State-dependent block of wild-type and inactivation-deficient Na + channels by flecainide

Journal of General Physiology

Volumn 122, Issue 3, 2003, Pages 365-374

  Wang, Ging Kuo ^a   Russell, Corinna ^a   Wang, Sho Ya ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Fast inactivation gate; Flecainide; Persistent sodium currents; Sodium channel; State dependent block

Indexed keywords

ANTIARRHYTHMIC AGENT; FLECAINIDE; SODIUM CHANNEL;

ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG BINDING SITE; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; HEART MUSCLE CELL; HEART REPOLARIZATION; HUMAN; HUMAN CELL; IC 50; LONG QT SYNDROME; SODIUM CURRENT; THOMSEN DISEASE; TIME; WILD TYPE;

ANTI-ARRHYTHMIA AGENTS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; FLECAINIDE; HUMANS; ION CHANNEL GATING; MUSCLE PROTEINS; MUTATION; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 0141848333     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.200308857     Document Type: Article

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