Arachidonate 5-lipoxygenase

Prostaglandins and Other Lipid Mediators

Volumn 68-69, Issue , 2002, Pages 211-234

  Rådmark, Olof ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

5 Lipoxygenase; Arachidonic acid; Eicosanoid; Leukotriene

Indexed keywords

2 CYCLOPENTYL 2 [4 (2 QUINOLINYLMETHOXY)PHENYL]ACETIC ACID; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACTIN; ADENOSINE TRIPHOSPHATE; ALPHA ACTININ; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; ARACHIDONIC ACID; CALCIMYCIN; CALCIUM ION; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; HYDROGEN PEROXIDE; PROTEIN; PROTEIN CLP; PROTEIN TRAP 1; UNCLASSIFIED DRUG; 5-LIPOXYGENASE-ACTIVATING PROTEIN; ACTIN BINDING PROTEIN; CALCIUM; CARRIER PROTEIN; COTL1 PROTEIN, HUMAN; GRB2 PROTEIN, HUMAN; LIPID PEROXIDE; MEMBRANE PROTEIN; RIBONUCLEASE; RIBONUCLEASE III; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TGFBRAP1 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; CATALYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INACTIVATION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME PURIFICATION; HUMAN; LEUKOCYTE; MICROSOME MEMBRANE; MOLECULAR CLONING; NONHUMAN; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; ANIMAL; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE; REVIEW;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOSINE TRIPHOSPHATE; ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; CALCIUM; CARRIER PROTEINS; CELL MEMBRANE; ENDORIBONUCLEASES; ENZYME ACTIVATION; GRB2 ADAPTOR PROTEIN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPID PEROXIDES; MEMBRANE PROTEINS; MICROFILAMENT PROTEINS; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RIBONUCLEASE III;

EID: 0036669849     PISSN: 00906980     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-6980(02)00032-1     Document Type: Article

References (175)

1. Borgeat P., Hamberg M., Samuelsson B. Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases. J. Biol. Chem. 251:1976;7816-7820.
2. Samuelsson B. Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science. 220:1983;568-575.
3. Powell W.S., Gravel S., Halwani F. 5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of L-selectin shedding, surface expression of CD11b, actin polymerization, and calcium mobilization in human eosinophils. Am J Respir. Cell Mol Biol. 20:1999;163-170.
4. Serhan C.N., Takano T., Gronert K., Chiang N., Clish C.B. Lipoxin and aspirin-triggered 15-epi-lipoxin cellular interactions anti-inflammatory lipid mediators. Clin Chem Lab Med. 37:1999;299-309.
5. Matsumoto T, Funk CD, Rådmark O, Höög JO, Jörnvall H, Samuelsson B. Molecular cloning and amino acid sequence of human 5-lipoxygenase. Proc Natl Acad Sci USA 1988;85:26-30. Erratum in Proc Natl Acad Sci USA 1988;85:3406.
6. Dixon R.A., Jones R.E., Diehl R.E., Bennett C.D., Kargman S., Rouzer C.A. Cloning of the cDNA for human 5-lipoxygenase. Proc. Natl. Acad. Sci. USA. 85:1988;416-420.
7. Balcarek J.M., Theisen T.W., Cook M.N., Varrichio A., Hwang S.M., Strohsacker M.W.et al. Isolation and characterization of a cDNA clone encoding rat 5-lipoxygenase. J. Biol. Chem. 263:1988;13937-13941.
8. Chen X.S., Naumann T.A., Kurre U., Jenkins N.A., Copeland N.G., Funk C.D. cDNA cloning expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase. J. Biol. Chem. 270:1995;17993-17999.
9. Kitzler J.W., Eling T.E. Cloning, sequencing and expression of a 5-lipoxygenase from Syrian hamster embryo fibroblasts. Prostaglandin Leukot Essent Fatty Acids. 55:1996;269-277.
10. Minor W., Steczko J., Bolin J.T., Otwinowski Z., Axelrod B. Crystallographic determination of the active site iron and its ligands in soybean lipoxygenase L-1. Biochemistry. 32:1993;6320-6323.
11. Prigge S.T., Boyington J.C., Gaffney B.J., Amzel L.M. Structure conservation in lipoxygenases: structural analysis of soybean lipoxygenase-1 and modeling of human lipoxygenases. Protein Struct. Funct. Genet. 24:1996;275-291.
12. Rådmark O. Arachidonate 5-lipoxygenase. J. Lipid Med Cell Signal. 12:1995;171-184.
13. Boado R.J., Pardridge W.M., Vinters H.V., Black K.L. Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors - evidence for the expression of a multitranscript family. Proc. Natl. Acad. Sci. USA. 89:1992;9044-9048.
14. Percival M.D. Human 5-lipoxygenase contains an essential iron. J. Biol. Chem. 266:1991;10058-10061.
15. Kroneck P.M.H., Cucurou C., Ullrich V., Ueda N., Suzuki H., Yoshimoto T.et al. Porcine leukocyte 5-lipoxygenases and 12-lipoxygenases are iron enzymes. FEBS Lett. 287:1991;105-107.
16. Chasteen N.D., Grady J.K., Skorey K.I., Neden K.J., Riendeau D., Percival M.D. Characterization of the non-heme iron center of human 5-lipoxygenase by electron paramagnetic resonance, fluorescence, and ultraviolet-visible spectroscopy - redox cycling between ferrous and ferric states. Biochemistry. 32:1993;9763-9771.
17. Hammarberg T., Kuprin S., Rådmark O., Holmgren A. EPR investigation of the active site of recombinant human 5-lipoxygenase: inhibition by selenide. Biochemistry. 40:2001;6371-6378.
18. Rådmark O. Mutagenesis studies of mammalian lipoxygenases. In: Serhan CN and Ward PA, editors. Molecular and Cellular Basis of Inflammation. Totowa: Humana Press, 2000. p. 93-108.
19. Boyington J.C., Gaffney B.J., Amzel L.M. The 3-dimensional structure of an arachidonic acid 15-lipoxygenase. Science. 260:1993;1482-1486.
20. Minor W., Steczko J., Stec B., Otwinowski Z., Bolin J.T., Walter R.et al. Crystal structure of soybean lipoxygenase L-1 at 1.4. Å resolution Biochemistry. 35:1996;10687-10701.
21. Skrzypczak-Jankun E., Amzel L.M., Kroa B.A., Funk M.O. Jr. Structure of soybean lipoxygenase L3 and a comparison with its L1 isoenzyme. Proteins. 29:1997;15-31.
22. Gillmor SA, Villasenor A, Fletterick R, Sigal E, Browner MF. The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity. Nat Struct Biol 1997;4:1003-9. Erratum in Nat Struct Biol 1998;3:242.
23. Hegg E.L., Que L. The 2-His-1-carboxylate facial triad - an emerging structural motif in mononuclear non-heme iron(II) enzymes. Eur. J. Biochem. 250:1997;625-629. [Review].
24. Schwarz K., Walther M., Anton M., Gerth C., Feussner I., Kuhn H. Structural basis for lipoxygenase specificity. Conversion of the human leukocyte 5-lipoxygenase to a 15-lipoxygenating enzyme species by site-directed mutagenesis. J. Biol. Chem. 276:2001;773-779.
25. Corey E.J., Lansbury J.P.T. Stereochemical course of 5-lipoxygenation of arachidonate by rat basophil leukemic cell (RBL-1) and potato enzymes. J. Am. Chem. Soc. 105:1983;4093-4094.
26. 4 synthesis from arachidonic acid. Proc. Natl. Acad. Sci. USA. 81:1984;689-693.
27. 4 synthase activities. Proc. Natl. Acad. Sci. USA. 83:1986;857-861.
28. Ueda N., Kaneko S., Yoshimoto T., Yamamoto S. Purification of arachidonate 5-lipoxygenase from porcine leukocytes and its reactivity with hydroperoxyeicosatetraenoic acids. J. Biol. Chem. 261:1986;7982-7988.
29. 4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase. Proc. Natl. Acad. Sci. USA. 83:1986;4175-4179.
30. 4 synthetase activities. Mol. Pharmacol. 30:1986;510-519.
31. Zhang Y.Y., Rådmark O., Samuelsson B. Mutagenesis of some conserved residues in human 5-lipoxygenase - effects on enzyme activity. Proc. Natl. Acad. Sci. USA. 89:1992;485-489.
32. Percival M.D., Ouellet M. The characterization of 5 histidine-serine mutants of human 5-lipoxygenase. Biochem. Biophys. Res. Commun. 186:1992;1265-1270.
33. 4 synthesis by 5-lipoxygenase from rat polymorphonuclear leukocytes. Biochemistry. 26:1987;5684-5689.
34. 4 synthase activity. FEBS Lett. 217:1987;265-268.
35. Wiseman J.S. Alpha-secondary isotope effects in the lipoxygenase reaction. Biochemistry. 28:1989;2106-2111.
36. 4 from 5(S)-hydroperoxy-6(E),8,11,14(Z)-eicosatetraenoic acid. Evidence for an organoiron intermediate. J. Am. Chem. Soc. 111:1989;1452-1455.
37. Rouzer C.A., Kargman S. Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187. J. Biol. Chem. 263:1988;10980-10988.
38. Hill E., Maclouf J., Murphy R.C., Henson P.M. Reversible membrane association of neutrophil 5-lipoxygenase is accompanied by retention of activity and a change in substrate specificity. J. Biol. Chem. 267:1992;22048-22053.
39. 4 synthetase activity. Bba-Lipid. Lipid. Metab. 1215:1994;300-306.
40. 2. J. Lipid Mediat. 6:1993;23-30.
41. Abramovitz M., Wong E., Cox M.E., Richardson C.D., Li C., Vickers P.J. 5-lipoxygenase-activating protein stimulates the utilization of arachidonic acid by 5-lipoxygenase. Eur. J. Biochem. 215:1993;105-111.
42. Noguchi M., Miyano M., Kuhara S., Matsumoto T., Noma M. Interfacial kinetic reaction of human 5-lipoxygenase. Eur. J. Biochem. 222:1994;285-292.
43. DeCarolis E., Denis D., Riendeau D. Oxidative inactivation of human 5-lipoxygenase in phosphatidylcholine vesicles. Eur J Biochem. 235:1996;416-423.
44. Ueda N., Yamamoto S. The 6R-oxygenase activity of arachidonate 5-lipoxygenase purified from porcine leukocytes. J Biol. Chem. 263:1988;1937-1941.
45. Riendeau D., Falgueyret J.P., Guay J., Ueda N., Yamamoto S. Pseudoperoxidase activity of 5-lipoxygenase stimulated by potent benzofuranol and N-hydroxyurea inhibitors of the lipoxygenase reaction. Biochem. J. 274:1991;287-292.
46. Falgueyret J.P., Desmarais S., Roy P.J., Riendeau D. N-(4-Chlorophenyl)-N-hydroxy-N′-(3-chlorophenyl)urea, a general reducing agent for 5-, 12-, and 15-lipoxygenases and a substrate for their pseudoperoxidase activities. Biochem Cell Biol. 70:1992;228-236.
47. Bach M.K., Brashler J.R. In vivo and in vitro production of a slow reacting substance in the rat upon treatment with calcium ionophores. J Immunol. 113:1974;2040-2044.
48. Borgeat P., Samuelsson B. Arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophore A23187. Proc. Natl. Acad. Sci. USA. 76:1979;2148-2152.
49. Jakschik B.A., Sun F.F., Lee L., Steinhoff M.M. Calcium stimulation of a novel lipoxygenase. Biochem Biophys Res Commun. 95:1980;103-110.
50. Aharony D., Stein R.L. Kinetic mechanism of guinea pig neutrophil 5-lipoxygenase. J. Biol. Chem. 261:1986;11512-11519.
51. Rouzer C.A., Samuelsson B. On the nature of the 5-lipoxygenase reaction in human leukocytes: enzyme purification and requirement for multiple stimulatory factors. Proc. Natl. Acad. Sci. USA. 82:1985;6040-6044.
52. Skorey K.I., Gresser M.J. Calcium is not required for 5-lipoxygenase activity at high phosphatidyl choline vesicle concentrations. Biochemistry. 37:1998;8027-8034.
53. 2+ activates 5-lipoxygenase in vitro: dependency on concentrations of phosphatidylcholine and arachidonic acid. Biochemistry. 39:2000;1840-1848.
54. 2 and inhibition by metal ions. Eur. J. Biochem. 210:1992;109-117.
55. Hammarberg T., Rådmark O. 5-lipoxygenase binds calcium. Biochemistry. 38:1999;4441-4447.
56. Schatz-Munding M., Hatzelmann A., Ullrich V. The involvement of extracellular calcium in the formation of 5-lipoxygenase metabolites by human polymorphonuclear leukocytes. Eur. J. Biochem. 197:1991;487-493.
57. Hammarberg T., Provost P., Persson B., Rådmark O. The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity. J. Biol. Chem. 275:2000;38787-38793.
58. Chen X.S., Funk C.D. The N-terminal "β-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation. J. Biol. Chem. 276:2001;811-818.
59. Soberman R.J., Harper T.W., Betteridge D., Lewis R.A., Austen K.F. Characterization and separation of the arachidonic acid 5-lipoxygenase and linoleic acid omega-6 lipoxygenase (arachidonic acid 15-lipoxygenase) of human polymorphonuclear leukocytes. J. Biol. Chem. 260:1985;4508-4515.
60. Mogul R., Johansen E., Holman T.R. Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase. Biochemistry. 39:2000;4801-4807.
61. Sailer E.R., Schweizer S., Boden S.E., Ammon H.P.T., Safayhi H. Characterization of an acetyl-11-keto-beta-boswellic acid and arachidonate-binding regulatory site of 5-lipoxygenase using photoaffinity labeling. Eur. J. Biochem. 256:1998;364-368.
62. Rouzer C.A., Shimizu T., Samuelsson B. On the nature of the 5-lipoxygenase reaction in human leukocytes: characterization of a membrane-associated stimulatory factor. Proc. Natl. Acad. Sci. USA. 82:1985;7505-7509.
63. Goetze A.M., Fayer L., Bouska J., Bornemeier D., Carter G.W. Purification of a mammalian 5-lipoxygenase from rat basophilic leukemia cells. Prostaglandins. 29:1985;689-701.
64. 2+ levels and phosphatidylcholine vesicles. Biochim. Biophys. Acta. 960:1988;261-267.
65. Ochi K., Yoshimoto T., Yamamoto S., Taniguchi K., Miyamoto T. Arachidonate 5-lipoxygenase of guinea pig peritoneal polymorphonuclear leukocytes. Activation by adenosine 5′-triphosphate. J. Biol. Chem. 258:1983;5754-5758.
66. Furukawa M., Yoshimoto T., Ochi K., Yamamoto S. Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells. Biochim. Biophys. Acta. 795:1984;458-465.
67. Falgueyret J.P., Denis D., Macdonald D., Hutchinson J.H., Riendeau D. Characterization of the arachidonate and ATP binding sites of human 5-lipoxygenase using photoaffinity labeling and enzyme immobilization. Biochemistry. 34:1995;13603-13611.
68. Noguchi M., Miyano M., Matsumoto T. Physicochemical characterization of ATP binding to human 5-lipoxygenase. Lipids. 31:1996;367-371.
69. Zhang Y.Y., Hammarberg T., Rådmark O., Samuelsson B., Ng C.F., Funk C.D.et al. Analysis of a nucleotide-binding site of 5-lipoxygenase by affinity labelling: binding characteristics and amino acid sequences. Biochem. J. 351:2000;697-707.
70. Rouzer C.A., Samuelsson B. The importance of hydroperoxide activation for the detection and assay of mammalian 5-lipoxygenase. FEBS. Lett. 204:1986;293-296.
71. Riendeau D., Denis D., Choo L.Y., Nathaniel D.J. Stimulation of 5-lipoxygenase activity under conditions which promote lipid peroxidation. Biochem. J. 263:1989;565-572.
72. Haurand M., Flohe L. Kinetic studies on arachidonate 5-lipoxygenase from rat basophilic leukemia cells. Biol Chem Hoppe Seyler. 369:1988;133-142.
73. Riendeau D., Falgueyret J.P., Nathaniel D.J., Rokach J., Ueda N., Yamamoto S. Sensitivity of immunoaffinity-purified porcine 5-lipoxygenase to inhibitors and activating lipid hydroperoxides. Biochem Pharmacol. 38:1989;2313-2321.
74. Straif D., Werz O., Kellner R., Bahr U., Steinhilber D. Glutathione peroxidase-1 but not 4 is involved in the regulation of cellular 5-lipoxygenase activity in monocytic cells. Biochem. J. 349:2000;455-461.
75. Zhang Y.Y., Hamberg M., Rådmark O., Samuelsson B. Stabilization of purified human 5-lipoxygenase with glutathione peroxidase and superoxide dismutase. Anal. Biochem. 220:1994;28-35.
76. Hatzelmann A., Ullrich V. Regulation of 5-lipoxygenase activity by the glutathione status in human polymorphonuclear leukocytes. Eur. J. Biochem. 169:1987;175-184.
77. Hatzelmann A., Schatz M., Ullrich V. Involvement of glutathione peroxidase activity in the stimulation of 5-lipoxygenase activity by glutathione-depleting agents in human polymorphonuclear leukocytes. Eur. J. Biochem. 180:1989;527-533.
78. Weitzel F., Wendel A. Selenoenzymes regulate the activity of leukocyte 5-lipoxygenase via the peroxide tone. J. Biol. Chem. 268:1993;6288-6292.
79. Werz O., Steinhilber D. Selenium-dependent peroxidases suppress 5-lipoxygenase activity in B-lymphocytes and immature myeloid cells. The presence of peroxidase-insensitive 5-lipoxygenase activity in differentiated myeloid cells. Eur. J. Biochem. 242:1996;90-97.
80. Imai H., Narashima K., Arai M., Sakamoto H., Chiba N., Nakagawa Y. Suppression of leukotriene formation in RBL-2H3 cells that overexpressed phospholipid hydroperoxide glutathione peroxidase. J. Biol. Chem. 273:1998;1990-1997.
81. Huang H.S., Chen C.J., Lu H.S., Chang W.C. Identification of a lipoxygenase inhibitor in A431 cells as a phospholipid hydroperoxide glutathione peroxidase. FEBS Lett. 424:1998;22-26.
82. Coffey M.J., Wilcoxen S.E., Sporn P.H., Peters-Golden M. Regulation of 5-lipoxygenase activity in mononuclear phagocytes: characterization of an endogenous cytosolic inhibitor. Prostaglandin Lipid Mediat. 56:1998;103-117.
83. Jakobsson P.J., Shaskin P., Larsson P., Feltenmark S., Odlander B., Aguilar-Santelises M.et al. Studies on the regulation and localization of 5-lipoxygenase in human B-lymphocytes. Eur. J. Biochem. 232:1995;37-46.
84. Werz O., Szellas D., Steinhilber D. Reactive oxygen species released from granulocytes stimulate 5-lipoxygenase activity in a B-lymphocytic cell line. Eur. J. Biochem. 267:2000;1263-1269.
85. Werz O., Klemm J., Rådmark O., Samuelsson B. p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line. J. Leuk. Biol. 70:2001;830-838.
86. Sporn P.H., Peters-Golden M. Hydrogen peroxide inhibits alveolar macrophage 5-lipoxygenase metabolism in association with depletion of ATP. J. Biol. Chem. 263:1988;14776-14783.
87. Werz O., Szellas D., Henseler M., Steinhilber D. Nonredox 5-lipoxygenase inhibitors require glutathione peroxidase for efficient inhibition of 5-lipoxygenase activity. Mol. Pharmacol. 54:1998;445-451.
88. Aharony D., Redkar B.D., Hubbs S.J., Stein R.L. Kinetic studies on the inactivation of 5-lipoxygenase by 5(S)-hydroperoxyeicosatetraenoic acid. Prostaglandins. 33:1987;85-100.
89. Lepley R.A., Fitzpatrick F.A. Irreversible inactivation of 5-lipoxygenase by leukotriene-A(4) characterization of product inactivation with purified enzyme and intact leukocytes. J. Biol. Chem. 269:1994;2627-2631.
90. Stadtman E.R., Oliver C.N. Metal-catalyzed oxidation of proteins. Physiological consequences [Review]. J. Biol. Chem. 266:1991;2005-2008.
91. Coffey M.J., Phare S.M., Peters-Golden M. Peroxynitrite-induced nitrotyrosination of proteins is blocked by direct 5-lipoxygenase inhibitor zileuton. J Pharmacol Exp Therapeut. 299:2001;198-203.
92. Peters-Golden M., McNish R.W., Sporn P.H., Balazovich K. Basal activation of protein kinase C in rat alveolar macrophages: implications for arachidonate metabolism. Am. J. Physiol. 261:1991;L462-L471.
93. Lepley R.A., Muskardin D.T., Fitzpatrick F.A. Tyrosine kinase activity modulates catalysis and translocation of cellular 5-lipoxygenase. J. Biol. Chem. 271:1996;6179-6184.
94. Lepley R.A., Fitzpatrick F.A. Inhibition of mitogen-activated protein kinase kinase blocks activation and redistribution of 5-lipoxygenase in HL-60 cells. Arch. Biochem. Biophys. 331:1996;141-144.
95. Lepley R.A., Fitzpatrick F.A. 5-lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins. J. Biol. Chem. 269:1994;24163-24168.
96. Werz O., Klemm J., Samuelsson B., Rådmark O. 5-Lipoxygenase is phosphorylated by p38 kinase dependent MAPKAP kinases. Proc. Natl. Acad. Sci. 97:2000;5261-5266.
97. Lee J.C., Kumar S., Griswold D.E., Underwood D.C., Votta B.J., Adams J.L. Inhibition of p38 MAP kinase as a therapeutic strategy. Immunopharmacology. 47:2000;185-201.
98. Obata T., Brown G.E., Yaffe M.B. MAP kinase pathways activated by stress: the p38 MAPK pathway. Crit. Care Med. 28:2000;N67-N77.
99. Herlaar E., Brown Z. p38 MAPK signalling cascades in inflammatory disease. Mol. Med. Today. 5:1999;439-447.
100. Werz O, Bürkert E, Samuelsson B, Rådmark O, Steinhilber D. Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes. Blood 2000;99:1044-1052.
101. Werz O., Klemm J., Samuelsson B., Rådmark O. Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes. Blood. 97:2001;2487-2495.
102. Wong A., Cook M.N., Hwang S.M., Sarau H.M., Foley J.J., Crooke S.T. Stimulation of leukotriene production and membrane translocation of 5-lipoxygenase by cross-linking of the IgE receptors in RBL-2H3 Cells. Biochemistry. 31:1992;4046-4053.
103. Rouzer C.A., Ford H.A., Morton H.E., Gillard J.W. MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes. J. Biol. Chem. 265:1990;1436-1442.
104. Miller D.K., Gillard J.W., Vickers P.J., Sadowski S., Leveille C., Mancini J.A.et al. Identification and isolation of a membrane protein necessary for leukotriene production. Nature. 343:1990;278-281.
105. Dixon R.A., Diehl R.E., Opas E., Rands E., Vickers P.J., Evans J.F.et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature. 343:1990;282-284.
106. Kargman S., Vickers P.J., Evans J.F. A23187-induced translocation of 5-lipoxygenase in osteosarcoma cells. J. Cell Biol. 119:1992;1701-1709.
107. Kargman S., Rousseau P., Reid G.K., Rouzer C.A., Mancini J.A., Rands E.et al. Leukotriene synthesis in U937 cells expressing recombinant 5-lipoxygenase. J Lipid Mediat. 7:1993;31-45.
108. Peters-Golden M., Mcnish R.W. Redistribution of 5-lipoxygenase and cytosolic phospholipase-A2 to the nuclear fraction upon macrophage activation. Biochem. Biophys. Res. Commun. 196:1993;147-153.
109. Woods J.W., Evans J.F., Ethier D., Scott S., Vickers P.J., Hearn L.et al. 5-lipoxygenase and 5-lipoxygenase activating protein are localized in the nuclear envelope of activated human leukocytes. J. Exp. Med. 178:1993;1935-1946.
110. Woods J.W., Coffey M.J., Brock T.G., Singer I.I., Peters-Golden M. 5-lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation. J. Clin. Invest. 95:1995;2035-2046.
111. Brock T.G., Mcnish R.W., Peters-Golden M. Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages. J. Biol. Chem. 270:1995;21652-21658.
112. Pouliot M., Mcdonald P.P., Krump E., Mancini J.A., Mccoll S.R., Weech P.K.et al. Colocalization of cytosolic phospholipase A(2), 5-lipoxygenase, and 5-lipoxygenase-activating protein at the nuclear membrane of A23187-stimulated human neutrophils. Eur. J. Biochem. 238:1996;250-258.
113. Coffey M., Peters-Golden M., Fantone J.C., Sporn P.H.S. Membrane association of active 5-lipoxygenase in resting cells - evidence for novel regulation of the enzyme in the rat alveolar macrophage. J. Biol. Chem. 267:1992;570-576.
114. Hatzelmann A., Fruchtmann R., Mohrs K.H., Raddatz S., Mullerpeddinghaus R. Mode of action of the new selective leukotriene synthesis inhibitor BAY X-1005 ((R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid) and structurally related compounds. Biochem. Pharmacol. 45:1993;101-111.
115. Brock T.G., McNish R.W., Peters-Golden M. Capacity for repeatable leukotriene generation after transient stimulation of mast cells and macrophages. Biochem. J. 329:1998;519-525.
116. Mancini J.A., Abramovitz M., Cox M.E., Wong E., Charleson S., Perrier H.et al. 5-Lipoxygenase-activating protein is an arachidonate binding Protein. FEBS Lett. 318:1993;277-281.
117. Hatzelmann A., Goossens J., Fruchtmann R., Mohrs K.H., Raddatz S., Mullerpeddinghaus R. Inversely-correlated inhibition of human 5-lipoxygenase activity by BAY X1005 and other quinoline derivatives in intact cells and a cell-free system - implications for the function of 5-lipoxygenase activating protein. Biochem. Pharmacol. 47:1994;2259-2268.
118. Charleson S., Evans J.F., Leger S., Perrier H., Prasit P., Wang Z.Y.et al. Structural requirements for the binding of fatty acids to 5-lipoxygenase-activating protein. Eur. J. Pharmacol. Mol. Pharm. 267:1994;275-280.
119. Mancini J.A., Waterman H., Riendeau D. Cellular oxygenation of 12-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid by 5-lipoxygenase is stimulated by 5-lipoxygenase-activating protein. J. Biol. Chem. 273:1998;32842-32847.
120. Battu S., Moalic S., Rigaud M., Beneytout J.L. Linoleic acid peroxidation by Solanum tuberosum lipoxygenase was activated in the presence of human 5-lipoxygenase-activating protein. Biochim Biophys Acta Lipid Lipid Metab. 1392:1998;340-350.
121. Ghosh J., Myers C.E. Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells. Proc. Natl. Acad. Sci. USA. 95:1998;13182-13187.
122. Datta K., Biswal S.S., Kehrer J.P. The 5-lipoxygenase-activating protein (FLAP) inhibitor, MK886, induces apoptosis independently of FLAP. Biochem. J. 340:1999;371-375.
123. Anderson K.M., Alrefai W.A., Bonomi P., Dudeja P., Ou D., Anderson C.et al. Altered oncogene tumor suppressor and cell-cycle gene expression in PANC-1 cells cultured with the pleiotrophic 5-lipoxygenase inhibitor, MK886, assessed with a gene chip. Anticancer Res. 19:1999;3873-3887.
124. Jakobsson P.J., Morgenstern R., Mancini J., Ford-Hutchinson A., Persson B. Membrane-associated proteins in eicosanoid A widespread protein superfamily. Am J Respir. Crit Care Med. 161:2000;S20-S24.
125. Vandernoot V.A., Fitzpatrick F.A. Competitive binding assay of Src homology domain 3 interactions between 5-lipoxygenase and growth factor receptor binding protein 2. Anal. Biochem. 230:1995;108-114.
126. Peters-Golden M., Brock T.G. Intracellular compartmentalization of leukotriene synthesis: unexpected nuclear secrets. FEBS Lett. 487:2001;323-326.
127. Kang L.T., Vanderhoek J.Y. Mono (S) hydroxy fatty acids: novel ligands for cytosolic actin. J Lipid Res. 39:1998;1476-1482.
128. 4 release from activated neutrophils. Proc. Natl. Acad. Sci. USA. 80:1983;4349-4353.
129. Haurand M., Flohe L. Leukotriene formation by human polymorphonuclear leukocytes from endogenous arachidonate. Physiological triggers and modulation by prostanoids. Biochem Pharmacol. 38:1989;2129-2137.
130. Peters-Golden M., McNish R.W., Davis J.A., Blackwood R.A., Brock T.G. Colchicine inhibits arachidonate release and 5-lipoxygenase action in alveolar macrophages. Am J Physiol Lung Cell Mol Physiol. 15:1996;L1004-L1013.
131. Pollard TD. Actin and associated prtoteins, introduction. In: Kreiss T, Vale R, editors. Guidebook to the cytoskeletal and motor proteins. New York, NY, USA: Oxford University Press, 1999. p. 3-11.
132. de Hostos E.L., Bradtke B., Lottspeich F., Gerisch G. Coactosin a 17 kDa F-actin binding protein from Dictyostelium discoideum. Cell Motil Cytoskelet. 26:1993;181-191.
133. Lappalainen P., Kessels M.M., Cope M.J., Drubin D.G. The ADF homology (ADF-H) domain: a highly exploited actin-binding module. Mol Biol Cell. 9:1998;1951-1959.
134. Rohrig U., Gerisch G., Morozova L., Schleicher M., Wegner A. Coactosin interferes with the capping of actin filaments. FEBS. Lett. 374:1995;284-286.
135. Chen K.S., Manian P., Koeuth T., Potocki L., Zhao Q., Chinault A.C.et al. Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome. Nat Genet. 17:1997;154-163.
136. Provost P., Samuelsson B., Rådmark O. Interaction of 5-lipoxygenase with cellular proteins. Proc. Natl. Acad. Sci. USA. 96:1999;1881-1885.
137. Provost P., Doucet J., Hanmmarberg T., Gerisch G., Samuelsson B., Rådmark O. 5-Lipoxygenase interacts with coactosin-like protein. J. Biol. Chem. 276:2001;16520-16527.
138. Provost P., Doucet J., Stock A., Gerisch G., Samuelsson B., Rådmark O. Coactosin-like protein a human F-actin-binding protein: critical role lysine-75. Biochem. J. 359:2001;255-263.
139. Miller Y.I., Chang M.K., Funk C.D., Feramisco J.R., Witztum J.L. 12/15-Lipoxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cells. J. Biol. Chem. 276:2001;19431-19439.
140. Charng M.J., Zhang D., Kinnunen P., Schneider M.D. A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor. J. Biol. Chem. 273:1998;9365-9368.
141. Wurthner J.U., Frank D.B., Felici A., Green H.M., Cao Z., Schneider M.D., McNally J.G.et al. Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. J. Biol. Chem. 276:2001;19495-19502.
142. Brungs M., Rådmark O., Samuelsson B., Steinhilber D. Sequential induction of 5-lipoxygenase gene expression and activity in Mono Mac 6 cells by transforming growth factor beta and 1,25-dihydroxyvitamin D-3. Proc. Natl. Acad. Sci. USA. 92:1995;107-111.
143. Matsuda S., Miyazaki K., Ichigotani Y., Kurata H., Takenouchi Y., Yamamoto T.et al. Molecular cloning and characterization of a novel human gene (NESCA) which encodes a putative adapter protein containing SH3. Biochim. Biophys. Acta. 1491:2000;321-326.
144. Bernstein E., Caudy A.A., Hammond S.M., Hannon G.J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature. 409:2001;363-366.
145. Matzke M., Matzke A.J., Kooter J.M. RNA: guiding gene silencing. Science. 293:2001;1080-1083.
146. Rouzer C.A., Samuelsson B. Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase. Proc. Natl. Acad. Sci. USA. 84:1987;7393-7397.
147. Wong A., Hwang S.M., Cook M.N., Hogaboom G.K., Crooke S.T. Interactions of 5-lipoxygenase with membranes: studies on the association of soluble enzyme with membranes and alterations in enzyme activity. Biochemistry. 27:1988;6763-6769.
148. Kargman S., Rouzer C.A. Studies on the regulation, biosynthesis, and activation of 5-lipoxygenase in differentiated HL60 cells. J. Biol. Chem. 264:1989;13313-13320.
149. Kargman S., Prasit P., Evans J.F. Translocation of HL-60 Cell 5-lipoxygenase. Inhibition of A23187- or N-formyl-methionyl-leucyl-phenylalanine-induced translocation by indole and quinoline leukotriene synthesis inhibitors. J. Biol. Chem. 266:1991;23745-23752.
150. Malaviya R., Malaviya R., Jakschik B.A. Reversible translocation of 5-lipoxygenase in mast cells upon IgE/antigen stimulation. J. Biol. Chem. 268:1993;4939-4944.
151. Brock T.G., Paine R., Peters-Golden M. Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells. J. Biol. Chem. 269:1994;22059-22066.
152. Brock T.G., McNish R.W., Bailie M.B., Peters-Golden M. Rapid import of cytosolic 5-lipoxygenase into the nucleus of neutrophils after in vivo recruitment and in vitro adherence. J. Biol. Chem. 272:1997;8276-8280.
153. Covin R.B., Brock T.G., BailiE M.B., Peters-Golden M. Altered expression and localization of 5-lipoxygenase accompany macrophage differentiation in the lung. Am J Physiol. 275:1998;L303-L310.
154. Sud'ina G.F., Brock T.G., Pushkareva M.A., Galkina S.I., Turutin D.V., Peters-Golden M., Ullrich V. Sulphatides trigger polymorphonuclear granulocyte spreading on collagen-coated surfaces and inhibit subsequent activation of 5-lipoxygenase. Biochem. J. 359:2001;621-629.
155. Spanbroek R., Stark H.J., Janssen T.U., Kraft S., Hildner M., Andl T., Bosch F.X., Fusenig N.E., Bieber T., Rådmark O., Samuelsson B., Habenicht A.J. 5-Lipoxygenase expression in Langerhans cells of normal human epidermis. Proc. Natl. Acad. Sci. USA. 95:1998;663-668.
156. Spanbroek R., Hildner M., Steinhilber D., Fusenig N., Yoneda K., Rådmark O.et al. 5-Lipoxygenase expression in dendritic cells generated from CD34(+) hematopoietic progenitors and in lymphoid organs. Blood. 96:2000;3857-3865.
157. Spanbroek R., Hildner M., Kohler A., Muller A., Zintl F., Kuhn H.et al. IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase. Proc. Natl. Acad. Sci. USA. 98:2001;5152-5157.
158. Bozza P.T., Yu W., Penrose J.F., Morgan E.S., Dvorak A.M., Weller P.F. Eosinophil lipid bodies: specific inducible intracellular sites for enhanced eicosanoid formation. J Exp Med. 186:1997;909-920.
159. Brock T.G., Anderson J.A., Fries F.P., Peters-Golden M., Sporn P.H. Decreased leukotriene C4 synthesis accompanies adherence-dependent nuclear import of 5-lipoxygenase in human blood eosinophils. J Immunol. 162:1999;1669-1676.
160. Cowburn A.S., Holgate S.T., Sampson A.P. IL-5 increases expression of 5-lipoxygenase-activating protein and translocates 5-lipoxygenase to the nucleus in human blood eosinophils. J Immunol. 163:1999;456-465.
161. Chen X.S., Zhang Y.Y., Funk C.D. Determinants of 5-lipoxygenase nuclear localization using green fluorescent protein 5-lipoxygenase fusion proteins. J. Biol. Chem. 273:1998;31237-31244.
162. Healy A.M., Peters-Golden M., Ping Yao J., Brock T.G. Identification of a bipartite nuclear localization sequence necessary for nuclear import of 5-lipoxygenase. J. Biol. Chem. 274:1999;29812-29818.
163. Lepley R.A., Fitzpatrick F.A. 5-Lipoxygenase compartmentalization in granulocytic cells is modulated by an internal bipartite nuclear localizing sequence and nuclear factor kappa B complex formation. Arch. Biochem. Biophys. 356:1998;71-76.
164. Davletov B., Perisic O., Williams R.L. Calcium-dependent membrane penetration is a hallmark of the C2 domain of cytosolic phospholipase A2 whereas the C2A domain of synaptotagmin binds membranes electrostatically. J. Biol. Chem. 273:1998;19093-19096.
165. 2+-activated C2 domain of cytosolic phospholipase A2. Biochemistry. 37:1998;17642-17650.
166. 4 hydrolase with 5-lipoxygenase in nuclei of alveolar macrophages and rat basophilic leukemia cells but not neutrophils. J. Biol. Chem. 276:2001;35071-35077.
167. Nalefski E.A., Falke J.J. The C2 domain calcium-binding motif: structural and functional diversity [Review]. Protein Sci. 5:1996;2375-2390.
168. 2+-binding domain. J. Biol. Chem. 273:1998;15879-15882.
169. Edwards A.S., Newton A.C. Regulation of protein kinase C betaII by its C2 domain. Biochemistry. 36:1997;15615-15623.
170. Qiu Z.H., Gijon M.A., deCarvalho M.S., Spencer D.M., Leslie C.C. The role of calcium and phosphorylation of cytosolic phospholipase A(2) in regulating arachidonic acid release in macrophages. J. Biol. Chem. 273:1998;8203-8211.
171. Gijon M.A., Spencer D.M., Kaiser A.L., Leslie C.C. Role of phosphorylation sites and the C2 domain in regulation of cytosolic phospholipase A2. J Cell Biol. 145:1999;1219-1232.
172. Nakamura M., Matsumoto T., Noguchi M., Yamashita I., Noma M. Expression of a cDNA encoding human 5-lipoxygenase under control of the STA1 promoter in Saccharomyces cerevisiae. Gene. 89:1990;231-237.
173. Denis D., Falgueyret J.P., Riendeau D., Abramovitz M. Characterization of the activity of purified recombinant human 5-lipoxygenase in the absence and presence of leukocyte factors. J. Biol. Chem. 266:1991;5072-5079.
174. Zhang Y.Y., Lind B., Rådmark O., Samuelsson B. Iron content of human 5-lipoxygenase, effects of mutations regarding conserved histidine residues. J. Biol. Chem. 268:1993;2535-2541.
175. Smith C.M., Anderson S.D. Inhalational challenge using hypertonic saline in asthmatic subjects: a comparison with responses to hyperpnoea, metacholine and water. Eur. Respir. J. 3:1990;144-151.