Identification of protein substrates of Ca2+/calmodulin-dependent protein kinase II in the postsynaptic density by protein sequencing and mass spectrometry

Biochemical and Biophysical Research Communications

Volumn 290, Issue 3, 2002, Pages 948-954

  Yoshimura, Yoshiyuki ^a   Kobayashi, Kana ^a   Yamauchi, Takashi ^a   Shinkawa, Takashi ^b   Isobe, Toshiaki ^b   Taoka, Masato ^b  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b TOKYO METROPOLITAN UNIVERSITY   (Japan)

Author keywords

Ca2+ calmodulin dependent protein kinase II (CaM kinase II); Cytoskeletal protein; Mass spectrometry; Phosphorylation; Postsynaptic density; PSD95 SAP90; SynGAP family; TOAD 64; Two dimensional gel electrophoresis

Indexed keywords

HOMER 1B PROTEIN; INSULIN RECEPTOR TYROSINE KINASE; ISOPROTEIN; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN SAP97; PROTEIN TOAD 64; PSD95 ASSOCIATED PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; ISOELECTRIC POINT; MASS SPECTROMETRY; MOLECULAR SIZE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; SYNAPSE; TWO DIMENSIONAL GEL ELECTROPHORESIS;

EID: 0036297663     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.6320     Document Type: Article

References (33)

1. The postsynaptic density
2. Enlightening the postsynaptic density
3. Signal-processing machines at the postsynaptic density
4. Molecular organization of the postsynaptic specialization
5. Biochemical and immunochemical evidence that "the major postsynaptic density protein" is a subunit of a calmodulin-dependent protein kinase
6. Identification of the major postsynaptic density protein as homologous with the major calmodulin-binding subunit of a calmodulin-dependent protein kinase
7. 2+/calmodulin dependent protein kinase
8. 2+/calmodulin-dependent protein kinases
9. The CaM kinase II hypothesis for the storage of synaptic memory
10. 2+/calmodulin-dependent protein kinase II translocated to the postsynaptic density
11. Translocation of autophosphorylated calcium/calmodulin-dependent protein kinase II to the postsynaptic density
12. 2+/calmodulin-dependent protein kinase II with the postsynaptic densities
13. Autophosphorylation-dependent targeting of calcium/calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl-D-aspartate receptor
14. 2+/calmodulin-dependent protein kinase II from postsynaptic densities
15. Protein profiling of rat cerebella during development
16. The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein
17. SAP90, a rat postsynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A
18. Cloning and characterization of hdlg: The human homologue of the Drosophila disc-large tumor suppressor binds to protein 4.1
19. TOAD-64, a gene expressed early in neuronal differentiation in the rat, is related to unc-33, a C. elegans gene involved in axon outgrowth
20. A synaptic ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II
21. SynGAP: A synaptic rasGAP that associates with the PSD-95/SAP90 protein family
22. Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinase
23. Myosin IIB is required for growth cone motility
24. A neurally enriched coronin-like protein, clipin c, is a novel candidate for an actin-cytoskeleton-cortical membrane-linking protein
25. Involvement of CRAF1, a relative of TRAF, in CD40 signaling
26. Identification of proteins in the postsynaptic density fraction by mass spectrometry
27. Identification of a phosphorylation site for calcium/calmodulin-dependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor
28. 2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor
29. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors
30. Deficient hippocampal long-term potentiation in α-calcium-calmodulin kinase II mutant mice
31. Impaired spatial learning in α-calcium-calmodulin kinase II mutant mice
32. Phosphorylation and regulation of glutamate receptors by calcium/calmodulin-dependent protein kinase II
33. Impairment of spatial but not contextual memory in CaM KII mutant mice with a selective loss of hippocampal LTP in the range of the θ frequency