New Lupane Derived Compounds with Pro-Apoptotic Activity in Cancer Cells: Synthesis and Structure-Activity Relationships

Journal of Medicinal Chemistry

Volumn 46, Issue 25, 2003, Pages 5402-5415

  Šarek, Jan ^a   Klinot, Jiří ^a   Džubák, Petr ^b   Klinotová, Eva ^a   Nosková, Věra ^a   Křeček, Václav ^a   Kořínková, Gabriela ^b   Thomson, Jean Oliver ^b   Janošt'Áková, Anna ^b   Wang, Shudong ^d   Parsons, Simon ^c   Fischer, Peter M ^d   Zhelev, Nikolai Z ^d   Hajdúch, Marián ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b PALACKÝ UNIVERSITY   (Czech Republic)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d CYCLACEL LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA,28 DIACETOXY 18 OXO 19,20,21,29,30 PENTANORLUPAN 22 OIC ACID; ANTINEOPLASTIC AGENT; BETULIC ACID; BETULIN; BETULININE DERIVATIVE; KETONE DERIVATIVE; LUPANE DERIVATIVE; METHYL 3BETA ACETOXY 21,22 DIOXOLUP 18 EN 28 OATE; OXYGEN; TRITERPENOID; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; OXYGENATION; STRUCTURE ACTIVITY RELATION;

EID: 10744224623     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020854p     Document Type: Article

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