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Volumn 82, Issue 2, 2010, Pages 417-430

Understanding the mechanisms of glutamine action in critically ill patients

Author keywords

Apoptosis; Cytokines; Glutamine; Heat shock protein

Indexed keywords


EID: 77954186450     PISSN: 00013765     EISSN: 16782690     Source Type: Journal    
DOI: 10.1590/s0001-37652010000200018     Document Type: Article
Times cited : (43)

References (81)
  • 1
    • 0029094490 scopus 로고
    • Glucocorticoids regulate rat glutamine synthetase expression in a tissue-specific manner
    • Abcouwer SF, Bode BP and Souba WW. 1995. Glucocorticoids regulate rat glutamine synthetase expression in a tissue-specific manner. J Surg Res 59: 59-65.
    • (1995) J Surg Res , vol.59 , pp. 59-65
    • Abcouwer, S.F.1    Bode, B.P.2    Souba, W.W.3
  • 3
    • 0034113617 scopus 로고    scopus 로고
    • HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine
    • Asea A, Kraeft SK, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, Koo GC and Calderwood SK. 2000. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 6: 435-442.
    • (2000) Nat Med , vol.6 , pp. 435-442
    • Asea, A.1    Kraeft, S.K.2    Kurt-Jones, E.A.3    Stevenson, M.A.4    Chen, L.B.5    Finberg, R.W.6    Koo, G.C.7    Calderwood, S.K.8
  • 4
    • 34347204830 scopus 로고    scopus 로고
    • Effects of glutamine supplementation on gut barrier, glutathione content and acute phase response in malnourished rats during inflammatory shock
    • Belmonte L et al. 2007. Effects of glutamine supplementation on gut barrier, glutathione content and acute phase response in malnourished rats during inflammatory shock. World J Gastroenterol 13: 2833-2840.
    • (2007) World J Gastroenterol , vol.13 , pp. 2833-2840
    • Belmonte, L.1
  • 7
    • 0023187249 scopus 로고
    • Gut-liver interaction in glutamine homeostasis: Portal ammonia role in uptake and metabolism
    • Buttrose M, McKellar D and Welbourne TC. 1987. Gut-liver interaction in glutamine homeostasis: portal ammonia role in uptake and metabolism. Am J Physiol 252: E746-750.
    • (1987) Am J Physiol , vol.252
    • Buttrose, M.1    McKellar, D.2    Welbourne, T.C.3
  • 8
    • 0344012568 scopus 로고    scopus 로고
    • Stress-induced Extracellular HSP72 is A Functionally Significant Danger Signal to The Immune System
    • Campisi J, Leem TH and Fleshner M. 2003. Stress-induced extracellular HSP72 is a functionally significant danger signal to the immune system. Cell Stress chaperones 8: 272-286.
    • (2003) Cell Stress Chaperones , vol.8 , pp. 272-286
    • Campisi, J.1    Leem, T.H.2    Fleshner, M.3
  • 9
    • 0033970533 scopus 로고    scopus 로고
    • Dual specificity phosphatases: A gene family for control of MAP kinase function
    • Camps M, Nichols A and Arkinstall S. 2000. Dual specificity phosphatases: a gene family for control of MAP kinase function. FASEB J 14: 6-16.
    • (2000) FASEB J , vol.14 , pp. 6-16
    • Camps, M.1    Nichols, A.2    Arkinstall, S.3
  • 10
    • 0032793662 scopus 로고    scopus 로고
    • Lymphocyte proliferation modulated by glutamine: Involved in the endogenous redox reaction
    • Chang WK, Yang KD and Shaio MF. 1999. Lymphocyte proliferation modulated by glutamine: involved in the endogenous redox reaction. Clin Exp Immunol 117: 482-488.
    • (1999) Clin Exp Immunol , vol.117 , pp. 482-488
    • Chang, W.K.1    Yang, K.D.2    Shaio, M.F.3
  • 11
    • 0036051315 scopus 로고    scopus 로고
    • Glutamine Protects Activated Human T Cells From Apoptosis By Up-regulating Glutathione and Bcl-2 Levels
    • Chang WK, Yang Kd, Chuang H, Jan JT and Shaio MF. 2002. Glutamine protects activated human T cells from apoptosis by up-regulating glutathione and Bcl-2 levels. Clin Immunol 104: 151-160.
    • (2002) Clin Immunol , vol.104 , pp. 151-160
    • Chang, W.K.1    Kd, Y.2    Chuang, H.3    Jan, J.T.4    Shaio, M.F.5
  • 13
    • 33644599450 scopus 로고    scopus 로고
    • L-alanyl-L-glutamine dipep-tide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: The French controlled, randomized, double-blind, multicenter study
    • Déchelotte P et al. 2006. L-alanyl-L-glutamine dipep-tide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter study. Crit Care Med 34: 598-604.
    • (2006) Crit Care Med , vol.34 , pp. 598-604
    • Déchelotte, P.1
  • 14
    • 0037713612 scopus 로고    scopus 로고
    • Effects of glutamine on intestinal permeability and bacterial translocation in TPN-rats with endotoxemia
    • Ding LA and Li JS. 2003. Effects of glutamine on intestinal permeability and bacterial translocation in TPN-rats with endotoxemia. World J Gastroenterol 9: 1327-1332.
    • (2003) World J Gastroenterol , vol.9 , pp. 1327-1332
    • Ding, L.A.1    Li, J.S.2
  • 15
    • 12544252469 scopus 로고    scopus 로고
    • The effect of preventive use of alanyl-glutamine on diaphragm muscle function in cecal ligation and puncture-induced sepsis model
    • DorukN, Buyukakilli B, Atici S, Cinel L, Tamer L, Avlan D, Bilgin E and Oral U. 2005. The effect of preventive use of alanyl-glutamine on diaphragm muscle function in cecal ligation and puncture-induced sepsis model. JPEN J Parenter Enteral Nutr 29: 36-43.
    • (2005) JPEN J Parenter Enteral Nutr , vol.29 , pp. 36-43
    • Doruk, N.1    Buyukakilli, B.2    Atici, S.3    Cinel, L.4    Tamer, L.5    Avlan, D.6    Bilgin, E.7    Oral, U.8
  • 16
    • 0032527412 scopus 로고    scopus 로고
    • Sepsis increases lung glutamine synthetase expression in the tumor-bearing host
    • Elgadi KM, Labow BI, Abcouwer SF and Souba WW. 1998. Sepsis increases lung glutamine synthetase expression in the tumor-bearing host. J Surg Res 78: 1822.
    • (1998) J Surg Res , vol.78 , pp. 1822
    • Elgadi, K.M.1    Labow, B.I.2    Abcouwer, S.F.3    Souba, W.W.4
  • 17
    • 32044470243 scopus 로고    scopus 로고
    • Reduced stress tolerance of glutamine-deprived human monocytic cells is associated with selective down-regulation of HSP 70 byde-creased mRNA stability
    • Eliasen MM, Brabec M, Gerner C, Pollheimer J, Auer H, Zellner M, Weingartmann G, Garo F, Roth E and Oehler R. 2006. Reduced stress tolerance of glutamine-deprived human monocytic cells is associated with selective down-regulation of HSP 70 byde-creased mRNA stability. J Mol Med 84: 147-158.
    • (2006) J Mol Med , vol.84 , pp. 147-158
    • Eliasen, M.M.1    Brabec, M.2    Gerner, C.3    Pollheimer, J.4    Auer, H.5    Zellner, M.6    Weingartmann, G.7    Garo, F.8    Roth, E.9    Oehler, R.10
  • 18
    • 45749135445 scopus 로고    scopus 로고
    • Efficacy of parenteral nutrition supplemented with glutamine dipeptide to decrease hospital infectious in critically ill surgical patients
    • Estívariz CF et al. 2008. Efficacy of parenteral nutrition supplemented with glutamine dipeptide to decrease hospital infectious in critically ill surgical patients. JPEN J Parenter Enteral Nutr 32: 389-402.
    • (2008) JPEN J Parenter Enteral Nutr , vol.32 , pp. 389-402
    • Estívariz, C.F.1
  • 19
    • 3042636977 scopus 로고    scopus 로고
    • Cat exposure induces both intra- and extra-cellular HSP72: The role of adrenal hormones
    • Fleshner M, Campisi J, Amiri L and Diamond DM. 2004. Cat exposure induces both intra- and extra-cellular HSP72: the role of adrenal hormones. Psychoneuroen-docrinology 29: 1142-1152.
    • (2004) Psychoneuroen-docrinology , vol.29 , pp. 1142-1152
    • Fleshner, M.1    Campisi, J.2    Amiri, L.3    Diamond, D.M.4
  • 21
    • 0029863077 scopus 로고    scopus 로고
    • A descriptive study of skeletal muscle metabolism in critically ill patients: Free amino acids, energy-rich phosphates, protein, nucleic acids, fat, ater, and electrolytes
    • Gamrin L, Essén P, Forsberg AM, Hultman E and Wernerman J. 1996. A descriptive study of skeletal muscle metabolism in critically ill patients: free amino acids, energy-rich phosphates, protein, nucleic acids, fat, ater, and electrolytes. Crit Care ed 24: 575-583.
    • (1996) Crit Care Ed , vol.24 , pp. 575-583
    • Gamrin, L.1    Essén, P.2    Forsberg, A.M.3    Hultman, E.4    Wernerman, J.5
  • 23
    • 0142088783 scopus 로고    scopus 로고
    • Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: A prospective, controlled, randomized clinical trial
    • Garrel D, Patenaude J, Nedelec B, Samson L, Dorais J, Champoux J, D'Elia M and Bernier J. 2003. Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: a prospective, controlled, randomized clinical trial. Crit Care Med 31: 2444-2449.
    • (2003) Crit Care Med , vol.31 , pp. 2444-2449
    • Garrel, D.1    Patenaude, J.2    Nedelec, B.3    Samson, L.4    Dorais, J.5    Champoux, J.6    D'Elia, M.7    Bernier, J.8
  • 24
    • 0036743765 scopus 로고    scopus 로고
    • Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients
    • Goeters C, Wenn A, Mertes N, Wempe C, Van AH, Stehle P and Bone HG. 2002. Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients. Crit Care Med 30: 2032-2037.
    • (2002) Crit Care Med , vol.30 , pp. 2032-2037
    • Goeters, C.1    Wenn, A.2    Mertes, N.3    Wempe, C.4    Van, A.H.5    Stehle, P.6    Bone, H.G.7
  • 25
    • 0030904577 scopus 로고    scopus 로고
    • Six-month of critically ill patients given glutamine-supplemented parenteral nutrition
    • Griffiths RD, Jones C and Palmer TE. 1997. Six-month of critically ill patients given glutamine-supplemented parenteral nutrition. Nutrition 13: 295-302.
    • (1997) Nutrition , vol.13 , pp. 295-302
    • Griffiths, R.D.1    Jones, C.2    Palmer, T.E.3
  • 26
    • 44949112466 scopus 로고    scopus 로고
    • Glutamine supplementation for young infants with severe gastrointestinal disease
    • CD005947
    • Grover Z, Tubman R and McGuire W. 2007. Glutamine supplementation for young infants with severe gastrointestinal disease. Cochrane Database Syst Rev 24: CD005947.
    • (2007) Cochrane Database Syst Rev , vol.24
    • Grover, Z.1    Tubman, R.2    McGuire, W.3
  • 28
    • 0042279261 scopus 로고    scopus 로고
    • Canadian Critical Care Clinical Practice Guidelines Committee. Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients
    • Heyland DK, Dhaliwal R, Drover JW, Gramlich L and Dodek P. 2003. Canadian Critical Care Clinical Practice Guidelines Committee. Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. JPEN J Parenter Enteral Nutr 27: 355-373.
    • (2003) JPEN J Parenter Enteral Nutr , vol.27 , pp. 355-373
    • Heyland, D.K.1    Dhaliwal, R.2    Drover, J.W.3    Gramlich, L.4    Dodek, P.5
  • 29
    • 33847302517 scopus 로고    scopus 로고
    • Canadian Critical Care Trials Group. Reducing deaths due to oxidative stress (The REDOXS Study): Rationale and study design for a randomized trial of glutamine and antioxidant supplementation in critically-ill patients
    • Heyland DK, Dhaliwal R, Day AG, Muscedere J, Drover J, Suchner U and Cook D. 2006. Canadian Critical Care Trials Group. Reducing deaths due to oxidative stress (The REDOXS Study): Rationale and study design for a randomized trial of glutamine and antioxidant supplementation in critically-ill patients. Proc Nutr Soc 65: 250-263.
    • (2006) Proc Nutr Soc , vol.65 , pp. 250-263
    • Heyland, D.K.1    Dhaliwal, R.2    Day, A.G.3    Muscedere, J.4    Drover, J.5    Suchner, U.6    Cook, D.7
  • 30
    • 0035197692 scopus 로고    scopus 로고
    • Insights into regulation and function of the major stress-induced hsp70 molecular chaperone in vivo: Analysis of mice with targeted gene disruption of the hsp70.1 or hsp-70.3
    • Huang L, Mivechi NF and Moskophidis D. 2001. Insights into regulation and function of the major stress-induced hsp70 molecular chaperone in vivo: analysis of mice with targeted gene disruption of the hsp70.1 or hsp-70.3. Mol Cell Biol 21: 8575-8591.
    • (2001) Mol Cell Biol , vol.21 , pp. 8575-8591
    • Huang, L.1    Mivechi, N.F.2    Moskophidis, D.3
  • 32
    • 33846054470 scopus 로고    scopus 로고
    • Enteral glutamine supplementation in critically ill patients with burn injuries: A retrospective case-control evaluation
    • Juang P, Fish DN, Jung R and MacLaren R. 2007. Enteral glutamine supplementation in critically ill patients with burn injuries: a retrospective case-control evaluation. Pharmacotherapy 27: 11-19.
    • (2007) Pharmacotherapy , vol.27 , pp. 11-19
    • Juang, P.1    Fish, D.N.2    Jung, R.3    Maclaren, R.4
  • 33
    • 0034855897 scopus 로고    scopus 로고
    • Glutamine metabolism in sepsis and infection
    • Karinch AM, Pan M, Lin CM, Strange R and Souba WW. 2001. Glutamine metabolism in sepsis and infection. J Nutr 131(Suppl 9): 2535S-2538S.
    • (2001) J Nutr , vol.131 , Issue.SUPPL. 9
    • Karinch, A.M.1    Pan, M.2    Lin, C.M.3    Strange, R.4    Souba, W.W.5
  • 34
    • 0035937134 scopus 로고    scopus 로고
    • Glutamine-dependent antiapoptotic interaction of human glutaminyl-t RNA synthetase with apoptosis signal-regulating kinase 1
    • Ko YG, Kim EY, Kim T, Park H, Park HS, Choi EJ and Kim S. 2001. Glutamine-dependent antiapoptotic interaction of human glutaminyl-t RNA synthetase with apoptosis signal-regulating kinase 1. J Biol Chem 276: 6030-6036.
    • (2001) J Biol Chem , vol.276 , pp. 6030-6036
    • Ko, Y.G.1    Kim, E.Y.2    Kim, T.3    Park, H.4    Park, H.S.5    Choi, E.J.6    Kim, S.7
  • 35
    • 33645819422 scopus 로고    scopus 로고
    • German Society for Nutritional Medicine and European Society for Parenteral and Enteral Nutrition. ESPEN Guidelines on Enteral Nutrition: Intensive care
    • Kreymann KG. 2006. German Society for Nutritional Medicine and European Society for Parenteral and Enteral Nutrition. ESPEN Guidelines on Enteral Nutrition: Intensive care. Clin Nutr 25: 210-223.
    • (2006) Clin Nutr , vol.25 , pp. 210-223
    • Kreymann, K.G.1
  • 36
    • 0031765621 scopus 로고    scopus 로고
    • Glutamine synthetase expression in the rat lung is regulated by protein stability
    • Labow BI, Abcouwer SF, Lin CM and Souba WW. 1998. Glutamine synthetase expression in the rat lung is regulated by protein stability. Am J Physiol 275: l877-1886.
    • (1998) Am J Physiol , vol.275
    • Labow, B.I.1    Abcouwer, S.F.2    Lin, C.M.3    Souba, W.W.4
  • 37
    • 0033067563 scopus 로고    scopus 로고
    • Glutamine synthetase expression in muscle is regulated by transcriptional and posttranscriptional mechanisms
    • Labow BI, Souba WW and Abcouver SF. 1999. Glutamine synthetase expression in muscle is regulated by transcriptional and posttranscriptional mechanisms. Am J Physiol276: 1136-1145.
    • (1999) Am J Physiol , vol.276 , pp. 1136-1145
    • Labow, B.I.1    Souba, W.W.2    Abcouver, S.F.3
  • 38
    • 0034847451 scopus 로고    scopus 로고
    • Mechanisms governing the expression of the enzymes of glutamine metabolism - Glutaminase and Glutaminase Synthetase
    • Labow BI, Souba WW and Abcouwer SF. 2001. Mechanisms governing the expression of the enzymes of glutamine metabolism - Glutaminase and Glutaminase Syn-thetase. J Nutr 131: 2467S-2474S.
    • (2001) J Nutr , vol.131
    • Labow, B.I.1    Souba, W.W.2    Abcouwer, S.F.3
  • 39
    • 33744938146 scopus 로고    scopus 로고
    • Effect of severe short-term malnutrition on diaphragm muscle signal transduction pathways influencing protein turnover
    • Lewis MI, Bodine SC, Kamagar N, Xu X, Da X and Fournier M. 2006. Effect of severe short-term malnutrition on diaphragm muscle signal transduction pathways influencing protein turnover. J Appl Physiol 100: 1799-1806.
    • (2006) J Appl Physiol , vol.100 , pp. 1799-1806
    • Lewis, M.I.1    Bodine, S.C.2    Kamagar, N.3    Xu, X.4    Da, X.5    Fournier, M.6
  • 42
    • 0023029455 scopus 로고
    • Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages
    • Newsholme P, Curi R, Gordon S and Newsholme EA. 1986. Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages. Biochem J 239: 121-125.
    • (1986) Biochem J , vol.239 , pp. 121-125
    • Newsholme, P.1    Curi, R.2    Gordon, S.3    Newsholme, E.A.4
  • 43
    • 0036742213 scopus 로고    scopus 로고
    • Glutamine supplementation in serious illness: A systematic review of the evidence
    • Novak F, Heyland DK, Avenell A, Drover JW and Su X. 2002. Glutamine supplementation in serious illness: a systematic review of the evidence. Crit Care Med 30: 2022-2029.
    • (2002) Crit Care Med , vol.30 , pp. 2022-2029
    • Novak, F.1    Heyland, D.K.2    Avenell, A.3    Drover, J.W.4    Su, X.5
  • 44
    • 2342530363 scopus 로고    scopus 로고
    • Oxidation of glucose, glutamate, and glutamine by isolated ovine enterocytes in vitro is decreased by the presence of other metabolic fuels
    • Oba M, Baldwin RL and Bequette B J. 2004. Oxidation of glucose, glutamate, and glutamine by isolated ovine enterocytes in vitro is decreased by the presence of other metabolic fuels. J Anim Sci 82: 479-486.
    • (2004) J Anim Sci , vol.82 , pp. 479-486
    • Oba, M.1    Baldwin, R.L.2    Bequette, B.J.3
  • 47
    • 34547899107 scopus 로고    scopus 로고
    • Parenteral versus enteral nutrition: Effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis
    • O'LearyMJ, XueA, Scarlett CJ, Sevette A, Kee AJ and Smith RC. 2007. Parenteral versus enteral nutrition: effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis. Crit Care 11: R79.
    • (2007) Crit Care , vol.11
    • O'Leary, M.J.1    Xue, A.2    Scarlett, C.J.3    Sevette, A.4    Kee, A.J.5    Smith, R.C.6
  • 49
    • 0025150173 scopus 로고
    • Does glutamine contribute to immunosuppression after major burns?
    • Parry-Billings M, Evans J, Calder PC and New-sholme EA. 1990. Does glutamine contribute to immunosuppression after major burns? Lancet 336: 523-25.
    • (1990) Lancet , vol.336 , pp. 523-525
    • Parry-Billings, M.1    Evans, J.2    Calder, P.C.3    New-Sholme, E.A.4
  • 50
    • 33947310361 scopus 로고    scopus 로고
    • Glutamine attenuation of cell death and inducible nitric oxide synthase expression following inflammatory cytokine-induced injury is dependent on heat shock factor-1 expression
    • Peng ZY, Hamiel CR, Banerjee A, Wischmeyer PE, Friese RS and Wischmeyer P. 2006. Glutamine attenuation of cell death and inducible nitric oxide synthase expression following inflammatory cytokine-induced injury is dependent on heat shock factor-1 expression. JPEN J Parenter Enteral Nutr 30: 400-406.
    • (2006) JPEN J Parenter Enteral Nutr , vol.30 , pp. 400-406
    • Peng, Z.Y.1    Hamiel, C.R.2    Banerjee, A.3    Wischmeyer, P.E.4    Friese, R.S.5    Wischmeyer, P.6
  • 51
    • 61449086443 scopus 로고    scopus 로고
    • Has mortality from acute respiratory distress syndrome decreased over time? A systematic review
    • PHUA J ET AL. 2009. Has mortality from acute respiratory distress syndrome decreased over time? A systematic review. Am J Respir Crit Care Med 179: 220-227.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 220-227
    • Phua, J.1
  • 52
    • 17744372861 scopus 로고    scopus 로고
    • Roles of the heat shock transcription factors in regulation of the heat shock response and beyond
    • PIRKKALA L, NYKANEN P AND SlSTONEN L. 2001. Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J 15: 1118-1131.
    • (2001) FASEB J , vol.15 , pp. 1118-1131
    • Pirkkala, L.1    Nykanen, P.2    Slstonen, L.3
  • 54
    • 22344449778 scopus 로고    scopus 로고
    • Anti-apoptotic effects of L-Gluta-mine-mediated transcriptional modulation of the heat shock protein 72 during heat shock
    • ROPELESKI MJ, RIEHM J, BAER KA, MUSCH Mw AND CHANG EB. 2005. Anti-apoptotic effects of L-Gluta-mine-mediated transcriptional modulation of the heat shock protein 72 during heat shock. Gastroenterology 129: 170-184.
    • (2005) Gastroenterology , vol.129 , pp. 170-184
    • Ropeleski, M.J.1    Riehm, J.2    Baer, K.A.3    Musch, M.W.4    Chang, E.B.5
  • 55
    • 0001956935 scopus 로고
    • Metabolic Disorders in Severe Abdominal Sepsis: Glutamine Deficiency In Skeletal Muscle
    • ROTH E, FUNOVICS J, MUHLBACHER F, SCHEMPER M, MAURITZ W AND FRITSCH A. 1982. Metabolic disorders in severe abdominal sepsis: Glutamine deficiency in skeletal muscle. Clin Nutr 1: 25-41.
    • (1982) Clin Nutr , vol.1 , pp. 25-41
    • Roth, E.1    Funovics, J.2    Muhlbacher, F.3    Schemper, M.4    Mauritz, W.5    Fritsch, A.6
  • 57
    • 60449083715 scopus 로고    scopus 로고
    • Glutamine Increases Autophagy Under Basal and Stressed Conditions in Intestinal Epithelial Cells
    • SAKIYAMA T, MUSCH MW, ROPELESKI MJ, TSUBOUCHI H AND CHANG EB. 2009. Glutamine increases autophagy under Basal and stressed conditions in intestinal epithelial cells. Gastroenterology 136: 924-932.
    • (2009) Gastroenterology , vol.136 , pp. 924-932
    • Sakiyama, T.1    Musch, M.W.2    Ropeleski, M.J.3    Tsubouchi, H.4    Chang, E.B.5
  • 58
    • 27944473920 scopus 로고    scopus 로고
    • Does the addition of glutamine to enteral feeds affect patient mortality?
    • SCHULMAN AS ET AL. 2005. Does the addition of glutamine to enteral feeds affect patient mortality? Crit Care Med 33: 2501-2506.
    • (2005) Crit Care Med , vol.33 , pp. 2501-2506
    • Schulman, A.S.1
  • 59
    • 33645567963 scopus 로고    scopus 로고
    • Does enteral glutamine supplementation decrease infectious morbidity?
    • SCHULMAN AS ET AL. 2006. Does enteral glutamine supplementation decrease infectious morbidity? Surg Infect (Larchmt) 7: 29-35.
    • (2006) Surg Infect (Larchmt) , vol.7 , pp. 29-35
    • Schulman, A.S.1
  • 60
    • 34248184997 scopus 로고    scopus 로고
    • Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression
    • Singleton KD and Wischmeyer PE. 2007. Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression. Am J Physiol Regul Integr Comp Physiol 292: R1839-1845.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.292
    • Singleton, K.D.1    Wischmeyer, P.E.2
  • 61
    • 45749100074 scopus 로고    scopus 로고
    • Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1
    • SINGLETON KD AND WISCHMEYER PE. 2008. Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1. JPEN J Parenter Enteral Nutr 32: 371-376.
    • (2008) JPEN J Parenter Enteral Nutr , vol.32 , pp. 371-376
    • Singleton, K.D.1    Wischmeyer, P.E.2
  • 62
    • 33646788790 scopus 로고    scopus 로고
    • Glutamine Prevents Activation of NF-kB and Stress Kinase Pathways, Attenuates Inflammatory Cytokine Release, and Prevents Acute Respiratory Distress Syndrome (ARDS) Following Sepsis
    • SINGLETON KD, BECKEY VE AND WISCHMEYER PE. 2005a. Glutamine prevents activation of NF-kB and stress kinase pathways, attenuates inflammatory cytokine release, and prevents acute respiratory distress syndrome (ARDS) following sepsis. Shock 24: 583-589.
    • (2005) Shock , vol.24 , pp. 583-589
    • Singleton, K.D.1    Beckey, V.E.2    Wischmeyer, P.E.3
  • 63
    • 20444463157 scopus 로고    scopus 로고
    • Glutamine attenuates lung injury and improves survival after sepsis: Role of enhanced heat shock protein expression
    • Singleton KD, Serkova N, Beckey VE and Wisch-meyer PE. 2005b. Glutamine attenuates lung injury and improves survival after sepsis: Role of enhanced heat shock protein expression. Crit Care Med 33: 1206-1213.
    • (2005) Crit Care Med , vol.33 , pp. 1206-1213
    • Singleton, K.D.1    Serkova, N.2    Beckey, V.E.3    Wisch-Meyer, P.E.4
  • 64
    • 13844266470 scopus 로고    scopus 로고
    • Glutamine attenuates endotoxin-induced lung metabolic dysfunction: Potential role of enhanced heat shock protein 70
    • Singleton KD, Serkova N, Banerjee A, Meng x, Gamboni-Robertson F and Wischmeyer PE. 2005c. Glutamine attenuates endotoxin-induced lung metabolic dysfunction: potential role of enhanced heat shock protein 70. Nutrition 21: 214-223.
    • (2005) Nutrition , vol.21 , pp. 214-223
    • Singleton, K.D.1    Serkova, N.2    Banerjee, A.3    Meng, X.4    Gamboni-Robertson, F.5    Wischmeyer, P.E.6
  • 65
    • 34249784854 scopus 로고    scopus 로고
    • Glutamine recombinant human growth hormone protects intestinal barrier function following portal hypertension surgery
    • Tang ZF, Ling YB, Lin N, Hao Z and Xu RY. 2007. Glutamine recombinant human growth hormone protects intestinal barrier function following portal hypertension surgery. World J Gastroenterol 13: 2223-2228.
    • (2007) World J Gastroenterol , vol.13 , pp. 2223-2228
    • Tang, Z.F.1    Ling, Y.B.2    Lin, N.3    Hao, Z.4    Xu, R.Y.5
  • 66
    • 0033801925 scopus 로고    scopus 로고
    • Early signs of critical illness polyneuropathy in ICU patients with systemic inflammatory response syndrome or sepsis
    • Tennila A, Salmi T, Pettila V, Roine RO, Varpula T and Takkunen O. 2000. Early signs of critical illness polyneuropathy in ICU patients with systemic inflammatory response syndrome or sepsis. Intensive Care Med 26: 1360-1363.
    • (2000) Intensive Care Med , vol.26 , pp. 1360-1363
    • Tennila, A.1    Salmi, T.2    Pettila, V.3    Roine, R.O.4    Varpula, T.5    Takkunen, O.6
  • 68
    • 84861921812 scopus 로고    scopus 로고
    • Glutamine supplementation to prevent morbidity and mortality in preterm infants
    • CD001457
    • Tubman TR, Thompson SW and McGuire W. 2005. Glutamine supplementation to prevent morbidity and mortality in preterm infants. Cochrane Database Syst Rev 25: CD001457.
    • (2005) Cochrane Database Syst Rev , vol.25
    • Tubman, T.R.1    Thompson, S.W.2    McGuire, W.3
  • 70
    • 0036900821 scopus 로고    scopus 로고
    • Longitudinal pattern of glutamine/glutamate balance across the leg in long-stay intensive care unit patients
    • Vesali RF, Klaude M, Rooyackers OE, Tjader I, Barle H and Wernerman J. 2002. Longitudinal pattern of glutamine/glutamate balance across the leg in long-stay intensive care unit patients. Clin Nutr 21: 505-514.
    • (2002) Clin Nutr , vol.21 , pp. 505-514
    • Vesali, R.F.1    Klaude, M.2    Rooyackers, O.E.3    Tjader, I.4    Barle, H.5    Wernerman, J.6
  • 71
    • 34548292474 scopus 로고    scopus 로고
    • Enhanced heat shock protein 70 expression alters proteasomal degradation of IkappaB kinase in experimental acute respiratory distress syndrome
    • Weiss YG, Bromberg Z, Raj N, Raphael J, Goloubinoff P, Ben-Neriah Y and Deustchman CS. 2007. Enhanced heat shock protein 70 expression alters proteasomal degradation of IkappaB kinase in experimental acute respiratory distress syndrome. Crit Care Med 35: 2128-2138.
    • (2007) Crit Care Med , vol.35 , pp. 2128-2138
    • Weiss, Y.G.1    Bromberg, Z.2    Raj, N.3    Raphael, J.4    Goloubinoff, P.5    Ben-Neriah, Y.6    Deustchman, C.S.7
  • 72
    • 0032731856 scopus 로고    scopus 로고
    • Glutathione status in critically-ill patients: Possibility of odulation by antioxidants
    • Wernerman J, Luo JL and Hammarqvist F. 1999. Glutathione status in critically-ill patients: possibility of odulation by antioxidants. Proc utr Soc 58: 677-680.
    • (1999) Proc Utr Soc , vol.58 , pp. 677-680
    • Wernerman, J.1    Luo, J.L.2    Hammarqvist, F.3
  • 73
    • 0035168102 scopus 로고    scopus 로고
    • Glutamine administration reduces Gram-negative bacteremia in severely burned patients: A prospective, randomized, double-blind trial versus isonitrogenous control
    • Wischmeyer PE, Lynch J, Liedel J, Wolfson R, Riehm J, Gottlieb L and Kahana M. 2001. Glutamine administration reduces Gram-negative bacteremia in severely burned patients: A prospective, randomized, double-blind trial versus isonitrogenous control. Crit Care Med 29: 2075-2080.
    • (2001) Crit Care Med , vol.29 , pp. 2075-2080
    • Wischmeyer, P.E.1    Lynch, J.2    Liedel, J.3    Wolfson, R.4    Riehm, J.5    Gottlieb, L.6    Kahana, M.7
  • 74
    • 0033850839 scopus 로고    scopus 로고
    • Elevated levels of circulanting heat shock protein 70 (HSP70) in peripheral and renal vascular disease
    • Wright BH, Corton JM, El-Nahas AM, Wood RF and Pockley AG. 2000. Elevated levels of circulanting heat shock protein 70 (HSP70) in peripheral and renal vascular disease. Heart Vessels 15: 18-22.
    • (2000) Heart Vessels , vol.15 , pp. 18-22
    • Wright, B.H.1    Corton, J.M.2    El-Nahas, A.M.3    Wood, R.F.4    Pockley, A.G.5
  • 75
    • 0012111663 scopus 로고
    • Human HSP70 promoter contains at least two distinct regulatory domains
    • Wu BJ, Kingston RE and Morimoto RI. 1986. Human HSP70 promoter contains at least two distinct regulatory domains. Proc Natl Acad Sci USA 83: 629-633.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 629-633
    • Wu, B.J.1    Kingston, R.E.2    Morimoto, R.I.3
  • 76
    • 23944432915 scopus 로고    scopus 로고
    • Dietary glutamine supplementation modulates Th1/Th2 cytokine and interleukin-6 expressions in septic mice
    • Yeh CL, Hsu CS, Yeh SL and Chen WJ. 2005. Dietary glutamine supplementation modulates Th1/Th2 cytokine and interleukin-6 expressions in septic mice. Cytokine 31: 329-334.
    • (2005) Cytokine , vol.31 , pp. 329-334
    • Yeh, C.L.1    Hsu, C.S.2    Yeh, S.L.3    Chen, W.J.4
  • 77
    • 33845894675 scopus 로고    scopus 로고
    • Glutamine dipeptide for parenteral nutrition in abdominal surgery: A meta-analysis of randomized controlled trials
    • Zheng YM, Li F, Zhang MM and Wu XT. 2006. Glutamine dipeptide for parenteral nutrition in abdominal surgery: a meta-analysis of randomized controlled trials. World J Gastroenterol 12: 7537-7541.
    • (2006) World J Gastroenterol , vol.12 , pp. 7537-7541
    • Zheng, Y.M.1    Li, F.2    Zhang, M.M.3    Wu, X.T.4
  • 78
    • 34047113993 scopus 로고    scopus 로고
    • Application of perioperative immunonutrition for gastrointestinal surgery: A meta-analysis of randomized controlled trials
    • Zheng YM, Li F, Qi B, Luo B, Sun H, Liu S and Wu X. 2007. Application of perioperative immunonutrition for gastrointestinal surgery: a meta-analysis of randomized controlled trials. Asia Pac J Clin Nutr 16 Suppl 1: 253257.
    • (2007) Asia Pac J Clin Nutr , vol.16 , Issue.SUPPL. 1 , pp. 253-257
    • Zheng, Y.M.1    Li, F.2    Qi, B.3    Luo, B.4    Sun, H.5    Liu, S.6    Wu, X.7
  • 79
    • 0023685295 scopus 로고
    • Increased intestinal permeability associated with infection in burn patients
    • Ziegler TR, Smith RJ, O'Dwyer ST, Demling RH and Wilmore DW. 1988. Increased intestinal permeability associated with infection in burn patients. Arch Surg 123: 1313-1319.
    • (1988) Arch Surg , vol.123 , pp. 1313-1319
    • Ziegler, T.R.1    Smith, R.J.2    O'Dwyer, S.T.3    Demling, R.H.4    Wilmore, D.W.5
  • 81
    • 0037247748 scopus 로고    scopus 로고
    • Nuclear factor-kappa B as a therapeutic target in critical care medicine
    • Zingarelli B, Sheehan M and Wong HR. 2003. Nuclear factor-kappa B as a therapeutic target in critical care medicine. Crit Care Med 31: S105-S111.
    • (2003) Crit Care Med , vol.31
    • Zingarelli, B.1    Sheehan, M.2    Wong, H.R.3


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