1,3-Dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 10, 2009, Pages 3618-3629

  Fernández, Franco ^a   Caamaño, Olga ^a   Isabel Nieto, M ^a   López, Carmen ^a   García Mera, Xerardo ^a   Stefanachi, Angela ^b   Nicolotti, Orazio ^b   Isabel Loza, M ^a   Brea, Jose ^a   Esteve, Cristina ^c   Segarra, Victor ^c   Vidal, Bernat ^c   Carotti, Angelo ^b  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIVERSITY OF BARI   (Italy)

^c Almirall Prodesfarma S A   (Spain)

Author keywords

9 Deazaxanthines; Adenosine receptor antagonists; Adenosine receptors (ARs); Carbamates

Indexed keywords

1,3 DIMETHYL N 3' THIENYL CARBAMATE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; BENZYLOXYCARBONYLAMINO 9 DEAZAXANTHINE DERIVATIVE; LIGAND; PHENOXYACETAMIDO 9 DEAZAXANTHINE DERIVATIVE; RECOMBINANT RECEPTOR; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; CARBAMATES; CELL LINE; DRUG DESIGN; HUMANS; MALE; MODELS, CHEMICAL; RATS; RATS, WISTAR; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A; RECEPTOR, ADENOSINE A2B; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; RECOMBINANT PROTEINS; XANTHINES;

EID: 65349154650     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.03.062     Document Type: Article

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