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Volumn 121, Issue 1, 2007, Pages 199-205

Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A

Author keywords

Amplification; Apoptosis; MDM4; Osteosarcoma; Therapy; TP53

Indexed keywords

ANTINEOPLASTIC AGENT; MDM2 ANTAGONIST; NUTLIN 3A; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 34248581595     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.22643     Document Type: Article
Times cited : (101)

References (35)
  • 1
    • 0026649648 scopus 로고
    • The mdm2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992;69:1237-45.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 2
    • 0027196974 scopus 로고
    • Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
    • Reifenberger G, Liu L, Ichimura K, Schmidt EE, Collins VP. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res 1993;53:2736-9.
    • (1993) Cancer Res , vol.53 , pp. 2736-2739
    • Reifenberger, G.1    Liu, L.2    Ichimura, K.3    Schmidt, E.E.4    Collins, V.P.5
  • 4
    • 33746646758 scopus 로고    scopus 로고
    • Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Mdm2 and Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia
    • Kojima K, Konopleva M, McQueen T, O'Brien S, Plunkett W, Andreeff M. Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Mdm2 and Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia. Blood 2006;108:993-1000.
    • (2006) Blood , vol.108 , pp. 993-1000
    • Kojima, K.1    Konopleva, M.2    McQueen, T.3    O'Brien, S.4    Plunkett, W.5    Andreeff, M.6
  • 7
    • 33750480907 scopus 로고    scopus 로고
    • Effect of an hdm-2 antagonist peptide inhibitor on cell cycle progression in p53-deficient H1299 human lung carcinoma cells
    • VanderBorght A, Valckx A, Van Dun J, Grand-Perret T, De Schepper S, Vialard J, Janicot M, Arts J. Effect of an hdm-2 antagonist peptide inhibitor on cell cycle progression in p53-deficient H1299 human lung carcinoma cells. Oncogene 2006;25:6672-7.
    • (2006) Oncogene , vol.25 , pp. 6672-6677
    • VanderBorght, A.1    Valckx, A.2    Van Dun, J.3    Grand-Perret, T.4    De Schepper, S.5    Vialard, J.6    Janicot, M.7    Arts, J.8
  • 9
    • 33748586754 scopus 로고    scopus 로고
    • Small molecule inhibition of HDM2 leads to p53-mediated cell death in retinoblastoma cells
    • Elison JR, Cobrinik D, Claros N, Abramson DH, Lee TC. Small molecule inhibition of HDM2 leads to p53-mediated cell death in retinoblastoma cells. Arch Ophthalmol 2006;124:1269-75.
    • (2006) Arch Ophthalmol , vol.124 , pp. 1269-1275
    • Elison, J.R.1    Cobrinik, D.2    Claros, N.3    Abramson, D.H.4    Lee, T.C.5
  • 14
  • 15
    • 33845256980 scopus 로고    scopus 로고
    • MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin
    • Hu B, Gilkes DM, Farooqi B, Sebti SM, Chen J. MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin. J Biol Chem 2006;281:33030-5.
    • (2006) J Biol Chem , vol.281 , pp. 33030-33035
    • Hu, B.1    Gilkes, D.M.2    Farooqi, B.3    Sebti, S.M.4    Chen, J.5
  • 18
    • 0025878872 scopus 로고
    • Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing
    • Keepers YP, Pizao PE, Peters GJ, van Ark-Otte J, Winograd B, Pinedo HM. Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing. Eur J Cancer 1991;27:897-900.
    • (1991) Eur J Cancer , vol.27 , pp. 897-900
    • Keepers, Y.P.1    Pizao, P.E.2    Peters, G.J.3    van Ark-Otte, J.4    Winograd, B.5    Pinedo, H.M.6
  • 20
    • 0028220206 scopus 로고
    • Validity and usefulness of human tumor models established by intratibial cell inoculation in nude rats
    • Kjonniksen I, Winderen M, Bruland O, Fodstad O. Validity and usefulness of human tumor models established by intratibial cell inoculation in nude rats. Cancer Res 1994;54:1715-9.
    • (1994) Cancer Res , vol.54 , pp. 1715-1719
    • Kjonniksen, I.1    Winderen, M.2    Bruland, O.3    Fodstad, O.4
  • 24
    • 0033956278 scopus 로고    scopus 로고
    • Wang KK. Calpain and caspase: can you tell the difference? by Kevin KW Wang, 23, pp. 20-26. Trends Neurosci 2000;23:59.
    • Wang KK. Calpain and caspase: can you tell the difference? by Kevin KW Wang, Vol.23, pp. 20-26. Trends Neurosci 2000;23:59.
  • 25
    • 0033963335 scopus 로고    scopus 로고
    • MdmX protects p53 from Mdm2-mediated degradation
    • Jackson MW, Berberich SJ. MdmX protects p53 from Mdm2-mediated degradation. Mol Cell Biol 2000;20:1001-7.
    • (2000) Mol Cell Biol , vol.20 , pp. 1001-1007
    • Jackson, M.W.1    Berberich, S.J.2
  • 26
    • 33645511223 scopus 로고    scopus 로고
    • Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3
    • Patton JT, Mayo LD, Singhi AD, Gudkov AV, Stark GR, Jackson MW. Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3. Cancer Res 2006;66:3169-76.
    • (2006) Cancer Res , vol.66 , pp. 3169-3176
    • Patton, J.T.1    Mayo, L.D.2    Singhi, A.D.3    Gudkov, A.V.4    Stark, G.R.5    Jackson, M.W.6
  • 30
    • 0042592947 scopus 로고    scopus 로고
    • MDM2 promotes ubiquitination and degradation of MDMX
    • Pan Y, Chen J. MDM2 promotes ubiquitination and degradation of MDMX. Mol Cell Biol 2003;23:5113-21.
    • (2003) Mol Cell Biol , vol.23 , pp. 5113-5121
    • Pan, Y.1    Chen, J.2
  • 32
    • 0036211680 scopus 로고    scopus 로고
    • Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines
    • Park YB, Park MJ, Kimura K, Shimizu K, Lee SH, Yokota J. Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines. Cancer Genet Cytogenet 2002;133:105-11.
    • (2002) Cancer Genet Cytogenet , vol.133 , pp. 105-111
    • Park, Y.B.1    Park, M.J.2    Kimura, K.3    Shimizu, K.4    Lee, S.H.5    Yokota, J.6
  • 33
    • 33645769536 scopus 로고    scopus 로고
    • A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network
    • Toledo F, Krummel KA, Lee CJ, Liu CW, Rodewald LW, Tang M, Wahl GM. A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell 2006;9:273-85.
    • (2006) Cancer Cell , vol.9 , pp. 273-285
    • Toledo, F.1    Krummel, K.A.2    Lee, C.J.3    Liu, C.W.4    Rodewald, L.W.5    Tang, M.6    Wahl, G.M.7
  • 35
    • 16444380911 scopus 로고    scopus 로고
    • Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors
    • Carvajal D, Tovar C, Yang H, Vu BT, Heimbrook DC, Vassilev LT. Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors. Cancer Res 2005;65:1918-24.
    • (2005) Cancer Res , vol.65 , pp. 1918-1924
    • Carvajal, D.1    Tovar, C.2    Yang, H.3    Vu, B.T.4    Heimbrook, D.C.5    Vassilev, L.T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.