메뉴 건너뛰기




Volumn 10, Issue 3, 2010, Pages 153-163

Characterizing proteins of unknown function: Orphan cytochrome P450 enzymes as a paradigm

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA CYANOPREGNENOLONE; ANANDAMIDE; ANTIBIOTIC AGENT; CODEINE; CYTOCHROME; CYTOCHROME P450; CYTOCHROME P450 154A1; CYTOCHROME P450 2D6; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; DUTASTERIDE; ERGOT ALKALOID; FINASTERIDE; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; LYSERGIC ACID; MORPHINE; MORPHINONE; ORIPAVINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STEROID 5ALPHA REDUCTASE; THEBAINE; UNCLASSIFIED DRUG;

EID: 77953512029     PISSN: 15340384     EISSN: 15432548     Source Type: Journal    
DOI: 10.1124/mi.10.3.6     Document Type: Review
Times cited : (36)

References (88)
  • 1
    • 72449145463 scopus 로고    scopus 로고
    • "Unknown" proteins and "orphan" enzymes: The missing half of the engineering parts list-and how to find it
    • Hanson AD, Pribat A, Waller JC, and Crecy-Lagard V (2010) "Unknown" proteins and "orphan" enzymes: The missing half of the engineering parts list-and how to find it Biochem J 425:1-11.
    • (2010) Biochem J , vol.425 , pp. 1-11
    • Hanson, A.D.1    Pribat, A.2    Waller, J.C.3    Crecy-Lagard, V.4
  • 2
    • 0024545638 scopus 로고
    • Gene regulation by steroid hormones
    • Beato, M (1989) Gene regulation by steroid hormones. Cell 56:335-344.
    • (1989) Cell , vol.56 , pp. 335-344
    • Beato, M.1
  • 3
    • 0022327612 scopus 로고
    • Steroid receptor regulated transcription of specific genes and gene networks
    • Yamamoto KR (1985) Steroid receptor regulated transcription of specific genes and gene networks. Annu Rev Genet 19:209-252.
    • (1985) Annu Rev Genet , vol.19 , pp. 209-252
    • Yamamoto, K.R.1
  • 4
    • 0023221667 scopus 로고
    • Cloning of human mineralocorticoid receptor complementary DNA: Structural and functional kinship with the glucocorticoid receptor
    • Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DE, and Evans RM (1987) Cloning of human mineralocorticoid receptor complementary DNA: Structural and functional kinship with the glucocorticoid receptor. Science 237:268-275. (Pubitemid 17095145)
    • (1987) Science , vol.237 , Issue.4812 , pp. 268-275
    • Arriza, J.L.1    Weinberger, C.2    Cerelli, G.3
  • 5
    • 0024372108 scopus 로고
    • DNA binding specificity of steroid receptors
    • Berg JM (1989) DNA binding specificity of steroid receptors. Cell 57:1065-1068.
    • (1989) Cell , vol.57 , pp. 1065-1068
    • Berg, J.M.1
  • 6
    • 0023913120 scopus 로고
    • The steroid and thyroid hormone receptor superfamily
    • Evans RM (1988) The steroid and thyroid hormone receptor superfamily. Science 240:889-895.
    • (1988) Science , vol.240 , pp. 889-895
    • Evans, R.M.1
  • 7
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann I and Green S (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645-650. (Pubitemid 120028995)
    • (1990) Nature , vol.347 , Issue.6294 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 9
    • 0343158399 scopus 로고    scopus 로고
    • The nuclear orphan receptor CAR-RXR heterodimer activates the phenobarbitalresponsive enhancer module of the CYP2B gene
    • Honkakoski P, Zelko I, Sueyoshi T, and Negishi M (1998) The nuclear orphan receptor CAR-RXR heterodimer activates the phenobarbitalresponsive enhancer module of the CYP2B gene. Mol Cell Biol 18:1-7.
    • (1998) Mol Cell Biol , vol.18 , pp. 1-7
    • Honkakoski, P.1    Zelko, I.2    Sueyoshi, T.3    Negishi, M.4
  • 12
    • 0034923923 scopus 로고    scopus 로고
    • Divergent evolution of enzymatic function: Mechanistically diverse superfamilies and functionally distinct suprafamilies
    • Gerlt JA and Babbitt PC (2001) Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafamilies. Annu Rev Biochem 70:209-246.
    • (2001) Annu Rev Biochem , vol.70 , pp. 209-246
    • Gerlt, J.A.1    Babbitt, P.C.2
  • 14
    • 33748802003 scopus 로고    scopus 로고
    • Structural basis for ligand promiscuity in cytochrome P450 3A4
    • Ekroos M and Sjögren T (2006) Structural basis for ligand promiscuity in cytochrome P450 3A4. Proc Natl Acad Sci USA 103:13682-13687.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 13682-13687
    • Ekroos, M.1    Sjögren, T.2
  • 15
    • 0024446655 scopus 로고
    • Expression cloning and regulation of steroid 5α-reductase, an enzyme essential for male sexual differentiation
    • Andersson S, Bishop RW, and Russell DW (1989) Expression cloning and regulation of steroid 5α-reductase, an enzyme essential for male sexual differentiation. J Biol Chem 264:16249-16255. (Pubitemid 19238390)
    • (1989) Journal of Biological Chemistry , vol.264 , Issue.27 , pp. 16249-16255
    • Andersson, S.1    Bishop, R.W.2    Russell, D.W.3
  • 17
    • 33646127626 scopus 로고    scopus 로고
    • Discovery and clinical development of dutasteride, a potent dual 5α-reductase inhibitor
    • Frye SV (2006) Discovery and clinical development of dutasteride, a potent dual 5α-reductase inhibitor. Curr Top Med Chem 6:405-421.
    • (2006) Curr Top Med Chem , vol.6 , pp. 405-421
    • Frye, S.V.1
  • 20
    • 70349431230 scopus 로고    scopus 로고
    • In vivo target validation using gene invalidation, RNA interference and protein functional knockout models: It is the time to combine
    • Vidalin O, Muslmani M, Estienne C, Echchakir H, and Abina AM (2009) In vivo target validation using gene invalidation, RNA interference and protein functional knockout models: It is the time to combine. Curr Opin Pharmacol 9:669-676.
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 669-676
    • Vidalin, O.1    Muslmani, M.2    Estienne, C.3    Echchakir, H.4    Abina, A.M.5
  • 23
    • 84984752764 scopus 로고    scopus 로고
    • Assignment of protein function in the postgenomic era
    • Saghatelian A and Cravatt BF (2005) Assignment of protein function in the postgenomic era. Nat Chem Biol 1:130-142.
    • (2005) Nat Chem Biol , vol.1 , pp. 130-142
    • Saghatelian, A.1    Cravatt, B.F.2
  • 24
    • 35848965006 scopus 로고    scopus 로고
    • Activity-based protein profiling for the functional annotation of enzymes
    • Barglow KT and Cravatt BF (2007) Activity-based protein profiling for the functional annotation of enzymes. Nat Methods 4:822-827.
    • (2007) Nat Methods , vol.4 , pp. 822-827
    • Barglow, K.T.1    Cravatt, B.F.2
  • 25
    • 68049107457 scopus 로고    scopus 로고
    • A suite of activity-based probes for human cytochrome P450 enzymes
    • Wright AT, Song JD, and Cravatt BF (2009) A suite of activity-based probes for human cytochrome P450 enzymes. J Am Chem Soc 131:10692-10700.
    • (2009) J Am Chem Soc , vol.131 , pp. 10692-10700
    • Wright, A.T.1    Song, J.D.2    Cravatt, B.F.3
  • 26
    • 25444526868 scopus 로고    scopus 로고
    • Processing methods for differential analysis of LC/MS profile data
    • Katajamaa M and Oresic M (2005) Processing methods for differential analysis of LC/MS profile data. BMC Bioinformatics 6:179.
    • (2005) BMC Bioinformatics , vol.6 , pp. 179
    • Katajamaa, M.1    Oresic, M.2
  • 28
    • 33644867564 scopus 로고    scopus 로고
    • MZmine: Toolbox for processing and visualization of mass spectrometry based molecular profile data
    • Oxford, UK
    • Katajamaa M, Miettinen J, and Oresic M (2006) MZmine: Toolbox for processing and visualization of mass spectrometry based molecular profile data. Bioinformatics (Oxford, UK) 22:634-636.
    • (2006) Bioinformatics , vol.22 , pp. 634-636
    • Katajamaa, M.1    Miettinen, J.2    Oresic, M.3
  • 29
    • 65249132985 scopus 로고    scopus 로고
    • MetAlign: Interface-driven, versatile metabolomics tool for hyphenated full-scan mass spectrometry data preprocessing
    • Lommen A (2009) MetAlign: interface-driven, versatile metabolomics tool for hyphenated full-scan mass spectrometry data preprocessing. Anal Chem 81:3079-3086.
    • (2009) Anal Chem , vol.81 , pp. 3079-3086
    • Lommen, A.1
  • 30
    • 32444446805 scopus 로고    scopus 로고
    • XCMS: Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification
    • Smith CA, Want EJ, O'Maille G, Abagyan R, and Siuzdak G (2006) XCMS: Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal Chem 78:779-787.
    • (2006) Anal Chem , vol.78 , pp. 779-787
    • Smith, C.A.1    Want, E.J.2    O'Maille, G.3    Abagyan, R.4    Siuzdak, G.5
  • 31
    • 67449147120 scopus 로고    scopus 로고
    • Parameter selection for peak alignment in chromatographic sample profiling: Objective quality indicators and use of control samples
    • Peters S, van Velzen E, and Janssen HG (2009) Parameter selection for peak alignment in chromatographic sample profiling: Objective quality indicators and use of control samples. Anal Bioanal Chem 394:1273-1281.
    • (2009) Anal Bioanal Chem , vol.394 , pp. 1273-1281
    • Peters, S.1    Van Velzen, E.2    Janssen, H.G.3
  • 32
    • 34248211291 scopus 로고    scopus 로고
    • Untargeted analysis of mass spectrometry data for elucidation of function of new enzymes
    • Sanchez-Ponce R and Guengerich FP (2007) Untargeted analysis of mass spectrometry data for elucidation of function of new enzymes. Anal Chem 79:3355-3362.
    • (2007) Anal Chem , vol.79 , pp. 3355-3362
    • Sanchez-Ponce, R.1    Guengerich, F.P.2
  • 33
    • 65249186716 scopus 로고    scopus 로고
    • Elucidation of functions of human cytochrome P450 enzymes: Identification of endogenous substrates in tissue extracts by LC-MS metabolomics and isotopic labeling approaches
    • Tang Z, Martin MV, and Guengerich FP (2009) Elucidation of functions of human cytochrome P450 enzymes: Identification of endogenous substrates in tissue extracts by LC-MS metabolomics and isotopic labeling approaches. Anal Chem 81:3071-3078.
    • (2009) Anal Chem , vol.81 , pp. 3071-3078
    • Tang, Z.1    Martin, M.V.2    Guengerich, F.P.3
  • 34
    • 33645781037 scopus 로고    scopus 로고
    • Identification of the cytochrome P450 monooxygenase that bridges the clavine and ergoline alkaloid pathways
    • Haarmann T, Ortel I, Tudzynski P, and Keller U (2006) Identification of the cytochrome P450 monooxygenase that bridges the clavine and ergoline alkaloid pathways. Chembiochem 7:645-652.
    • (2006) Chembiochem , vol.7 , pp. 645-652
    • Haarmann, T.1    Ortel, I.2    Tudzynski, P.3    Keller, U.4
  • 35
    • 34548440174 scopus 로고    scopus 로고
    • Novel properties of P450s in Streptomyces coelicolor
    • Zhao B and Waterman MR (2007) Novel properties of P450s in Streptomyces coelicolor. Drug Metab Rev 39:343-352.
    • (2007) Drug Metab Rev , vol.39 , pp. 343-352
    • Zhao, B.1    Waterman, M.R.2
  • 36
  • 37
    • 58549119938 scopus 로고    scopus 로고
    • cDNA cloning and functional characterisation of CYP98A14 and NADPH:Cytochrome P450 reductase from Coleus blumei involved in rosmarinic acid biosynthesis
    • Eberle D, Ullmann P, Werck-Reichhart D, and Petersen M (2009) cDNA cloning and functional characterisation of CYP98A14 and NADPH:cytochrome P450 reductase from Coleus blumei involved in rosmarinic acid biosynthesis. Plant Mol Biol 69:239-253.
    • (2009) Plant Mol Biol , vol.69 , pp. 239-253
    • Eberle, D.1    Ullmann, P.2    Werck-Reichhart, D.3    Petersen, M.4
  • 39
    • 34347387493 scopus 로고    scopus 로고
    • CYP703 is an ancient cytochrome P450 in land plants catalyzing in-chain hydroxylation of lauric acid to provide building blocks for sporopollenin synthesis in pollen
    • Morant M, Jorgensen K, Schaller H, Pinot F, Møller BL, Werck-Reichhart D, and Bak S (2007) CYP703 is an ancient cytochrome P450 in land plants catalyzing in-chain hydroxylation of lauric acid to provide building blocks for sporopollenin synthesis in pollen. Plant Cell 19:1473-1487.
    • (2007) Plant Cell , vol.19 , pp. 1473-1487
    • Morant, M.1    Jorgensen, K.2    Schaller, H.3    Pinot, F.4    Møller, B.L.5    Werck-Reichhart, D.6    Bak, S.7
  • 40
    • 34447099968 scopus 로고    scopus 로고
    • A medium-throughput screening assay to determine catalytic activities of oxygen-consuming enzymes:A new tool for functional characterization of cytochrome P450 and other oxygenases
    • Olry A, Schneider-Belhaddad F, Heintz D, and Werck-Reichhart D (2007) A medium-throughput screening assay to determine catalytic activities of oxygen-consuming enzymes:A new tool for functional characterization of cytochrome P450 and other oxygenases. Plant J 51:331-340.
    • (2007) Plant J , vol.51 , pp. 331-340
    • Olry, A.1    Schneider-Belhaddad, F.2    Heintz, D.3    Werck-Reichhart, D.4
  • 41
    • 34248662705 scopus 로고    scopus 로고
    • Functional annotation of the Arabidopsis P450 superfamily based on large-scale coexpression analysis
    • Ehlting J, Provart NJ, and Werck-Reichhart D (2006) Functional annotation of the Arabidopsis P450 superfamily based on large-scale coexpression analysis. Biochem Soc Trans 34:1192-1198.
    • (2006) Biochem Soc Trans , vol.34 , pp. 1192-1198
    • Ehlting, J.1    Provart, N.J.2    Werck-Reichhart, D.3
  • 43
    • 42249110738 scopus 로고    scopus 로고
    • Molecular cloning and characterization of CYP80G2, a cytochrome P450 that catalyzes an intramolecular C-C phenol coupling of (S)-reticuline in magnoflorine biosynthesis, from cultured Coptis japonica cells
    • Ikezawa N, Iwasa K, and Sato F (2008) Molecular cloning and characterization of CYP80G2, a cytochrome P450 that catalyzes an intramolecular C-C phenol coupling of (S)-reticuline in magnoflorine biosynthesis, from cultured Coptis japonica cells. J Biol Chem 283:8810-8821.
    • (2008) J Biol Chem , vol.283 , pp. 8810-8821
    • Ikezawa, N.1    Iwasa, K.2    Sato, F.3
  • 44
    • 69949174213 scopus 로고    scopus 로고
    • CYP719B1 is salutaridine synthase, the C-C phenol-coupling enzyme of morphine biosynthesis in opium poppy
    • Gesell A, Rolf M, Ziegler J, Diaz Chavez ML, Huang FC, and Kutchan TM (2009) CYP719B1 is salutaridine synthase, the C-C phenol-coupling enzyme of morphine biosynthesis in opium poppy. J Biol Chem 284:24432-24442.
    • (2009) J Biol Chem , vol.284 , pp. 24432-24442
    • Gesell, A.1    Rolf, M.2    Ziegler, J.3    Diaz Chavez, M.L.4    Huang, F.C.5    Kutchan, T.M.6
  • 45
    • 58149242229 scopus 로고    scopus 로고
    • CYP719A subfamily of cytochrome P450 oxygenases and isoquinoline alkaloid biosynthesis in Eschscholzia californica
    • Ikezawa N, Iwasa K, and Sato F (2009) CYP719A subfamily of cytochrome P450 oxygenases and isoquinoline alkaloid biosynthesis in Eschscholzia californica. Plant Cell Rep 28:123-133.
    • (2009) Plant Cell Rep , vol.28 , pp. 123-133
    • Ikezawa, N.1    Iwasa, K.2    Sato, F.3
  • 46
    • 0038240578 scopus 로고    scopus 로고
    • Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase
    • Yu AM, Idle JR, Herraiz T, Küpfer A, and Gonzalez FJ (2003) Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase. Pharmacogenetics 13:307-319.
    • (2003) Pharmacogenetics , vol.13 , pp. 307-319
    • Yu, A.M.1    Idle, J.R.2    Herraiz, T.3    Küpfer, A.4    Gonzalez, F.J.5
  • 47
    • 0141732321 scopus 로고    scopus 로고
    • De-orphanization of cytochrome P450 2R1: A microsomal vitamin D 25-hydroxylase
    • Cheng JB, Motola DL, Mangelsdorf DJ, and Russell DW (2003) De-orphanization of cytochrome P450 2R1: A microsomal vitamin D 25-hydroxylase. J Biol Chem 278:38084-38093.
    • (2003) J Biol Chem , vol.278 , pp. 38084-38093
    • Cheng, J.B.1    Motola, D.L.2    Mangelsdorf, D.J.3    Russell, D.W.4
  • 48
    • 72949114663 scopus 로고    scopus 로고
    • Oxidation of endobiotics mediated by xenobiotic-metabolizing forms of human cytochrome P450
    • in press
    • Niwa T, Murayama N, and Yamazaki H Oxidation of endobiotics mediated by xenobiotic-metabolizing forms of human cytochrome P450. Curr Drug Metab., in press.
    • Curr Drug Metab
    • Niwa, T.1    Murayama, N.2    Yamazaki, H.3
  • 49
    • 74149088519 scopus 로고    scopus 로고
    • Human cytochrome P450 4F11: Heterologons expression in bacteria, purification, and characterization of catalytic function
    • Tang Z, Salamanca-Pinzón SG, Wu Z-L, Xiao Y, and Guengerich FP (2010) Human cytochrome P450 4F11: Heterologons expression in bacteria, purification, and characterization of catalytic function. Arch Biochem Biophys 494:86-93.
    • (2010) Arch Biochem Biophys , vol.494 , pp. 86-93
    • Tang, Z.1    Salamanca-Pinzón, S.G.2    Wu, Z.-L.3    Xiao, Y.4    Guengerich, F.P.5
  • 50
    • 0023658664 scopus 로고
    • Synthesis of the skeleton of the morphine molecule by mammalian liver
    • Weitz CJ, Faull KF, and Goldstein A (1987) Synthesis of the skeleton of the morphine molecule by mammalian liver. Nature 330:674-677.
    • (1987) Nature , vol.330 , pp. 674-677
    • Weitz, C.J.1    Faull, K.F.2    Goldstein, A.3
  • 53
    • 69949188699 scopus 로고    scopus 로고
    • Mammalian cytochrome P450 enzymes catalyze the phenolcoupling step in endogenous morphine biosynthesis
    • Grobe N, Zhang B, Fisinger U, Kutchan TM, Zenk MH, and Guengerich FP (2009) Mammalian cytochrome P450 enzymes catalyze the phenolcoupling step in endogenous morphine biosynthesis. J Biol Chem 284:24425-24431.
    • (2009) J Biol Chem , vol.284 , pp. 24425-24431
    • Grobe, N.1    Zhang, B.2    Fisinger, U.3    Kutchan, T.M.4    Zenk, M.H.5    Guengerich, F.P.6
  • 54
    • 0023884310 scopus 로고
    • Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation
    • Dayer P, Desmeules J, Leemann T, and Striberni R (1988) Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation. Biochem Biophys Res Commun 152:411-416.
    • (1988) Biochem Biophys Res Commun , vol.152 , pp. 411-416
    • Dayer, P.1    Desmeules, J.2    Leemann, T.3    Striberni, R.4
  • 55
    • 42949125548 scopus 로고    scopus 로고
    • Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11
    • Dhar M, Sepkovic DW, Hirani V, Magnusson RP, and Lasker JM (2008) Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11. J Lipid Res 49:612-624.
    • (2008) J Lipid Res , vol.49 , pp. 612-624
    • Dhar, M.1    Sepkovic, D.W.2    Hirani, V.3    Magnusson, R.P.4    Lasker, J.M.5
  • 58
    • 70350332200 scopus 로고    scopus 로고
    • Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase
    • Nakano M, Kelly EJ, and Rettie AE (2009) Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase. Drug Metab Dispos 37:2119-2122.
    • (2009) Drug Metab Dispos , vol.37 , pp. 2119-2122
    • Nakano, M.1    Kelly, E.J.2    Rettie, A.E.3
  • 59
    • 50549083650 scopus 로고    scopus 로고
    • Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide
    • Stark K, Dostalek M, and Guengerich FP (2008) Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. FEBS J 275:3706-3717.
    • (2008) FEBS J , vol.275 , pp. 3706-3717
    • Stark, K.1    Dostalek, M.2    Guengerich, F.P.3
  • 62
    • 0014429295 scopus 로고
    • Role of hemoprotein P-450 in fatty acid ω-hydroxylation in a soluble enzyme system from liver microsomes
    • Lu AYH and Coon MJ (1968) Role of hemoprotein P-450 in fatty acid ω-hydroxylation in a soluble enzyme system from liver microsomes. J Biol Chem 243:1331-1332.
    • (1968) J Biol Chem , vol.243 , pp. 1331-1332
    • Lu, A.Y.H.1    Coon, M.J.2
  • 63
    • 0002211689 scopus 로고
    • Detoxication enzymes
    • (Jakoby WB, ed.) Academic Press, New York
    • Jakoby WB (1980) Detoxication enzymes, in Enzymatic Basis of Detoxication, Vol. 1 (Jakoby WB, ed.) pp. 1-6, Academic Press, New York.
    • (1980) Enzymatic Basis of Detoxication , vol.1 , pp. 1-6
    • Jakoby, W.B.1
  • 64
    • 0037225752 scopus 로고    scopus 로고
    • Study of P450 function using gene knockout and transgenic mice
    • Gonzalez FJ and Kimura S (2003) Study of P450 function using gene knockout and transgenic mice. Arch Biochem Biophys 409:153-158.
    • (2003) Arch Biochem Biophys , vol.409 , pp. 153-158
    • Gonzalez, F.J.1    Kimura, S.2
  • 65
    • 0038507099 scopus 로고    scopus 로고
    • Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: Impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase
    • Gu J, Weng Y, Zhang QY, Cui H, Behr M, Wu L, Yang W, Zhang L, and Ding X (2003) Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. J Biol Chem 278:25895-25901.
    • (2003) J Biol Chem , vol.278 , pp. 25895-25901
    • Gu, J.1    Weng, Y.2    Zhang, Q.Y.3    Cui, H.4    Behr, M.5    Wu, L.6    Yang, W.7    Zhang, L.8    Ding, X.9
  • 66
    • 0037790603 scopus 로고    scopus 로고
    • Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase
    • Henderson CJ, Otto DM, Carrie D, Magnuson MA, McLaren AW, Rosewell I, and Wolf CR (2003) Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. J Biol Chem 278:13480-13486.
    • (2003) J Biol Chem , vol.278 , pp. 13480-13486
    • Henderson, C.J.1    Otto, D.M.2    Carrie, D.3    Magnuson, M.A.4    McLaren, A.W.5    Rosewell, I.6    Wolf, C.R.7
  • 67
    • 4444312707 scopus 로고    scopus 로고
    • Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids
    • Kalsotra A, Turman CM, Kikuta Y, and Strobel HW (2004) Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids. Toxicol Appl Pharmacol 199:295-304.
    • (2004) Toxicol Appl Pharmacol , vol.199 , pp. 295-304
    • Kalsotra, A.1    Turman, C.M.2    Kikuta, Y.3    Strobel, H.W.4
  • 68
    • 66149100484 scopus 로고    scopus 로고
    • Screening of type I and II drug binding to human cytochrome P450-3A4 in nanodiscs by localized surface plasmon resonance spectroscopy
    • Das A, Zhao J, Schatz GC, Sligar SG, and Van Duyne RP (2009) Screening of type I and II drug binding to human cytochrome P450-3A4 in nanodiscs by localized surface plasmon resonance spectroscopy. Anal Chem 81:3754-3759.
    • (2009) Anal Chem , vol.81 , pp. 3754-3759
    • Das, A.1    Zhao, J.2    Schatz, G.C.3    Sligar, S.G.4    Van Duyne, R.P.5
  • 69
    • 0014059179 scopus 로고
    • Spectral studies of drug interaction with hepatic microsomal cytochrome P-450
    • Schenkman JB, Remmer H, and Estabrook RW (1967) Spectral studies of drug interaction with hepatic microsomal cytochrome P-450. Mol Pharmaco 3:113-123.
    • (1967) Mol Pharmaco , vol.3 , pp. 113-123
    • Schenkman, J.B.1    Remmer, H.2    Estabrook, R.W.3
  • 71
    • 73149115280 scopus 로고    scopus 로고
    • Cataloging the repertoire of nature's blowtorch, P450
    • Guengerich FP (2009) Cataloging the repertoire of nature's blowtorch, P450. Chem Biol 16:1215-1216.
    • (2009) Chem Biol , vol.16 , pp. 1215-1216
    • Guengerich, F.P.1
  • 72
    • 33745137491 scopus 로고    scopus 로고
    • Recombinant enzymes over-expressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1
    • Wu Z-L, Sohl CD, Shimada T, and Guengerich FP (2006) Recombinant enzymes over-expressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. Mol Pharmacol 69:2007-2014.
    • (2006) Mol Pharmacol , vol.69 , pp. 2007-2014
    • Wu, Z.-L.1    Sohl, C.D.2    Shimada, T.3    Guengerich, F.P.4
  • 75
    • 34249724969 scopus 로고    scopus 로고
    • A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P450 2S1 by both dioxin and hypoxia
    • Rivera SP, Wang F, Saarikoski ST, Taylor RT, Chapman B, Zhang R, and Hankinson O (2007) A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P450 2S1 by both dioxin and hypoxia. J Biol Chem 282:10881-10893.
    • (2007) J Biol Chem , vol.282 , pp. 10881-10893
    • Rivera, S.P.1    Wang, F.2    Saarikoski, S.T.3    Taylor, R.T.4    Chapman, B.5    Zhang, R.6    Hankinson, O.7
  • 76
    • 0037454384 scopus 로고    scopus 로고
    • Cutaneous expression of cytochrome P450 CYP2S1: Individuality in regulation by therapeutic agents for psoriasis and other skin diseases
    • Smith G, Wolf CR, Deeni YY, Dawe RS, Evans AT, Comrie MM, Ferguson J, and Ibbotson SH (2003) Cutaneous expression of cytochrome P450 CYP2S1: Individuality in regulation by therapeutic agents for psoriasis and other skin diseases. Lancet 361:1336-1343.
    • (2003) Lancet , vol.361 , pp. 1336-1343
    • Smith, G.1    Wolf, C.R.2    Deeni, Y.Y.3    Dawe, R.S.4    Evans, A.T.5    Comrie, M.M.6    Ferguson, J.7    Ibbotson, S.H.8
  • 78
    • 70350434097 scopus 로고    scopus 로고
    • Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli
    • Bui PH and Hankinson O (2009) Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli. Mol Pharmacol 76:1031-1043.
    • (2009) Mol Pharmacol , vol.76 , pp. 1031-1043
    • Bui, P.H.1    Hankinson, O.2
  • 79
    • 0015868089 scopus 로고
    • Microsomal-catalyzed hydroperoxide-dependent C-oxidation of amines
    • Kadlubar FF, Morton KC, and Ziegler DM.(1973) Microsomal-catalyzed hydroperoxide-dependent C-oxidation of amines. Biochem Biophys Res Commun 54:1255-1261.
    • (1973) Biochem Biophys Res Commun , vol.54 , pp. 1255-1261
    • Kadlubar, F.F.1    Morton, K.C.2    Ziegler, D.M.3
  • 80
    • 0017113579 scopus 로고
    • Studies on hydroperoxide-dependent substrate hydroxylation by purified liver microsomal cytochrome P-450
    • Nordblom GD, White RE, and Coon MJ (1976) Studies on hydroperoxide- dependent substrate hydroxylation by purified liver microsomal cytochrome P-450. Arch Biochem Biophys 175:524-533.
    • (1976) Arch Biochem Biophys , vol.175 , pp. 524-533
    • Nordblom, G.D.1    White, R.E.2    Coon, M.J.3
  • 81
    • 70350455899 scopus 로고    scopus 로고
    • Fatty acid hydroperoxides support cytochrome P450 2S1-mediated bioactivation of benzo[a]pyrene-7,8-dihydrodiol
    • Bui PH, Hsu EL, and Hankinson O (2009) Fatty acid hydroperoxides support cytochrome P450 2S1-mediated bioactivation of benzo[a]pyrene-7,8-dihydrodiol. Mol Pharmacol 76:1044-1052.
    • (2009) Mol Pharmacol , vol.76 , pp. 1044-1052
    • Bui, P.H.1    Hsu, E.L.2    Hankinson, O.3
  • 82
    • 0035877779 scopus 로고    scopus 로고
    • Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus
    • Wang T, Arifoglu P, Ronai Z, and Tew KD (2001) Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus. J Biol Chem 276:20999-21003.
    • (2001) J Biol Chem , vol.276 , pp. 20999-21003
    • Wang, T.1    Arifoglu, P.2    Ronai, Z.3    Tew, K.D.4
  • 83
    • 85012860213 scopus 로고    scopus 로고
    • Quinone reductases
    • Biotransformation (Guengerich, FP, ed.), (McQueen, C.A., series ed.) Elsevier Science, New York, in press
    • Ross D and Siegel D (2010) Quinone reductases, in Biotransformation (Guengerich, FP, ed.), Vol. 4 of Comprehensive Toxicology (McQueen, C.A., series ed.) Elsevier Science, New York, in press.
    • (2010) Comprehensive Toxicology , vol.4
    • Ross, D.1    Siegel, D.2
  • 84
    • 50049131787 scopus 로고    scopus 로고
    • Heterologous expression and mRNA distribution of orphan cytochrome P450 20A1
    • Stark K, Wu Z-L, Bartleson CJ, and Guengerich FP (2008) Heterologous expression and mRNA distribution of orphan cytochrome P450 20A1. Drug Metab Dispos 36:1930-1937.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1930-1937
    • Stark, K.1    Wu, Z.-L.2    Bartleson, C.J.3    Guengerich, F.P.4
  • 85
    • 29244442685 scopus 로고    scopus 로고
    • Heterologous expression, purification, and properties of human cytochrome P450 27C1
    • Wu Z-L, Bartleson CJ, Ham A-J, and Guengerich FP (2006) Heterologous expression, purification, and properties of human cytochrome P450 27C1. Arch Biochem Biophys 445:138-146.
    • (2006) Arch Biochem Biophys , vol.445 , pp. 138-146
    • Wu, Z.-L.1    Bartleson, C.J.2    Ham, A.-J.3    Guengerich, F.P.4
  • 86
    • 0034283075 scopus 로고    scopus 로고
    • A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization
    • Cui X, Nelson DR, and Strobel HW (2000) A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization. Genomics 68:161-166.
    • (2000) Genomics , vol.68 , pp. 161-166
    • Cui, X.1    Nelson, D.R.2    Strobel, H.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.