Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study

Mediators of Inflammation

Volumn 2010, Issue , 2010, Pages

  Burdon, Kathryn P ^a   Rudock, Megan E ^a   Lehtinen, Allison B ^a   Langefeld, Carl D ^a   Bowden, Donald W ^a   Register, Thomas C ^a   Liu, Yongmei ^a   Freedman, Barry I ^a   Carr, J Jeffrey ^a   Hedrick, Catherine C ^b   Rich, Stephen S ^a,b,c  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; C REACTIVE PROTEIN; ESTROGEN; INTERCELLULAR ADHESION MOLECULE 1; PROTEIN ALOX5AP; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; ISOENZYME;

ADULT; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAROTID ATHEROSCLEROSIS; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; DISEASE MARKER; DISEASE SEVERITY; FAMILIAL DISEASE; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SIBLING; SINGLE NUCLEOTIDE POLYMORPHISM; AGED; ANIMAL; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE;

AGED; ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; ISOENZYMES; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 77953519631     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2010/170153     Document Type: Article

References (47)

1. Steinberg D., Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime Nature Medicine 2002 8 11 1211 1217
2. Mehrabian M., Allayee H., Wong J., Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice Circulation Research 2002 91 2 120 126
3. Dwyer J. H., Allayee H., Dwyer K. M., Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis The New England Journal of Medicine 2004 350 1 29 37
4. Lotzer K., Funk C. D., Habenicht A. J. R., The 5-lipoxygenase pathway in arterial wall biology and atherosclerosis Biochimica et Biophysica Acta 2005 1736 1 30 37
5. Hakonarson H., Thorvaldsson S., Helgadottir A., Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial Journal of the American Medical Association 2005 293 18 2245 2256
6. Helgadottir A., Gretarsdottir S., St. Clair D., Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population American Journal of Human Genetics 2005 76 3 505 509
7. Helgadottir A., Manolescu A., Thorleifsson G., The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke Nature Genetics 2004 36 3 233 239
8. George J., Afek A., Shaish A., 12/15-lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice Circulation 2001 104 14 1646 1650
9. Steinberg D., Parthasarathy S., Carew T. E., Khoo J. C., Witztum J. L., Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity The New England Journal of Medicine 1989 320 14 915 924
10. Yamamoto S., Mammalian lipoxygenases: molecular structures and functions Biochimica et Biophysica Acta 1992 1128 2-3 117 131
11. Cyrus T., Witztum J. L., Rader D. J., Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice Journal of Clinical Investigation 1999 103 11 1597 1604
12. Harats D., Shaish A., George J., Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient mice Arteriosclerosis, Thrombosis, and Vascular Biology 2000 20 9 2100 2105
13. Yla-Herttuala S., Rosenfeld M. E., Parthasarathy S., Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions Proceedings of the National Academy of Sciences of the United States of America 1990 87 18 6959 6963
14. Lange L. A., Bowden D. W., Langefeld C. D., Heritability of carotid artery intima-medial thickness in type 2 diabetes Stroke 2002 33 7 1876 1881
15. Wagenknecht L. E., Bowden D. W., Carr J. J., Langefeld C. D., Freedman B. I., Rich S. S., Familial aggregation of coronary artery calcium in families with type 2 diabetes Diabetes 2001 50 4 861 866
16. Wagenknecht L. E., Langefeld C. D., Carr J. J., Race-specific relationships between coronary and carotid artery calcification and carotid intimal medial thickness Stroke 2004 35 5 e97 99
17. Carr J. J., Nelson J. C., Wong N. D., Calcified coronary artery plaque measurement with cardiac CT in population-based studies: standardized protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) study Radiology 2005 234 1 35 43
18. Zeger S. L., Liang K. Y., Longitudinal data analysis for discrete and continuous outcomes Biometrics 1986 42 1 121 130
19. Dudbridge F., Pedigree disequilibrium tests for multilocus haplotypes Genetic Epidemiology 2003 25 2 115 121
20. Libby P., Inflammation in atherosclerosis Nature 2002 420 6917 868 874
21. Funk C. D., Prostaglandins and leukotrienes: advances in eicosanoid biology Science 2001 294 5548 1871 1875
22. Rdmark O., Arachidonate 5-lipoxygenase Prostaglandins and Other Lipid Mediators 2002 68-69 211 234
23. Hatley M. E., Srinivasan S., Reilly K. B., Bolick D. T., Hedrick C. C., Increased production of 12/15 lipoxygenase eicosanoids accelerates monocyte/endothelial interactions in diabetic db/db mice Journal of Biological Chemistry 2003 278 28 25369 25375
24. Reilly K. B., Srinivasan S., Hatley M. E., 12/15-lipoxygenase activity mediates inflammatory monocyte/endothelial interactions and atherosclerosis in vivo Journal of Biological Chemistry 2004 279 10 9440 9450
25. Qiao J.-H., Tripathi J., Mishra N. K., Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice American Journal of Pathology 1997 150 5 1687 1699
26. Spanbroek R., Grabner R., Lotzer K., Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis Proceedings of the National Academy of Sciences of the United States of America 2003 100 3 1238 1243
27. Serhan C. N., Jain A., Marleau S., Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators Journal of Immunology 2003 171 12 6856 6865
28. Shen J., Herderick E., Cornhill J. F., Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development Journal of Clinical Investigation 1996 98 10 2201 2208
29. Chiang N., Arita M., Serhan C. N., Anti-inflammatory circuitry: lipoxin, aspirin-triggered lipoxins and their receptor ALX Prostaglandins Leukotrienes and Essential Fatty Acids 2005 73 3-4 163 177
30. Fierro I. M., Serhan C. N., Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins Brazilian Journal of Medical and Biological Research 2001 34 5 555 566
31. Serhan C. N., Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution Prostaglandins Leukotrienes and Essential Fatty Acids 2005 73 3-4 141 162
32. Gaeta G., De Michele M., Cuomo S., Arterial abnormalities in the offspring of patients with premature myocardial infarction The New England Journal of Medicine 2000 343 12 840 846
33. Hopkins P. N., Williams R. R., Human genetics and coronary heart disease: a public health perspective Annual Review of Nutrition 1989 9 1 303 345
34. Duggirala R., Gonzalez C., O'Leary D. H., Stern M. P., Blangero J., Genetic basis of variation in carotid artery wall thickness Stroke 1996 27 5 833 837
35. Xiang A. H., Azen S. P., Buchanan T. A., Heritability of subclinical atherosclerosis in Latino families ascertained through a hypertensive parent Arteriosclerosis, Thrombosis, and Vascular Biology 2002 22 5 843 848
36. Lange L. A., Lange E. M., Bielak L. F., Autosomal genome-wide scan for coronary artery calcification loci in sibships at high risk for hypertension Arteriosclerosis, Thrombosis, and Vascular Biology 2002 22 3 418 423
37. Hunt K. J., Duggirala R., Goring H. H. H., Genetic basis of variation in carotid artery plaque in the San Antonio Family Heart Study Stroke 2002 33 12 2775 2780
38. Moskau S., Golla A., Grothe C., Boes M., Pohl C., Klockgether T., Heritability of carotid artery atherosclerotic lesions: an ultrasound study in 154 families Stroke 2005 36 1 5 8
39. O'Donnell C. J., Chazaro I., Wilson P. W. F., Evidence for heritability of abdominal aortic calcific deposits in the Framingham Heart Study Circulation 2002 106 3 337 341
40. Cyrus T., Pratic D., Zhao L., Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice Circulation 2001 103 18 2277 2282
41. Zhao L., Cuff C. A., Moss E., Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia Journal of Biological Chemistry 2002 277 38 35350 35356
42. Mehrabian M., Wong J., Wang X., Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia Circulation Research 2001 89 2 125 130
43. Welch C. L., Bretschger S., Latib N., Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model Proceedings of the National Academy of Sciences of the United States of America 2001 98 14 7946 7951
44. Bck M., Bu D.-X., Brnstrm R., Sheikine Y., Yan Z.-Q., Hansson G. K., Leukotriene B4 signaling through NF- B-dependent BLT 1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia Proceedings of the National Academy of Sciences of the United States of America 2005 102 48 17501 17506
45. Helgadottir A., Manolescu A., Helgason A., A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction Nature Genetics 2006 38 1 68 74
46. O'Donnell C. J., Shea M. K., Price P. A., Matrix Gla protein is associated with risk factors for atherosclerosis but not with coronary artery calcification Arteriosclerosis, Thrombosis, and Vascular Biology 2006 26 12 2769 2774
47. Ghazalpour A., Doss S., Yang X., Thematic review series: the pathogenesis of atherosclerosis. Toward a biological network for atherosclerosis Journal of Lipid Research 2004 45 10 1793 1805