Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia

Journal of Biological Chemistry

Volumn 277, Issue 38, 2002, Pages 35350-35356

  Zhao, Lei ^a,b,c   Cuff, Carolyn A ^a,b,c   Moss, Erin ^a,b,c   Wille, Ulrike ^a,b,c   Cyrus, Tillmann ^a,b,c   Klein, Eric A ^a,b,c   Praticò, Domenico ^a,b,c   Rader, Daniel J ^a,b,c   Hunter, Christopher A ^a,b,c   Puré, Ellen ^a,b,c   Funk, Colin D ^a,b,c  

^a Center for Experimental Therapeutics   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; DISEASES; GENES; NITROGEN OXIDES; POLYPEPTIDES; RNA;

NECROSIS;

ENZYMES;

APOLIPOPROTEIN E; INTERLEUKIN 12; LIPOPROTEIN RECEPTOR; LIPOXYGENASE;

ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; AUTOIMMUNITY; CELL INTERACTION; COMPLEX FORMATION; ENZYME DEFICIENCY; FAMILIAL HYPERCHOLESTEROLEMIA; GENE DISRUPTION; GENE TARGETING; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; RNA EDITING; STRAIN DIFFERENCE;

ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; ARTERIOSCLEROSIS; CYTIDINE DEAMINASE; DISEASE MODELS, ANIMAL; HYPERLIPOPROTEINEMIA TYPE II; INTERLEUKIN-12; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, LDL;

ANIMALIA;

EID: 0037144594     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205738200     Document Type: Article

References (38)