-
2
-
-
0021238287
-
Receptor theories and quantitative effect versus dose-concentration relationship
-
R. J. Tallarida. Receptor theories and quantitative effect versus dose-concentration relationship. Drug Metab. Rev. 15:345-363 (1984).
-
(1984)
Drug Metab. Rev.
, vol.15
, pp. 345-363
-
-
Tallarida, R.J.1
-
3
-
-
0028784648
-
A general conceptual model for non-steady state pharmacokinetic/ pharmacodynamic data
-
D. Verotta and L. B. Sheiner. A general conceptual model for non-steady state pharmacokinetic/pharmacodynamic data. J. Pharmacokin. Biopharm. 23:1-4 (1995).
-
(1995)
J. Pharmacokin. Biopharm.
, vol.23
, pp. 1-4
-
-
Verotta, D.1
Sheiner, L.B.2
-
4
-
-
0027769745
-
Comparison of four basic models of indirect pharmacodynamic responses
-
N. Dayneka, V. Garg, and W. Jusko. Comparison of four basic models of indirect pharmacodynamic responses. J. Pharmacokinet. Biopharm. 21:457-478 (1993).
-
(1993)
J. Pharmacokinet. Biopharm.
, vol.21
, pp. 457-478
-
-
Dayneka, N.1
Garg, V.2
Jusko, W.3
-
5
-
-
0028075942
-
Mechanism-based pharmacodynamic modeling
-
G. Levy. Mechanism-based pharmacodynamic modeling. Clin. Pharmacol. Therapeut. 56:356-358 (1994).
-
(1994)
Clin. Pharmacol. Therapeut.
, vol.56
, pp. 356-358
-
-
Levy, G.1
-
6
-
-
0030427104
-
Concepts, properties, and applications of linear systems to describe the distribution, identify input, and control endogenous substances and drugs in biological systems
-
D. Verotta. Concepts, properties, and applications of linear systems to describe the distribution, identify input, and control endogenous substances and drugs in biological systems. CRC Crit. Rev. Biomol. Eng. 24:73-139 (1996).
-
(1996)
CRC Crit. Rev. Biomol. Eng.
, vol.24
, pp. 73-139
-
-
Verotta, D.1
-
7
-
-
0344522265
-
Semi-parametric direct and indirect action models for pharmacokinetics/pharmacodynamic data
-
Las Vegas, Nevada, USA
-
D. Verotta. Semi-parametric direct and indirect action models for pharmacokinetics/pharmacodynamic data. In: Proceedings Society Computer Simulation Western Multiconference, Las Vegas, Nevada, USA, 1995.
-
(1995)
Proceedings Society Computer Simulation Western Multiconference
-
-
Verotta, D.1
-
8
-
-
0014341045
-
Kinetics of interaction between drugs and biological system
-
G. Segre. Kinetics of interaction between drugs and biological system. Il Farmaco Ed. Sci. 23:907-918 (1968).
-
(1968)
Il Farmaco Ed. Sci.
, vol.23
, pp. 907-918
-
-
Segre, G.1
-
9
-
-
0013909219
-
Kinetics of pharmacologic effects
-
G. Levy. Kinetics of pharmacologic effects. Clin Pharm Therapeut. 7:362-372 (1966).
-
(1966)
Clin Pharm Therapeut.
, vol.7
, pp. 362-372
-
-
Levy, G.1
-
10
-
-
78651145136
-
Relationship between elimination rate of drugs and rate of decline of their pharmacological effect
-
G. Levy. Relationship between elimination rate of drugs and rate of decline of their pharmacological effect. J. Pharm. Sci. 53:343-343 (1964).
-
(1964)
J. Pharm. Sci.
, vol.53
, pp. 343-343
-
-
Levy, G.1
-
11
-
-
0006891224
-
Theoretical relationship between dose, elimination rate, and duration of pharmacologic effect of drugs
-
G. Levy and E. Nelson. Theoretical relationship between dose, elimination rate, and duration of pharmacologic effect of drugs. J. Pharm. Sci. 54:812 (1965).
-
(1965)
J. Pharm. Sci.
, vol.54
, pp. 812
-
-
Levy, G.1
Nelson, E.2
-
12
-
-
0006892932
-
Apparent potentiating effect of a second dose of drug
-
G. Levy. Apparent potentiating effect of a second dose of drug. Nature 206:517-519 (1965).
-
(1965)
Nature
, vol.206
, pp. 517-519
-
-
Levy, G.1
-
13
-
-
0014318562
-
Kinetics of pharmacologic response. I. Proposed relationships between response and drug concentration in the intact animal and man
-
J. Wagner. Kinetics of pharmacologic response. I. Proposed relationships between response and drug concentration in the intact animal and man. J. Theoret. Biol. 20:173-201 (1968).
-
(1968)
J. Theoret. Biol.
, vol.20
, pp. 173-201
-
-
Wagner, J.1
-
14
-
-
0000457493
-
The mode of action of biologically active compounds
-
G De Stevens (ed.), Academic Press, New York
-
E. Ariens. The mode of action of biologically active compounds. In: G De Stevens (ed.), Molecular Pharmacology. Academic Press, New York, 1964.
-
(1964)
Molecular Pharmacology
-
-
Ariens, E.1
-
15
-
-
0021058380
-
Operational models of pharmacological agonism
-
J. W. Black and P. Leff. Operational models of pharmacological agonism. Proc. R. Soc. Lond. B. 220:141-162 (1983).
-
(1983)
Proc. R. Soc. Lond. B.
, vol.220
, pp. 141-162
-
-
Black, J.W.1
Leff, P.2
-
16
-
-
0032927364
-
Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: Midazolam and ∝-OH-midazolam
-
B. Tuk, M. Van Oostenbruggen, and V. M. M. Herben et al. Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: Midazolam and ∝-OH-midazolam. J. Pharmacol. Exp. Therapeut. 289:1067-1074 (1999).
-
(1999)
J. Pharmacol. Exp. Therapeut.
, vol.289
, pp. 1067-1074
-
-
Tuk, B.1
Van Oostenbruggen, M.2
Herben, V.M.M.3
-
18
-
-
0000137448
-
The pharmacology of vascular smooth muscle
-
R. Furchgott. The pharmacology of vascular smooth muscle. Pharm. Res. 7:183-265 (1955).
-
(1955)
Pharm. Res.
, vol.7
, pp. 183-265
-
-
Furchgott, R.1
-
19
-
-
0001223011
-
The use of chemical potentials as indices of toxicity
-
J. Ferguson. The use of chemical potentials as indices of toxicity. Proc. Roy. Soc. London, s.B. 127:387-404 (1939).
-
(1939)
Proc. Roy. Soc. London, S.B.
, vol.127
, pp. 387-404
-
-
Ferguson, J.1
-
20
-
-
84866252988
-
SAAM manual
-
Washington, DC, U.S. Government Printing Office
-
M. Berman and M. F. Weiss. SAAM manual. U.S. Department of Health, Education and Welfare, Public Health Service Publication No. 1703. Washington, DC, U.S. Government Printing Office, 200 pp. 1967.
-
(1967)
U.S. Department of Health, Education and Welfare, Public Health Service Publication No. 1703
-
-
Berman, M.1
Weiss, M.F.2
-
21
-
-
0019403610
-
Conversational SAAM - An interactive program for kinetic analysis of biological systems
-
C. Boston, P. C. Greif, and M. Berman. Conversational SAAM - An interactive program for kinetic analysis of biological systems. Comput. Programs Biomed. 1981: 111-119 (1981).
-
(1981)
Comput. Programs Biomed.
, vol.1981
, pp. 111-119
-
-
Boston, C.1
Greif, P.C.2
Berman, M.3
-
22
-
-
33745769878
-
-
Seattle, WA: SAAM Institute, Inc.
-
SAAM. In Series. Seattle, WA: SAAM Institute, Inc. http://www.saam.com/ software/saam2/saam2software.htm.
-
Series
-
-
-
24
-
-
0014500691
-
Multicompartment pkarmacokinetic models and pharmacologic effects
-
G. Levy, M. Gibaldi, and W. Jusko. Multicompartment pkarmacokinetic models and pharmacologic effects. J. Pharm. Sci. 58:422-424 (1969).
-
(1969)
J. Pharm. Sci.
, vol.58
, pp. 422-424
-
-
Levy, G.1
Gibaldi, M.2
Jusko, W.3
-
25
-
-
0017188890
-
Relationship between the pharmacokinetics and pharmacodynamics of procainamide
-
R. Galeazzi, L. Benet, and L. Sheiner. Relationship between the pharmacokinetics and pharmacodynamics of procainamide. Clin. Pharmacol. Ther. 20:278-289 (1976).
-
(1976)
Clin. Pharmacol. Ther.
, vol.20
, pp. 278-289
-
-
Galeazzi, R.1
Benet, L.2
Sheiner, L.3
-
26
-
-
0018425729
-
Pharmacokinetics of digoxin: Relationship between response intensity and predicted compartmental drug levels in man
-
W. Kramer, A. Kolibash, and R. Lewis et al. Pharmacokinetics of digoxin: Relationship between response intensity and predicted compartmental drug levels in man. J. Pharmacokinet. Biopharm. 7:47-61 (1979).
-
(1979)
J. Pharmacokinet. Biopharm.
, vol.7
, pp. 47-61
-
-
Kramer, W.1
Kolibash, A.2
Lewis, R.3
-
27
-
-
0026396751
-
Estimation of amobarbital plasma-effect site equilibration kinetics. Relevance of polyexponential conductance functions
-
J. Mandema, P. Veng-Pedersen, and M. Danhof. Estimation of amobarbital plasma-effect site equilibration kinetics. Relevance of polyexponential conductance functions. J. Pharmacokinet. Biopharm. 19:617-634 (1991).
-
(1991)
J. Pharmacokinet. Biopharm.
, vol.19
, pp. 617-634
-
-
Mandema, J.1
Veng-Pedersen, P.2
Danhof, M.3
-
28
-
-
0018394195
-
Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine
-
L. Sheiner, D. Stanski, and S. Vozeh et al. Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine. Clin. Pharmacol. Ther. 25:358-371 (1979).
-
(1979)
Clin. Pharmacol. Ther.
, vol.25
, pp. 358-371
-
-
Sheiner, L.1
Stanski, D.2
Vozeh, S.3
-
29
-
-
0015071439
-
Pharmacodynamics of chemotherapeutic effects: Dose-time-response relationships for phase-non-specific agents
-
W. Jusko. Pharmacodynamics of chemotherapeutic effects: Dose-time-response relationships for phase-non-specific agents. J. Pharm. Sci. 60:892-895 (1971).
-
(1971)
J. Pharm. Sci.
, vol.60
, pp. 892-895
-
-
Jusko, W.1
-
30
-
-
0015730041
-
A pharmacodynamic model for cell-cycle-specific chemotherapeutic agents
-
W. Jusko. A pharmacodynamic model for cell-cycle-specific chemotherapeutic agents. J. Pharmacokinet. Biopharm. 1:175-200 (1973).
-
(1973)
J. Pharmacokinet. Biopharm.
, vol.1
, pp. 175-200
-
-
Jusko, W.1
-
31
-
-
0014441225
-
Kinetics of pharmacologic effects in man: The anticoagulant action of warfarin
-
R. Nagashima, R. O'Reilly, and G. Levy. Kinetics of pharmacologic effects in man: The anticoagulant action of warfarin. Clin. Pharmacol. Ther. 10:22-35 (1969).
-
(1969)
Clin. Pharmacol. Ther.
, vol.10
, pp. 22-35
-
-
Nagashima, R.1
O'Reilly, R.2
Levy, G.3
-
32
-
-
0014623892
-
Computer-aided long-term anticoagulation therapy
-
L. Sheiner. Computer-aided long-term anticoagulation therapy. Comput. Biomed. Res. 2:507-518 (1969).
-
(1969)
Comput. Biomed. Res.
, vol.2
, pp. 507-518
-
-
Sheiner, L.1
-
33
-
-
0015579402
-
Multiple-dose kinetics of oral anticoagulants: Methods of analysis and optimised dosing
-
T. Theophanus and R. Barile. Multiple-dose kinetics of oral anticoagulants: Methods of analysis and optimised dosing. J. Pharm. Sci. 62:261-266 (1973).
-
(1973)
J. Pharm. Sci.
, vol.62
, pp. 261-266
-
-
Theophanus, T.1
Barile, R.2
-
34
-
-
0020260327
-
Evaluation of a computer-assisted method for individualized anticoagulation: Retrospective an prospective studies with a pharmacodynamic model
-
P. Abbrecht, T. O'Leary, and D. Behrendt. Evaluation of a computer-assisted method for individualized anticoagulation: Retrospective an prospective studies with a pharmacodynamic model. Clin. Pharmacol. Ther. 32: 129-136 (1982).
-
(1982)
Clin. Pharmacol. Ther.
, vol.32
, pp. 129-136
-
-
Abbrecht, P.1
O'Leary, T.2
Behrendt, D.3
-
35
-
-
0019841822
-
Predicting oral anticoagulant response using a pharmacodynamic model
-
T. O'Leary, P. Abbrecht. Predicting oral anticoagulant response using a pharmacodynamic model. Ann. Biomed. Eng. 9: 199-216 (1981).
-
(1981)
Ann. Biomed. Eng.
, vol.9
, pp. 199-216
-
-
O'Leary, T.1
Abbrecht, P.2
-
36
-
-
0031742890
-
Precursor-dependant indirect pharmacodynamic response model for tolerance and rebound phenomena
-
A. Sharma. Precursor-dependant indirect pharmacodynamic response model for tolerance and rebound phenomena. J. Pharm. Sci. 87:1577-1584 (1998).
-
(1998)
J. Pharm. Sci.
, vol.87
, pp. 1577-1584
-
-
Sharma, A.1
-
37
-
-
10244221083
-
Assessment of drug interactions relevant to pharmacodynamic indirect response models
-
J. Earp, W. Krzyzanski, and A. Chakraborty et al. Assessment of drug interactions relevant to pharmacodynamic indirect response models. J. Pharmacokine. Pharmacodynam. 31:345-380 (2004).
-
(2004)
J. Pharmacokine. Pharmacodynam.
, vol.31
, pp. 345-380
-
-
Earp, J.1
Krzyzanski, W.2
Chakraborty, A.3
-
38
-
-
0026318570
-
Two-compartment basophil cell trafficking model for methylprednisolone pharmacodynamics
-
J. Wald. Two-compartment basophil cell trafficking model for methylprednisolone pharmacodynamics. J. Pharmacokinet. Biopharm. 19:521-536 (1991).
-
(1991)
J. Pharmacokinet. Biopharm.
, vol.19
, pp. 521-536
-
-
Wald, J.1
-
39
-
-
0024805238
-
Pharmacokinetics and pharmacodynamic modeling of direct suppression effects of methylprednisolone on serum cortisol and blood histamine in human subjects
-
A. Kong, E. Ludwig, and R. Slaughter et al. Pharmacokinetics and pharmacodynamic modeling of direct suppression effects of methylprednisolone on serum cortisol and blood histamine in human subjects. Clin. Pharmacol. Therpeut. 46:616-628 (1989).
-
(1989)
Clin. Pharmacol. Therpeut.
, vol.46
, pp. 616-628
-
-
Kong, A.1
Ludwig, E.2
Slaughter, R.3
-
40
-
-
0025869631
-
Pharmacokinetics and pharmacodynamics of methylprednisolone in obese and on-obese men
-
T. Dunn, E. Ludwig, and R. Slaughter et al. Pharmacokinetics and pharmacodynamics of methylprednisolone in obese and on-obese men. Clin. Pharmacol. Therpeut. 50:536-549 (1991).
-
(1991)
Clin. Pharmacol. Therpeut.
, vol.50
, pp. 536-549
-
-
Dunn, T.1
Ludwig, E.2
Slaughter, R.3
-
41
-
-
0021723695
-
Pharmacokinetics of three different prednisolone produrgs: Effect on circulating lymphocyte subsets and function
-
B. Frey, C. Walker, and F. Frey et al. Pharmacokinetics of three different prednisolone produrgs: effect on circulating lymphocyte subsets and function. J. Immunol. 133: 2479-2487 (1984).
-
(1984)
J. Immunol.
, vol.133
, pp. 2479-2487
-
-
Frey, B.1
Walker, C.2
Frey, F.3
-
42
-
-
0003099238
-
Glucocorticoid receptors and mechanisms of action of steroid hormones
-
Marcel Dekker, New York
-
A. Munck and K. Leung. Glucocorticoid receptors and mechanisms of action of steroid hormones. Receptors and Mechanisms of Action of Steroid Hormones. Marcel Dekker, New York, 1977, pp. 311-397.
-
(1977)
Receptors and Mechanisms of Action of Steroid Hormones
, pp. 311-397
-
-
Munck, A.1
Leung, K.2
-
43
-
-
0023913120
-
The steroid and thyroid hormone receptor superfamily
-
R. Evans. The steroid and thyroid hormone receptor superfamily. Science 240: 889-895 (1988).
-
(1988)
Science
, vol.240
, pp. 889-895
-
-
Evans, R.1
-
45
-
-
0024390992
-
Second generation model for prednisolone pharmacodynamics in the rat
-
A. Nichols. Second generation model for prednisolone pharmacodynamics in the rat. J. Pharmacokinet. Biopharm. 17:209-227 (1989).
-
(1989)
J. Pharmacokinet. Biopharm.
, vol.17
, pp. 209-227
-
-
Nichols, A.1
-
46
-
-
0031835741
-
Transit compartments versus gamma distribution function to model signal transduction processes in pharmacodynamics
-
Y. Sun and W. Jusko. Transit compartments versus gamma distribution function to model signal transduction processes in pharmacodynamics. J. Pharm. Sci. 87:732-737 (1998).
-
(1998)
J. Pharm. Sci.
, vol.87
, pp. 732-737
-
-
Sun, Y.1
Jusko, W.2
-
47
-
-
0022503203
-
Pharmacokinetic-pharmacodynamic modeling of terbutaline bronchodilation in asthma
-
B. Oosterhuis, M. Braat, and C. Roos et al. Pharmacokinetic- pharmacodynamic modeling of terbutaline bronchodilation in asthma. Clin. Pharmacol. Therpeut 40:469-475 (1986).
-
(1986)
Clin. Pharmacol. Therpeut
, vol.40
, pp. 469-475
-
-
Oosterhuis, B.1
Braat, M.2
Roos, C.3
-
48
-
-
0034832459
-
Pharmacodynamic modeling of time-dependent transduction systems
-
D. Mager and W. Jusko. Pharmacodynamic modeling of time-dependent transduction systems. Clin. Pharmacol. Therpeut. 70:210-216 (2001).
-
(2001)
Clin. Pharmacol. Therpeut.
, vol.70
, pp. 210-216
-
-
Mager, D.1
Jusko, W.2
-
49
-
-
85046916618
-
Pharmacodynamic modeling of chemotherapeutic effects: Application of a transit compartment model to characterize methotrexate effects in vitro
-
E. Lobo and J. Balthasar. Pharmacodynamic modeling of chemotherapeutic effects: Application of a transit compartment model to characterize methotrexate effects in vitro. AAPS Pharmaceut. Sci. 4:1-11 (2002).
-
(2002)
AAPS Pharmaceut. Sci.
, vol.4
, pp. 1-11
-
-
Lobo, E.1
Balthasar, J.2
-
50
-
-
0020285913
-
Kinetics of drug effect by distributed lags analysis: An application to cocaine
-
R. Zahler, P. Wachter, and P. Jatlow et al. Kinetics of drug effect by distributed lags analysis: An application to cocaine. Clin. Pharmacol. Therpeut. 31:775-782 (1982).
-
(1982)
Clin. Pharmacol. Therpeut.
, vol.31
, pp. 775-782
-
-
Zahler, R.1
Wachter, P.2
Jatlow, P.3
-
51
-
-
0021296818
-
A model eliciting transient responses
-
E. Ekbad and V. Licko. A model eliciting transient responses. Am. J. Physiol. 246:R114-R121 (1984).
-
(1984)
Am. J. Physiol.
, vol.246
-
-
Ekbad, E.1
Licko, V.2
-
52
-
-
0022129536
-
Kinetics of cocaine distribution, elimination, and chronotropic effects
-
M. Chow, J. Ambre, and T. Ruo et al. Kinetics of cocaine distribution, elimination, and chronotropic effects. Clin. Pharmacol. Therpeutic. 38:318-324 (1985).
-
(1985)
Clin. Pharmacol. Therpeutic.
, vol.38
, pp. 318-324
-
-
Chow, M.1
Ambre, J.2
Ruo, T.3
-
53
-
-
0021954756
-
Acute tolerance to furosemide diuresis in humans. Pharmacokinetic- Pharmacodynamic modelling
-
M. Hammarlund, B. Odling, and L. Paalzow. Acute tolerance to furosemide diuresis in humans. Pharmacokinetic-Pharmacodynamic modelling. J. Pharmacol. Exp. Therpeut. 233:447-453 (1985).
-
(1985)
J. Pharmacol. Exp. Therpeut.
, vol.233
, pp. 447-453
-
-
Hammarlund, M.1
Odling, B.2
Paalzow, L.3
-
55
-
-
0027441595
-
Pharmacokinetic-pharmacodynamic modeling of caffeine: Tolerance to pressor effects
-
J. Shi, N. Benowitz, and C. Denaro et al. Pharmacokinetic-pharmacodynamic modeling of caffeine: Tolerance to pressor effects. Clin. Pharmacol. Therpeut. 53:6-14 (1993).
-
(1993)
Clin. Pharmacol. Therpeut.
, vol.53
, pp. 6-14
-
-
Shi, J.1
Benowitz, N.2
Denaro, C.3
-
56
-
-
33645489787
-
Pharmacodynamic model for acute tolerance development to the electroencephalographic effects of alfentanil in the rat
-
J. W. Mandema and D. Wada. Pharmacodynamic model for acute tolerance development to the electroencephalographic effects of alfentanil in the rat. J. Pharmacol. Exp. Therpeut. 279:1035-1042 (1995).
-
(1995)
J. Pharmacol. Exp. Therpeut.
, vol.279
, pp. 1035-1042
-
-
Mandema, J.W.1
Wada, D.2
-
57
-
-
0023852556
-
Testing computer-controlled infusion pumps by simulation
-
S. L. Shafer, L. C. Siegel, and J. E. Cooke et al. Testing computer-controlled infusion pumps by simulation. Anesthesiology 68:261-266 (1988).
-
(1988)
Anesthesiology
, vol.68
, pp. 261-266
-
-
Shafer, S.L.1
Siegel, L.C.2
Cooke, J.E.3
-
58
-
-
0026752822
-
Algorithms to rapidly achieve and maintain stable drug concentrations at the site of drug effect with a computer controlled infusion pump
-
S. L. Shafer and K. M. Gregg. Algorithms to rapidly achieve and maintain stable drug concentrations at the site of drug effect with a computer controlled infusion pump. J. Pharmacokinet Biopharm. 20:147-169 (1992).
-
(1992)
J. Pharmacokinet Biopharm.
, vol.20
, pp. 147-169
-
-
Shafer, S.L.1
Gregg, K.M.2
-
59
-
-
0032894064
-
A general solution for non-parametric control of a linear system using computer controlled infusion pumps
-
D. Verotta. A general solution for non-parametric control of a linear system using computer controlled infusion pumps. IEEE Trans. Biomed. Eng. 46:44-50 (1999).
-
(1999)
IEEE Trans. Biomed. Eng.
, vol.46
, pp. 44-50
-
-
Verotta, D.1
-
60
-
-
0030771208
-
Application of pharmacodynamic modeling for designing time variant dosing regimens to overcome nitroglycerin tolerance in experimental heart failure
-
J. Bauer, J. Balthasar, and H. Fung. Application of pharmacodynamic modeling for designing time variant dosing regimens to overcome nitroglycerin tolerance in experimental heart failure. Pharm. Res. 14:114-145 (1997).
-
(1997)
Pharm. Res.
, vol.14
, pp. 114-145
-
-
Bauer, J.1
Balthasar, J.2
Fung, H.3
-
61
-
-
0026095847
-
Mathematical model for in vivo pharmacodynamics integrating fluctuation of the response: Application to the prolactin suppressant effect of the dopaminomimetic drug DCN203-922
-
P. Francheteau, J. Steimer, and C. Dubray et al. Mathematical model for in vivo pharmacodynamics integrating fluctuation of the response: Application to the prolactin suppressant effect of the dopaminomimetic drug DCN203-922. J. Pharmacokinet. Biopharm. 19:287-309 (1991).
-
(1991)
J. Pharmacokinet. Biopharm.
, vol.19
, pp. 287-309
-
-
Francheteau, P.1
Steimer, J.2
Dubray, C.3
-
62
-
-
0027365895
-
Gender-based effects on methylprednisolone pharmacokinetics and pharmacodynmamics
-
K. Lew, E. Ludwig, and M. Milad et al. Gender-based effects on methylprednisolone pharmacokinetics and pharmacodynmamics. Clin. Pharmacol. Therpeut. 54: 402-414 (1993).
-
(1993)
Clin. Pharmacol. Therpeut.
, vol.54
, pp. 402-414
-
-
Lew, K.1
Ludwig, E.2
Milad, M.3
-
64
-
-
0018168892
-
A pharmacodynamic model for pancuronium
-
C. Hull, H. Van Beem, and K. McLeod et al. A pharmacodynamic model for pancuronium. Brit. J. Anaesth. 50:1113-1123 (1978).
-
(1978)
Brit. J. Anaesth.
, vol.50
, pp. 1113-1123
-
-
Hull, C.1
Van Beem, H.2
McLeod, K.3
-
65
-
-
0021263542
-
Simultaneous modeling of pharmacokinetic and pharmacodynamics with a nonparametric model
-
E. Fuseau and L. Sheiner. Simultaneous modeling of pharmacokinetic and pharmacodynamics with a nonparametric model. Clin. Pharmacol. Therpeut. 35:733-741 (1984).
-
(1984)
Clin. Pharmacol. Therpeut.
, vol.35
, pp. 733-741
-
-
Fuseau, E.1
Sheiner, L.2
-
66
-
-
0022503230
-
Simultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric and dynamic models
-
J. Unadkat, F. Bartha, and L. Sheiner. Simultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric and dynamic models. Clin. Pharmacol. Therpeut. 40:86-93 (1986).
-
(1986)
Clin. Pharmacol. Therpeut.
, vol.40
, pp. 86-93
-
-
Unadkat, J.1
Bartha, F.2
Sheiner, L.3
-
67
-
-
0023450020
-
Simultaneous modeling of pharmacokinetics and pharmacodynamics: An improved algorithm
-
D. Verotta and L. Sheiner. Simultaneous modeling of pharmacokinetics and pharmacodynamics: An improved algorithm. Comput. Appl. Biostat. 3:345-349 (1987).
-
(1987)
Comput. Appl. Biostat.
, vol.3
, pp. 345-349
-
-
Verotta, D.1
Sheiner, L.2
-
68
-
-
0024518838
-
Semiparametric approach to pharmacokinetic-pharmacodynamic data
-
D. Verotta, S. Beal, and L. Sheiner. Semiparametric approach to pharmacokinetic-pharmacodynamic data. Am. J. Physiol. 256:R1005-R1010 (1989).
-
(1989)
Am. J. Physiol.
, vol.256
-
-
Verotta, D.1
Beal, S.2
Sheiner, L.3
-
69
-
-
0024309374
-
An inequality-constrained least-squares deconvolution method
-
D. Verotta. An inequality-constrained least-squares deconvolution method. J. Pharmacokinet. Biopharm. 17:269-289 (1989).
-
(1989)
J. Pharmacokinet. Biopharm.
, vol.17
, pp. 269-289
-
-
Verotta, D.1
-
70
-
-
0025996762
-
A system approach to pharmacodynamics. III: An algorithm and computer program, COLAPS, for pharmacodynamic modeling
-
P. Veng-Pedersen, J. Mandema, and M. Danhof. A system approach to pharmacodynamics. III: An algorithm and computer program, COLAPS, for pharmacodynamic modeling. J. Pharm. Sci. 80:488-495 (1991).
-
(1991)
J. Pharm. Sci.
, vol.80
, pp. 488-495
-
-
Veng-Pedersen, P.1
Mandema, J.2
Danhof, M.3
-
71
-
-
0030666686
-
The impact of arteriovenous concentration differences on pharmacodynamic parameter estimates
-
B. Tuk, M. Danhof, and J. Mandema. The impact of arteriovenous concentration differences on pharmacodynamic parameter estimates. J. Pharmacokinet. Biopharm. 25:39-60 (1997).
-
(1997)
J. Pharmacokinet. Biopharm.
, vol.25
, pp. 39-60
-
-
Tuk, B.1
Danhof, M.2
Mandema, J.3
-
72
-
-
0031934529
-
Relevance of arteriovenous concentration differences in pharmacokinetic-pharmacodynamic modeling of midazolam
-
B. Tuk, V. Herben, and J. Mandema et al. Relevance of arteriovenous concentration differences in pharmacokinetic-pharmacodynamic modeling of midazolam. J. Pharmacol. Exp. Therpeut. 284:202-207 (1998).
-
(1998)
J. Pharmacol. Exp. Therpeut.
, vol.284
, pp. 202-207
-
-
Tuk, B.1
Herben, V.2
Mandema, J.3
-
73
-
-
0026400983
-
Semiparametric analysis of non-steady-state pharmacodynamic data
-
D. Verotta and L. B. Sheiner. Semiparametric analysis of non-steady-state pharmacodynamic data. J. Pharmacokin. Biopharm. 19:691-712 (1991).
-
(1991)
J. Pharmacokin. Biopharm.
, vol.19
, pp. 691-712
-
-
Verotta, D.1
Sheiner, L.B.2
-
75
-
-
0025651571
-
Concepts and usefulness of pharmacokinetic-pharmacodynamic modeling
-
N. Holford. Concepts and usefulness of pharmacokinetic-pharmacodynamic modeling. Fundament. Clin. Pharmacol. Therapeut. 4:93-101 (1990).
-
(1990)
Fundament. Clin. Pharmacol. Therapeut.
, vol.4
, pp. 93-101
-
-
Holford, N.1
-
77
-
-
0015405814
-
Modeling of individual pharmacokinetics for computer-aided drug dosage
-
L. Sheiner, B. Rosenberg, and K. Melmon. Modeling of individual pharmacokinetics for computer-aided drug dosage. Comput. Biomed Res. 5:441-459 (1972).
-
(1972)
Comput. Biomed Res.
, vol.5
, pp. 441-459
-
-
Sheiner, L.1
Rosenberg, B.2
Melmon, K.3
-
78
-
-
33745805019
-
-
Technical Report, Division of Clinical Pharmacology, University of California at San Francisco
-
S. Beal and L. B. Sheiner. NONMEM I Users Guide. Technical Report, Division of Clinical Pharmacology, University of California at San Francisco, 1984.
-
(1984)
NONMEM I Users Guide
-
-
Beal, S.1
Sheiner, L.B.2
-
79
-
-
0028453062
-
Population pharmacokinetic/pharmacodynamic methodology and applications: A bibliography
-
L. Yuh, S. Beal, and M. Davidian et al. Population pharmacokinetic/ pharmacodynamic methodology and applications: A bibliography. Biometrics. 50:566-575 (1994).
-
(1994)
Biometrics
, vol.50
, pp. 566-575
-
-
Yuh, L.1
Beal, S.2
Davidian, M.3
-
81
-
-
0020359255
-
Bayesian individualisation of pharmacokinetics: Simple implementation and comparison with non-Bayesian methods
-
L. Sheiner and S. Beal. Bayesian individualisation of pharmacokinetics: Simple implementation and comparison with non-Bayesian methods. J. Pharm. Sci. 71:1344-1348 (1982).
-
(1982)
J. Pharm. Sci.
, vol.71
, pp. 1344-1348
-
-
Sheiner, L.1
Beal, S.2
-
82
-
-
0031691162
-
Expanding clinical applications of population pharmacodynamic modeling
-
C. Minto. Expanding clinical applications of population pharmacodynamic modeling. Brit. J. Clin. Pharmaco. 46:321-333 (1998).
-
(1998)
Brit. J. Clin. Pharmaco.
, vol.46
, pp. 321-333
-
-
Minto, C.1
-
83
-
-
0003747347
-
-
Technical Report, Division of Clinical Pharmacology, University of California at San Francisco
-
A. J. Boeckmann, S. L. Beal, and L. B. Sheiner. NONMEM V Users Guides. Technical Report, Division of Clinical Pharmacology, University of California at San Francisco, 1998.
-
(1998)
NONMEM V Users Guides
-
-
Boeckmann, A.J.1
Beal, S.L.2
Sheiner, L.B.3
-
84
-
-
33745767367
-
-
WinNonmix®. Pharsight. http://www.pharsight.com/products/winnonmix/ index.php.
-
WinNonmix®. Pharsight
-
-
-
86
-
-
33745773989
-
-
PopKinetics. SI, INC. http://www.saam.com/software/popKinetics/ popKineticsSoftware.htm.
-
-
-
-
87
-
-
33745775298
-
-
MRC Biostatistics Unit, Cambridge, UK
-
PKBUGS. MRC Biostatistics Unit, Cambridge, UK. http://www.mrc-bsu.cam.ac. uk/bugs/winbugs/pkbugs.shtml.
-
-
-
-
88
-
-
0029973997
-
Modelling a bivariate control system: LH and testosterone response to the GnRH antagonist Antide
-
K. Fattinger, D. Verotta, and H. Porchet et al. Modelling a bivariate control system: LH and testosterone response to the GnRH antagonist Antide. Am. J. Physiol. 271: E775-E787 (1996).
-
(1996)
Am. J. Physiol.
, vol.271
-
-
Fattinger, K.1
Verotta, D.2
Porchet, H.3
-
89
-
-
0035658567
-
A set-point model with oscillatory behaviour predicts the time course of (8-)-OH-DPAT induced hypothermia
-
K. Zuideveld, H. Maas, and N. Treijtel et al. A set-point model with oscillatory behaviour predicts the time course of (8-)-OH-DPAT induced hypothermia. Am. J. Physiol. 281: R2059-R2071 (2001).
-
(2001)
Am. J. Physiol.
, vol.281
-
-
Zuideveld, K.1
Maas, H.2
Treijtel, N.3
-
90
-
-
0027477927
-
The relationship between endogenous testosterone and gonadotropin secretion
-
N. A. Bridges, P. C. Hindsmarsh, and P. J. Pringle et al. The relationship between endogenous testosterone and gonadotropin secretion. Clin. Endocrinol. 38:373-378 (1993).
-
(1993)
Clin. Endocrinol.
, vol.38
, pp. 373-378
-
-
Bridges, N.A.1
Hindsmarsh, P.C.2
Pringle, P.J.3
-
92
-
-
0025871325
-
Mathematical biology of HIV infections: Antigenetic variation and diversity threshold
-
M. A. Nowak and R. M. May. Mathematical biology of HIV infections: Antigenetic variation and diversity threshold. Math. Biosci. 106:1-21 (1991).
-
(1991)
Math. Biosci.
, vol.106
, pp. 1-21
-
-
Nowak, M.A.1
May, R.M.2
-
93
-
-
0031581661
-
Anti-viral drug treatment: Dynamics of resistance in free virus and infected cell population
-
M. A. Nowak, S. Bonhoeffer, and G. M. Shaw et al. Anti-viral drug treatment: Dynamics of resistance in free virus and infected cell population. J. Theoret. Biol. 184:203-217 (1997).
-
(1997)
J. Theoret. Biol.
, vol.184
, pp. 203-217
-
-
Nowak, M.A.1
Bonhoeffer, S.2
Shaw, G.M.3
-
94
-
-
0032492830
-
Mathematical analysis of antiretroviral therapy aimed at HIV-1 eradication or maintenance of low viral loads
-
L. M. Wein, R. M. DAmato, and A. S. Perelson. Mathematical analysis of antiretroviral therapy aimed at HIV-1 eradication or maintenance of low viral loads. J. Theoret. Biol. 192: 81-98 (1998).
-
(1998)
J. Theoret. Biol.
, vol.192
, pp. 81-98
-
-
Wein, L.M.1
Damato, R.M.2
Perelson, A.S.3
-
95
-
-
0034615789
-
Modelling plasma virus concentration during primary HIV infection
-
M. A. Stafford, L. Corey, and Y. Cao et al. Modelling plasma virus concentration during primary HIV infection. J. Theoret. Biol. 203: 285-301 (2000).
-
(2000)
J. Theoret. Biol.
, vol.203
, pp. 285-301
-
-
Stafford, M.A.1
Corey, L.2
Cao, Y.3
-
96
-
-
16344379952
-
Mechanistic PK/PD modeling of antiretroviral therapies in AIDS clinical trials
-
Kluwer Academic Publishers, Boston
-
Y. Huang and L. Wu. Mechanistic PK/PD modeling of antiretroviral therapies in AIDS clinical trials. In Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis, Vol. III. Kluwer Academic Publishers, Boston, 2004, pp. 221-238.
-
(2004)
Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
, vol.3
, pp. 221-238
-
-
Huang, Y.1
Wu, L.2
-
97
-
-
0027057399
-
Coexistence and competition in HIV infections
-
M. A. Nowak and R. M. May. Coexistence and competition in HIV infections. J. Theoret. Biol. 159:329-342 (1992).
-
(1992)
J. Theoret. Biol.
, vol.159
, pp. 329-342
-
-
Nowak, M.A.1
May, R.M.2
-
98
-
-
0030952479
-
Decay characteristics of HIV-1 infected compartments during combination therapy
-
A. S. Perelson and P. Essunger. Decay characteristics of HIV-1 infected compartments during combination therapy. Nature 387:188-191 (1997).
-
(1997)
Nature
, vol.387
, pp. 188-191
-
-
Perelson, A.S.1
Essunger, P.2
-
99
-
-
0029967721
-
HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
-
A. S. Perelson, A. U. Neumann, and M. Markowitz et al. HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time. Science 271:1582-1587 (1996).
-
(1996)
Science
, vol.271
, pp. 1582-1587
-
-
Perelson, A.S.1
Neumann, A.U.2
Markowitz, M.3
-
100
-
-
0032967837
-
Population HIV-1 dynamics in vivo: Applicable models and inferential tools for virological data from AIDS clinical trials
-
H. Wu and A. A. Ding. Population HIV-1 dynamics in vivo: Applicable models and inferential tools for virological data from AIDS clinical trials. Biometrics 55:410-418 (1999).
-
(1999)
Biometrics
, vol.55
, pp. 410-418
-
-
Wu, H.1
Ding, A.A.2
-
101
-
-
0034019536
-
A comparison study of models and fitting procedures for biphasic viral dynamics in HIV-1 infected patients treated with antiviral therapies
-
A. A. Ding and H. Wu. A comparison study of models and fitting procedures for biphasic viral dynamics in HIV-1 infected patients treated with antiviral therapies. Biometrics 56:293-300 (2000).
-
(2000)
Biometrics
, vol.56
, pp. 293-300
-
-
Ding, A.A.1
Wu, H.2
-
102
-
-
0036229527
-
Non-linear dynamics models characterizing long-term virological data from AIDS clinical trials
-
D. Verotta and F. Schaedeli. Non-linear dynamics models characterizing long-term virological data from AIDS clinical trials. Math. Biosci. 176: 163-183 (2002).
-
(2002)
Math. Biosci.
, vol.176
, pp. 163-183
-
-
Verotta, D.1
Schaedeli, F.2
-
103
-
-
0023074363
-
Nonlinearity and complex behavior in simple ecological and epidemiological models
-
R. M. May. Nonlinearity and complex behavior in simple ecological and epidemiological models. Perspect. Biol. Dynam. Theoret. Med. 504:1-15 (1987).
-
(1987)
Perspect. Biol. Dynam. Theoret. Med.
, vol.504
, pp. 1-15
-
-
May, R.M.1
-
104
-
-
23344442813
-
Models and estimation methods for clinical HIV-1 data
-
in press
-
D. Verotta. Models and estimation methods for clinical HIV-1 data. J. Comput. Appl. Math., in press.
-
J. Comput. Appl. Math.
-
-
Verotta, D.1
-
105
-
-
84950442333
-
Compliance as an explanatory variable in clinical trial
-
B. Efron and D. Feldman. Compliance as an explanatory variable in clinical trial. J. Am. Stat.Assoc. 86:9-17 (1991).
-
(1991)
J. Am. Stat.Assoc.
, vol.86
, pp. 9-17
-
-
Efron, B.1
Feldman, D.2
-
106
-
-
0032520248
-
Contending paradigms for the interpretation of data on patient compliance with therapeutic drug regimens
-
J. Urquhart and E. De Klerk. Contending paradigms for the interpretation of data on patient compliance with therapeutic drug regimens. Stat. Med. 17:251-267: discussion 387-259 (1998).
-
Stat. Med.
, vol.17
, pp. 251-267
-
-
Urquhart, J.1
De Klerk, E.2
-
107
-
-
33745801666
-
-
Homer. Iliad, Book XIII; c.
-
Homer. Iliad, Book XIII; c. 850 BC.
-
, vol.850
-
-
-
108
-
-
9044248336
-
-
The Upjohn Co. Techn. Rep. 7292/69/7292/005. Kalama 700. Mich.
-
C. M. Metzler. A user's manual for NONLIN. The Upjohn Co. Techn. Rep. 7292/69/7292/005. Kalama 700. Mich., 1969.
-
(1969)
A User's Manual for NONLIN
-
-
Metzler, C.M.1
-
110
-
-
0021436459
-
Multiexponential, multicompartmental, and noncompartmental modeling. I. Methodological limitations and physiological interpretations
-
J. J. Distefano-III and E. M. Landaw. Multiexponential, multicompartmental, and noncompartmental modeling. I. Methodological limitations and physiological interpretations. Am. J. Physiol. Regulat. Integrat. Comp. Physiol. 15:(1984).
-
(1984)
Am. J. Physiol. Regulat. Integrat. Comp. Physiol.
, vol.15
-
-
Distefano III, J.J.1
Landaw, E.M.2
-
111
-
-
0346040525
-
Volterra series in pharmacokinetics and pharmacodynamic
-
D. Verotta. Volterra series in pharmacokinetics and pharmacodynamic. J. Pharmacokinet. Pharmacodynam. 30:337-362 (2003).
-
(2003)
J. Pharmacokinet. Pharmacodynam.
, vol.30
, pp. 337-362
-
-
Verotta, D.1
-
113
-
-
0027688143
-
Identification of nonlinear biological systems using laguerre expansions of kernels
-
V. Z. Marmarelis. Identification of nonlinear biological systems using laguerre expansions of kernels. Ann. Biomed. Eng. 21:573-589 (1993).
-
(1993)
Ann. Biomed. Eng.
, vol.21
, pp. 573-589
-
-
Marmarelis, V.Z.1
|