: 69249102126     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.07.034     Document Type: Article

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