Glutamine synthetase expression in rat lung is regulated by protein stability

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 275, Issue 5 19-5, 1998, Pages

  Labow, Brian I ^a   Abcouwer, Steve F ^a,b   Lin, Cheng Mao ^a   Souba, Wiley W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Glutamate ammonia ligase; Methionine sulfoximine; Parenteral infusion

Indexed keywords

GLUCOCORTICOID;

AMINO ACID ANALYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; ENZYME REGULATION; FEEDBACK SYSTEM; GENE EXPRESSION; HOMEOSTASIS; HORMONE DETERMINATION; HYPOTHESIS; IMMUNOBLOTTING; LUNG PARENCHYMA; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN STABILITY; RAT; STATISTICAL ANALYSIS; STRESS;

EID: 0031765621     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1998.275.5.l877     Document Type: Article

References (20)

1. Abcouwer, S. F., B. P. Bode, and W. W. Souba. Glucocorticoids regulate rat glutamine synthetase expression in a tissue-specific manner. J. Surg. Res. 59: 59-65, 1995.
2. Abcouwer, S. F., G. C. Lukascewicz, U. S. Ryan, and W. W. Souba. Molecular regulation of lung endothelial glutamine synthetase expression. Surgery 118: 325-334, 1995.
3. Abcouwer, S. F., G. C. Lukaszewicz, and W. W. Souba. Glucocorticoids regulate glutamine synthetase expression in lung epithelial cells. Am. J. Physiol. 270 (Lung Cell. Mol. Physiol. 14): L141-L151, 1996.
4. Arad, G., A. Freikopf, and R. G. Kulka. Glutamine-stimulated modification and degradation of glutamine synthetase in hepatoma tissue culture cells. Cell 8: 95-101, 1976.
5. Ardawi, M. S. Glutamine and alanine metabolism in lungs of septic rats. Clin. Sci. (Colch.) 81: 603-609, 1991.
6. Ardawi, M. S. Glutamine metabolism in the lungs of glucocorticoid-treated rats. Clin. Sci. (Colch.) 81: 37-42, 1991.
7. Ardawi, M. S. Glutamine-synthesizing activity in lungs of fed, starved, acidotic, diabetic, injured and septic rats. Biochem. J. 270: 829-832, 1990.
8. Askanazi, J., Y.A. Carpentier, C. B. Michelson, D. H. Elwyn, P. Hurst, L. R. Kantrowitz, F. E. Gump, and J. M. Kinney. Muscle and plasma amino acids following injury. Ann. Surg. 192: 78-85, 1980.
9. Austgen, T. R., M. K. Chen, R. M. Salloum, and W. W. Souba. Glutamine metabolism by the endotoxin-injured lung. J. Trauma 31: 1068-1074, 1991.
10. Brosnan, J. T., K. C. Man, D. E. Hall, S. A. Colbourne, and M. E. Brosnan. Interorgan metabolism of amino acids in streptozotocin-diabetic ketoacidotic rat. Am. J. Physiol. 244 (Endocrinol. Metab. 7): E151-E158, 1983.
11. Chomczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
12. Crook, R. B., and G. M. Tomkins. Effect of glutamine on the degradation of glutamine synthetase in hepatoma tissue-culture cells. Biochem. J. 176: 47-52, 1978.
13. Freikopf, A., and R. G. Kulka. Specificity of the glutamine-binding site involved in the regulation of glutamine-synthetase activity in hepatoma tissue-cultured cells. Eur. J. Biochem. 56: 483-492, 1975.
14. Greig, J. E., D. Keast, P. Garcia-Webb, and P. Crawford. Inter-relationships between glutamine and other biochemical and immunological changes after major vascular surgery. Br. J. Biomed. Sci. 53: 116-121, 1996.
15. Heeneman, S., and N. E. Deutz. Effects of decreased glutamine supply on gut and liver metabolism in vivo in rats. Clin. Sci. (Colch.) 85:437-444, 1993.
16. Hickson, R. C., L. E. Wegrzyn, D. F. Osborne, and I. E. Karl. Glutamine interferes with glucocorticoid induced expression of glutamine synthetase in skeletal muscle. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E912-E917, 1996.
17. Horvath, K., M. Jami, I. D. Hill, J. C. Papadimtriou, L. S. Magder, and S. Chanasongcram. Isocaloric glutamine-free diet and the morphology and function of rat small intestine. JPEN J. Parenter. Enteral Nutr. 20: 128-134, 1996.
18. Hughey, R. P., B. B. Rankin, and N. P. Curthoys. Acute acidosis and renal arteriovenous differences of glutamine in normal and adrenalectomized rats. Am. J. Physiol. 238 (Renal Fluid Electrolyte Physiol. 7): F199-F204, 1980.
19. Lamar, C. The duration of the inhibition of glutamine synthetase by methionine sulfoximine. Biochem. Pharmacol. 17: 636-640, 1968.
20. Legrain, C., S. Vissers, E. Dubois, M. Legrain, and J. M. Wiame. Regulation of glutamine synthetase from Saccharomyces cerevisiae by repression, inactivation and proteolysis. Eur. J. Biochem. 123: 611-616, 1982.