Quantitative structure-activity relationships for cycloguanil analogs as PfDHFR inhibitors using mathematical molecular descriptors

SAR and QSAR in Environmental Research

Volumn 21, Issue 3, 2010, Pages 215-229

  Basak, S C ^a   Mills, D ^a  

^a UNIVERSITY OF MINNESOTA DULUTH   (United States)

Author keywords

Cycloguanil analogues; Differential QSARs; Dihydrofolate reductase (DHFR) inhibitors; High dimensional pharmacophore; Plasmodium falciparum (Pf); Ridge regression

Indexed keywords

BINDING ENERGY; CARBON; COMPUTATIONAL CHEMISTRY; DISEASES; ENZYMES; LEAST SQUARES APPROXIMATIONS; MOLECULAR GRAPHICS; PRINCIPAL COMPONENT ANALYSIS; REGRESSION ANALYSIS;

CYCLOGUANIL ANALOG; DIFFERENTIAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; HIGH-DIMENSIONAL; HIGH-DIMENSIONAL PHARMACOPHORE; HIGHER-DIMENSIONAL; PHARMACOPHORES; PLASMODIUM FALCIPARUM; QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP; REDUCTASE INHIBITORS; RIDGE REGRESSION;

MOLECULES;

PLASMODIUM FALCIPARUM;

EID: 77953575554     PISSN: 1062936X     EISSN: 1029046X     Source Type: Journal    
DOI: 10.1080/10629361003770951     Document Type: Article

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