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Volumn 5, Issue 7, 2010, Pages 673-679

Opportunities and limits of cell-based assay miniaturization in drug discovery

Author keywords

Assay development; Drug discovery; Microfluidic chip; Microfluidics

Indexed keywords

BLOOD SAMPLING; ELECTRONICS; FLUID FLOW; HIGH THROUGHPUT SCREENING; HUMAN; IN VIVO STUDY; MICROCHIP ANALYSIS; MICROFLUIDIC ANALYSIS; PRIORITY JOURNAL; REVIEW;

EID: 77953700164     PISSN: 17460441     EISSN: None     Source Type: Journal    
DOI: 10.1517/17460441.2010.488264     Document Type: Review
Times cited : (5)

References (44)
  • 1
    • 37649010665 scopus 로고    scopus 로고
    • Microfluidics for drug discovery and development: From target selection to product lifecycle management
    • Kang L, Chung BG, Langer R, Khademhosseini A. Microfluidics for drug discovery and development: from target selection to product lifecycle management. Drug Discov Today 2008;13:1-13
    • (2008) Drug Discov Today , vol.13 , pp. 1-13
    • Kang, L.1    Chung, B.G.2    Langer, R.3    Khademhosseini, A.4
  • 2
    • 33644777646 scopus 로고    scopus 로고
    • Lab-on-a-chip: Microfluidics in drug discovery
    • Dittrich P, Manz A. Lab-on-a-chip: microfluidics in drug discovery. Nat Rev 2006;5:210-218
    • (2006) Nat Rev , vol.5 , pp. 210-218
    • Dittrich, P.1    Manz, A.2
  • 3
    • 33845342557 scopus 로고    scopus 로고
    • Microfluidic digital PCR enables multigene analysis of individual environmental bacteria
    • Ottesen EA, Hong JW, Quake SR, Leadbetter JR. Microfluidic digital PCR enables multigene analysis of individual environmental bacteria. Science 2006;314:41464-41467
    • (2006) Science , vol.314 , pp. 41464-41467
    • Ottesen, E.A.1    Hong, J.W.2    Quake, S.R.3    Leadbetter, J.R.4
  • 4
    • 0034908917 scopus 로고    scopus 로고
    • Microfluidics-downsizing large-scale biology
    • Mitchell P. Microfluidics-downsizing large-scale biology. Nat Biotechnol 2001;19:717-721
    • (2001) Nat Biotechnol , vol.19 , pp. 717-721
    • Mitchell, P.1
  • 6
    • 33745792813 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic modelling: History and perspectives
    • Csajka C, Verotta D. Pharmacokinetic-pharmacodynamic modelling: history and perspectives. J Pharmacokinet Pharmacodyn 2006;33:227-279
    • (2006) J Pharmacokinet Pharmacodyn , vol.33 , pp. 227-279
    • Csajka, C.1    Verotta, D.2
  • 7
    • 0842288281 scopus 로고    scopus 로고
    • Microfluidic tools for high-throughput screening
    • Thorsen TA. Microfluidic tools for high-throughput screening. BioTechniques 2004;36:197-199
    • (2004) BioTechniques , vol.36 , pp. 197-199
    • Thorsen, T.A.1
  • 8
    • 36448935709 scopus 로고    scopus 로고
    • Versatile, fully automated, microfluidic cell culture system
    • Gómez-Sj€oberg R, Leyrat AA, Pirone DM, et al. Versatile, fully automated, microfluidic cell culture system. Anal Chem 2007;79:8557-8563
    • (2007) Anal Chem , vol.79 , pp. 8557-8563
    • Gómez-Sjoberg, R.1    Leyrat, A.A.2    Pirone, D.M.3
  • 9
    • 35348902108 scopus 로고    scopus 로고
    • Biological cells on microchips: New technologies and applications
    • Tanaka Y, Sato K, Shimizu T, et al. Biological cells on microchips: new technologies and applications. Biosens Bioelectron 2007;23:449-458
    • (2007) Biosens Bioelectron , vol.23 , pp. 449-458
    • Tanaka, Y.1    Sato, K.2    Shimizu, T.3
  • 10
    • 74049137840 scopus 로고    scopus 로고
    • Single cells as experimentation units in lab-on-a-chip devices
    • Le Gac S, van den Berg A. Single cells as experimentation units in lab-on-a-chip devices. Trends Biotechnol 2010;28:55-62
    • (2010) Trends Biotechnol , vol.28 , pp. 55-62
    • Le Gac, S.1    Van Den Berg, A.2
  • 12
    • 33847356130 scopus 로고    scopus 로고
    • A novel 3D mammalian cell perfusion-culture system in microfluidic channels
    • Toh YC, Zhang C, Zhang J, et al. A novel 3D mammalian cell perfusion-culture system in microfluidic channels. Lab Chip 2007;7:302-309
    • (2007) Lab Chip , vol.7 , pp. 302-309
    • Toh, Y.C.1    Zhang, C.2    Zhang, J.3
  • 13
    • 67650000887 scopus 로고    scopus 로고
    • Microfluidic single-cell array cytometry for the analysis of tumor apoptosis
    • Wlodkowic D, Faley S, Zagnoni M, et al. Microfluidic single-cell array cytometry for the analysis of tumor apoptosis. Anal Chem 2009;81:5517-5523
    • (2009) Anal Chem , vol.81 , pp. 5517-5523
    • Wlodkowic, D.1    Faley, S.2    Zagnoni, M.3
  • 14
    • 33750478294 scopus 로고    scopus 로고
    • Dynamic single cell culture array
    • Carlo DD, Wu LY, Lee LP. Dynamic single cell culture array. Lab Chip 2006;6:1445-1449
    • (2006) Lab Chip , vol.6 , pp. 1445-1449
    • Carlo, D.D.1    Wu, L.Y.2    Lee, L.P.3
  • 15
    • 1342281273 scopus 로고    scopus 로고
    • The integration of pharmacokinetics and pharmacodynamics: Understanding dose-response
    • Abdel-Rahman SM, Kauffman RE. The integration of pharmacokinetics and pharmacodynamics: understanding dose-response. Annu Rev Pharmacol Toxicol 2004;44:111-136
    • (2004) Annu Rev Pharmacol Toxicol , vol.44 , pp. 111-136
    • Abdel-Rahman, S.M.1    Kauffman, R.E.2
  • 17
    • 0038670237 scopus 로고    scopus 로고
    • Microfluidic memory and control devices
    • Groisman A, Enzelberger M, Quake SR. Microfluidic memory and control devices. Science 2003;300:955-958
    • (2003) Science , vol.300 , pp. 955-958
    • Groisman, A.1    Enzelberger, M.2    Quake, S.R.3
  • 18
    • 0242268611 scopus 로고    scopus 로고
    • Drug delivery-controlling the flow
    • Brazil M. Drug delivery-Controlling the flow. Nat Rev Drug Discov 2003;2:510
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 510
    • Brazil, M.1
  • 20
    • 33646540414 scopus 로고    scopus 로고
    • Controlled microfluidic encapsulation of cells, proteins, and microbeads in lipid vesicles
    • Tan YC, Hettiarachchi K, Siu M, et al. Controlled microfluidic encapsulation of cells, proteins, and microbeads in lipid vesicles. J Am Chem Soc 2006;128:5656-5658
    • (2006) J Am Chem Soc , vol.128 , pp. 5656-5658
    • Tan, Y.C.1    Hettiarachchi, K.2    Siu, M.3
  • 21
    • 13444280469 scopus 로고    scopus 로고
    • Generation of monodisperse particles by using microfluidics: Control over size, shape, and composition
    • Xu S, Nie Z, Seo M, et al. Generation of monodisperse particles by using microfluidics: control over size, shape, and composition. Angew Chem Int Ed Engl 2005;44:724-728
    • (2005) Angew Chem Int Ed Engl , vol.44 , pp. 724-728
    • Xu, S.1    Nie, Z.2    Seo, M.3
  • 22
    • 9144257375 scopus 로고    scopus 로고
    • Controlled production of monodisperse double emulsions by two-step droplet breakup in microfluidic devices
    • Okushima S, Nisisako T, Torii T, Higuchi T. Controlled production of monodisperse double emulsions by two-step droplet breakup in microfluidic devices. Langmuir 2004;20:9905-9908
    • (2004) Langmuir , vol.20 , pp. 9905-9908
    • Okushima, S.1    Nisisako, T.2    Torii, T.3    Higuchi, T.4
  • 24
    • 34548316287 scopus 로고    scopus 로고
    • Integrated siphon-based metering and sedimentation of whole blood on a hydrophilic lab-on-a-disk
    • Steigert J, Brenner T, Grumann M, et al. Integrated siphon-based metering and sedimentation of whole blood on a hydrophilic lab-on-a-disk. Biomed Microdevices 2007;9:675-679
    • (2007) Biomed Microdevices , vol.9 , pp. 675-679
    • Steigert, J.1    Brenner, T.2    Grumann, M.3
  • 25
    • 33746558539 scopus 로고    scopus 로고
    • Fully integrated whole blood testing by real-time absorption measurement on a centrifugal platform
    • Steigert J, Grumann M, Brenner T, et al. Fully integrated whole blood testing by real-time absorption measurement on a centrifugal platform. Lab Chip 2006;6:1040-1044
    • (2006) Lab Chip , vol.6 , pp. 1040-1044
    • Steigert, J.1    Grumann, M.2    Brenner, T.3
  • 26
    • 33947360186 scopus 로고    scopus 로고
    • A capillary-based microfluidic instrument suitable for immunoaffinity chromatography
    • Peoples MC, Phillips TM, Karnes HT. A capillary-based microfluidic instrument suitable for immunoaffinity chromatography. J Chromatogr B 2007;848:200-207
    • (2007) J Chromatogr B , vol.848 , pp. 200-207
    • Peoples, M.C.1    Phillips, T.M.2    Karnes, H.T.3
  • 27
    • 33644636333 scopus 로고    scopus 로고
    • Gelatin based microfluidic devices for cell culture
    • Paguirigan A, Beebe DJ. Gelatin based microfluidic devices for cell culture. Lab Chip 2006;6:407-413
    • (2006) Lab Chip , vol.6 , pp. 407-413
    • Paguirigan, A.1    Beebe, D.J.2
  • 28
    • 77950863285 scopus 로고    scopus 로고
    • Detection of single-molecule H2O2 signalling from epidermal growth factor receptor using fluorescent single-walled carbon nanotubes
    • Jin H, Heller DA, Kalbacova M, et al. Detection of single-molecule H2O2 signalling from epidermal growth factor receptor using fluorescent single-walled carbon nanotubes. Nat Nanotechnol 2010;5:302-309
    • (2010) Nat Nanotechnol , vol.5 , pp. 302-309
    • Jin, H.1    Heller, D.A.2    Kalbacova, M.3
  • 29
    • 77953722119 scopus 로고    scopus 로고
    • Dielectrophoretic cell assembly of artificial liver sinusoids in a microfluidic system for use in substance screening
    • Schuette J, Angres B, Benz K, et al. Dielectrophoretic cell assembly of artificial liver sinusoids in a microfluidic system for use in substance screening. Proc MicroTAS 2009;1:1847-1849
    • (2009) Proc MicroTAS , vol.1 , pp. 1847-1849
    • Schuette, J.1    Angres, B.2    Benz, K.3
  • 30
    • 67749115964 scopus 로고    scopus 로고
    • Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human
    • Chao P, Maguire T, Novik E, et al. Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human. Biochem Pharmacol 2009;78:625-632
    • (2009) Biochem Pharmacol , vol.78 , pp. 625-632
    • Chao, P.1    Maguire, T.2    Novik, E.3
  • 31
    • 77449119885 scopus 로고    scopus 로고
    • A microfluidic hepatic coculture platform for cell-based drug metabolism studies
    • Novik E, Maguire TJ, Cheng CKC, Yarmush ML. A microfluidic hepatic coculture platform for cell-based drug metabolism studies. Biochem Pharmacol 2010;79:1036-1044
    • (2010) Biochem Pharmacol , vol.79 , pp. 1036-1044
    • Novik, E.1    Maguire, T.J.2    Ckc, C.3    Yarmush, M.L.4
  • 32
    • 56749156418 scopus 로고    scopus 로고
    • Accordion-like honeycombs for tissue engineering of cardiac anisotropy
    • Engelmayr GC, Cheng M, Bettinger CJ, et al. Accordion-like honeycombs for tissue engineering of cardiac anisotropy. Nat Mater 2008;7(12):1003-1010
    • (2008) Nat Mater , vol.7 , Issue.12 , pp. 1003-1010
    • Engelmayr, G.C.1    Cheng, M.2    Bettinger, C.J.3
  • 33
    • 33747090983 scopus 로고    scopus 로고
    • Control and detection of chemical reactions in microfluidic systems
    • DeMello AJ. Control and detection of chemical reactions in microfluidic systems. Nature 2006;442:394-402
    • (2006) Nature , vol.442 , pp. 394-402
    • Demello, A.J.1
  • 34
    • 5144223105 scopus 로고    scopus 로고
    • Systematic investigation of protein phase behavior with a microfluidic formulator
    • Hansen CL, Sommer MO, Quake SR. Systematic investigation of protein phase behavior with a microfluidic formulator. Proc Natl Acad Sci USA 2004;101(40):14431-14436
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.40 , pp. 14431-14436
    • Hansen, C.L.1    Sommer, M.O.2    Quake, S.R.3
  • 35
    • 75149179483 scopus 로고    scopus 로고
    • Microfluidic devices for cell based high throughput screening
    • Upadhyaya S, Selvaganapathy PR. Microfluidic devices for cell based high throughput screening. Lab Chip 2010;10:341-348
    • (2010) Lab Chip , vol.10 , pp. 341-348
    • Upadhyaya, S.1    Selvaganapathy, P.R.2
  • 36
    • 65549112285 scopus 로고    scopus 로고
    • High-throughput cellular microarray platforms: Applications in drug discovery, toxicology and stem cell research
    • Fernandes TG, Diogo MM, Clark DS, et al. High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research. Trends Biotechnol 2009;27:342-349
    • (2009) Trends Biotechnol , vol.27 , pp. 342-349
    • Fernandes, T.G.1    Diogo, M.M.2    Clark, D.S.3
  • 37
    • 77951583526 scopus 로고    scopus 로고
    • Three-dimensional cell culture microarray for high-throughput studies of stem cell fate
    • Fernandes TG, Kwo SJ, Bal SS, et al. Three-dimensional cell culture microarray for high-throughput studies of stem cell fate. Biotechnol Bioeng 2010;106:106-118
    • (2010) Biotechnol Bioeng , vol.106 , pp. 106-118
    • Fernandes, T.G.1    Kwo, S.J.2    Bal, S.S.3
  • 38
    • 69549138236 scopus 로고    scopus 로고
    • Hype, hope and hubris: The quest for the killer application in microfluidics
    • Becker H. Hype, hope and hubris: the quest for the killer application in microfluidics. Lab Chip 2009;15:2119-2122
    • (2009) Lab Chip , vol.15 , pp. 2119-2122
    • Becker, H.1
  • 39
    • 2142734863 scopus 로고    scopus 로고
    • Microfluidic toolbox: Tools and standardization solutions for microfluidic devices for life sciences applications
    • San Jose: SPIE
    • Gärtner C, Becker H, Anton B, R€otting O. Microfluidic toolbox: tools and standardization solutions for microfluidic devices for life sciences applications. Proceedings "Microfluidics, BioMEMS, and Medical Microsystems II" Volume 5345. San Jose: SPIE, 2003. p. 159-162
    • (2003) Proceedings "microfluidics, BioMEMS, and Medical Microsystems II" , vol.5345 , pp. 159-162
    • Gärtner, C.1    Becker, H.2    Anton, B.3    Rotting, O.4
  • 40
    • 69549126224 scopus 로고    scopus 로고
    • Microfluidics: The great divide
    • Blow N. Microfluidics: the great divide. Nat Methods 2009;6:683-686
    • (2009) Nat Methods , vol.6 , pp. 683-686
    • Blow, N.1
  • 41
    • 0031783806 scopus 로고    scopus 로고
    • Miniaturization of analytical systems
    • Kricka L. Miniaturization of analytical systems. Clin Chem 1998;44:2008-2014
    • (1998) Clin Chem , vol.44 , pp. 2008-2014
    • Kricka, L.1
  • 42
    • 40049110139 scopus 로고    scopus 로고
    • Single-molecule detection of DNA via sequence-specific links between F1-ATPase motors and gold nanorod sensors
    • York J, Spetzler D, Xiong F, Frasch WD. Single-molecule detection of DNA via sequence-specific links between F1-ATPase motors and gold nanorod sensors. Lab Chip 2008;8:415-419
    • (2008) Lab Chip , vol.8 , pp. 415-419
    • York, J.1    Spetzler, D.2    Xiong, F.3    Frasch, W.D.4
  • 43
    • 76749092617 scopus 로고    scopus 로고
    • SERS as tool for the analysis of DNA-chips in a microfluidic platform
    • Strelau KK, Kretschmer R, M€oller R, et al. SERS as tool for the analysis of DNA-chips in a microfluidic platform. Anal Bioanal Chem 2010;396:1381-1384
    • (2010) Anal Bioanal Chem , vol.396 , pp. 1381-1384
    • Strelau, K.K.1    Kretschmer, R.2    Moller, R.3
  • 44
    • 54749087430 scopus 로고    scopus 로고
    • Electronic and optical properties of electromigrated molecular junctions
    • Ward DR, Scott GD, Keane ZK, et al. Electronic and optical properties of electromigrated molecular junctions. J Phys Condens Matter 2008;20:374118
    • (2008) J Phys Condens Matter , vol.20 , pp. 374118
    • Ward, D.R.1    Scott, G.D.2    Keane, Z.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.