메뉴 건너뛰기




Volumn 184, Issue 11, 2010, Pages 6359-6366

Identification of a novel human MD-2 splice variant that negatively regulates lipopolysaccharide-induced TLR4 signaling

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; PROTEIN MD 2; TOLL LIKE RECEPTOR 4; ISOPROTEIN; LY96 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

EID: 77953468489     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0903543     Document Type: Article
Times cited : (29)

References (47)
  • 1
    • 39349100844 scopus 로고    scopus 로고
    • Signalling of toll-like receptors
    • Brikos, C., and L. A. O'Neill. 2008. Signalling of toll-like receptors. Handb. Exp. Pharmacol. (183) 21-50.
    • (2008) Handb. Exp. Pharmacol. , Issue.183 , pp. 21-50
    • Brikos, C.1    O'Neill, L.A.2
  • 2
    • 0034650427 scopus 로고    scopus 로고
    • Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
    • Ohashi, K., V. Burkart, S. Flohé, and H. Kolb. 2000. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J. Immunol. 164: 558-561. (Pubitemid 30043672)
    • (2000) Journal of Immunology , vol.164 , Issue.2 , pp. 558-561
    • Ohashi, K.1    Burkart, V.2    Flohe, S.3    Kolb, H.4
  • 7
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide evidence for TLR4 as the Lps gene product
    • Hoshino, K., O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, Y. Takeda, K. Takeda, and S. Akira. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162: 3749-3752. (Pubitemid 29314747)
    • (1999) Journal of Immunology , vol.162 , Issue.7 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3    Sanjo, H.4    Ogawa, T.5    Takeda, Y.6    Takeda, K.7    Akira, S.8
  • 8
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov, R., P. Preston-Hurlburt, and C. A. Janeway, Jr. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394-397.
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr., C.A.3
  • 10
    • 0025166114 scopus 로고
    • CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
    • Wright, S. D., R. A. Ramos, P. S. Tobias, R. J. Ulevitch, and J. C. Mathison. 1990. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249: 1431-1433.
    • (1990) Science , vol.249 , pp. 1431-1433
    • Wright, S.D.1    Ramos, R.A.2    Tobias, P.S.3    Ulevitch, R.J.4    Mathison, J.C.5
  • 11
    • 0033532629 scopus 로고    scopus 로고
    • MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    • Shimazu, R., S. Akashi, H. Ogata, Y. Nagai, K. Fukudome, K. Miyake, and M. Kimoto. 1999. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189: 1777-1782.
    • (1999) J. Exp. Med. , vol.189 , pp. 1777-1782
    • Shimazu, R.1    Akashi, S.2    Ogata, H.3    Nagai, Y.4    Fukudome, K.5    Miyake, K.6    Kimoto, M.7
  • 12
    • 3242698794 scopus 로고    scopus 로고
    • A coding mutation within the first exon of the human MD-2 gene results in decreased lipopolysaccharide-induced signaling
    • Hamann, L., O. Kumpf, M. Müller, A. Visintin, J. Eckert, P. M. Schlag, and R. R. Schumann. 2004. A coding mutation within the first exon of the human MD-2 gene results in decreased lipopolysaccharide-induced signaling. Genes Immun. 5: 283-288.
    • (2004) Genes Immun. , vol.5 , pp. 283-288
    • Hamann, L.1    Kumpf, O.2    Müller, M.3    Visintin, A.4    Eckert, J.5    Schlag, P.M.6    Schumann, R.R.7
  • 13
    • 41349102757 scopus 로고    scopus 로고
    • Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria
    • DOI 10.1182/blood-2007-06-097782
    • Tissières, P., I. Dunn-Siegrist, M. Schäppi, G. Elson, R. Comte, V. Nobre, and J. Pugin. 2008. Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria. Blood 111: 2122-2131. (Pubitemid 351451524)
    • (2008) Blood , vol.111 , Issue.4 , pp. 2122-2131
    • Tissieres, P.1    Dunn-Siegrist, I.2    Schappi, M.3    Elson, G.4    Comte, R.5    Nobre, V.6    Pugin, J.7
  • 14
    • 67349182481 scopus 로고    scopus 로고
    • The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
    • Park, B. S., D. H. Song, H. M. Kim, B.-S. Choi, H. Lee, and J.-O. Lee. 2009. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458: 1191-1195.
    • (2009) Nature , vol.458 , pp. 1191-1195
    • Park, B.S.1    Song, D.H.2    Kim, H.M.3    Choi, B.-S.4    Lee, H.5    Lee, J.-O.6
  • 15
    • 10644236977 scopus 로고    scopus 로고
    • Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes
    • Kolek, M. J., J. F. Carlquist, J. B. Muhlestein, B. M. Whiting, B. D. Horne, T. L. Bair, and J. L. Anderson. 2004. Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes. Am. Heart J. 148: 1034-1040.
    • (2004) Am. Heart J. , vol.148 , pp. 1034-1040
    • Kolek, M.J.1    Carlquist, J.F.2    Muhlestein, J.B.3    Whiting, B.M.4    Horne, B.D.5    Bair, T.L.6    Anderson, J.L.7
  • 16
    • 0037121946 scopus 로고    scopus 로고
    • Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen
    • Eisenbarth, S. C., D. A. Piggott, J. W. Huleatt, I. Visintin, C. A. Herrick, and K. Bottomly. 2002. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 196: 1645-1651.
    • (2002) J. Exp. Med. , vol.196 , pp. 1645-1651
    • Eisenbarth, S.C.1    Piggott, D.A.2    Huleatt, J.W.3    Visintin, I.4    Herrick, C.A.5    Bottomly, K.6
  • 17
    • 0034672088 scopus 로고    scopus 로고
    • Cutting edge: Naturally occurring soluble form of mouse Toll-like receptor 4 inhibits lipopolysaccharide signaling
    • Iwami, K. I., T. Matsuguchi, A. Masuda, T. Kikuchi, T. Musikacharoen, and Y. Yoshikai. 2000. Cutting edge: naturally occurring soluble form of mouse Toll-like receptor 4 inhibits lipopolysaccharide signaling. J. Immunol. 165: 6682-6686.
    • (2000) J. Immunol. , vol.165 , pp. 6682-6686
    • Iwami, K.I.1    Matsuguchi, T.2    Masuda, A.3    Kikuchi, T.4    Musikacharoen, T.5    Yoshikai, Y.6
  • 18
    • 35148842078 scopus 로고    scopus 로고
    • Kinetics of Toll-like receptor-4 splice variants expression in lipopolysaccharide-stimulated antigen presenting cells of healthy donors and patients with cystic fibrosis
    • DOI 10.1016/j.micinf.2007.06.009, PII S128645790700233X
    • Jaresová, I., D. Rozková, R. Spísek, A. Janda, J. Brázová, and A. Sedivá. 2007. Kinetics of Toll-like receptor-4 splice variants expression in lipopolysaccharide-stimulated antigen presenting cells of healthy donors and patients with cystic fibrosis. Microbes Infect. 9: 1359-1367. (Pubitemid 47539210)
    • (2007) Microbes and Infection , vol.9 , Issue.11 , pp. 1359-1367
    • Jaresova, I.1    Rozkova, D.2    Spisek, R.3    Janda, A.4    Brazova, J.5    Sediva, A.6
  • 19
    • 0036006290 scopus 로고    scopus 로고
    • Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88
    • Janssens, S., K. Burns, J. Tschopp, and R. Beyaert. 2002. Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88. Curr. Biol. 12: 467-471.
    • (2002) Curr. Biol. , vol.12 , pp. 467-471
    • Janssens, S.1    Burns, K.2    Tschopp, J.3    Beyaert, R.4
  • 21
    • 4544254589 scopus 로고    scopus 로고
    • Identification of a novel isoform of MD-2 that downregulates lipopolysaccharide signaling
    • Ohta, S., U. Bahrun, M. Tanaka, and M. Kimoto. 2004. Identification of a novel isoform of MD-2 that downregulates lipopolysaccharide signaling. Biochem. Biophys. Res. Commun. 323: 1103-1108.
    • (2004) Biochem. Biophys. Res. Commun. , vol.323 , pp. 1103-1108
    • Ohta, S.1    Bahrun, U.2    Tanaka, M.3    Kimoto, M.4
  • 22
    • 0036565888 scopus 로고    scopus 로고
    • Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma: A molecular basis for priming and synergism with bacterial lipopolysaccharide
    • DOI 10.1182/blood.V99.9.3427
    • Bosisio, D., N. Polentarutti, M. Sironi, S. Bernasconi, K. Miyake, G. R. Webb, M. U. Martin, A. Mantovani, and M. Muzio. 2002. Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma: a molecular basis for priming and synergism with bacterial lipopolysaccharide. Blood 99: 3427-3431. (Pubitemid 34525326)
    • (2002) Blood , vol.99 , Issue.9 , pp. 3427-3431
    • Bosisio, D.1    Polentarutti, N.2    Sironi, M.3    Bernasconi, S.4    Miyake, K.5    Webb, G.R.6    Martin, M.U.7    Mantovani, A.8    Muzio, M.9
  • 23
    • 0037036469 scopus 로고    scopus 로고
    • TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells
    • Abreu, M. T., E. T. Arnold, L. S. Thomas, R. Gonsky, Y. Zhou, B. Hu, and M. Arditi. 2002. TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells. J. Biol. Chem. 277: 20431-20437.
    • (2002) J. Biol. Chem. , vol.277 , pp. 20431-20437
    • Abreu, M.T.1    Arnold, E.T.2    Thomas, L.S.3    Gonsky, R.4    Zhou, Y.5    Hu, B.6    Arditi, M.7
  • 24
    • 0035885127 scopus 로고    scopus 로고
    • N-linked glycosylations at Asn (26) and Asn(114) of human MD-2 are required for toll-like receptor 4-mediated activation of NF-kappaB by lipopolysaccharide
    • Ohnishi, T., M. Muroi, and K. Tanamoto. 2001. N-linked glycosylations at Asn (26) and Asn(114) of human MD-2 are required for toll-like receptor 4-mediated activation of NF-kappaB by lipopolysaccharide. J. Immunol. 167: 3354-3359.
    • (2001) J. Immunol. , vol.167 , pp. 3354-3359
    • Ohnishi, T.1    Muroi, M.2    Tanamoto, K.3
  • 25
    • 0036558018 scopus 로고    scopus 로고
    • ML - A conserved domain involved in innate immunity and lipid metabolism
    • Inohara, N., and G. Nuñez. 2002. ML - a conserved domain involved in innate immunity and lipid metabolism. Trends Biochem. Sci. 27: 219-221.
    • (2002) Trends Biochem. Sci. , vol.27 , pp. 219-221
    • Inohara, N.1    Nuñez, G.2
  • 26
    • 0035834135 scopus 로고    scopus 로고
    • Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4
    • Visintin, A., A. Mazzoni, J. A. Spitzer, and D. M. Segal. 2001. Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4. Proc. Natl. Acad. Sci. USA 98: 12156-12161.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12156-12161
    • Visintin, A.1    Mazzoni, A.2    Spitzer, J.A.3    Segal, D.M.4
  • 27
    • 0034235120 scopus 로고    scopus 로고
    • ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive, systems of embryonic and adult mice
    • Kato, K., A. M. Morrison, T. Nakano, K. Tashiro, and T. Honjo. 2000. ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mice. Blood 96: 362-364. (Pubitemid 30456495)
    • (2000) Blood , vol.96 , Issue.1 , pp. 362-364
    • Kato, K.1    Morrison, A.M.2    Nakano, T.3    Tashiro, K.4    Honjo, T.5
  • 28
    • 4544250809 scopus 로고    scopus 로고
    • A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4
    • Kennedy, M. N., G. E. Mullen, C. A. Leifer, C. Lee, A. Mazzoni, K. N. Dileepan, and D. M. Segal. 2004. A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4. J. Biol. Chem. 279: 34698-34704.
    • (2004) J. Biol. Chem. , vol.279 , pp. 34698-34704
    • Kennedy, M.N.1    Mullen, G.E.2    Leifer, C.A.3    Lee, C.4    Mazzoni, A.5    Dileepan, K.N.6    Segal, D.M.7
  • 29
    • 52049108073 scopus 로고    scopus 로고
    • Isolation of monomeric and dimeric secreted MD-2. Endotoxin.sCD14 and Toll-like receptor 4 ectodomain selectively react with the monomeric form of secreted MD-2
    • Teghanemt, A., R. L. Widstrom, T. L. Gioannini, and J. P. Weiss. 2008. Isolation of monomeric and dimeric secreted MD-2. Endotoxin.sCD14 and Toll-like receptor 4 ectodomain selectively react with the monomeric form of secreted MD-2. J. Biol. Chem. 283: 21881-21889.
    • (2008) J. Biol. Chem. , vol.283 , pp. 21881-21889
    • Teghanemt, A.1    Widstrom, R.L.2    Gioannini, T.L.3    Weiss, J.P.4
  • 30
    • 0034177888 scopus 로고    scopus 로고
    • Cutting edge: Cell surface expression and lipopolysaccharide signaling via the Toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages
    • Akashi, S., R. Shimazu, H. Ogata, Y. Nagai, K. Takeda, M. Kimoto, and K. Miyake. 2000. Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages. J. Immunol. 164: 3471-3475. (Pubitemid 30169795)
    • (2000) Journal of Immunology , vol.164 , Issue.7 , pp. 3471-3475
    • Akashi, S.1    Shimazu, R.2    Ogata, H.3    Nagai, Y.4    Takeda, K.5    Kimoto, M.6    Miyake, K.7
  • 32
    • 34250813748 scopus 로고    scopus 로고
    • Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa
    • Ohto, U., K. Fukase, K. Miyake, and Y. Satow. 2007. Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa. Science 316: 1632-1634.
    • (2007) Science , vol.316 , pp. 1632-1634
    • Ohto, U.1    Fukase, K.2    Miyake, K.3    Satow, Y.4
  • 34
    • 0346850824 scopus 로고    scopus 로고
    • Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction
    • Visintin, A., E. Latz, B. G. Monks, T. Espevik, and D. T. Golenbock. 2003. Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction. J. Biol. Chem. 278: 48313-48320.
    • (2003) J. Biol. Chem. , vol.278 , pp. 48313-48320
    • Visintin, A.1    Latz, E.2    Monks, B.G.3    Espevik, T.4    Golenbock, D.T.5
  • 36
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • Angus, D. C., W. T. Linde-Zwirble, J. Lidicker, G. Clermont, J. Carcillo, and M. R. Pinsky. 2001. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 29: 1303-1310.
    • (2001) Crit. Care Med. , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 38
    • 0028835740 scopus 로고
    • Regulation of interleukin-1 receptor antagonist by Th1 and Th2 cytokines
    • Kline, J. N., P. A. Fisher, M. M. Monick, and G. W. Hunninghake. 1995. Regulation of interleukin-1 receptor antagonist by Th1 and Th2 cytokines. Am. J. Physiol. 269: L92-L98.
    • (1995) Am. J. Physiol. , vol.269
    • Kline, J.N.1    Fisher, P.A.2    Monick, M.M.3    Hunninghake, G.W.4
  • 40
    • 0242495481 scopus 로고    scopus 로고
    • Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness
    • Re, F., and J. L. Strominger. 2003. Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness. J. Immunol. 171: 5272-5276.
    • (2003) J. Immunol. , vol.171 , pp. 5272-5276
    • Re, F.1    Strominger, J.L.2
  • 41
    • 0036289969 scopus 로고    scopus 로고
    • Identification of LPS-binding peptide fragment of MD-2, a toll-receptor accessory protein
    • Mancek, M., P. Pristovsek, and R. Jerala. 2002. Identification of LPS-binding peptide fragment of MD-2, a toll-receptor accessory protein. Biochem. Biophys. Res. Commun. 292: 880-885.
    • (2002) Biochem. Biophys. Res. Commun. , vol.292 , pp. 880-885
    • Mancek, M.1    Pristovsek, P.2    Jerala, R.3
  • 42
    • 38349186906 scopus 로고    scopus 로고
    • Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin
    • Teghanemt, A., F. Re, P. Prohinar, R. Widstrom, T. L. Gioannini, and J. P. Weiss. 2008. Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin. J. Biol. Chem. 283: 1257-1266.
    • (2008) J. Biol. Chem. , vol.283 , pp. 1257-1266
    • Teghanemt, A.1    Re, F.2    Prohinar, P.3    Widstrom, R.4    Gioannini, T.L.5    Weiss, J.P.6
  • 47
    • 0025021471 scopus 로고
    • Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist
    • Eisenberg, S. P., R. J. Evans, W. P. Arend, E. Verderber, M. T. Brewer, C. H. Hannum, and R. C. Thompson. 1990. Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature 343: 341-346.
    • (1990) Nature , vol.343 , pp. 341-346
    • Eisenberg, S.P.1    Evans, R.J.2    Arend, W.P.3    Verderber, E.4    Brewer, M.T.5    Hannum, C.H.6    Thompson, R.C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.