Expression and characterization of CYP4V2 as a fatty acid ω-hydroxylase

Drug Metabolism and Disposition

Volumn 37, Issue 11, 2009, Pages 2119-2122

  Nakano, Mariko ^a   Kelly, Edward J ^a   Rettie, Allan E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKANE 1 MONOOXYGENASE; CYTOCHROME P450; CYTOCHROME P450 4V2; FORMAMIDINE; MYRISTIC ACID; N HYDROXY N' (4 N BUTYL 2 METHYLPHENYL FORMANIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIETTI CRYSTALLINE DYSTROPHY; CATALYSIS; CONTROLLED STUDY; EYE DISEASE; GENE MUTATION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALKANE 1-MONOOXYGENASE; AMIDINES; ANIMALS; BACULOVIRIDAE; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LENS, CRYSTALLINE; MICROSOMES; RABBITS; RECOMBINANT PROTEINS; RETINAL DEGENERATION; SPODOPTERA;

EID: 70350332200     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.028530     Document Type: Article

References (15)

1. Bietti G (1937) Ueber familiaeres vorkommen von 'retinitis punctata albescens' (verbunden mit dystrophia marginalis cristallinea corneae), glitzern des glaskoerpers und anderen degenerativen augenveraenderungen. Klin Mbl Augenheilk 99:737-757.
2. Fisher MB, Zheng YM, and Rettie AE (1998) Positional specificity of rabbit CYP4B1 for omega-hydroxylation1 of short-medium chain fatty acids and hydrocarbons. Biochem Biophys Res Commun 248:352-355.
3. Guan X, Fisher MB, Lang DH, Zheng YM, Koop DR, and Rettie AE (1998) Cytochrome P450-dependent desaturation of lauric acid: isoform selectivity and mechanism of formation of 11-dodecenoic acid. Chem Biol Interact 110:103-121. (Pubitemid 28157367)
4. Hardwick JP (2008) Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases. Biochem Pharmacol 75:2263-2275.
5. Hsu MH, Savas U, Griffin KJ, and Johnson EF (2007) Human cytochrome P450 family 4 enzymes: function, genetic variation and regulation. Drug Metab Rev 39:515-538. (Pubitemid 47355735)
6. Li A, Jiao X, Munier FL, Schorderet DF, Yao W, Iwata F, Hayakawa M, Kanai A, Shy Chen M, Alan Lewis R, et al. (2004) Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2. Am J Hum Genet 74:817-826. (Pubitemid 38568957)
7. Lillemin D, Cadiot P, and Kuetagan P (1984) A new synthesis of ω-hydroxyalkanoic acids via copper catalysis. Synthesis 3:230-231.
8. Maier KG and Roman RJ (2001) Cytochrome P450 metabolites of arachidonic acid in the control of renal function. Curr Opin Nephrol Hypertens 10:81-87. (Pubitemid 32102227)
9. Miyata N, Seki T, Tanaka Y, Omura T, Taniguchi K, Doi M, Bandou K, Kametani S, Sato M, Okuyama S, et al. (2005) Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4- morpholin-4-yl) phenyl-N′-hydroxyimido formamide], on hemorrhagic and ischemic stroke. J Pharmacol Exp Ther 314:77-85. (Pubitemid 41058243)
10. Miyata N, Taniguchi K, Seki T, Ishimoto T, Sato-Watanabe M, Yasuda Y, Doi M, Kametani S, Tomishima Y, Ueki T, et al. (2001) HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme. Br J Pharmacol 133:325-329. (Pubitemid 33027767)
11. Nakamura M, Lin J, Nishiguchi K, Kondo M, Sugita J, and Miyake Y (2006) Bietti crystalline corneoretinal dystrophy associated with CYP4V2 gene mutations. Adv Exp Med Biol 572:49-53. (Pubitemid 44249752)
12. Okita RT and Okita JR (2001) Cytochrome P450 4A fatty acid omega hydroxylases. Curr Drug Metab 2:265-281.
13. Rettie AE and Kelly EJ (2008) The CYP4 family, in Cytochrome P450: Role in the Metabolism and Toxicity of Drugs and Other Xenobiotics (C. Ioannides ed), Royal Society of Chemistry, London.
14. Stark K and Guengerich FP (2007) Characterization of orphan human cytochromes P450. Drug Metab Rev 39:627-637. (Pubitemid 47355742)
15. Wada Y, Itabashi T, Sato H, Kawamura M, Tada A, and TamaiM(2005) Screening for mutations in CYP4V2 gene in Japanese patients with Bietti's crystalline corneoretinal dystrophy. Am J Ophthalmol 139:894-899.