Glutamine synthetase expression in muscle is regulated by transcriptional and posttranscriptional mechanisms

American Journal of Physiology - Endocrinology and Metabolism

Volumn 276, Issue 6 39-6, 1999, Pages

  Labow, Brian I ^a   Souba, Wiley W ^a   Abcouwer, Steve F ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Dexamethasone; Gene expression regulation; Glutamate ammonia ligase; Methionine sulfoximine; Starvation

Indexed keywords

DEXAMETHASONE; GLUTAMATE AMMONIA LIGASE; METHIONINE SULFOXIMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANOREXIA; ARTICLE; CONTROLLED STUDY; ENZYME BLOOD LEVEL; ENZYME REGULATION; GENE EXPRESSION REGULATION; MALE; MUSCLE LEVEL; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUADRICEPS FEMORIS MUSCLE; RAT; REGULATORY MECHANISM; SKELETAL MUSCLE; STRESS; WEIGHT REDUCTION; WESTERN BLOTTING;

EID: 0033067563     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.276.6.e1136     Document Type: Article

References (26)

1. Abcouwer, S. F., B. P. Bode, and W. W. Souba. Glucocorticoids regulate rat glutamine synthetase expression in a tissue-specific manner. J. Surg. Res. 59: 59-65, 1995.
2. Ardawi, M. S., and Y. S. Jamal. Glutamine metabolism in skeletal muscle of glucocorticoid-treated rats. Clin. Sci. (Colch.) 79: 139-147, 1990.
3. Arola, L., A. Palou, X. Remesar, and M. Alemany. Glutamine synthetase activity in the organs of fed and 24-hour fasted rats. Horm. Metab. Res. 13: 199-202, 1981.
4. Babij, P., H. S. Hundal, M. J. Rennie, and P. W. Watt. Effects of corticosteroids on glutamine transport in rat skeletal muscle (Abstract). J. Physiol. Lond. 347: 35P, 1986.
5. Chang, T. W., and A. L. Goldberg. The metabolic fates of amino acids and the formation of glutamine in skeletal muscle. J. Biol. Chem. 253: 3685-3695, 1978.
6. Chomczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159, 1987.
7. Clowes, G. H. A., Jr., H. T. Randall, and A. C. J. Cha. Amino acid and energy metabolism in septic and traumatized patients. J. Parenter. Enteral Nutr. 4: 195-205, 1980.
8. Falduto, M. T., A. P. Young, and R. C. Hickson. Exercise inhibits glucocorticoid-induced glutamine synthetase expression in red skeletal muscles. Am. J. Physiol. 262 (Cell Physiol. 31): C214-C220, 1992.
9. Feng, B., S. K. Shiber, and S. R. Max. Glutamine regulates glutamine synthetase expression in skeletal muscle cells in culture. J. Cell. Physiol. 145: 376-380, 1990.
10. Freikopf, A., and R. G. Kulka. Specificity of the glutamine-binding site involved in the regulation of glutamine-synthetase activity in hepatoma tissue-cultured cells. Eur. J. Biochem. 56: 483-492, 1975.
11. Goldberg, A. L., and T. W. Chang. Regulation and significance of amino acid metabolism in skeletal muscle. Federation Proc. 37: 2301-2307, 1978.
12. Goldstein, L. Interorgan glutamine relationships. Federation Proc. 45: 2176-2179, 1986.
13. Hankard, R. G., M. W. Raymond, and D. Darmaun. Role of glutamine as a glucose precursor in fasting humans. Diabetes 46: 1535-1541, 1997.
14. Heeneman, S., and N. E. Deutz. Effects of decreased glutamine supply on gut and liver metabolism in vivo in rats. Clin. Sci. (Colch.) 85: 437-444, 1993.
15. Hickson, R. C., L. E. Wegrzyn, D. F. Osborne, and I. E. Karl. Glutamine interferes with glucocorticoid induced expression of glutamine synthetase in skeletal muscle. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E912-E917, 1996.
16. Horvath, K., M. Jami, I. D. Hill, J. C. Papadimitriou, L. S. Magder, and S. Chanasongeram. Isocaloric glutamine-free diet and the morphology and function of rat small intestine. J. Parenter. Enteral Nutr. 20: 128-134, 1996.
17. Hundal, H. S., P. Babij, P. W. Watt, M. R. Ward, and M. J. Rennie. Glutamine transport and metabolism in denervated rat skeletal muscle. Am. J. Physiol. 259 (Endocrinol. Metab. 22): E148-E154, 1990.
18. Kaloyianni, M., and R. A. Freedland. Contribution of several amino acids and lactate to gluconeogenesis in hepatocytes isolated from rats fed various diets. J. Nutr. 120: 116-122, 1990.
19. Labow, B. I., S. F. Abcouwer, C.-M. Lin, and W. W. Souba. Glutamine synthetase expression in rat lung is regulated by protein stability. Am. J. Physiol. 275 (Lung Cell. Mol. Physiol. 19): L877-L886, 1998.
20. Lamar, C. The duration of the inhibition of glutamine synthetase by methionine sulfoximine. Biochem. Pharmacol. 17: 636-640, 1968.
21. Lukaszewicz, G. C., W. W. Souba, and S. F. Abcouwer. Induction of muscle glutamine synthetase gene expression during endotoxemia is adrenal gland dependent. Shock 7: 1-7, 1997.
22. Max, S. R. Glucocorticoid-mediated induction of glutamine synthetase in skeletal muscle. Med. Sci. Sports Exerc. 22: 325-330, 1990.
23. Max, S. R., J. Mill, K. Mearow, M. Konagaya, Y. Konagaya, J. W. Thomas, C. Banner, and L. Vitković. Dexamethasone regulates glutamine synthetase expression in rat skeletal muscles. Am. J. Physiol. 255 (Endocrinol. Metab. 18): E397-E402, 1988.
24. Odessey, R., E. A. Khairallah, and A. L. Goldberg. Origin and possible significance of alanine production by muscle. J. Biol. Chem. 249: 229-238, 1974.
25. Sambrook, J., E. F. Fritsch, and A. T. Maniatis. Molecular Cloning: A Laboratory Manual (2nd ed.). Cold Spring Harbor, NY: Cold Spring Harbor Press, 1989.
26. Souba, W. W., D. A. Plumley, R. M. Salloum, and E. M. Copeland III. Effects of glucocorticoids on lung glutamine and alanine metabolism. Surgery 108: 213-219, 1990.