Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor γ independently of cannabinoid receptors 1 and 2

Molecular Pharmacology

Volumn 70, Issue 1, 2006, Pages 101-111

  Rockwell, Cheryl E ^a   Snider, Natasha T ^a   Thompson, Jerry T ^b   Vanden Heuvel, John P ^b   Kaminski, Norbert E ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 2 CHLORO 5 NITRO N (4 PYRIDYL) BENZAMIDE; BENZAMIDE DERIVATIVE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; LUCIFERASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; FEMALE; GENETIC TRANSFECTION; LEUKEMIA CELL LINE; LEUKOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

3T3-L1 CELLS; ADIPOGENESIS; ANIMALS; ARACHIDONIC ACIDS; BENZAMIDES; CELLS, CULTURED; FATTY ACID-BINDING PROTEINS; FEMALE; GENE EXPRESSION; GLYCERIDES; HUMANS; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; JURKAT CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PPAR GAMMA; PROSTAGLANDIN D2; PROTEIN BINDING; PYRIDINES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; RESPONSE ELEMENTS; T-LYMPHOCYTES; THIAZOLIDINEDIONES;

EID: 33745280979     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.019117     Document Type: Article

References (41)

1. Bell-Parikh LC, Ide T, Lawson JA, McNamara P, Reilly M, and FitzGerald GA (2003) Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma. J Clin Investig 112:945-955.
2. Beltramo M and Piomelli D (2000) Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol. Neuroreport 11:1231-1235.
3. Berdyshev EV (2000) Cannabinoid receptors and the regulation of immune response. Chem Phys Lipids 108:169-190.
4. Berdyshev EV, Schmid PC, Krebsbach RJ, and Schmid HH (2001) Activation of PAF receptors results in enhanced synthesis of 2- arachidonoylglycerol (2-AG) in immune cells. FASEB J 15:2171-2178.
5. Bility MT, Thompson JT, McKee RH, David RM, Butala JH, Vanden Heuvel JP, and Peters JM (2004) Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters. Toxicol Sci 82:170-182.
6. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
7. Chang YH, Lee ST, and Lin WW (2001) Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids. J Cell Biochem 81:715-723.
8. Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P, and Evans RM (2001) PPARgamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med 7:48-52.
9. Chawla A and Lazar MA (1993) Induction of Rev-ErbA α, an orphan receptor encoded on the opposite strand of the α-thyroid hormone receptor gene, during adipocyte differentiation. J Biol Chem 268:16265-16269.
10. Clark RB, Bishop-Bailey D, Estrada-Hernandez T, Hla T, Puddington L, and Padula SJ (2000) The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses. J Immunol 164:1364-1371.
11. Das SK, Paria BC, Chakraborty I, and Dey SK (1995) Cannabinoid ligand-receptor signaling in the mouse uterus. Proc Natl Acad Sci USA 92:4332-4336.
12. Daynes RA and Jones DC (2002) Emerging roles of PPARs in inflammation and immunity. Nat Rev Immunol 2:748-759.
13. Facchinetti F, Del Giudice E, Furegato S, Passarotto M, and Leon A (2003) Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide. Glia 41:161-168.
14. Farraj AK, Harkema JR, and Kaminski NE (2004) Allergic rhinitis induced by intranasal sensitization and challenge with trimellitic anhydride but not with dinitrochlorobenzene or oxazolone in A/J mice. Toxicol Sci 79:315-325.
15. Faubert Kaplan BL, Rockwell CR, and Kaminski NE (2003) Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes. J Pharmacol Exp Ther 306:1077-1085.
16. Gallily R, Breuer A, and Mechoulam R (2000) 2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-alpha production in murine macrophages and in mice. Eur J Pharmacol 406:R5-R7.
17. Hanus L, Abu-Lafi S, Fride E, Breuer A, Vogel Z, Shalev DE, Kustanovich I, and Mechoulam R (2001) 2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc Natl Acad Sci USA 98:3662-3665.
18. Hillard CJ and Jarrahian (2003) A Cellular accumulation of anandamide: consensus and controversy. Br J Pharmacol 140:802-808.
19. Jarai Z, Wagner JA, Varga K, Lake KD, Compton DR, Martin BR, Zimmer AM, Bonner TI, Buckley NE, Mezey E, et al. (1999) Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc Natl Acad Sci USA 96:14136-14141.
20. Kaminski NE, Abood ME, Kessler FK, Martin BR, and Schatz AR (1992) Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation. Mol Pharmacol 42:736-742.
21. Kishimoto S, Gokoh M, Oka S, Muramatsu M, Kajiwara T, Waku K, and Sugiura T (2003) 2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism. J Biol Chem 278:24469-24475.
22. Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, and Lehmann JM (1995) A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 83:813-819.
23. Kozak KR, Crews BC, Morrow JD, Wang LH, Ma YH, Weinander R, Jakobsson PJ, and Marnett LJ (2002a) Metabolism of the endocannabinoids, 2- arachidonylglycerol and anandamide, into prostaglandin, thromboxane and prostacyclin glycerol esters and ethanolamides. J Biol Chem 277:44877-44885.
24. Kozak KR, Gupta RA, Moody JS, Ji C, Boeglin WE, DuBois RN, Brash AR, and Marnett LJ (2002b) 15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist. J Biol Chem 277:23278-23286.
25. Lee M, Yang KH, and Kaminski NE (1995) Effects of putative cannabinoid receptor ligands, anandamide and 2- arachidonyl-glycerol, on immune function in B6C3F1 mouse splenocytes. J Pharmacol Exp Ther 275:529-536.
26. Maccarrone M, Bari M, Battista N, and Finazzi-Agro A (2002) Endocannabinoid degradation, endotoxic shock and inflammation. Curr Drug Targets Inflamm Allergy 1:53-63.
27. Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, and Bonner TI (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346:561-564.
28. Mechoulam R, Ben-Shabat S, Hanus L, Ligumsky M, Kaminski NE, Schatz AR, Gopher A, Almog S, Martin BR, Compton DR, et al. (1995) Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 50:83-90.
29. Motobe T, Hashiguchi T, Uchimura T, Yamakuchi M, Taniguchi N, Komiya S, and Maruyama I (2004) Endogenous cannabinoids are candidates for lipid mediators of bone cement implantation syndrome. Shock 21:8-12.
30. Munro S, Thomas KL, and Abu-Shaar M (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature (Lond) 365:61-65.
31. Natarajan C and Bright JJ (2002) Peroxisome proliferator-activated receptorgamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation. Genes Immun 3:59-70.
32. Ouyang Y, Hwang SG, Han SH, and Kaminski NE (1998) Suppression of interleukin-2 by the putative endogenous cannabinoid 2-arachidonyl-glycerol is mediated through down-regulation of the nuclear factor of activated T cells. Mol Pharmacol 53:676-683.
33. Ricote M, Li AC, Willson TM, Kelly CJ, and Glass CK (1998) The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature (Lond) 391:79-82.
34. Rockwell CE and Kaminski NE (2004) A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. J Pharmacol Exp Ther 311:683-690.
35. Schmidt S, Moric E, Schmidt M, Sastre M, Feinstein DL, and Heneka MT (2004) Anti-inflammatory and antiproliferative actions of PPAR-gamma agonists on T lymphocytes derived from MS patients. J Leukoc Biol 75:478-485.
36. Sugiura T, Kondo S, Kishimoto S, Miyashita T, Nakane S, Kodaka T, Suhara Y, Takayama H, and Waku K (2000) Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. J Biol Chem 275:605-612.
37. Tontonoz P, Hu E, Graves RA, Budavari AI, and Spiegelman BM (1994) mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 8:1224-1234.
38. Wang Y, Liu Y, Ito Y, Hashiguchi T, Kitajima I, Yamakuchi M, Shimizu H, Matsuo S, Imaizumi H, and Maruyama I (2001) Simultaneous measurement of anandamide and 2-arachidonoylglycerol by polymyxin B-selective adsorption and subsequent high-performance liquid chromatography analysis: increase in endogenous cannabinoids in the sera of patients with endotoxic shock. Anal Biochem 294:73-82.
39. Wang YL, Frauwirth KA, Rangwala SM, Lazar MA, and Thompson CB (2002) Thiazolidinedione activation of peroxisome proliferator-activated receptor γ can enhance mitochondrial potential and promote cell survival. J Biol Chem 27:31781-31788.
40. Yang XY, Wang LH, Chen T, Hodge DR, Resau JH, DaSilva L, and Farrar WL (2000) Activation of human T lymphocytes is inhibited by peroxisome proliferatoractivated receptor gamma (PPARγ) agonists. PPARγco-association with transcription factor NFAT. J Biol Chem 275:4541-4544.
41. Zhu LX, Sharma S, Stolina M, Gardner B, Roth MD, Tashkin DP, and Dubinett SM (2000) Delta-9-tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway. J Immunol 165:373-380.