Cutting edge: Neosynthesis is required for the presentation of a T cell epitope from a long-lived viral protein

Journal of Immunology

Volumn 167, Issue 9, 2001, Pages 4801-4804

  Khan, S ^a   De Giuli, R ^a   Schmidtke, G ^a   Bruns, M ^a   Buchmeier, M ^a   Van den Broek, M ^a   Groettrup, M ^a  

^a CANTONAL HOSPITAL ST GALLEN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; POLYPEPTIDE; PROTEASOME; TETRACYCLINE; VIRUS NUCLEOPROTEIN; VIRUS PROTEIN;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HALF LIFE TIME; NONHUMAN; PRIORITY JOURNAL; RIBOSOME; RNA TRANSLATION; VIRUS MENINGITIS;

EID: 0035500453     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.9.4801     Document Type: Article

References (8)

1. The selective proteasome inhibitors lactacystin and expoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses
2. Defective ribosomal products (DRiPs): A major source of antigenic peptides for MHC class I molecules
3. Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
4. The major substrates for TAP in vivo are derived from newly synthesized proteins
5. Overexpression of the proteasome sub-units LMP2, LMP7, and MECL-1, but not PA28αβ. enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope
6. A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice
7. T cell receptor (TCR) β chain homodimers on the surface of immature but not mature α, γ, δ chain deficient T cell lines
8. T cell-recognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions: A hypothesis