Calcium and the mechanotransduction in cardiac myocytes

Frontiers in Bioscience - Elite

Volumn 1 E, Issue 1, 2009, Pages 189-199

  Judice, Carla C ^a   Marin, Talita M ^a   Franchini, Kleber G ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Heart; Hypertrophy; Mechanical stress; Review; Signal transduction

Indexed keywords

CALCIUM;

CARDIOMEGALY; COSTAMERE; HEART MUSCLE CELL; HUMAN; MECHANICAL STRESS; MECHANOTRANSDUCTION; METABOLISM; PHYSIOLOGY; REVIEW;

CALCIUM; CARDIOMEGALY; COSTAMERES; HUMANS; MECHANOTRANSDUCTION, CELLULAR; MYOCYTES, CARDIAC; STRESS, MECHANICAL;

EID: 77953623942     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: None     Document Type: Article

References (106)

1. A. M. Samarel: Costameres, focal adhesions, and cardiomyocyte mechanotransduction. Am J Physiol Heart Circ Physiol 289, (6) H2291-301 (2005)
2. M. Hoshijima: Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures. Am J Physiol Heart Circ Physiol 290, (4) H1313-25 (2006)
3. M. A. Sussman, A. McCulloch and T. K. Borg: Dance band on the Titanic: biomechanical signaling in cardiac hypertrophy. Circ Res 91, (10) 888-98 (2002) (Pubitemid 35373588)
4. J. Sadoshima and S. Izumo: The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol 59, 551-71 (1997) (Pubitemid 27142455)
5. D. Frank, C. Kuhn, H. A. Katus and N. Frey: The sarcomeric Z-disc: a nodal point in signalling and disease. J Mol Med 84, (6) 446-68 (2006) (Pubitemid 43801324)
6. J. V. Pardo, J. D. Siliciano and S. W. Craig: Vinculin is a component of an extensive network of myofibrilsarcolemma attachment regions in cardiac muscle fibers. J Cell Biol 97, (4) 1081-8 (1983) (Pubitemid 13019368)
7. W. G. Pyle and R. J. Solaro: At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function. Circ Res 94, (3) 296-305 (2004) (Pubitemid 38240720)
8. V. Vogel: Mechanotransduction involving multimodular proteins: converting force into biochemical signals. Annu Rev Biophys Biomol Struct 35, 459-88 (2006) (Pubitemid 43877387)
9. S. Y. Shai, A. E. Harpf, C. J. Babbitt, M. C. Jordan, M. C. Fishbein, J. Chen, M. Omura, T. A. Leil, K. D. Becker, M. Jiang, D. J. Smith, S. R. Cherry, J. C. Loftus, and R. S. Ross: Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res 90, (4) 458-64 (2002) (Pubitemid 34633916)
10. A. S. Torsoni, S. S. Constancio, W. Nadruz, Jr., S. K. Hanks and K. G. Franchini: Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes. Circ Res 93, (2) 140-7 (2003) (Pubitemid 36919701)
11. X. Peng, M. S. Kraus, H. Wei, T. L. Shen, R. Pariaut, A. Alcaraz, G. Ji, L. Cheng, Q. Yang, M. I. Kotlikoff, J. Chen, K. Chien, H. Gu, and J. L. Guan: Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. J Clin Invest 116, (1) 217-27 (2006) (Pubitemid 43121807)
12. L. A. DiMichele, J. T. Doherty, M. Rojas, H. E. Beggs, L. F. Reichardt, C. P. Mack and J. M. Taylor: Myocyterestricted focal adhesion kinase deletion attenuates pressure overload-induced hypertrophy. Circ Res 99, (6) 636-45 (2006) (Pubitemid 44401455)
13. P. M. Fonseca, R. Y. Inoue, C. B. Kobarg, D. P. Crosara-Alberto, J. Kobarg and K. G. Franchini: Targeting to Cterminal myosin heavy chain may explain mechanotransduction involving focal adhesion kinase in cardiac myocytes. Circ Res 96, (1) 73-81 (2005) (Pubitemid 40095756)
14. A. S. Torsoni, T. M. Marin, L. A. Velloso and K. G. Franchini: RhoA/ROCK signaling is critical to FAK activation by cyclic stretch in cardiac myocytes. Am J Physiol Heart Circ Physiol 289, (4) H1488-96 (2005)
15. C. F. M. Z. Clemente, T. F. Tornatore, T. H. Theizen, A. C. Deckmann, T. C. Pereira, I. T. Lopes-Cences, J. R. M. Sousa and K. G. Franchini: Targeting focal adhesion kinase with siRNA prevents and reverses load-induced cardiac hypertrophy in mice. Circ Res (in press) (2007)
16. G. E. Hannigan, J. G. Coles and S. Dedhar: Integrinlinked kinase at the heart of cardiac contractility, repair, and disease. Circ Res 100, (10) 1408-14 (2007) (Pubitemid 46834753)
17. A. L. Bayer, M. C. Heidkamp, N. Patel, M. J. Porter, S. J. Engman and A. M. Samarel: PYK2 expression and phosphorylation increases in pressure overload-induced left ventricular hypertrophy. Am J Physiol Heart Circ Physiol 283, (2) H695-706 (2002) (Pubitemid 34790865)
18. J. M. Ervasti: Costameres: the Achilles' heel of Herculean muscle. J Biol Chem 278, (16) 13591-4 (2003) (Pubitemid 36799888)
19. G. A. Porter, G. M. Dmytrenko, J. C. Winkelmann and R. J. Bloch: Dystrophin colocalizes with beta-spectrin in distinct subsarcolemmal domains in mammalian skeletal muscle. J Cell Biol 117, (5) 997-1005 (1992)
20. V. Straub, R. E. Bittner, J. J. Leger and T. Voit: Direct visualization of the dystrophin network on skeletal muscle fiber membrane. J Cell Biol 119, (5) 1183-91 (1992)
21. I. N. Rybakova, J. R. Patel and J. M. Ervasti: The dystrophin complex forms a mechanically strong link between the sarcolemma and costameric actin. J Cell Biol 150, (5) 1209-14 (2000)
22. D. J. Blake, A. Weir, S. E. Newey and K. E. Davies: Function and genetics of dystrophin and dystrophin-related proteins in muscle. Physiol Rev 82, (2) 291-329 (2002) (Pubitemid 34654455)
23. R. Knoll, M. Hoshijima, H. M. Hoffman, V. Person, I. Lorenzen-Schmidt, M. L. Bang, T. Hayashi, N. Shiga, H. Yasukawa, W. Schaper, W. McKenna, M. Yokoyama, N. J. Schork, J. H. Omens, A. D. McCulloch, A. Kimura, C. C. Gregorio, W. Poller, J. Schaper, H. P. Schultheiss, and K. R. Chien: The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell 111, (7) 943-55 (2002) (Pubitemid 36044687)
24. J. Heineke, H. Ruetten, C. Willenbockel, S. C. Gross, M. Naguib, A. Schaefer, T. Kempf, D. Hilfiker-Kleiner, P. Caroni, T. Kraft, R. A. Kaiser, J. D. Molkentin, H. Drexler, and K. C. Wollert: Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc. Proc Natl Acad Sci U S A 102, (5) 1655-60 (2005) (Pubitemid 40209223)
25. B. J. Wilkins and J. D. Molkentin: Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochem Biophys Res Commun 322, (4) 1178-91 (2004) (Pubitemid 39164648)
26. M. M. LeWinter, Y. Wu, S. Labeit and H. Granzier: Cardiac titin: structure, functions and role in disease. Clin Chim Acta 375, (1-2) 1-9 (2007) (Pubitemid 44584235)
27. C. C. Gregorio, K. Trombitas, T. Centner, B. Kolmerer, G. Stier, K. Kunke, K. Suzuki, F. Obermayr, B. Herrmann, H. Granzier, H. Sorimachi, and S. Labeit: The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity. J Cell Biol 143, (4) 1013-27 (1998) (Pubitemid 28547400)
28. A. Mues, P. F. van der Ven, P. Young, D. O. Furst and M. Gautel: Two immunoglobulin-like domains of the Zdisc portion of titin interact in a conformation-dependent way with telethonin. FEBS Lett 428, (1-2) 111-4 (1998) (Pubitemid 28266840)
29. T. Furukawa, Y. Ono, H. Tsuchiya, Y. Katayama, M. L. Bang, D. Labeit, S. Labeit, N. Inagaki and C. C. Gregorio: Specific interaction of the potassium channel betasubunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system. J Mol Biol 313, (4) 775-84 (2001) (Pubitemid 33063426)
30. A. Kontrogianni-Konstantopoulos and R. J. Bloch: The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin. J Biol Chem 278, (6) 3985-91 (2003) (Pubitemid 36801130)
31. S. Lange, F. Xiang, A. Yakovenko, A. Vihola, P. Hackman, E. Rostkova, J. Kristensen, B. Brandmeier, G. Franzen, B. Hedberg, L. G. Gunnarsson, S. M. Hughes, S. Marchand, T. Sejersen, I. Richard, L. Edstrom, E. Ehler, B. Udd, and M. Gautel: The kinase domain of titin controls muscle gene expression and protein turnover. Science 308, (5728) 1599-603 (2005) (Pubitemid 40807503)
32. M. J. Berridge, M. D. Bootman and H. L. Roderick: Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 4, (7) 517-29 (2003) (Pubitemid 36773404)
33. M. J. Berridge: Calcium microdomains: organization and function. Cell Calcium 40, (5-6) 405-12 (2006) (Pubitemid 44752611)
34. F. Brette and C. Orchard: T-tubule function in mammalian cardiac myocytes. Circ Res 92, (11) 1182-92 (2003) (Pubitemid 36723645)
35. F. Brette and C. Orchard: Resurgence of cardiac ttubule research. Physiology (Bethesda) 22, 167-73 (2007)
36. S. Q. Wang, L. S. Song, E. G. Lakatta and H. Cheng: Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells. Nature 410, (6828) 592-6 (2001) (Pubitemid 32267204)
37. T. Gao, T. S. Puri, B. L. Gerhardstein, A. J. Chien, R. D. Green and M. M. Hosey: Identification and subcellular localization of the subunits of L-type calcium channels and adenylyl cyclase in cardiac myocytes. J Biol Chem 272, (31) 19401-7 (1997) (Pubitemid 27337736)
38. J. Yang, J. A. Drazba, D. G. Ferguson and M. Bond: Akinase anchoring protein 100 (AKAP100) is localized in multiple subcellular compartments in the adult rat heart. J Cell Biol 142, (2) 511-22 (1998) (Pubitemid 28361556)
39. M. A. Laflamme and P. L. Becker: G (s) and adenylyl cyclase in transverse tubules of heart: implications for cAMP-dependent signaling. Am J Physiol 277, (5 Pt 2) H1841-8 (1999)
40. M. A. Davare, V. Avdonin, D. D. Hall, E. M. Peden, A. Burette, R. J. Weinberg, M. C. Horne, T. Hoshi and J. W. Hell: A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2. Science 293, (5527) 98-101 (2001) (Pubitemid 32625503)
41. L. A. Barouch, R. W. Harrison, M. W. Skaf, G. O. Rosas, T. P. Cappola, Z. A. Kobeissi, I. A. Hobai, C. A. Lemmon, A. L. Burnett, B. O'Rourke, E. R. Rodriguez, P. L. Huang, J. A. Lima, D. E. Berkowitz, and J. M. Hare: Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature 416, (6878) 337-9 (2002)
42. L. F. Santana, E. G. Chase, V. S. Votaw, M. T. Nelson and R. Greven: Functional coupling of calcineurin and protein kinase A in mouse ventricular myocytes. J Physiol 544, (Pt 1) 57-69 (2002) (Pubitemid 35153813)
43. A. L. Bauman, J. J. Michel, E. Henson, K. L. Dodge-Kafka and M. S. Kapiloff: The mAKAP signalosome and cardiac myocyte hypertrophy. IUBMB Life 59, (3) 163-9 (2007) (Pubitemid 46752479)
44. B. Boivin, L. R. Villeneuve, N. Farhat, D. Chevalier and B. G. Allen: Sub-cellular distribution of endothelin signaling pathway components in ventricular myocytes and heart: lack of preformed caveolar signalosomes. J Mol Cell Cardiol 38, (4) 665-76 (2005) (Pubitemid 40461830)
45. D. R. Scriven, A. Klimek, P. Asghari, K. Bellve and E. D. Moore: Caveolin-3 is adjacent to a group of extradyadic ryanodine receptors. Biophys J 89, (3) 1893-901 (2005) (Pubitemid 41233544)
46. S. Calaghan and E. White: Caveolae modulate excitation-contraction coupling and beta2-adrenergic signalling in adult rat ventricular myocytes. Cardiovasc Res 69, (4) 816-24 (2006) (Pubitemid 43227980)
47. S. C. Calaghan and M. J. Taggart: Compartmentalized signaling in cardiomyocyte lipid domains-do structure and function match up? J Mol Cell Cardiol 41, (1) 1-3 (2006) (Pubitemid 43946970)
48. C. Croci, J. H. Brandstatter and R. Enz: ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. J Biol Chem 278, (8) 6128-35 (2003)
49. Y. Yoshimura, T. Shinkawa, M. Taoka, K. Kobayashi, T. Isobe and T. Yamauchi: Identification of protein substrates of Ca (2+)/calmodulin-dependent protein kinase II in the postsynaptic density by protein sequencing and mass spectrometry. Biochem Biophys Res Commun 290, (3) 948-54 (2002) (Pubitemid 34687453)
50. D. Mauceri, F. Cattabeni, M. Di Luca and F. Gardoni: Calcium/calmodulin- dependent protein kinase II phosphorylation drives synapse-associated protein 97 into spines. J Biol Chem 279, (22) 23813-21 (2004) (Pubitemid 38685699)
51. K. Tasken and E. M. Aandahl: Localized effects of cAMP mediated by distinct routes of protein kinase A. Physiol Rev 84, (1) 137-67 (2004) (Pubitemid 38049878)
52. S. Wagner, N. Dybkova, E. C. Rasenack, C. Jacobshagen, L. Fabritz, P. Kirchhof, S. K. Maier, T. Zhang, G. Hasenfuss, J. H. Brown, D. M. Bers, and L. S. Maier: Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest 116, (12) 3127-38 (2006) (Pubitemid 44878627)
53. L. G. Fong, J. K. Ng, J. Lammerding, T. A. Vickers, M. Meta, N. Cote, B. Gavino, X. Qiao, S. Y. Chang, S. R. Young, S. H. Yang, C. L. Stewart, R. T. Lee, C. F. Bennett, M. O. Bergo, and S. G. Young: Prelamin A and lamin A appear to be dispensable in the nuclear lamina. J Clin Invest 116, (3) 743-52 (2006) (Pubitemid 43326883)
54. M. J. Berridge: Remodelling Ca2+ signalling systems and cardiac hypertrophy. Biochem Soc Trans 34, (Pt 2) 228-31 (2006)
55. T. Tomida, K. Hirose, A. Takizawa, F. Shibasaki and M. Iino: NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation. Embo J 22, (15) 3825-32 (2003) (Pubitemid 36975710)
56. S. Kostin, D. Scholz, T. Shimada, Y. Maeno, H. Mollnau, S. Hein and J. Schaper: The internal and external protein scaffold of the T-tubular system in cardiomyocytes. Cell Tissue Res 294, (3) 449-60 (1998) (Pubitemid 28510857)
57. C. G. van der Wees, W. H. Bax, E. J. van der Valk and A. van der Laarse: Integrin stimulation induces calcium signalling in rat cardiomyocytes by a NO-dependent mechanism. Pflugers Arch 451, (4) 588-95 (2006) (Pubitemid 41789798)
58. A. L. Bayer, M. C. Heidkamp, A. L. Howes, J. Heller Brown, K. L. Byron and A. M. Samarel: Protein kinase C epsilon-dependent activation of proline-rich tyrosine kinase 2 in neonatal rat ventricular myocytes. J Mol Cell Cardiol 35, (9) 1121-33 (2003) (Pubitemid 37083256)
59. M. C. Heidkamp, B. T. Scully, K. Vijayan, S. J. Engman, E. L. Szotek and A. M. Samarel: PYK2 regulates SERCA2 gene expression in neonatal rat ventricular myocytes. Am J Physiol Cell Physiol 289, (2) C471-82 (2005) (Pubitemid 41008894)
60. S. Hirotani, Y. Higuchi, K. Nishida, H. Nakayama, O. Yamaguchi, S. Hikoso, T. Takeda, K. Kashiwase, T. Watanabe, M. Asahi, M. Taniike, I. Tsujimoto, Y. Matsumura, T. Sasaki, M. Hori, and K. Otsu: Ca (2+) - sensitive tyrosine kinase Pyk2/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy. J Mol Cell Cardiol 36, (6) 799-807 (2004) (Pubitemid 38639765)
61. S. Y. Park, H. K. Avraham and S. Avraham: RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner. J Biol Chem 279, (32) 33315-22 (2004) (Pubitemid 39062979)
62. H. Hu and F. Sachs: Stretch-activated ion channels in the heart. J Mol Cell Cardiol 29, (6) 1511-23 (1997) (Pubitemid 27270223)
63. P. J. Woolf, S. Lu, R. Cornford-Nairn, M. Watson, X. H. Xiao, S. M. Holroyd, L. Brown and A. J. Hoey: Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle. Am J Physiol Heart Circ Physiol 290, (6) H2439-45 (2006)
64. I. A. Williams and D. G. Allen: Intracellular calcium handling in ventricular myocytes from mdx mice. Am J Physiol Heart Circ Physiol 292, (2) H846-55 (2007)
65. A. Franco-Obregon, Jr. and J. B. Lansman: Mechanosensitive ion channels in skeletal muscle from normal and dystrophic mice. J Physiol 481(Pt 2), 299-309 (1994)
66. C. Vandebrouck, G. Duport, C. Cognard and G. Raymond: Cationic channels in normal and dystrophic human myotubes. Neuromuscul Disord 11, (1) 72-9 (2001) (Pubitemid 32109218)
67. S. Yasuda, D. Townsend, D. E. Michele, E. G. Favre, S. M. Day and J. M. Metzger: Dystrophic heart failure blocked by membrane sealant poloxamer. Nature 436, (7053) 1025-9 (2005) (Pubitemid 41191686)
68. N. Frey, J. A. Richardson and E. N. Olson: Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. Proc Natl Acad Sci U S A 97, (26) 14632-7 (2000) (Pubitemid 32016627)
69. G. Faulkner, A. Pallavicini, A. Comelli, M. Salamon, G. Bortoletto, C. Ievolella, S. Trevisan, S. Kojic, F. Dalla Vecchia, P. Laveder, G. Valle, and G. Lanfranchi: FATZ, a filamin-, actinin-, and telethonin-binding protein of the Zdisc of skeletal muscle. J Biol Chem 275, (52) 41234-42 (2000) (Pubitemid 32054956)
70. N. Frey and E. N. Olson: Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. J Biol Chem 277, (16) 13998-4004 (2002) (Pubitemid 34968008)
71. F. Takada, D. L. Vander Woude, H. Q. Tong, T. G. Thompson, S. C. Watkins, L. M. Kunkel and A. H. Beggs: Myozenin: an alpha-actinin-and gamma-filamin-binding protein of skeletal muscle Z lines. Proc Natl Acad Sci U S A 98, (4) 1595-600 (2001) (Pubitemid 32165544)
72. N. Frey, T. Barrientos, J. M. Shelton, D. Frank, H. Rutten, D. Gehring, C. Kuhn, M. Lutz, B. Rothermel, R. Bassel-Duby, J. A. Richardson, H. A. Katus, J. A. Hill, and E. N. Olson: Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress. Nat Med 10, (12) 1336-43 (2004) (Pubitemid 40022715)
73. P. Young, E. Ehler and M. Gautel: Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly. J Cell Biol 154, (1) 123-36 (2001) (Pubitemid 34289283)
74. M. W. Russell, M. O. Raeker, K. A. Korytkowski and K. J. Sonneman: Identification, tissue expression and chromosomal localization of human Obscurin-MLCK, a member of the titin and Dbl families of myosin light chain kinases. Gene 282, (1-2) 237-46 (2002) (Pubitemid 34117580)
75. P. Bagnato, V. Barone, E. Giacomello, D. Rossi and V. Sorrentino: Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles. J Cell Biol 160, (2) 245-53 (2003) (Pubitemid 36254958)
76. P. J. Mohler, A. O. Gramolini and V. Bennett: The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1, 4, 5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes. J Biol Chem 277, (12) 10599-607 (2002) (Pubitemid 34968184)
77. S. Arber, G. Halder and P. Caroni: Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation. Cell 79, (2) 221-31 (1994) (Pubitemid 24324913)
78. S. Kawamura, S. Miyamoto and J. H. Brown: Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: cytoskeletal regulation of ERK translocation. J Biol Chem 278, (33) 31111-7 (2003) (Pubitemid 36994626)
79. O. Feron and J. L. Balligand: Caveolins and the regulation of endothelial nitric oxide synthase in the heart. Cardiovasc Res 69, (4) 788-97 (2006) (Pubitemid 43227977)
80. S. Kudoh, H. Akazawa, H. Takano, Y. Zou, H. Toko, T. Nagai and I. Komuro: Stretch-modulation of second messengers: effects on cardiomyocyte ion transport. Prog Biophys Mol Biol 82, (1-3) 57-66 (2003) (Pubitemid 36551206)
81. H. W. Lim, L. J. De Windt, L. Steinberg, T. Taigen, S. A. Witt, T. R. Kimball and J. D. Molkentin: Calcineurin expression, activation, and function in cardiac pressureoverload hypertrophy. Circulation 101, (20) 2431-7 (2000) (Pubitemid 30329136)
82. T. Meguro, C. Hong, K. Asai, G. Takagi, T. A. McKinsey, E. N. Olson and S. F. Vatner: Cyclosporine attenuates pressure-overload hypertrophy in mice while enhancing susceptibility to decompensation and heart failure. Circ Res 84, (6) 735-40 (1999) (Pubitemid 29157342)
83. K. Hongo, E. White, J. Y. Le Guennec and C. H. Orchard: Changes in (Ca2+) i, (Na+) i and Ca2+ current in isolated rat ventricular myocytes following an increase in cell length. J Physiol 491(Pt 3), 609-19 (1996)
84. S. J. Sollott and E. G. Lakatta: Novel method to alter length and load in isolated mammalian cardiac myocytes. Am J Physiol 267, (4 Pt 2) H1619-29 (1994)
85. D. G. Allen and S. Kurihara: The effects of muscle length on intracellular calcium transients in mammalian cardiac muscle. J Physiol 327, 79-94 (1982) (Pubitemid 12086440)
86. J. C. Kentish and A. Wrzosek: Changes in force and cytosolic Ca2+ concentration after length changes in isolated rat ventricular trabeculae. J Physiol 506(Pt 2), 431-44 (1998) (Pubitemid 28048371)
87. S. C. Calaghan, A. Belus and E. White: Do stretchinduced changes in intracellular calcium modify the electrical activity of cardiac muscle? Prog Biophys Mol Biol 82, (1-3) 81-95 (2003) (Pubitemid 36551208)
88. N. Matsuda, N. Hagiwara, M. Shoda, H. Kasanuki and S. Hosoda: Enhancement of the L-type Ca2+ current by mechanical stimulation in single rabbit cardiac myocytes. Circ Res 78, (4) 650-9 (1996)
89. M. J. Lab, B. Y. Zhou, C. I. Spencer, S. M. Horner and W. A. Seed: Effects of gadolinium on length-dependent force in guinea-pig papillary muscle. Exp Physiol 79, (2) 249-55 (1994) (Pubitemid 2057381)
90. B. V. Alvarez, N. G. Perez, I. L. Ennis, M. C. Camilion de Hurtado and H. E. Cingolani: Mechanisms underlying the increase in force and Ca (2+) transient that follow stretch of cardiac muscle: a possible explanation of the Anrep effect. Circ Res 85, (8) 716-22 (1999) (Pubitemid 29480812)
91. S. Calaghan and E. White: Activation of Na+-H+ exchange and stretch-activated channels underlies the slow inotropic response to stretch in myocytes and muscle from the rat heart. J Physiol 559, (Pt 1) 205-14 (2004) (Pubitemid 39206963)
92. N. G. Perez, M. C. de Hurtado and H. E. Cingolani: Reverse mode of the Na+-Ca2+ exchange after myocardial stretch: underlying mechanism of the slow force response. Circ Res 88, (4) 376-82 (2001) (Pubitemid 32200109)
93. D. von Lewinski, B. Stumme, L. S. Maier, C. Luers, D. M. Bers and B. Pieske: Stretch-dependent slow force response in isolated rabbit myocardium is Na+ dependent. Cardiovasc Res 57, (4) 1052-61 (2003) (Pubitemid 36324610)
94. K. Petrecca, R. Atanasiu, S. Grinstein, J. Orlowski and A. Shrier: Subcellular localization of the Na+/H+ exchanger NHE1 in rat myocardium. Am J Physiol 276, (2 Pt 2) H709-17 (1999) (Pubitemid 29100641)
95. D. M. Bers, W. H. Barry and S. Despa: Intracellular Na+ regulation in cardiac myocytes. Cardiovasc Res 57, (4) 897-912 (2003)
96. I. L. Ennis, C. D. Garciarena, E. M. Escudero, N. G. Perez, R. A. Dulce, M. C. Camilion de Hurtado and H. E. Cingolani: Normalization of the calcineurin pathway underlies the regression of hypertensive hypertrophy induced by Na+/H+ exchanger-1 (NHE-1) inhibition. Can J Physiol Pharmacol 85, (3-4) 301-10 (2007) (Pubitemid 47262234)
97. M. A. Spassova, T. Hewavitharana, W. Xu, J. Soboloff and D. L. Gill: A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc Natl Acad Sci U S A 103, (44) 16586-91 (2006) (Pubitemid 44715239)
98. K. Kuwahara, Y. Wang, J. McAnally, J. A. Richardson, R. Bassel-Duby, J. A. Hill and E. N. Olson: TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. J Clin Invest 116, (12) 3114-26 (2006) (Pubitemid 44878626)
99. J. S. Brenner and R. E. Dolmetsch: TrpC3 regulates hypertrophy-associated gene expression without affecting myocyte beating or cell size. PLoS ONE 2, (8) e802 (2007)
100. J. N. Muth, I. Bodi, W. Lewis, G. Varadi and A. Schwartz: A Ca (2+)-dependent transgenic model of cardiac hypertrophy: A role for protein kinase Calpha. Circulation 103, (1) 140-7 (2001) (Pubitemid 32050449)
101. H. Nakayama, X. Chen, C. P. Baines, R. Klevitsky, X. Zhang, H. Zhang, N. Jaleel, B. H. Chua, T. E. Hewett, J. Robbins, S. R. Houser, and J. D. Molkentin: Ca2+-and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. J Clin Invest 117, (9) 2431-44 (2007) (Pubitemid 47494345)
102. D. Fatkin, B. K. McConnell, J. O. Mudd, C. Semsarian, I. G. Moskowitz, F. J. Schoen, M. Giewat, C. E. Seidman and J. G. Seidman: An abnormal Ca (2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy. J Clin Invest 106, (11) 1351-9 (2000)
103. P. E. Massart, J. Donckier, J. Kyselovic, T. Godfraind, G. R. Heyndrickx and M. Wibo: Carvedilol and lacidipine prevent cardiac hypertrophy and endothelin-1 gene overexpression after aortic banding. Hypertension 34, (6) 1197-201 (1999) (Pubitemid 30002382)
104. T. Shimada, M. Yoshiyama, K. Takeuchi, T. Omura, Y. Takemoto, S. Kim, H. Iwao and J. Yoshikawa: Long acting calcium antagonist amlodipine prevents left ventricular remodeling after myocardial infarction in rats. Cardiovasc Res 37, (3) 618-26 (1998) (Pubitemid 28231156)
105. A. C. Hinken and R. J. Solaro: A dominant role of cardiac molecular motors in the intrinsic regulation of ventricular ejection and relaxation. Physiology (Bethesda) 22, 73-80 (2007)
106. J. N. Peterson, W. C. Hunter and M. R. Berman: Estimated time course of Ca2+ bound to troponin C during relaxation in isolated cardiac muscle. Am J Physiol 260, (3 Pt 2) H1013-24 (1991)