GSTTI-dependent induction of centromere-negative and -positive micronuclei by 1,2:3,4-diepoxybutane in cultured human lymphocytes

Mutagenesis

Volumn 12, Issue 5, 1997, Pages 397-403

  Vlachodimitropoulos, Dimitris ^a,b   Norppa, Hannu ^a   Autio, Kirsi ^a,e   Catalán, Julia ^a,c   Hirvonen, Ari ^a   Tasa, Gunnar ^a,d   Uusküla, Mart ^a,d   Demopoulos, Nikos A ^b   Sorsa, Marja ^a,f  

^a FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

^b UNIVERSITY OF PATRAS   (Greece)

^c UNIVERSITY OF ZARAGOZA   (Spain)

^d UNIVERSITY OF TARTU   (Estonia)

^e UNIVERSITY OF HELSINKI   (Finland)

^f Opetusministerio Finland   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BUTADIENE DIEPOXIDE; GLUTATHIONE TRANSFERASE; ISOENZYME; SATELLITE DNA; EPOXIDE; MUTAGENIC AGENT;

ALLELE; ANEUPLOIDY; ARTICLE; CENTROMERE; CONTROLLED STUDY; CYTOKINESIS; DNA PROBE; ENZYME POLYMORPHISM; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENE LOSS; GENOTOXICITY; GENOTYPE; HUMAN; HUMAN CELL; LYMPHOCYTE; LYMPHOCYTE CULTURE; MALE; MICRONUCLEUS; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE; TECHNIQUE; ADULT; CELL CULTURE; CELL DIVISION; DRUG EFFECT; ENZYMOLOGY; GENETICS; HOMOZYGOTE; MICRONUCLEUS TEST; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY;

ADULT; ALLELES; CELL DIVISION; CELLS, CULTURED; CENTROMERE; EPOXY COMPOUNDS; FEMALE; GLUTATHIONE TRANSFERASE; HOMOZYGOTE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOCYTES; MALE; MICRONUCLEUS TESTS; MIDDLE AGED; MUTAGENS;

EID: 0030612557     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/12.5.397     Document Type: Article

References (60)

1. Abramsson Zetterberg,L. (1997) Chromosome aberrations detected by the flow cytometer based micronucleus assay. Dissertation, Uppsala University, Uppsala, Sweden.
2. Anttila,S., Hirvonen,A., Husgafvel-Pursiainen,K., Karjalainen,A., Nurminen,T. and Vainio,H. (1994) Combined effect of CYP1A1 inducibility and GSTM1 polymorphism on histological type of lung cancer. Carcinogenesis, 15, 1133-1135.
3. Bell,D.A., Taylor,J.A.,Paulson,D.R. Robertson,C.N., Mohler,J.L. and Lucier,G.W. (1993) Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase Ml (GSTM1) that increase susceptibility to bladder cancer. J. Natl Cancer Inst., 85, 1159-1164.
4. Bernardini,S., Pelin,K., Peltonen,K., Järventaus,H., Hirvonen,A., Neagu,C., Sorsa,M. and Norppa,H. (1996) Induction of sister-chromatid exchange by 3,4-epoxybutane-1,2-diol in cultured human lymphocytes of different GSTT1 and GSTM1 genotypes. Mutat. Res., 361, 121-127.
5. Boogaard,P.J., Sumner,S.C.-J., Turner,M.J. and Bond,J.A. (1996) Hepatic and pulmonary glutathione conjugation of l,2:3,4-diepoxybutane in human, rat, and mouse in vitro. Toxicology, 113, 297-299.
6. Brockmoller,J., Kerb,R., Drakoulis,N., Nitz,M. and Roots,I. (1993) Genotype and phenotype of glutathione S-transferase class μ isoenzymes μ and ψ in lung cancer patients and controls. Cancer Res., 53, 1004-1011.
7. Brockmoller,J., Kerb,R., Drakoulis,N., Staffeldt,B. and Roots,I. (1994) Glutathione S-transfcrasc M1 and its variants A and B as host factor of bladder cancer susceptibility: a case-control study. Cancer Res., 54, 4103-4111.
8. Catalan,J., Autio,K., Wessman,M., Lindholm,C., Knuutila,S., Sorsa,M. and Norppa,H. (1995) Age-associated micronuclei containing centromeres and the X chromosome in lymphocytes of women. Cytogenet. Cell Genet., 68, 11-16.
9. Chen,H.W., Sandler,D.R. Taylor,J.A., Shore,D.L., Liu,E., Bloomfield,C.D. and Bell,D.A. (1996) Increased risk for myelodysplastic syndromes in individuals with glutathione S-transferase theta l (GSTT1) gene defect. Lancet, 347, 295-297.
10. Csanddy,G.A., Guengerich,F.P. and Bond,J.A. (1992) Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide by hepatic and pulmonary tissues from humans, rats and mice. Carcinogenesis, 13, 1143-1153.
11. Daly,A.K., Thomas,D.J., Cooper,J., Pearson,W.R., Neal,D.E. and Idle,J.R. (1993) Homozygous deletion of gene for glutathione S-transferase M1 in bladder cancer. Br. Med. J., 307, 481-482.
12. Elexpuru-Camiruaga,J., Buxton,N., Kandula,V., Pilatha,S.D., Campbell,D., McIntosh,J., Broome,J., Jones,P., Inskip,A., Alldersea,J., Fryer,A. and Strange,R.C. (1995) Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) loci. Cancer Res., 554, 237-239.
13. Fenech,M. and Morley,A.A. (1985) Measurements of micronuclei in lymphocytes. Mutat. Res., 147, 29-36.
14. Fryer,A.A., Zhao,L., Alldersea,J., Boggild,M.D., Perrett,C.W., Clayton,R.N. Jones,P.W. and Strange,R.C. (1993) The glutathione S-transferase: polymerase chain reaction studies on the frequency of the GSTM1 0 genotype in patients with pituitary adenomas. Carcinogenesis, 14, 563-566.
15. Hallier,E., Langhof T., Dannappel,D., Leutbecher,M., Schröder,K., Goergens,H.W., Müller,A. and Bolt,H.M. (1993) Polymorphism of glutathione conjugation of methyl bromide, ethylene oxide and dichloromethane in human blood: influence on the induction of sister chromatid exchanges (SCE) in lymphocytes. Arch. Toxicol., 67, 173-178.
16. Heagerty,A.H., Fitzgerald,D., Smith,A., Jones,P., Fryer,A.A., Zhao,L., Alldersea,J. and Strange,R.C. (1994) Glutathione S-transferase GSTM1 phenotype and protection against cutaneous tumours. Lancet, 343, 266-268.
17. Henderson,R.F., Bechtold,W.E., Sabourin,P.J., Malpes,K.R. and Dahl,A.R. (1993) Species differences in the metabolism of 1,3-butadiene in vivo. In Sorsa,M., Peltonen,K., Vainio,H. and Hemminki,K. (eds), Butadiene and Styrene: Assessment of Health Hazards, IARC Scientific Publication no. 127. IARC, Lyon, France, pp. 57-64.
18. Hirvonen,A., Husgafvel-Pursiainen,K., Anttila,S. and Vainio,H. (1993) The GSTM 1 null genotype as a potential risk modifier for squamous cell carcinoma of the lung. Carcinogenesis, 14, 1479-1481.
19. Hirvonen,A., Pelin,K., Tammilehto,L., Karjalainen,A., Mattson,K and Linnainmaa,K. (1995) Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma. Cancer Res., 55, 2981-2983.
20. Hirvonen,A., Saarikoski,S.T., Linnainmaa,K., Koskinen,K., Husgafvel-Pursiainen,K., Mattson,K. and Vainio,H. (1996) Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disorders. J. Natl Cancer Inst., 88, 1853-1856.
21. International Agency for Research on Cancer (IARC) (1992) 1,3-Butadiene. In IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 54, Occupational Exposures to Mists and Vapours from Strong Inorganic Acids; and other Industrial Chemicals. IARC, Lyon, France, pp. 237-285.
22. Johnson,G.D., Nogueira-Araujo,G.M.C. (1981) A simple method of reducing the fading of immunofluorescence during microscopy. J. Immunol. Methods, 43, 349-350.
23. Kelsey,K.T., Christian,D.C. and Wiencke,I.K. (1991) Biomodal distribution of sensitivity to SCE induction by diepoxybutane in human lymphocytes. II. Relationship to baseline SCE frequency. Mutat. Res., 248, 27-33.
24. Kelsey,K.T., Wiencke,J.K., Ward,J., Bechtold,W. and Fajen,J. (1995) Sister chromatid exchanges, glutathione S-transferase θ deletion and cytogenetic sensitivity to diepoxybutane in lymphocytes from butadiene monomer production workers. Mutat. Res., 335, 267-273.
25. Ketterer,B., Harris,J.M., Talaska,G., Meyer,D.J., Pemble,S.E., Taylor,J.B., Lang,N.P. and Kadlubar,F.F. (1992) The human glutathione S-transferase supergene family, its polymorphism, and its effects on susceptibility to lung cancer. Environm. Hlth Perspect., 98, 87-94.
26. Kihara,M., Kihara,M. and Noda,K. (1994) Lung cancer risk of GSTM1 null genotype is dependent of the extent of tobacco smoke exposure. Carcinogenesis, 15, 415-418.
27. Kihara,M., Kihara,M. and Noda,K. (1995) Risk of smoking for squamous and small cell carcinomas of the lung modulated by combinations of CYP1A1 and GSTM1 gene polymorphisms in a Japanese population. Carcinogenesis, 16, 2331-2336.
28. Landi,S., Ponzanelli,I. and Barale,R. (1995) Effect of red cells and plasma blood in determining individual lymphocytes sensitivity to diepoxybutane assessed by in vitro induced sister chromatid exchange. Mutat Res., 348, 117-123.
29. Landi,S., Frenzilli,G., Sbrana,I. and Barale,R. (1996a) Modulating factors of individual sensitivity to diepoxybutane: sister chromatid exchanges induced in vitro in human lymphocytes. Mutat. Res., 357, 75-82.
30. Landi,S., Ponzanelli,I., Hirvonen,A., Norppa,H. and Barale,R. (1996b) Repeated analysis of sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes: effect of glutathione S-transferase T1 and M1 genotype. Mutat. Res., 351, 79-85.
31. Landi,S., Ponzanelli,I., Cipollini,G., Frezilli,G., Luccini,A., Milillo,C., Sbrana,I. and Barale,R. (1997) Modulating factors of individual sensitivity to diepoxybutane: chromosome aberration induced in vitro in human lymphocytes. Mutagenesis, 12, 17-22.
32. Lin,H.J., Han,C-Y., Bernstain,D.A., Hsiao,W., Lin,B.K. and Hardy,S. (1994) Ethnic distribution of the glutathione transferase Mu 1-1 (GSTM1) null genotype in 1473 individuals and application to bladder cancer susceptibility. Carcinogenesis, 15, 1077-1081.
33. Luomahaara,S. and Norppa,H. (1994) Induction of micronuclei in cultured human lymphocytes treated with vinblastine before and after mitogen stimulation. Mutal. Res., 324, 29-34.
34. Mannervik,B., Awasthi,Y.C., Board,P.G., Hayes,J.D., Di Ilio,C., Ketterer,B., Listowski,I., Morgenstern,R., Muramatsu,M., Pearson,W., Pickett,C.B., Sato,K., Widersten,M. and Wolf,C.R. (1991) Nomenclature for human glutathione transferases. Biochem. J., 282, 305-308.
35. Meyer,D.J., Coles,B., Pemble,S.E., Gilmore,K.S., Fraser,G.M. and Ketterer,B. (1991) Theta, a new class of glutathione transferases purified from rat and man. Biochem. J., 274, 409-414.
36. Millard,J.T. and White,M.M. (1993) Diepoxybutane cross-links DNA at 5′-GNC sequences. Biochemistry, 32, 2120-2124.
37. Nelson,H.H., Wiencke,J.K., Christiani,D.C., Cheng,T.J., Zuo,Z.-F., Schwartz,B,S., Lee,B.-K., Spitz,M.R., Wang,M., Xu,X and Kelsey,K.T. (1995) Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta. Carcinogenesis, 16, 1243-1245.
38. Norppa,H., Renzi,L. and Lindholm,C. (1993) Detection of whole chromosomes in micronuclei of cytokinesis-blocked human lymphocytes by antikinetochore staining and in situ hybridization. Mutagenesis, 8, 519-525.
39. Norppa,H., Hirvonen,A., Järventaus,H., Uusküla,M.,Tasa,G. and Sorsa.M. (1995) Role of GSTT1 and GSTM1 genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes. Carcinogenesis, 16, 1261-1264.
40. Pelin,K., Hirvonen,A. and Norppa,H. (1996) Influence of erythrocyte glutathione S-transferase T1 on sister chromatid exchanges induced by diepoxybutane in cultured human lymphocytes. Mutagenesis, 11, 213-215.
41. Pemble,S., Schroeder,K.R., Spencer,S.R., Meyer,D.J., Hallier,E., Bolt,H.M., Ketterer,B. and Taylor,J.B. (1994) Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem. J., 300, 271-276.
42. Peter,H., Deutschmann,S., Reichel,C. and Hallier,E. (1989) Metabolism of a new glutathione S-transferase activity in human erythroeytes. Biochem. Pharmacol., 63, 351-355.
43. Rosendorff,J. and Bernstein,R. (1988) Fanconi's anaemia-chromosome breakage studies in homozygotes and heterozygotes. Cancer Genet. Cytogenet., 33, 175-183.
44. Sasiadek,M., Norppa,H. and Sorsa,M. (1991) 1,3-Butadiene and its epoxides induce sister-chromatid exchanges in human lymphocytes in vitro. Mutat. Res., 261, 117-121,
45. Seaton,M.J., Follansbee,M.H. and Bond,J.A. (1995) Oxidation of 1,2-epoxy-3-butene to l,2:3,4-diepoxybutane by cDNA-expressed human cytochrome P450 2E1 and #A4 and human, mouse and rat liver microsomes. Carcinogenesis, 16, 2287-2293.
46. Sjöblom,T. and Lahdetie,J. (1996) Micronuclei are induced in rat spermatids in vitro by 1,2,3,4-diepoxybutane but not 1,2-epoxy-3-butene and 1,2-dihydroxy-3,4-butane. Mutagenesis, 11, 525-528.
47. Sorsa,M., Ostennan-Golkar,S, Peltonen,K, Saarikoski,S and Srám,R. (1996) Assessment of exposure to butadiene in the process industry. Toxicology, 113, 77-83.
48. Thornton-Manning,J.R., Dahl,A.R., Bechtold,W.E., Griffith,W.C. and Henderson,R.F. (1995) Disposition of butadiene monoepoxide and butadiene diepoxide in various tissues of rats and mice following a low-level inhalation exposure to 1,3-butadiene. Carcinogenesis, 16, 1723-1731.
49. Uusküla,M., Järventaus,H., Hirvonen,A., Sorsa,M. and Norppa,H. (1995) Influence of GSTM1 genotype on sister chromatid exchange induction by styrene-7,8-oxide and 1,2-epoxy-3-butene in cultured human lymphocytes. Carcinogenesis, 16, 947-950.
50. van Poppel,G., de Vogel,N., van Balderen,P.J. and Kok,F.J. (1992) Increased cytogenetic damage in smokers deficient in glutathione S-transferase isoenzyme. Carcinogenesis, 13, 303-305.
51. Warholm,M., Rane,R., Alexandrie,A.-K., Monaghan,G. and Rannug,A. (1995) Genotypic and phenotypic determination of polymorphic glutathione transferase T1 in Swedish population. Pharmacogenetics, 5, 252-254.
52. Wiencke,J.K. and Kelsey,K.T. (1993) Susceptibility to induction of chromosomal damage by metabolites of 1,3-butadiene and its relationship to 'spontaneous' sister chromatid exchange frequencies in human lymphocytes. In Sorsa,M., Peltonen,K., Vainio,H. and Hemminki,K. (eds), Butadiene and Styrene: Assessment of Health Hazards, IARC Scientific Publication no. 127. IARC, Lyon, France, pp. 1-10.
53. Wiencke,J.K., Kelsey,K.T., Lamela,R.A. and Toscano,W.A. (1990) Human glutathione S-transferase deficiency as a marker of susceptibility to epoxide-induced cytogenetic damage. Cancer Res., 50, 1585-1590.
54. Wiencke,J.K., Christiani,D.C. and Kelsey,K.T. (1991a) Bimodal distribution of sensitivity to SCE induction by diepoxybutane in human lymphocytes. I. Correlation with chromosomal aberrations. Mutat. Res., 248, 17-26.
55. Wiencke,J.K., Wrensch,M.R., Miike,R. and Petrakis,N.L. (1991b) Individual susceptibility to induced chromosome damage and its implications for detecting genotoxic exposure in human populations. Cancer Res., 51, 5266-5269.
56. Wiencke,J.K., Pemble,S., Ketterer,B. and Kelsey,K.T. (1995) Gene deletion of glutathione S-transferase θ: correlation with induced genetic damage and potential role in endogenous mutagenesis. Cancer Epidemiol. Biomonitoring Prevent., 4, 253-259.
57. Xiao,Y. and Tates,A.D. (1995) Clastogenic effects of 1,3-butadiene and its metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane in splenocytes and germ cells of rats and mice in vivo. Environ. Mol. Mutagen., 26, 97-108.
58. Xiao,Y., de Stoppelaar,J.M., Hoebee,B., Schriever-Schwemmer,G., Adler,I.-D. and Tates,A.D. (1996) Analysis of micronuclei induced by 1,3-butadiene and its metabolites using fluorescence in situ hybridization. Mutat. Res., 354, 49-57.
59. Zhong,S., Howie,A.F., Ketterer,B., Taylor,J., Hayes,J.D., Beckett,G.J., Wathen,C.G., Wolf,C.R. and Spurr,N.K. (1991) Glutathione S-transferase mu locus: use of genotyping and phenotyping assays association with lung cancer susceptibility. Carcinogenesis, 12, 1533-1537.
60. Zhong,S., Wyllie,A.H., Barnes,D., Wolf,C.R. and Spurr,N.K. (1993) Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis, 14, 1821-1824.