-
1
-
-
72449145463
-
"Unknown" proteins and "orphan" enzymes: The missing half of the engineering parts list-and how to find it
-
Hanson AD, Pribat A, Waller JC, and Crecy-Lagard V (2010) "Unknown" proteins and "orphan" enzymes: The missing half of the engineering parts list-and how to find it Biochem J 425:1-11.
-
(2010)
Biochem J
, vol.425
, pp. 1-11
-
-
Hanson, A.D.1
Pribat, A.2
Waller, J.C.3
Crecy-Lagard, V.4
-
2
-
-
0024545638
-
Gene regulation by steroid hormones
-
Beato, M (1989) Gene regulation by steroid hormones. Cell 56:335-344.
-
(1989)
Cell
, vol.56
, pp. 335-344
-
-
Beato, M.1
-
3
-
-
0022327612
-
Steroid receptor regulated transcription of specific genes and gene networks
-
Yamamoto KR (1985) Steroid receptor regulated transcription of specific genes and gene networks. Annu Rev Genet 19:209-252.
-
(1985)
Annu Rev Genet
, vol.19
, pp. 209-252
-
-
Yamamoto, K.R.1
-
4
-
-
0023221667
-
Cloning of human mineralocorticoid receptor complementary DNA: Structural and functional kinship with the glucocorticoid receptor
-
Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DE, and Evans RM (1987) Cloning of human mineralocorticoid receptor complementary DNA: Structural and functional kinship with the glucocorticoid receptor. Science 237:268-275. (Pubitemid 17095145)
-
(1987)
Science
, vol.237
, Issue.4812
, pp. 268-275
-
-
Arriza, J.L.1
Weinberger, C.2
Cerelli, G.3
-
5
-
-
0024372108
-
DNA binding specificity of steroid receptors
-
Berg JM (1989) DNA binding specificity of steroid receptors. Cell 57:1065-1068.
-
(1989)
Cell
, vol.57
, pp. 1065-1068
-
-
Berg, J.M.1
-
6
-
-
0023913120
-
The steroid and thyroid hormone receptor superfamily
-
Evans RM (1988) The steroid and thyroid hormone receptor superfamily. Science 240:889-895.
-
(1988)
Science
, vol.240
, pp. 889-895
-
-
Evans, R.M.1
-
7
-
-
0025132245
-
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
-
Issemann I and Green S (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645-650. (Pubitemid 120028995)
-
(1990)
Nature
, vol.347
, Issue.6294
, pp. 645-650
-
-
Issemann, I.1
Green, S.2
-
8
-
-
0032498303
-
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
-
DOI 10.1016/S0092-8674(00)80900-9
-
Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Wilson TM, Zetterstörm RH, et al. (1998) An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92:73-82. (Pubitemid 28053299)
-
(1998)
Cell
, vol.92
, Issue.1
, pp. 73-82
-
-
Kliewer, S.A.1
Moore, J.T.2
Wade, L.3
Staudinger, J.L.4
Watson, M.A.5
Jones, S.A.6
McKee, D.D.7
Oliver, B.B.8
Willson, T.M.9
Zetterstrom, R.H.10
Perlmann, T.11
Lehmann, J.M.12
-
9
-
-
0343158399
-
The nuclear orphan receptor CAR-RXR heterodimer activates the phenobarbitalresponsive enhancer module of the CYP2B gene
-
Honkakoski P, Zelko I, Sueyoshi T, and Negishi M (1998) The nuclear orphan receptor CAR-RXR heterodimer activates the phenobarbitalresponsive enhancer module of the CYP2B gene. Mol Cell Biol 18:1-7.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 1-7
-
-
Honkakoski, P.1
Zelko, I.2
Sueyoshi, T.3
Negishi, M.4
-
10
-
-
0025161416
-
Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3)
-
Wrighton SA, Brian WR, Sari MA, Iwasaki M, Guengerich FP, Raucy JL, Molowa DT, and VandenBranden, M (1990) Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3). Mol Pharmacol 38:207-213. (Pubitemid 20255306)
-
(1990)
Molecular Pharmacology
, vol.38
, Issue.2
, pp. 207-213
-
-
Wrighton, S.A.1
Brian, W.R.2
Sari, M.-A.3
Iwasaki, M.4
Guengerich, F.P.5
Raucy, J.L.6
Molowa, D.T.7
Vandenbranden, M.8
-
12
-
-
0034923923
-
Divergent evolution of enzymatic function: Mechanistically diverse superfamilies and functionally distinct suprafamilies
-
Gerlt JA and Babbitt PC (2001) Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafamilies. Annu Rev Biochem 70:209-246.
-
(2001)
Annu Rev Biochem
, vol.70
, pp. 209-246
-
-
Gerlt, J.A.1
Babbitt, P.C.2
-
14
-
-
33748802003
-
Structural basis for ligand promiscuity in cytochrome P450 3A4
-
Ekroos M and Sjögren T (2006) Structural basis for ligand promiscuity in cytochrome P450 3A4. Proc Natl Acad Sci USA 103:13682-13687.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 13682-13687
-
-
Ekroos, M.1
Sjögren, T.2
-
15
-
-
0024446655
-
Expression cloning and regulation of steroid 5α-reductase, an enzyme essential for male sexual differentiation
-
Andersson S, Bishop RW, and Russell DW (1989) Expression cloning and regulation of steroid 5α-reductase, an enzyme essential for male sexual differentiation. J Biol Chem 264:16249-16255. (Pubitemid 19238390)
-
(1989)
Journal of Biological Chemistry
, vol.264
, Issue.27
, pp. 16249-16255
-
-
Andersson, S.1
Bishop, R.W.2
Russell, D.W.3
-
17
-
-
33646127626
-
Discovery and clinical development of dutasteride, a potent dual 5α-reductase inhibitor
-
Frye SV (2006) Discovery and clinical development of dutasteride, a potent dual 5α-reductase inhibitor. Curr Top Med Chem 6:405-421.
-
(2006)
Curr Top Med Chem
, vol.6
, pp. 405-421
-
-
Frye, S.V.1
-
19
-
-
0037019339
-
RNA interference in adult mice
-
McCaffrey AP, Meuse L, Pham TT, Conklin DS, Hannon GJ, and Kay MA (2002) RNA interference in adult mice. Nature 418:38-39.
-
(2002)
Nature
, vol.418
, pp. 38-39
-
-
McCaffrey, A.P.1
Meuse, L.2
Pham, T.T.3
Conklin, D.S.4
Hannon, G.J.5
Kay, M.A.6
-
20
-
-
70349431230
-
In vivo target validation using gene invalidation, RNA interference and protein functional knockout models: It is the time to combine
-
Vidalin O, Muslmani M, Estienne C, Echchakir H, and Abina AM (2009) In vivo target validation using gene invalidation, RNA interference and protein functional knockout models: It is the time to combine. Curr Opin Pharmacol 9:669-676.
-
(2009)
Curr Opin Pharmacol
, vol.9
, pp. 669-676
-
-
Vidalin, O.1
Muslmani, M.2
Estienne, C.3
Echchakir, H.4
Abina, A.M.5
-
21
-
-
66049149024
-
Identification of an endogenous ligand bound to a native orphan nuclear receptor
-
Yuan X, Ta TC, Lin M, Evans JR, Dong Y, Bolotin E, Sherman MA, Forman BM, and Sladek FM (2009) Identification of an endogenous ligand bound to a native orphan nuclear receptor. PloS One 4:e5609.
-
(2009)
PloS One
, vol.4
-
-
Yuan, X.1
Ta, T.C.2
Lin, M.3
Evans, J.R.4
Dong, Y.5
Bolotin, E.6
Sherman, M.A.7
Forman, B.M.8
Sladek, F.M.9
-
23
-
-
84984752764
-
Assignment of protein function in the postgenomic era
-
Saghatelian A and Cravatt BF (2005) Assignment of protein function in the postgenomic era. Nat Chem Biol 1:130-142.
-
(2005)
Nat Chem Biol
, vol.1
, pp. 130-142
-
-
Saghatelian, A.1
Cravatt, B.F.2
-
24
-
-
35848965006
-
Activity-based protein profiling for the functional annotation of enzymes
-
Barglow KT and Cravatt BF (2007) Activity-based protein profiling for the functional annotation of enzymes. Nat Methods 4:822-827.
-
(2007)
Nat Methods
, vol.4
, pp. 822-827
-
-
Barglow, K.T.1
Cravatt, B.F.2
-
25
-
-
68049107457
-
A suite of activity-based probes for human cytochrome P450 enzymes
-
Wright AT, Song JD, and Cravatt BF (2009) A suite of activity-based probes for human cytochrome P450 enzymes. J Am Chem Soc 131:10692-10700.
-
(2009)
J Am Chem Soc
, vol.131
, pp. 10692-10700
-
-
Wright, A.T.1
Song, J.D.2
Cravatt, B.F.3
-
26
-
-
25444526868
-
Processing methods for differential analysis of LC/MS profile data
-
Katajamaa M and Oresic M (2005) Processing methods for differential analysis of LC/MS profile data. BMC Bioinformatics 6:179.
-
(2005)
BMC Bioinformatics
, vol.6
, pp. 179
-
-
Katajamaa, M.1
Oresic, M.2
-
27
-
-
27144506971
-
Fusion of mass spectrometry-based metabolomics data
-
Smilde AK, van der Werf MJ, Bijlsma S, van der Werff-van der Vat BJ, and Jellema RH (2005) Fusion of mass spectrometry-based metabolomics data. Anal Chem 77:6729-6736.
-
(2005)
Anal Chem
, vol.77
, pp. 6729-6736
-
-
Smilde, A.K.1
Van Der Werf, M.J.2
Bijlsma, S.3
Van Der Werff-van Der Vat, B.J.4
Jellema, R.H.5
-
28
-
-
33644867564
-
MZmine: Toolbox for processing and visualization of mass spectrometry based molecular profile data
-
Oxford, UK
-
Katajamaa M, Miettinen J, and Oresic M (2006) MZmine: Toolbox for processing and visualization of mass spectrometry based molecular profile data. Bioinformatics (Oxford, UK) 22:634-636.
-
(2006)
Bioinformatics
, vol.22
, pp. 634-636
-
-
Katajamaa, M.1
Miettinen, J.2
Oresic, M.3
-
29
-
-
65249132985
-
MetAlign: Interface-driven, versatile metabolomics tool for hyphenated full-scan mass spectrometry data preprocessing
-
Lommen A (2009) MetAlign: interface-driven, versatile metabolomics tool for hyphenated full-scan mass spectrometry data preprocessing. Anal Chem 81:3079-3086.
-
(2009)
Anal Chem
, vol.81
, pp. 3079-3086
-
-
Lommen, A.1
-
30
-
-
32444446805
-
XCMS: Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification
-
Smith CA, Want EJ, O'Maille G, Abagyan R, and Siuzdak G (2006) XCMS: Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal Chem 78:779-787.
-
(2006)
Anal Chem
, vol.78
, pp. 779-787
-
-
Smith, C.A.1
Want, E.J.2
O'Maille, G.3
Abagyan, R.4
Siuzdak, G.5
-
31
-
-
67449147120
-
Parameter selection for peak alignment in chromatographic sample profiling: Objective quality indicators and use of control samples
-
Peters S, van Velzen E, and Janssen HG (2009) Parameter selection for peak alignment in chromatographic sample profiling: Objective quality indicators and use of control samples. Anal Bioanal Chem 394:1273-1281.
-
(2009)
Anal Bioanal Chem
, vol.394
, pp. 1273-1281
-
-
Peters, S.1
Van Velzen, E.2
Janssen, H.G.3
-
32
-
-
34248211291
-
Untargeted analysis of mass spectrometry data for elucidation of function of new enzymes
-
Sanchez-Ponce R and Guengerich FP (2007) Untargeted analysis of mass spectrometry data for elucidation of function of new enzymes. Anal Chem 79:3355-3362.
-
(2007)
Anal Chem
, vol.79
, pp. 3355-3362
-
-
Sanchez-Ponce, R.1
Guengerich, F.P.2
-
33
-
-
65249186716
-
Elucidation of functions of human cytochrome P450 enzymes: Identification of endogenous substrates in tissue extracts by LC-MS metabolomics and isotopic labeling approaches
-
Tang Z, Martin MV, and Guengerich FP (2009) Elucidation of functions of human cytochrome P450 enzymes: Identification of endogenous substrates in tissue extracts by LC-MS metabolomics and isotopic labeling approaches. Anal Chem 81:3071-3078.
-
(2009)
Anal Chem
, vol.81
, pp. 3071-3078
-
-
Tang, Z.1
Martin, M.V.2
Guengerich, F.P.3
-
34
-
-
33645781037
-
Identification of the cytochrome P450 monooxygenase that bridges the clavine and ergoline alkaloid pathways
-
Haarmann T, Ortel I, Tudzynski P, and Keller U (2006) Identification of the cytochrome P450 monooxygenase that bridges the clavine and ergoline alkaloid pathways. Chembiochem 7:645-652.
-
(2006)
Chembiochem
, vol.7
, pp. 645-652
-
-
Haarmann, T.1
Ortel, I.2
Tudzynski, P.3
Keller, U.4
-
35
-
-
34548440174
-
Novel properties of P450s in Streptomyces coelicolor
-
Zhao B and Waterman MR (2007) Novel properties of P450s in Streptomyces coelicolor. Drug Metab Rev 39:343-352.
-
(2007)
Drug Metab Rev
, vol.39
, pp. 343-352
-
-
Zhao, B.1
Waterman, M.R.2
-
36
-
-
34547118130
-
Electron transfer pathway for a streptomyces cytochrome P450. Cytochrome P450 105D5-catalyzed fatty acid hydroxylation in Streptomyces coelicolor A3(2)
-
Chun Y-J, Shimada T, Sanchez-Ponce R, Martin MV, Lee L, Zhao B, Kelly SL, Waterman MR, Lamb DC, and Guengerich FP (2007) Electron transfer pathway for a streptomyces cytochrome P450. Cytochrome P450 105D5-catalyzed fatty acid hydroxylation in Streptomyces coelicolor A3(2). J Biol Chem 282:17486-17500.
-
(2007)
J Biol Chem
, vol.282
, pp. 17486-17500
-
-
Chun, Y.-J.1
Shimada, T.2
Sanchez-Ponce, R.3
Martin, M.V.4
Lee, L.5
Zhao, B.6
Kelly, S.L.7
Waterman, M.R.8
Lamb, D.C.9
Guengerich, F.P.10
-
37
-
-
58549119938
-
cDNA cloning and functional characterisation of CYP98A14 and NADPH:Cytochrome P450 reductase from Coleus blumei involved in rosmarinic acid biosynthesis
-
Eberle D, Ullmann P, Werck-Reichhart D, and Petersen M (2009) cDNA cloning and functional characterisation of CYP98A14 and NADPH:cytochrome P450 reductase from Coleus blumei involved in rosmarinic acid biosynthesis. Plant Mol Biol 69:239-253.
-
(2009)
Plant Mol Biol
, vol.69
, pp. 239-253
-
-
Eberle, D.1
Ullmann, P.2
Werck-Reichhart, D.3
Petersen, M.4
-
39
-
-
34347387493
-
CYP703 is an ancient cytochrome P450 in land plants catalyzing in-chain hydroxylation of lauric acid to provide building blocks for sporopollenin synthesis in pollen
-
Morant M, Jorgensen K, Schaller H, Pinot F, Møller BL, Werck-Reichhart D, and Bak S (2007) CYP703 is an ancient cytochrome P450 in land plants catalyzing in-chain hydroxylation of lauric acid to provide building blocks for sporopollenin synthesis in pollen. Plant Cell 19:1473-1487.
-
(2007)
Plant Cell
, vol.19
, pp. 1473-1487
-
-
Morant, M.1
Jorgensen, K.2
Schaller, H.3
Pinot, F.4
Møller, B.L.5
Werck-Reichhart, D.6
Bak, S.7
-
40
-
-
34447099968
-
A medium-throughput screening assay to determine catalytic activities of oxygen-consuming enzymes:A new tool for functional characterization of cytochrome P450 and other oxygenases
-
Olry A, Schneider-Belhaddad F, Heintz D, and Werck-Reichhart D (2007) A medium-throughput screening assay to determine catalytic activities of oxygen-consuming enzymes:A new tool for functional characterization of cytochrome P450 and other oxygenases. Plant J 51:331-340.
-
(2007)
Plant J
, vol.51
, pp. 331-340
-
-
Olry, A.1
Schneider-Belhaddad, F.2
Heintz, D.3
Werck-Reichhart, D.4
-
41
-
-
34248662705
-
Functional annotation of the Arabidopsis P450 superfamily based on large-scale coexpression analysis
-
Ehlting J, Provart NJ, and Werck-Reichhart D (2006) Functional annotation of the Arabidopsis P450 superfamily based on large-scale coexpression analysis. Biochem Soc Trans 34:1192-1198.
-
(2006)
Biochem Soc Trans
, vol.34
, pp. 1192-1198
-
-
Ehlting, J.1
Provart, N.J.2
Werck-Reichhart, D.3
-
42
-
-
43949145613
-
An extensive (co-)expression analysis tool for the cytochrome P450 superfamily in Arabidopsis thaliana
-
Ehlting J, Sauveplane V, Olry A, Ginglinger JF, Provart NJ, and Werck-Reichhart D (2008) An extensive (co-)expression analysis tool for the cytochrome P450 superfamily in Arabidopsis thaliana. BMC Plant Biol 8:47.
-
(2008)
BMC Plant Biol
, vol.8
, pp. 47
-
-
Ehlting, J.1
Sauveplane, V.2
Olry, A.3
Ginglinger, J.F.4
Provart, N.J.5
Werck-Reichhart, D.6
-
43
-
-
42249110738
-
Molecular cloning and characterization of CYP80G2, a cytochrome P450 that catalyzes an intramolecular C-C phenol coupling of (S)-reticuline in magnoflorine biosynthesis, from cultured Coptis japonica cells
-
Ikezawa N, Iwasa K, and Sato F (2008) Molecular cloning and characterization of CYP80G2, a cytochrome P450 that catalyzes an intramolecular C-C phenol coupling of (S)-reticuline in magnoflorine biosynthesis, from cultured Coptis japonica cells. J Biol Chem 283:8810-8821.
-
(2008)
J Biol Chem
, vol.283
, pp. 8810-8821
-
-
Ikezawa, N.1
Iwasa, K.2
Sato, F.3
-
44
-
-
69949174213
-
CYP719B1 is salutaridine synthase, the C-C phenol-coupling enzyme of morphine biosynthesis in opium poppy
-
Gesell A, Rolf M, Ziegler J, Diaz Chavez ML, Huang FC, and Kutchan TM (2009) CYP719B1 is salutaridine synthase, the C-C phenol-coupling enzyme of morphine biosynthesis in opium poppy. J Biol Chem 284:24432-24442.
-
(2009)
J Biol Chem
, vol.284
, pp. 24432-24442
-
-
Gesell, A.1
Rolf, M.2
Ziegler, J.3
Diaz Chavez, M.L.4
Huang, F.C.5
Kutchan, T.M.6
-
45
-
-
58149242229
-
CYP719A subfamily of cytochrome P450 oxygenases and isoquinoline alkaloid biosynthesis in Eschscholzia californica
-
Ikezawa N, Iwasa K, and Sato F (2009) CYP719A subfamily of cytochrome P450 oxygenases and isoquinoline alkaloid biosynthesis in Eschscholzia californica. Plant Cell Rep 28:123-133.
-
(2009)
Plant Cell Rep
, vol.28
, pp. 123-133
-
-
Ikezawa, N.1
Iwasa, K.2
Sato, F.3
-
46
-
-
0038240578
-
Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase
-
Yu AM, Idle JR, Herraiz T, Küpfer A, and Gonzalez FJ (2003) Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase. Pharmacogenetics 13:307-319.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 307-319
-
-
Yu, A.M.1
Idle, J.R.2
Herraiz, T.3
Küpfer, A.4
Gonzalez, F.J.5
-
47
-
-
0141732321
-
De-orphanization of cytochrome P450 2R1: A microsomal vitamin D 25-hydroxylase
-
Cheng JB, Motola DL, Mangelsdorf DJ, and Russell DW (2003) De-orphanization of cytochrome P450 2R1: A microsomal vitamin D 25-hydroxylase. J Biol Chem 278:38084-38093.
-
(2003)
J Biol Chem
, vol.278
, pp. 38084-38093
-
-
Cheng, J.B.1
Motola, D.L.2
Mangelsdorf, D.J.3
Russell, D.W.4
-
48
-
-
72949114663
-
Oxidation of endobiotics mediated by xenobiotic-metabolizing forms of human cytochrome P450
-
in press
-
Niwa T, Murayama N, and Yamazaki H Oxidation of endobiotics mediated by xenobiotic-metabolizing forms of human cytochrome P450. Curr Drug Metab., in press.
-
Curr Drug Metab
-
-
Niwa, T.1
Murayama, N.2
Yamazaki, H.3
-
49
-
-
74149088519
-
Human cytochrome P450 4F11: Heterologons expression in bacteria, purification, and characterization of catalytic function
-
Tang Z, Salamanca-Pinzón SG, Wu Z-L, Xiao Y, and Guengerich FP (2010) Human cytochrome P450 4F11: Heterologons expression in bacteria, purification, and characterization of catalytic function. Arch Biochem Biophys 494:86-93.
-
(2010)
Arch Biochem Biophys
, vol.494
, pp. 86-93
-
-
Tang, Z.1
Salamanca-Pinzón, S.G.2
Wu, Z.-L.3
Xiao, Y.4
Guengerich, F.P.5
-
50
-
-
0023658664
-
Synthesis of the skeleton of the morphine molecule by mammalian liver
-
Weitz CJ, Faull KF, and Goldstein A (1987) Synthesis of the skeleton of the morphine molecule by mammalian liver. Nature 330:674-677.
-
(1987)
Nature
, vol.330
, pp. 674-677
-
-
Weitz, C.J.1
Faull, K.F.2
Goldstein, A.3
-
51
-
-
0000465151
-
Transformation of thebaine to oripavine, codeine, and morphine by rat liver, kidney, and brain microsomes
-
Kodaira H and Spector S (1988) Transformation of thebaine to oripavine, codeine, and morphine by rat liver, kidney, and brain microsomes. Proc Natl Acad Sci USA 85:1267-1271. (Pubitemid 18073990)
-
(1988)
Proceedings of the National Academy of Sciences of the United States of America
, vol.85
, Issue.4
, pp. 1267-1271
-
-
Kodaira, H.1
Spector, S.2
-
52
-
-
4644225656
-
Endogenous formation of morphine in human cells
-
DOI 10.1073/pnas.0405430101
-
Poeaknapo C, Schmidt J, Brandsch M, Drager B, and Zenk MH (2004) Endogenous formation of morphine in human cells. Proc Natl Acad Sci USA 101:14091-14096. (Pubitemid 39305035)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.39
, pp. 14091-14096
-
-
Poeaknapo, C.1
Schmid, J.2
Brandsch, M.3
Drager, B.4
Zenk, M.H.5
-
53
-
-
69949188699
-
Mammalian cytochrome P450 enzymes catalyze the phenolcoupling step in endogenous morphine biosynthesis
-
Grobe N, Zhang B, Fisinger U, Kutchan TM, Zenk MH, and Guengerich FP (2009) Mammalian cytochrome P450 enzymes catalyze the phenolcoupling step in endogenous morphine biosynthesis. J Biol Chem 284:24425-24431.
-
(2009)
J Biol Chem
, vol.284
, pp. 24425-24431
-
-
Grobe, N.1
Zhang, B.2
Fisinger, U.3
Kutchan, T.M.4
Zenk, M.H.5
Guengerich, F.P.6
-
54
-
-
0023884310
-
Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation
-
Dayer P, Desmeules J, Leemann T, and Striberni R (1988) Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation. Biochem Biophys Res Commun 152:411-416.
-
(1988)
Biochem Biophys Res Commun
, vol.152
, pp. 411-416
-
-
Dayer, P.1
Desmeules, J.2
Leemann, T.3
Striberni, R.4
-
55
-
-
42949125548
-
Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11
-
Dhar M, Sepkovic DW, Hirani V, Magnusson RP, and Lasker JM (2008) Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11. J Lipid Res 49:612-624.
-
(2008)
J Lipid Res
, vol.49
, pp. 612-624
-
-
Dhar, M.1
Sepkovic, D.W.2
Hirani, V.3
Magnusson, R.P.4
Lasker, J.M.5
-
56
-
-
10744226053
-
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes ω-and (ω-1)-hydroxylation of fatty acids
-
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, and Korczak B (2004) CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes ω-and (ω-1)-hydroxylation of fatty acids. J Biol Chem 279:6305-6314.
-
(2004)
J Biol Chem
, vol.279
, pp. 6305-6314
-
-
Chuang, S.S.1
Helvig, C.2
Taimi, M.3
Ramshaw, H.A.4
Collop, A.H.5
Amad, M.6
White, J.A.7
Petkovich, M.8
Jones, G.9
Korczak, B.10
-
57
-
-
1242272848
-
Characterization and tissue distribution of a novel human cytochrome P450-CYP2U1
-
Karlgren M, Backlund M, Johansson I, Oscarson M, and Ingelman-Sundberg M (2004) Characterization and tissue distribution of a novel human cytochrome P450-CYP2U1. Biochem Biophys Res Commun 315:679-685.
-
(2004)
Biochem Biophys Res Commun
, vol.315
, pp. 679-685
-
-
Karlgren, M.1
Backlund, M.2
Johansson, I.3
Oscarson, M.4
Ingelman-Sundberg, M.5
-
58
-
-
70350332200
-
Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase
-
Nakano M, Kelly EJ, and Rettie AE (2009) Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase. Drug Metab Dispos 37:2119-2122.
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 2119-2122
-
-
Nakano, M.1
Kelly, E.J.2
Rettie, A.E.3
-
59
-
-
50549083650
-
Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide
-
Stark K, Dostalek M, and Guengerich FP (2008) Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. FEBS J 275:3706-3717.
-
(2008)
FEBS J
, vol.275
, pp. 3706-3717
-
-
Stark, K.1
Dostalek, M.2
Guengerich, F.P.3
-
60
-
-
64849114373
-
Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid
-
Zöllner A, Dragan CA, Pistorius D, Muller R, Bode HB, Peters FT, Maurer HH, and Bureik M (2009) Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid. Biol Chem 390:313-317.
-
(2009)
Biol Chem
, vol.390
, pp. 313-317
-
-
Zöllner, A.1
Dragan, C.A.2
Pistorius, D.3
Muller, R.4
Bode, H.B.5
Peters, F.T.6
Maurer, H.H.7
Bureik, M.8
-
61
-
-
84892335196
-
Cytochrome P450 and the metabolism and bioactivation of arachidonic acid and eicosanoids
-
rd Ed. (Ortiz de Montellano, P.R., ed.) Kluwer Academic/Plenum Publishers, New York
-
rd Ed. (Ortiz de Montellano, P.R., ed.) pp. 531-551, Kluwer Academic/Plenum Publishers, New York.
-
(2005)
Cytochrome P450: Structure, Mechanism, and Biochemistry
, pp. 531-551
-
-
Capdevila, J.1
Holla, V.R.2
Falck, J.R.3
-
62
-
-
0014429295
-
Role of hemoprotein P-450 in fatty acid ω-hydroxylation in a soluble enzyme system from liver microsomes
-
Lu AYH and Coon MJ (1968) Role of hemoprotein P-450 in fatty acid ω-hydroxylation in a soluble enzyme system from liver microsomes. J Biol Chem 243:1331-1332.
-
(1968)
J Biol Chem
, vol.243
, pp. 1331-1332
-
-
Lu, A.Y.H.1
Coon, M.J.2
-
63
-
-
0002211689
-
Detoxication enzymes
-
(Jakoby WB, ed.) Academic Press, New York
-
Jakoby WB (1980) Detoxication enzymes, in Enzymatic Basis of Detoxication, Vol. 1 (Jakoby WB, ed.) pp. 1-6, Academic Press, New York.
-
(1980)
Enzymatic Basis of Detoxication
, vol.1
, pp. 1-6
-
-
Jakoby, W.B.1
-
64
-
-
0037225752
-
Study of P450 function using gene knockout and transgenic mice
-
Gonzalez FJ and Kimura S (2003) Study of P450 function using gene knockout and transgenic mice. Arch Biochem Biophys 409:153-158.
-
(2003)
Arch Biochem Biophys
, vol.409
, pp. 153-158
-
-
Gonzalez, F.J.1
Kimura, S.2
-
65
-
-
0038507099
-
Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: Impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase
-
Gu J, Weng Y, Zhang QY, Cui H, Behr M, Wu L, Yang W, Zhang L, and Ding X (2003) Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. J Biol Chem 278:25895-25901.
-
(2003)
J Biol Chem
, vol.278
, pp. 25895-25901
-
-
Gu, J.1
Weng, Y.2
Zhang, Q.Y.3
Cui, H.4
Behr, M.5
Wu, L.6
Yang, W.7
Zhang, L.8
Ding, X.9
-
66
-
-
0037790603
-
Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase
-
Henderson CJ, Otto DM, Carrie D, Magnuson MA, McLaren AW, Rosewell I, and Wolf CR (2003) Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. J Biol Chem 278:13480-13486.
-
(2003)
J Biol Chem
, vol.278
, pp. 13480-13486
-
-
Henderson, C.J.1
Otto, D.M.2
Carrie, D.3
Magnuson, M.A.4
McLaren, A.W.5
Rosewell, I.6
Wolf, C.R.7
-
67
-
-
4444312707
-
Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids
-
Kalsotra A, Turman CM, Kikuta Y, and Strobel HW (2004) Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids. Toxicol Appl Pharmacol 199:295-304.
-
(2004)
Toxicol Appl Pharmacol
, vol.199
, pp. 295-304
-
-
Kalsotra, A.1
Turman, C.M.2
Kikuta, Y.3
Strobel, H.W.4
-
68
-
-
66149100484
-
Screening of type I and II drug binding to human cytochrome P450-3A4 in nanodiscs by localized surface plasmon resonance spectroscopy
-
Das A, Zhao J, Schatz GC, Sligar SG, and Van Duyne RP (2009) Screening of type I and II drug binding to human cytochrome P450-3A4 in nanodiscs by localized surface plasmon resonance spectroscopy. Anal Chem 81:3754-3759.
-
(2009)
Anal Chem
, vol.81
, pp. 3754-3759
-
-
Das, A.1
Zhao, J.2
Schatz, G.C.3
Sligar, S.G.4
Van Duyne, R.P.5
-
69
-
-
0014059179
-
Spectral studies of drug interaction with hepatic microsomal cytochrome P-450
-
Schenkman JB, Remmer H, and Estabrook RW (1967) Spectral studies of drug interaction with hepatic microsomal cytochrome P-450. Mol Pharmaco 3:113-123.
-
(1967)
Mol Pharmaco
, vol.3
, pp. 113-123
-
-
Schenkman, J.B.1
Remmer, H.2
Estabrook, R.W.3
-
70
-
-
70449370313
-
Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries
-
Veith H, Southall N, Huang R, James T, Fayne D, Artemenko N, Shen M, Inglese J, Austin CP, Lloyd DG, et al. (2009) Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries. Nat Biotechnol 27:1050-1055.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 1050-1055
-
-
Veith, H.1
Southall, N.2
Huang, R.3
James, T.4
Fayne, D.5
Artemenko, N.6
Shen, M.7
Inglese, J.8
Austin, C.P.9
Lloyd, D.G.10
-
71
-
-
73149115280
-
Cataloging the repertoire of nature's blowtorch, P450
-
Guengerich FP (2009) Cataloging the repertoire of nature's blowtorch, P450. Chem Biol 16:1215-1216.
-
(2009)
Chem Biol
, vol.16
, pp. 1215-1216
-
-
Guengerich, F.P.1
-
72
-
-
33745137491
-
Recombinant enzymes over-expressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1
-
Wu Z-L, Sohl CD, Shimada T, and Guengerich FP (2006) Recombinant enzymes over-expressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. Mol Pharmacol 69:2007-2014.
-
(2006)
Mol Pharmacol
, vol.69
, pp. 2007-2014
-
-
Wu, Z.-L.1
Sohl, C.D.2
Shimada, T.3
Guengerich, F.P.4
-
73
-
-
31444443707
-
Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1
-
Karlgren M, Gomez A, Stark K, Svard J, Rodriguez-Antona C, Oliw E, Bernal ML, Ramón y Cajal S, Johansson I, and Ingelman-Sundberg M (2006) Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1. Biochem Biophys Res Commun 341:451-458.
-
(2006)
Biochem Biophys Res Commun
, vol.341
, pp. 451-458
-
-
Karlgren, M.1
Gomez, A.2
Stark, K.3
Svard, J.4
Rodriguez-Antona, C.5
Oliw, E.6
Bernal, M.L.7
Ramón Y Cajal, S.8
Johansson, I.9
Ingelman-Sundberg, M.10
-
74
-
-
0034808733
-
Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1)
-
DOI 10.1006/bbrc.2001.4390
-
Rylander T, Neve EPA, Ingelman-Sundberg M, and Oscarson M (2001) Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1). Biochem Biophys Res Commun 281:529-535. (Pubitemid 32928187)
-
(2001)
Biochemical and Biophysical Research Communications
, vol.281
, Issue.2
, pp. 529-535
-
-
Rylander, T.1
Neve, E.P.A.2
Ingelman-Sundberg, M.3
Oscarson, M.4
-
75
-
-
34249724969
-
A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P450 2S1 by both dioxin and hypoxia
-
Rivera SP, Wang F, Saarikoski ST, Taylor RT, Chapman B, Zhang R, and Hankinson O (2007) A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P450 2S1 by both dioxin and hypoxia. J Biol Chem 282:10881-10893.
-
(2007)
J Biol Chem
, vol.282
, pp. 10881-10893
-
-
Rivera, S.P.1
Wang, F.2
Saarikoski, S.T.3
Taylor, R.T.4
Chapman, B.5
Zhang, R.6
Hankinson, O.7
-
76
-
-
0037454384
-
Cutaneous expression of cytochrome P450 CYP2S1: Individuality in regulation by therapeutic agents for psoriasis and other skin diseases
-
Smith G, Wolf CR, Deeni YY, Dawe RS, Evans AT, Comrie MM, Ferguson J, and Ibbotson SH (2003) Cutaneous expression of cytochrome P450 CYP2S1: Individuality in regulation by therapeutic agents for psoriasis and other skin diseases. Lancet 361:1336-1343.
-
(2003)
Lancet
, vol.361
, pp. 1336-1343
-
-
Smith, G.1
Wolf, C.R.2
Deeni, Y.Y.3
Dawe, R.S.4
Evans, A.T.5
Comrie, M.M.6
Ferguson, J.7
Ibbotson, S.H.8
-
78
-
-
70350434097
-
Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli
-
Bui PH and Hankinson O (2009) Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli. Mol Pharmacol 76:1031-1043.
-
(2009)
Mol Pharmacol
, vol.76
, pp. 1031-1043
-
-
Bui, P.H.1
Hankinson, O.2
-
80
-
-
0017113579
-
Studies on hydroperoxide-dependent substrate hydroxylation by purified liver microsomal cytochrome P-450
-
Nordblom GD, White RE, and Coon MJ (1976) Studies on hydroperoxide- dependent substrate hydroxylation by purified liver microsomal cytochrome P-450. Arch Biochem Biophys 175:524-533.
-
(1976)
Arch Biochem Biophys
, vol.175
, pp. 524-533
-
-
Nordblom, G.D.1
White, R.E.2
Coon, M.J.3
-
81
-
-
70350455899
-
Fatty acid hydroperoxides support cytochrome P450 2S1-mediated bioactivation of benzo[a]pyrene-7,8-dihydrodiol
-
Bui PH, Hsu EL, and Hankinson O (2009) Fatty acid hydroperoxides support cytochrome P450 2S1-mediated bioactivation of benzo[a]pyrene-7,8-dihydrodiol. Mol Pharmacol 76:1044-1052.
-
(2009)
Mol Pharmacol
, vol.76
, pp. 1044-1052
-
-
Bui, P.H.1
Hsu, E.L.2
Hankinson, O.3
-
82
-
-
0035877779
-
Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus
-
Wang T, Arifoglu P, Ronai Z, and Tew KD (2001) Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus. J Biol Chem 276:20999-21003.
-
(2001)
J Biol Chem
, vol.276
, pp. 20999-21003
-
-
Wang, T.1
Arifoglu, P.2
Ronai, Z.3
Tew, K.D.4
-
83
-
-
85012860213
-
Quinone reductases
-
Biotransformation (Guengerich, FP, ed.), (McQueen, C.A., series ed.) Elsevier Science, New York, in press
-
Ross D and Siegel D (2010) Quinone reductases, in Biotransformation (Guengerich, FP, ed.), Vol. 4 of Comprehensive Toxicology (McQueen, C.A., series ed.) Elsevier Science, New York, in press.
-
(2010)
Comprehensive Toxicology
, vol.4
-
-
Ross, D.1
Siegel, D.2
-
84
-
-
50049131787
-
Heterologous expression and mRNA distribution of orphan cytochrome P450 20A1
-
Stark K, Wu Z-L, Bartleson CJ, and Guengerich FP (2008) Heterologous expression and mRNA distribution of orphan cytochrome P450 20A1. Drug Metab Dispos 36:1930-1937.
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 1930-1937
-
-
Stark, K.1
Wu, Z.-L.2
Bartleson, C.J.3
Guengerich, F.P.4
-
85
-
-
29244442685
-
Heterologous expression, purification, and properties of human cytochrome P450 27C1
-
Wu Z-L, Bartleson CJ, Ham A-J, and Guengerich FP (2006) Heterologous expression, purification, and properties of human cytochrome P450 27C1. Arch Biochem Biophys 445:138-146.
-
(2006)
Arch Biochem Biophys
, vol.445
, pp. 138-146
-
-
Wu, Z.-L.1
Bartleson, C.J.2
Ham, A.-J.3
Guengerich, F.P.4
-
86
-
-
0034283075
-
A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization
-
Cui X, Nelson DR, and Strobel HW (2000) A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization. Genomics 68:161-166.
-
(2000)
Genomics
, vol.68
, pp. 161-166
-
-
Cui, X.1
Nelson, D.R.2
Strobel, H.W.3
-
87
-
-
2342537802
-
Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2
-
Li A, Jiao X, Munier FL, Schorderet DF, Yao W, Iwata F, Hayakawa M, Kanai A, Shy Chen M, Lewis RA, et al. (2004) Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2. Am J Hum Genet 74:817-826.
-
(2004)
Am J Hum Genet
, vol.74
, pp. 817-826
-
-
Li, A.1
Jiao, X.2
Munier, F.L.3
Schorderet, D.F.4
Yao, W.5
Iwata, F.6
Hayakawa, M.7
Kanai, A.8
Shy Chen, M.9
Lewis, R.A.10
-
88
-
-
1942532186
-
Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma
-
Rieger MA, Ebner R, Bell DR, Kiessling A, Rohayem J, Schmitz M, Temme A, Rieber EP, and Weigle B (2004) Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma. Cancer Res 64:2357-2364.
-
(2004)
Cancer Res
, vol.64
, pp. 2357-2364
-
-
Rieger, M.A.1
Ebner, R.2
Bell, D.R.3
Kiessling, A.4
Rohayem, J.5
Schmitz, M.6
Temme, A.7
Rieber, E.P.8
Weigle, B.9
|