Preparation and NMR characterization of highly substituted N-trimethyl chitosan chloride

Carbohydrate Polymers

Volumn 36, Issue 2-3, 1998, Pages 157-165

  Sieval, A B ^a,d   Thanou, M ^a   Kotze A F ^b   Verhoef, J C ^a   Brussee, J ^c   Junginger, H E ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b NORTH WEST UNIVERSITY   (South Africa)

^c LEIDEN UNIVERSITY   (Netherlands)

^d WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Absorption enhancers; Chitosan; N,N,N Trimethyl chitosan chloride; NMR; Synthesis

Indexed keywords

EID: 0032114947     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0144-8617(98)00009-5     Document Type: Article

References (10)

1. Artursson, P., Lindmark, T., Davis, S.S., & Illum, L. (1994). Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharm. Res., 11, 1358-1361.
2. Borchard, G., Lueßen, H.L., De Boer, A.G., Verhoef, J.C., Lehr, C.-M., & Junginger, H.E. (1996). The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III. Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro. J. Control. Rel., 39, 131-138.
3. Domard, A., Rinaudo, M., & Terrassin, C. (1986). New method for the quaternization of chitosan. Int. J. Biol. Macromol., 8, 105-107.
4. 1H n.m.r. spectroscopy of chitosan and N-trimethyl chloride derivatives. Int. J. Biol. Macromol., 9, 233-237.
5. Illum, L., Farray, N.F., & Davis, S.S. (1994). Chitosan as a novel nasal delivery system for peptide drugs. Pharm. Res., 11, 1186-1189.
6. Le Dung, P., Milas, M., Rinaudo, M., & Desbrières, J. (1994). Water soluble derivatives obtained by controlled chemical modifications of chitosan. Carbohydrate Polymers, 24, 209-214.
7. Lueßen, H.L., De Leeuw, B.J., Langemeijer, M.W.E., De Boer, A.G., Verhoef, J.C., & Junginger, H.E. (1996). Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo. Pharm. Res., 13, 1668-1672.
8. Lueßen, H.L., Rentel, C.-O., Kotzé, A.F., Lehr, C.-M., De Boer, A.G., Verhoef, J.C., & Junginger, H.E. (1997). Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro. J. Control. Rel., 45, 15-23.
9. Muzzarelli, R.A.A., & Tanfani, F. (1985). The N-permethylation of chitosan and the preparation of N-trimethyl chitosan iodide. Carbohydrate Polymers, 5, 297-307.
10. Muzzarelli, R.A.A., Tanfani, F., Emanuelli, M., & Mariotti, S. (1982). N-(Carboxymethylidene)chitosans and N-(carboxymethyl)chitosans: novel chelating polyampholytes obtained from chitosan glyoxylate. Carbohydrate Res., 107, 199-214.