Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma

British Journal of Cancer

Volumn 103, Issue 1, 2010, Pages 43-51

  Eichenmuller M ^a   Hemmerlein, B ^b,c   Von Schweinitz, D ^a   Kappler, R ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c HELIOS Clinic Krefeld   (Germany)

Author keywords

apoptosis; betulinic acid; hedgehog; rhabdomyosarcoma; xenograft

Indexed keywords

BETULIC ACID; LUCIFERASE; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; ANTINEOPLASTIC AGENT; TRITERPENE;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CLONOGENIC ASSAY; CYTOTOXICITY; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; MEMBRANE POTENTIAL; MITOCHONDRION; NEOVASCULARIZATION (PATHOLOGY); PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA; SIGNAL TRANSDUCTION; WESTERN BLOTTING; XENOGRAFT; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; FEMALE; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; HEDGEHOG PROTEINS; HUMANS; MICE; MITOCHONDRIA; RHABDOMYOSARCOMA; SIGNAL TRANSDUCTION; TRITERPENES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77954176611     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605715     Document Type: Article

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