Microfluidic memory and control devices

Science

Volumn 300, Issue 5621, 2003, Pages 955-958

  Groisman, Alex ^a,b   Enzelberger, Markus ^a   Quake, Stephen R ^a  

^a California Institute of Technology   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTROL SYSTEM ANALYSIS; MEDICAL APPLICATIONS; NON NEWTONIAN FLOW; RHEOLOGY; SIGNAL INTERFERENCE; VISCOELASTICITY;

MICROFLUIDIC MEMORY;

FLUIDICS;

POLYMER;

CONTROL SYSTEM; FLUID; MEMORY;

AQUEOUS SOLUTION; ARTICLE; DEVICE; DRUG DELIVERY SYSTEM; ELECTROMAGNETIC FIELD; ELECTRONICS; MEMORY; MICROSCOPY; PRIORITY JOURNAL; SOLID STATE; VISCOELASTICITY;

EID: 0038670237     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1083694     Document Type: Article

References (18)

1. E. F. Humphrey, D. H. Turamoto, Eds., Fluidics (Fluid Amplifier Associates, Boston, MA, 1965).
2. K. Foster, G. A. Parker, Fluidics, Components and Circuits (Wiley-Interscience, London, 1970).
3. The Reynolds number characterizes the ratio of inertial to viscous forces in a flow and the strength of nonlinear inertial effects.
4. T. Thorsen, R. W. Roberts, F. H. Arnold, S. R. Quake, Phys. Rev. Lett. 86, 4163 (2001).
5. D. J. Beebe et al., Nature 404, 588 (2000).
6. R. B. Bird, C. Curtiss, R. C. Armstrong, O. Hassager, Dynamics of Polymeric Liquids (Wiley, New York, 1987), vols. 1 and 2.
7. S. J. Muller, R. G. Larson, E. S. G. Shaqfeh, Rheol. Acta 28, 499 (1989).
8. A, Groisman, V. Steinberg, Nature 405, 53 (2000).
9. Microchannels were fabricated by molding an optically transparent silicon elastomer, polydimethylsiloxane (PDMS). Molds were prepared by spin coating a silicon wafer with a layer about 100 μm thick of an ultraviolet (UV)-curable epoxy (MicroChem SU8-50) and exposing it to UV light through a photomask, which had a resolution of 7.1 μm. The mold was used to make a 4-mm thick cast of PDMS (RTV 61S by General Electric) with 100-μm-deep rectangular grooves on its surface. Finally, holes were punched through the elastomer for feeding the liquids, and the side with the grooves was bonded to a microscope coverslip by overnight baking in an 80°C oven. To fabricate the pressure sensors for the device in Fig. 3B, we performed two consecutive photolithography steps in mold fabrication; the first used a S-μm-thick coating of SU8-200S, whereas the second was as described above.
10. s.
11. T. T. Perkins, D. E. Smith, S. Chu, Science 276, 2016 (1997).
12. V. Tirtaatmadja, T. Sridhar, J. Rheol. 37, 1081 (1993).
13. s.
14. D. V. Boger, K. Walters, Rheological Phenomena in Focus (Elsevier, Amsterdam, 1993).
15. U. Cartalos, J. M. Piau, J. Non-Newtonian Fluid Mech. 45, 231 (1992).
16. J. P. Rothstein, G. H. McKinley, J. Non-Newtonian Fluid Mech. 98, 33 (2001).
17. M. A. Unger, H.-P. Chou, T. Thorsen, A. Scherer, S. R. Quake, Science 288, 113 (2000).
18. This work was supported in part by the Defense Advanced Research Projects Agency, by a North Atlantic Treaty Organization postdoctoral fellowship to M.E., and by a Rothschild fellowship to A.G.