Insights into regulation and function of the major stress-induced hsp70 molecular chaperone in vivo: Analysis of mice with targeted gene disruption of the hsp70.1 or hsp70.3 gene

Molecular and Cellular Biology

Volumn 21, Issue 24, 2001, Pages 8575-8591

  Huang, L ^a   Mivechi, N F ^a   Moskophidis, D ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CHAPERONE; HEAT SHOCK PROTEIN 70;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; GENE CONTROL; GENE DISRUPTION; GENE EXPRESSION; GENE INACTIVATION; HEAT STRESS; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION;

ALLELES; ANIMALS; APOPTOSIS; BETA-GALACTOSIDASE; BLOTTING, WESTERN; BONE MARROW CELLS; CASPASES; CELL SURVIVAL; CYTOCHROME C GROUP; EVOLUTION, MOLECULAR; FEVER; GENE LIBRARY; GENOTYPE; HEAT; HSP70 HEAT-SHOCK PROTEINS; MICE; MICE, INBRED C57BL; MODELS, GENETIC; MOLECULAR CHAPERONES; MUTAGENESIS, SITE-DIRECTED; PROTOZOAN PROTEINS; STRESS; TEMPERATURE; TIME FACTORS; TISSUE DISTRIBUTION; TRANSCRIPTION, GENETIC;

ANIMALIA; MURINAE; RODENTIA;

EID: 0035197692     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.24.8575-8591.2001     Document Type: Article

References (50)

1. Role of molecular chaperones in cytoplasmic protein folding
2. Stress-management heat shock protein-70 and the regulation of apoptosis
3. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome
4. Stress (heat shock) proteins, molecular chaperones in cardiovascular biology and disease
5. Developmental activation of an episomic hsp 70 gene promoter in two-cell mouse embryos by transcription factor SP1
6. The HSP-70 and HSP-60 chaperone machines
7. Hop as an adaptor in the hsp 70 and hsp 90 chaperone machinery
8. Developmental control of heat shock and chaperone gene expression
9. The consequences of expressing hsp70 in Drosophila cells at normal temperatures
10. Heat shock proteins, molecular chaperones, and the stress response: Evolutionary and ecological physiology
11. Complex expression of murine heat shock transcription factors
12. Heat shock factor-4 (HSF-4a) represses basal transcription through interaction with TFIIF
13. Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death
14. Localization of a mouse heat shock Hsp70 gene within the H-2 complex
15. Induced thermal resistance in HeLa cells
16. Protein folding in the cell
17. Hsp104, Hsp-70 and Hsp-40: A novel chaperone system that rescues previously aggregated proteins
18. Genetic aspects of the hsp 70 multigene family in vertebrates
19. Characterization and sequence of a mouse hsp 70 gene and its expression in mouse cell lines
20. Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development
21. Genetic and molecular analysis of the 87A7 and 87C1 heat-inducible loci of D. melanogaster
22. Overexpression of hsp70 confers tumorigenecity to mouse fibrosarcoma cells
23. Role of heat shock response and molecular chaperones in oncogenesis and cell death
24. Inducible expression of an hsp68-lacZ hybrid gene in transgenic mice
25. Cell-lineage-specific expression of the mouse hsp68 gene during embryogenesis
26. Protein kinase cascades activated by stress and inflammatory cytokines
27. Heat shock protein 70
28. The heat shock response
29. The heat shock proteins
30. Expression of hsp 70 in healing wounds of diabetic and nondiabetic mice
31. Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: A novel pathway controlled by HSP72
32. Mutational analysis of the human hsp 70 protein: Distinct domains for nucleolar localization and adenosine triphosphate binding
33. Lack of development of thermotolerance in early progenitors of murine bone marrow cells
34. Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors, molecular chaperones, and negative regulators
35. The chaperone function of hsp70 is required for protection against stress-induced apoptosis
36. The heat shock stress response after brain lesions: Induction of 72 kDa heat shock protein (cell types involved, axonal transport, transcriptional regulation) and protein synthesis inhibition
37. Function and regulation of heat shock factor 2 during mouse embryogenesis
38. The RNA polymerase II molecule at the 5′ end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged
39. Negative regulation of the Apaf-1 apoptosome by Hsp70
40. Molecular chaperones: Biology and prospects for pharmacological intervention
41. The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing
42. Tissue-specific expression of heat shock proteins of the mouse in the absence of stress
43. Progressive maturation of chromatin structure regulates hsp 70.1 gene expression in the preimplantation mouse embryo
44. Oncogenic potential of hsp 72
45. Developmentally regulated nuclear transport of transcription factors in Drosophila embryos enable the heat shock response
46. The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I
47. Heat shock transcription factors: Structure and regulation
48. HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice
49. Prevention of apoptosis by Bcl2: Release of cytochrome c from mitochondria blocked