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Volumn 1, Issue 6, 2009, Pages 965-982

New trends in epidermal growth factor receptor-directed monoclonal antibodies

Author keywords

Cancer; Cetuximab; EGF receptor; KRAS; Matuzumab; Monoclonal antibody; Panitumumab

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CETUXIMAB; CISPLATIN; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIRUBICIN; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; IRINOTECAN; MATUZUMAB; MEMBRANE RECEPTOR; MONOCLONAL ANTIBODY; NAVELBINE; OXALIPLATIN; PACLITAXEL; PANITUMUMAB; PEMETREXED;

EID: 77953389316     PISSN: 1750743X     EISSN: None     Source Type: Journal    
DOI: 10.2217/imt.09.66     Document Type: Review
Times cited : (11)

References (116)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA: The hallmarks of cancer. Cell 100(1), 57-70 (2000).
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0013825447 scopus 로고
    • The stimulation of epidermal proliferation by a specific protein (EGF)
    • Cohen S: The stimulation of epidermal proliferation by a specific protein (EGF). Dev. Biol. 12(3), 394-407 (1965).
    • (1965) Dev. Biol. , vol.12 , Issue.3 , pp. 394-407
    • Cohen, S.1
  • 3
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • Mendelsohn J, Baselga J: Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J. Clin. Oncol. 21(14), 2787-2799 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , Issue.14 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 4
    • 33745828702 scopus 로고    scopus 로고
    • EGF-ERBB signalling: Towards the systems level
    • Elegant review of signal transduction using a more comprehensive, broad-based approach
    • Citri A, Yarden Y: EGF-ERBB signalling: towards the systems level. Nat. Rev. Mol. Cell Biol. 7(7), 505-516 (2006). • Elegant review of signal transduction using a more comprehensive, broad-based approach.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , Issue.7 , pp. 505-516
    • Citri, A.1    Yarden, Y.2
  • 5
    • 0021273420 scopus 로고
    • Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
    • Ullrich A, Coussens L, Hayflick JS et al.: Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 309(5967), 418-425 (1984). (Pubitemid 14102443)
    • (1984) Nature , vol.309 , Issue.5967 , pp. 418-425
    • Ullrich, A.1    Coussens, L.2    Hayflick, J.S.3
  • 10
    • 0034773992 scopus 로고    scopus 로고
    • The EGFR family and its ligands in human cancer. Signalling mechanisms and therapeutic opportunities
    • Yarden Y: The EGFR family and its ligands in human cancer. Signalling mechanisms and therapeutic opportunities. Eur. J. Cancer 37 (Suppl. 4), S3-S8 (2001).
    • (2001) Eur. J. Cancer , vol.37 , Issue.SUPPL. 4
    • Yarden, Y.1
  • 11
    • 0031900740 scopus 로고    scopus 로고
    • Signal transduction through MAP kinase cascades
    • Lewis TS, Shapiro PS, Ahn NG: Signal transduction through MAP kinase cascades. Adv. Cancer Res. 74, 49-139 (1998).
    • (1998) Adv. Cancer Res. , vol.74 , pp. 49-139
    • Lewis, T.S.1    Shapiro, P.S.2    Ahn, N.G.3
  • 12
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer 2(7), 489-501 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 13
    • 0030795612 scopus 로고    scopus 로고
    • The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions
    • DOI 10.1016/S0014-5793(97)00412-2, PII S0014579397004122
    • Alroy I, Yarden Y: The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett. 410(1), 83-86 (1997). (Pubitemid 27283389)
    • (1997) FEBS Letters , vol.410 , Issue.1 , pp. 83-86
    • Alroy, I.1    Yarden, Y.2
  • 14
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman JA, Luo J, Cantley LC: The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat. Rev. Genet. 7(8), 606-619 (2006).
    • (2006) Nat. Rev. Genet. , vol.7 , Issue.8 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 16
    • 0036500831 scopus 로고    scopus 로고
    • Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: A new paradigm for cancer therapy
    • Herbst RS, Shin DM: Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy. Cancer 94(5), 1593-1611 (2002).
    • (2002) Cancer , vol.94 , Issue.5 , pp. 1593-1611
    • Herbst, R.S.1    Shin, D.M.2
  • 17
    • 0034777482 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer is correlated with survival
    • Brabender J, Danenberg KD, Metzger R et al.: Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer is correlated with survival. Clin. Cancer Res. 7(7), 1850-1855 (2001).
    • (2001) Clin. Cancer Res. , vol.7 , Issue.7 , pp. 1850-1855
    • Brabender, J.1    Danenberg, K.D.2    Metzger, R.3
  • 18
    • 0029025332 scopus 로고
    • Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas
    • Wikstrand CJ, Hale LP, Batra SK et al.: Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas. Cancer Res. 55(14), 3140-3148 (1995).
    • (1995) Cancer Res. , vol.55 , Issue.14 , pp. 3140-3148
    • Wikstrand, C.J.1    Hale, L.P.2    Batra, S.K.3
  • 19
    • 0030787340 scopus 로고    scopus 로고
    • Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII)
    • Chu CT, Everiss KD, Wikstrand CJ, Batra SK, Kung HJ, Bigner DD: Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII). Biochem. J. 324 (Pt 3), 855-861 (1997).
    • (1997) Biochem. J. , vol.324 , Issue.PART 3 , pp. 855-861
    • Chu, C.T.1    Everiss, K.D.2    Wikstrand, C.J.3    Batra, S.K.4    Kung, H.J.5    Bigner, D.D.6
  • 20
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler G, Milstein C: Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256(5517), 495-497 (1975).
    • (1975) Nature , vol.256 , Issue.5517 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 21
    • 0002706854 scopus 로고
    • Chimeric immunoglobulin genes
    • Honjo T, Alt F, Rabbitts T (Eds). Academic Press, London, UK
    • Morrison S, Oi V: Chimeric immunoglobulin genes. In: Chimeric Immunoglobulin Genes. Honjo T, Alt F, Rabbitts T (Eds). Academic Press, London, UK 260-274 (1989).
    • (1989) Chimeric Immunoglobulin Genes , pp. 260-274
    • Morrison, S.1    Oi, V.2
  • 22
    • 0023911111 scopus 로고
    • Reshaping human antibodies for therapy
    • Riechmann L, Clark M, Waldmann H, Winter G: Reshaping human antibodies for therapy. Nature 332(6162), 323-327 (1988).
    • (1988) Nature , vol.332 , Issue.6162 , pp. 323-327
    • Riechmann, L.1    Clark, M.2    Waldmann, H.3    Winter, G.4
  • 23
    • 0027963484 scopus 로고
    • Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs
    • Green LL, Hardy MC, Maynard-Currie CE et al.: Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs. Nat. Genet. 7(1), 13-21 (1994).
    • (1994) Nat. Genet. , vol.7 , Issue.1 , pp. 13-21
    • Green, L.L.1    Hardy, M.C.2    Maynard-Currie, C.E.3
  • 24
    • 0027479277 scopus 로고
    • Analysis of homozygous mutant chimeric mice: Deletion of the immunoglobulin heavy-chain joining region blocks B-cell development and antibody production
    • Jakobovits A, Vergara GJ, Kennedy JL et al.: Analysis of homozygous mutant chimeric mice: deletion of the immunoglobulin heavy-chain joining region blocks B-cell development and antibody production. Proc. Natl Acad. Sci. USA 90(6), 2551-2555 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , Issue.6 , pp. 2551-2555
    • Jakobovits, A.1    Vergara, G.J.2    Kennedy, J.L.3
  • 25
    • 33644819090 scopus 로고    scopus 로고
    • Fully human therapeutic monoclonal antibodies
    • Weiner LM: Fully human therapeutic monoclonal antibodies: J. Immunother. 29(1), 1-9 (2006).
    • (2006) J. Immunother. , vol.29 , Issue.1 , pp. 1-9
    • Weiner, L.M.1
  • 26
    • 0028819660 scopus 로고
    • Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model
    • Goldstein NI, Prewett M, Zuklys K, Rockwell P, Mendelsohn J: Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin. Cancer Res. 1(11), 1311-1318 (1995).
    • (1995) Clin. Cancer Res. , vol.1 , Issue.11 , pp. 1311-1318
    • Goldstein, N.I.1    Prewett, M.2    Zuklys, K.3    Rockwell, P.4    Mendelsohn, J.5
  • 27
    • 0020933452 scopus 로고
    • Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors
    • Sato JD, Kawamoto T, Le AD, Mendelsohn J, Polikoff J, Sato GH: Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors. Mol. Biol. Med. 1(5), 511-529 (1983).
    • (1983) Mol. Biol. Med. , vol.1 , Issue.5 , pp. 511-529
    • Sato, J.D.1    Kawamoto, T.2    Le, A.D.3    Mendelsohn, J.4    Polikoff, J.5    Sato, G.H.6
  • 28
    • 0035409904 scopus 로고    scopus 로고
    • IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody, for treatment of head and neck cancer
    • Herbst RS, Kim ES, Harari PM: IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody, for treatment of head and neck cancer. Expert Opin. Biol. Ther. 1(4), 719-732 (2001).
    • (2001) Expert Opin. Biol. Ther. , vol.1 , Issue.4 , pp. 719-732
    • Herbst, R.S.1    Kim, E.S.2    Harari, P.M.3
  • 29
    • 0029776415 scopus 로고    scopus 로고
    • 1 arrest in prostatic cancer cell line DU145
    • Peng D, Fan Z, Lu Y, DeBlasio T, Scher H, Mendelsohn J: Anti-epidermal growth factor receptor monoclonal antibody 225 up-regulates p27KIP1 and induces G1 arrest in prostatic cancer cell line DU145. Cancer Res. 56(16), 3666-3669 (1996). (Pubitemid 26272010)
    • (1996) Cancer Research , vol.56 , Issue.16 , pp. 3666-3669
    • Peng, D.1    Fan, Z.2    Lu, Y.3    Deblasio, T.4    Scher, H.5    Mendelsohn, J.6
  • 30
    • 0032972944 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
    • Perrotte P, Matsumoto T, Inoue K et al.: Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin. Cancer Res. 5(2), 257-265 (1999).
    • (1999) Clin. Cancer Res. , vol.5 , Issue.2 , pp. 257-265
    • Perrotte, P.1    Matsumoto, T.2    Inoue, K.3
  • 31
    • 0036561431 scopus 로고    scopus 로고
    • Molecular inhibition of angiogenesis and metastatic potential in human squamous cell carcinomas after epidermal growth factor receptor blockade
    • Huang SM, Li J, Harari PM: Molecular inhibition of angiogenesis and metastatic potential in human squamous cell carcinomas after epidermal growth factor receptor blockade. Mol. Cancer Ther. 1(7), 507-514 (2002).
    • (2002) Mol. Cancer Ther. , vol.1 , Issue.7 , pp. 507-514
    • Huang, S.M.1    Li, J.2    Harari, P.M.3
  • 32
    • 0034084314 scopus 로고    scopus 로고
    • Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis
    • Huang SM, Harari PM: Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clin. Cancer Res. 6(6), 2166-2174 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , Issue.6 , pp. 2166-2174
    • Huang, S.M.1    Harari, P.M.2
  • 33
    • 19244366949 scopus 로고    scopus 로고
    • Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin
    • Baselga J, Pfister D, Cooper MR et al.: Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. J. Clin. Oncol. 18(4), 904-914 (2000).
    • (2000) J. Clin. Oncol. , vol.18 , Issue.4 , pp. 904-914
    • Baselga, J.1    Pfister, D.2    Cooper, M.R.3
  • 35
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • DOI 10.1200/JCO.2004.10.182
    • Saltz LB, Meropol NJ, Loehrer PJ Sr, Needle MN, Kopit J, Mayer RJ: Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin. Oncol. 22(7), 1201-1208 (2004). (Pubitemid 41079832)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.7 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer Sr., P.J.3    Needle, M.N.4    Kopit, J.5    Mayer, R.J.6
  • 36
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Landmark study leading to regulatory approval of cetuximab in metastatic colorectal cancer (mCRC)
    • Cunningham D, Humblet Y, Siena S et al.: Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Engl. J. Med. 351(4), 337-345 (2004). •• Landmark study leading to regulatory approval of cetuximab in metastatic colorectal cancer (mCRC).
    • (2004) N. Engl. J. Med. , vol.351 , Issue.4 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 37
    • 36148941301 scopus 로고    scopus 로고
    • Cetuximab for the treatment of colorectal cancer
    • Landmark study leading to regulatory approval of cetuximab in mCRC
    • Jonker DJ, O'Callaghan CJ, Karapetis CS et al.: Cetuximab for the treatment of colorectal cancer. N. Engl. J. Med. 357(20), 2040-2048 (2007). •• Landmark study leading to regulatory approval of cetuximab in mCRC.
    • (2007) N. Engl. J. Med. , vol.357 , Issue.20 , pp. 2040-2048
    • Jonker, D.J.1    O'Callaghan, C.J.2    Karapetis, C.S.3
  • 39
    • 33644697486 scopus 로고    scopus 로고
    • Cetuximab and irinotecan/5-fluorouracil/folinic acid is a safe combination for the first-line treatment of patients with epidermal growth factor receptor expressing metastatic colorectal carcinoma
    • Folprecht G, Lutz MP, Schoffski P et al.: Cetuximab and irinotecan/5-fluorouracil/folinic acid is a safe combination for the first-line treatment of patients with epidermal growth factor receptor expressing metastatic colorectal carcinoma. Ann. Oncol. 17(3), 450-456 (2006).
    • (2006) Ann. Oncol. , vol.17 , Issue.3 , pp. 450-456
    • Folprecht, G.1    Lutz, M.P.2    Schoffski, P.3
  • 43
    • 36749067866 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer
    • Tabernero J, Van Cutsem E, Diaz-Rubio E et al.: Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer. J. Clin. Oncol. 25(33), 5225-5232 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.33 , pp. 5225-5232
    • Tabernero, J.1    Van Cutsem, E.2    Diaz-Rubio, E.3
  • 44
    • 48749119784 scopus 로고    scopus 로고
    • Cetuximab in combination with weekly 5-fluorouracil/folinic acid and oxaliplatin (FUFOX) in untreated patients with advanced colorectal cancer: A Phase Ib/II study of the AIO GI Group
    • Arnold D, Hohler T, Dittrich C et al.: Cetuximab in combination with weekly 5-fluorouracil/folinic acid and oxaliplatin (FUFOX) in untreated patients with advanced colorectal cancer: a Phase Ib/II study of the AIO GI Group. Ann. Oncol. 19(8), 1442-1449 (2008).
    • (2008) Ann. Oncol. , vol.19 , Issue.8 , pp. 1442-1449
    • Arnold, D.1    Hohler, T.2    Dittrich, C.3
  • 45
    • 46249096899 scopus 로고    scopus 로고
    • Adding cetuximab to capecitabine plus oxaliplatin (XELOX) in first-line treatment of metastatic colorectal cancer: A randomized Phase II trial of the Swiss Group for Clinical Cancer Research SAKK
    • Borner M, Koeberle D, Von Moos R et al.: Adding cetuximab to capecitabine plus oxaliplatin (XELOX) in first-line treatment of metastatic colorectal cancer: a randomized Phase II trial of the Swiss Group for Clinical Cancer Research SAKK. Ann. Oncol. 19(7), 1288-1292 (2008).
    • (2008) Ann. Oncol. , vol.19 , Issue.7 , pp. 1288-1292
    • Borner, M.1    Koeberle, D.2    Von Moos, R.3
  • 46
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • Bokemeyer C, Bondarenko I, Makhson A et al. : Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J. Clin. Oncol. 27(5), 663-671 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.5 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3
  • 47
    • 65649086838 scopus 로고    scopus 로고
    • Cetuximab in combination with irinotecan/5-fluorouracil/folinic acid (FOLFIRI) in the initial treatment of metastatic colorectal cancer: A multicentre two-part Phase I/II study
    • Raoul JL, Van Laethem JL, Peeters M et al.: Cetuximab in combination with irinotecan/5-fluorouracil/folinic acid (FOLFIRI) in the initial treatment of metastatic colorectal cancer: a multicentre two-part Phase I/II study. BMC Cancer. 9, 112 (2009).
    • (2009) BMC Cancer , vol.9 , pp. 112
    • Raoul, J.L.1    Van Laethem, J.L.2    Peeters, M.3
  • 48
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E, Kohne CH, Hitre E et al.: Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N. Engl. J. Med. 360(14), 1408-1417 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , Issue.14 , pp. 1408-1417
    • Van Cutsem, E.1    Kohne, C.H.2    Hitre, E.3
  • 49
    • 44249111440 scopus 로고    scopus 로고
    • EPIC: Phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
    • Sobrero AF, Maurel J, Fehrenbacher L et al.: EPIC: Phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J. Clin. Oncol. 26(14), 2311-2319 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.14 , pp. 2311-2319
    • Sobrero, A.F.1    Maurel, J.2    Fehrenbacher, L.3
  • 51
    • 0032490124 scopus 로고    scopus 로고
    • Kirsten ras mutations in patients with colorectal cancer: The multicenter 'RASCAL' study
    • Andreyev HJ, Norman AR, Cunningham D, Oates JR, Clarke PA: Kirsten ras mutations in patients with colorectal cancer: the multicenter 'RASCAL' study. J. Natl Cancer Inst. 90(9), 675-684 (1998).
    • (1998) J. Natl Cancer Inst. , vol.90 , Issue.9 , pp. 675-684
    • Andreyev, H.J.1    Norman, A.R.2    Cunningham, D.3    Oates, J.R.4    Clarke, P.A.5
  • 53
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • First description of KRAS as a negative predictor of efficacy when using monoclonal antibodies (mAbs) targeting EGF receptor (EGFR)
    • Lievre A, Bachet JB, Le Corre D et al.: KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 66(8), 3992-3995 (2006). • First description of KRAS as a negative predictor of efficacy when using monoclonal antibodies (mAbs) targeting EGF receptor (EGFR).
    • (2006) Cancer Res. , vol.66 , Issue.8 , pp. 3992-3995
    • Lievre, A.1    Bachet, J.B.2    Le Corre, D.3
  • 54
    • 34047248571 scopus 로고    scopus 로고
    • Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
    • Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F et al.: Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res. 67(6), 2643-2648 (2007).
    • (2007) Cancer Res. , vol.67 , Issue.6 , pp. 2643-2648
    • Benvenuti, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3
  • 55
    • 34247278727 scopus 로고    scopus 로고
    • Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by cetuximab plus chemotherapy
    • Di Fiore F, Blanchard F, Charbonnier F et al.: Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by cetuximab plus chemotherapy. Br. J. Cancer. 96(8), 1166-1169 (2007).
    • (2007) Br. J. Cancer. , vol.96 , Issue.8 , pp. 1166-1169
    • Di Fiore, F.1    Blanchard, F.2    Charbonnier, F.3
  • 56
    • 34548238762 scopus 로고    scopus 로고
    • Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
    • Khambata-Ford S, Garrett CR, Meropol NJ et al.: Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J. Clin. Oncol. 15(11), 3230-3237 (2007).
    • (2007) J. Clin. Oncol. , vol.15 , Issue.11 , pp. 3230-3237
    • Khambata-Ford, S.1    Garrett, C.R.2    Meropol, N.J.3
  • 57
    • 38649099966 scopus 로고    scopus 로고
    • KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
    • Lievre A, Bachet JB, Boige V et al.: KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J. Clin. Oncol. 26(3), 374-379 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.3 , pp. 374-379
    • Lievre, A.1    Bachet, J.B.2    Boige, V.3
  • 58
    • 40149088765 scopus 로고    scopus 로고
    • KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
    • De Roock W, Piessevaux H, De Schutter J et al.: KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann. Oncol. 19(3), 508-515 (2008).
    • (2008) Ann. Oncol. , vol.19 , Issue.3 , pp. 508-515
    • De Roock, W.1    Piessevaux, H.2    De Schutter, J.3
  • 59
    • 46349092797 scopus 로고    scopus 로고
    • Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients
    • Cappuzzo F, Varella-Garcia M, Finocchiaro G et al.: Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients. Br. J. Cancer. 99(1), 83-89 (2008).
    • (2008) Br. J. Cancer. , vol.99 , Issue.1 , pp. 83-89
    • Cappuzzo, F.1    Varella-Garcia, M.2    Finocchiaro, G.3
  • 60
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado RG, Wolf M, Peeters M et al.: Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J. Clin. Oncol. 26(10), 1626-1634 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.10 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 61
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis CS, Khambata-Ford S, Jonker DJ et al.: K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N. Engl. J. Med. 359(17), 1757-1765 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , Issue.17 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 62
    • 0033818695 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells
    • Ciardiello F, Bianco R, Damiano V et al.: Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells. Clin. Cancer Res. 6(9), 3739-3747 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , Issue.9 , pp. 3739-3747
    • Ciardiello, F.1    Bianco, R.2    Damiano, V.3
  • 63
    • 17944370631 scopus 로고    scopus 로고
    • Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors
    • Shaheen RM, Ahmad SA, Liu W et al.: Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors. Br. J. Cancer. 85(4), 584-589 (2001).
    • (2001) Br. J. Cancer , vol.85 , Issue.4 , pp. 584-589
    • Shaheen, R.M.1    Ahmad, S.A.2    Liu, W.3
  • 64
    • 34147130694 scopus 로고    scopus 로고
    • The role of VEGF and EGFR inhibition: Implications for combining anti-VEGF and anti-EGFR agents
    • Tabernero J: The role of VEGF and EGFR inhibition: implications for combining anti-VEGF and anti-EGFR agents. Mol. Cancer Res. 5(3), 203-220 (2007).
    • (2007) Mol. Cancer Res. , vol.5 , Issue.3 , pp. 203-220
    • Tabernero, J.1
  • 65
    • 35648941728 scopus 로고    scopus 로고
    • Randomized Phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND-2 study
    • Saltz LB, Lenz HJ, Kindler HL et al.: Randomized Phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study. J. Clin. Oncol. 25(29), 4557-4561 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.29 , pp. 4557-4561
    • Saltz, L.B.1    Lenz, H.J.2    Kindler, H.L.3
  • 66
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
    • Tol J, Koopman M, Cats A et al.: Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N. Engl. J. Med. 360(6), 563-572 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , Issue.6 , pp. 563-572
    • Tol, J.1    Koopman, M.2    Cats, A.3
  • 67
    • 77953469904 scopus 로고    scopus 로고
    • Cetuximab plus FOLFOX6 or cetuximab plus FOLFIRI as neoadjuvant treatment of nonresectable colorectal liver metastases: A randomized multicenter study (CELIM-study)
    • Presented at
    • Folprecht G, Gruenberger T, Hartmann J et al.: Cetuximab plus FOLFOX6 or cetuximab plus FOLFIRI as neoadjuvant treatment of nonresectable colorectal liver metastases: a randomized multicenter study (CELIM-study). Presented at: ASCO Gastrointestinal Cancers Symposium. Orlando, FL, USA, January 15-17 2009.
    • ASCO Gastrointestinal Cancers Symposium. Orlando, FL, USA, January 15-17 2009
    • Folprecht, G.1    Gruenberger, T.2    Hartmann, J.3
  • 68
    • 0033392005 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition in cancer therapy: Biology, rationale and preliminary clinical results
    • Huang SM, Harari PM: Epidermal growth factor receptor inhibition in cancer therapy: biology, rationale and preliminary clinical results. Invest. New Drugs 17(3), 259-269 (1999).
    • (1999) Invest. New Drugs , vol.17 , Issue.3 , pp. 259-269
    • Huang, S.M.1    Harari, P.M.2
  • 69
    • 0035398021 scopus 로고    scopus 로고
    • Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer
    • Robert F, Ezekiel MP, Spencer SA et al.: Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer. J. Clin. Oncol. 19(13), 3234-3243 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , Issue.13 , pp. 3234-3243
    • Robert, F.1    Ezekiel, M.P.2    Spencer, S.A.3
  • 70
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
    • Landmark study leading to approval of cetuximab in squamous cell cancer of the head and neck (SCCHN)
    • Bonner JA, Harari PM, Giralt J et al.: Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl. J. Med. 354(6), 567-578 (2006). •• Landmark study leading to approval of cetuximab in squamous cell cancer of the head and neck (SCCHN).
    • (2006) N Engl. J. Med. , vol.354 , Issue.6 , pp. 567-578
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3
  • 71
    • 34250180582 scopus 로고    scopus 로고
    • Open-label, uncontrolled, multicenter Phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy
    • Vermorken JB, Trigo J, Hitt R et al.: Open-label, uncontrolled, multicenter Phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy. J. Clin. Oncol. 25(16), 2171-2177 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.16 , pp. 2171-2177
    • Vermorken, J.B.1    Trigo, J.2    Hitt, R.3
  • 72
    • 23844523253 scopus 로고    scopus 로고
    • Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinum-refractory metastatic and/or recurrent squamous cell carcinoma of the head and neck
    • Landmark study leading to approval of cetuximab in SCCHN
    • Baselga J, Trigo JM, Bourhis J et al.: Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinum-refractory metastatic and/or recurrent squamous cell carcinoma of the head and neck. J. Clin. Oncol. 23(24), 5568-5577 (2005). •• Landmark study leading to approval of cetuximab in SCCHN.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.24 , pp. 5568-5577
    • Baselga, J.1    Trigo, J.M.2    Bourhis, J.3
  • 73
    • 51649085865 scopus 로고    scopus 로고
    • Platinum-based chemotherapy plus cetuximab in head and neck cancer
    • Vermorken JB, Mesia R, Rivera F et al.: Platinum-based chemotherapy plus cetuximab in head and neck cancer. N. Engl. J. Med. 359(11), 1116-1127 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , Issue.11 , pp. 1116-1127
    • Vermorken, J.B.1    Mesia, R.2    Rivera, F.3
  • 74
    • 38849114239 scopus 로고    scopus 로고
    • Randomized Phase II study of cetuximab plus cisplatin/vinorelbine compared with cisplatin/vinorelbine alone as first-line therapy in EGFR-expressing advanced non-small-cell lung cancer
    • Rosell R, Robinet G, Szczesna A et al.: Randomized Phase II study of cetuximab plus cisplatin/vinorelbine compared with cisplatin/vinorelbine alone as first-line therapy in EGFR-expressing advanced non-small-cell lung cancer. Ann. Oncol. 19(2), 362-369 (2008).
    • (2008) Ann. Oncol. , vol.19 , Issue.2 , pp. 362-369
    • Rosell, R.1    Robinet, G.2    Szczesna, A.3
  • 75
    • 33144484457 scopus 로고    scopus 로고
    • Multicenter Phase I/II study of cetuximab with paclitaxel and carboplatin in untreated patients with stage IV non-small-cell lung cancer
    • Thienelt CD, Bunn PA Jr, Hanna N et al.: Multicenter Phase I/II study of cetuximab with paclitaxel and carboplatin in untreated patients with stage IV non-small-cell lung cancer. J. Clin. Oncol. 23(34), 8786-8793 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.34 , pp. 8786-8793
    • Thienelt, C.D.1    Bunn Jr., P.2    Hanna, N.3
  • 76
    • 37649022615 scopus 로고    scopus 로고
    • Randomized Phase II study of gemcitabine plus cisplatin or carboplatin [corrected], with or without cetuximab, as first-line therapy for patients with advanced or metastatic non small-cell lung cancer
    • Butts CA, Bodkin D, Middleman EL et al.: Randomized Phase II study of gemcitabine plus cisplatin or carboplatin [corrected], with or without cetuximab, as first-line therapy for patients with advanced or metastatic non small-cell lung cancer. J. Clin. Oncol. 25(36), 5777-5784 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.36 , pp. 5777-5784
    • Butts, C.A.1    Bodkin, D.2    Middleman, E.L.3
  • 80
    • 4344590997 scopus 로고    scopus 로고
    • Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter Phase II trial
    • Xiong HQ, Rosenberg A, LoBuglio A et al.: Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter Phase II trial. J. Clin. Oncol. 22(13), 2610-2616 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , Issue.13 , pp. 2610-2616
    • Xiong, H.Q.1    Rosenberg, A.2    Lobuglio, A.3
  • 83
    • 58749089260 scopus 로고    scopus 로고
    • Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer
    • Han SW, Oh DY, Im SA et al.: Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer. Br. J. Cancer. 100(2), 298-304 (2009).
    • (2009) Br. J. Cancer , vol.100 , Issue.2 , pp. 298-304
    • Han, S.W.1    Oh, D.Y.2    Im, S.A.3
  • 85
    • 77953364566 scopus 로고    scopus 로고
    • A prospective Phase II study of cetuximab in combination with capecitabine and oxaliplatin (XELOX) in patients with metastatic and/or recurrent advanced gastric cancer
    • Presented at
    • Kim C, Lee J, Ryu M et al.: A prospective Phase II study of cetuximab in combination with capecitabine and oxaliplatin (XELOX) in patients with metastatic and/or recurrent advanced gastric cancer. Presented at: ASCO Gastrointestinal Cancers Symposium. Orlando, FL, USA, January 15-17 2009.
    • ASCO Gastrointestinal Cancers Symposium. Orlando, FL, USA, January 15-17 2009
    • Kim, C.1    Lee, J.2    Ryu, M.3
  • 89
    • 0033559606 scopus 로고    scopus 로고
    • Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy
    • Yang XD, Jia XC, Corvalan J R, Wang P, Davis CG, Jakobovits A: Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy. Cancer Res. 59(6), 1236-1243 (1999). (Pubitemid 29136253)
    • (1999) Cancer Research , vol.59 , Issue.6 , pp. 1236-1243
    • Yang, X.-D.1    Jia, X.-C.2    Corvalan, J.R.F.3    Wang, P.4    Davis, C.G.5    Jakobovits, A.6
  • 90
    • 0035117355 scopus 로고    scopus 로고
    • Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy
    • Yang XD, Jia XC, Corvalan JR, Wang P, Davis CG: Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit. Rev. Oncol. Hematol. 38(1), 17-23 (2001).
    • (2001) Crit. Rev. Oncol. Hematol. , vol.38 , Issue.1 , pp. 17-23
    • Yang, X.D.1    Jia, X.C.2    Corvalan, J.R.3    Wang, P.4    Davis, C.G.5
  • 91
    • 38949178132 scopus 로고    scopus 로고
    • Dose and schedule study of panitumumab monotherapy in patients with advanced solid malignancies
    • Weiner LM, Belldegrun AS, Crawford J et al.: Dose and schedule study of panitumumab monotherapy in patients with advanced solid malignancies. Clin. Cancer Res. 14(2), 502-508 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.2 , pp. 502-508
    • Weiner, L.M.1    Belldegrun, A.S.2    Crawford, J.3
  • 93
    • 34147103678 scopus 로고    scopus 로고
    • Open-label Phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer
    • Registration study for panitumumab as monotherapy in mCRC
    • Van Cutsem E, Peeters M, Siena S et al.: Open-label Phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J. Clin. Oncol. 25(13), 1658-1664 (2007). •• Registration study for panitumumab as monotherapy in mCRC.
    • (2007) J. Clin. Oncol. , vol.25 , Issue.13 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2    Siena, S.3
  • 94
    • 65349189958 scopus 로고    scopus 로고
    • American Society of Clinical Oncology provisional clinical opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
    • Summary statement of relevance of and need to assess KRAS mutation prior to EGFR mAb use in mCRC
    • Allegra CJ, Jessup JM, Somerfield MR et al.: American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J. Clin. Oncol. 27(12), 2091-2096 (2009). •• Summary statement of relevance of and need to assess KRAS mutation prior to EGFR mAb use in mCRC.
    • (2009) J. Clin. Oncol. , vol.27 , Issue.12 , pp. 2091-2096
    • Allegra, C.J.1    Jessup, J.M.2    Somerfield, M.R.3
  • 95
    • 59949102930 scopus 로고    scopus 로고
    • A randomized Phase HIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht JR, Mitchell E, Chidiac T et al.: A randomized Phase HIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J. Clin. Oncol. 27(5), 672-680 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.5 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3
  • 97
    • 4143050397 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and activity of ABX-EGF, a fully human anti-epidermal growth factor receptor monoclonal antibody in patients with metastatic renal cell cancer
    • Rowinsky EK, Schwartz GH, Gollob JA et al.: Safety, pharmacokinetics, and activity of ABX-EGF, a fully human anti-epidermal growth factor receptor monoclonal antibody in patients with metastatic renal cell cancer. J. Clin. Oncol. 22(15), 3003-3015 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , Issue.15 , pp. 3003-3015
    • Rowinsky, E.K.1    Schwartz, G.H.2    Gollob, J.A.3
  • 99
    • 1542344622 scopus 로고    scopus 로고
    • Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumors that express the epidermal growth factor receptor
    • Vanhoefer U, Tewes M, Rojo F et al.: Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumors that express the epidermal growth factor receptor. J. Clin. Oncol. 22(1), 175-184 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , Issue.1 , pp. 175-184
    • Vanhoefer, U.1    Tewes, M.2    Rojo, F.3
  • 100
    • 33846950834 scopus 로고    scopus 로고
    • A Phase II trial of EMD72000 (matuzumab), a humanized anti-EGFR monoclonal antibody, in patients with platinum-resistant ovarian and primary peritoneal malignancies
    • Seiden MV, Burris HA, Matulonis U et al.: A Phase II trial of EMD72000 (matuzumab), a humanized anti-EGFR monoclonal antibody, in patients with platinum-resistant ovarian and primary peritoneal malignancies. Gynecol. Oncol. 104(3), 727-731 (2007).
    • (2007) Gynecol. Oncol. , vol.104 , Issue.3 , pp. 727-731
    • Seiden, M.V.1    Burris, H.A.2    Matulonis, U.3
  • 102
    • 63449142391 scopus 로고    scopus 로고
    • Association of progression-free survival, overall survival, and patient-reported outcomes by skin toxicity and KRAS status in patients receiving panitumumab monotherapy
    • Peeters M, Siena S, Van Cutsem E et al.: Association of progression-free survival, overall survival, and patient-reported outcomes by skin toxicity and KRAS status in patients receiving panitumumab monotherapy. Cancer 115(7), 1544-1554 (2009).
    • (2009) Cancer , vol.115 , Issue.7 , pp. 1544-1554
    • Peeters, M.1    Siena, S.2    Van Cutsem, E.3
  • 103
    • 77953404178 scopus 로고    scopus 로고
    • Phase I/II study of cetuximab dose-escalation in patients with metastatic colorectal cancer (mCRC) with no or slight skin reactions on cetuximab standard dose treatment (EVEREST): Pharmacokinetic (PK), Pharmacodynamic (PD) and efficacy data
    • Presented at Proof-of-principle study prospectively demonstrating the correlation between cetuximab associated skin toxicity and efficacy
    • th Annual Meeting of the American Society of Clinical Oncology. Chicago, IL, USA, June 1-5 2007. • Proof-of-principle study prospectively demonstrating the correlation between cetuximab associated skin toxicity and efficacy.
    • th Annual Meeting of the American Society of Clinical Oncology. Chicago, IL, USA, June 1-5 2007
    • Tejpar, S.1    Peeters, M.2    Humblet, Y.3
  • 104
    • 42449113089 scopus 로고    scopus 로고
    • New York: ImCIone Systems Inc. and Princeton, NJ, USA: Bristol-Myers Squibb Company
    • Erbitux®(cetuximab). Package insert. New York: ImCIone Systems Inc. and Princeton, NJ, USA: Bristol-Myers Squibb Company (2007).
    • (2007) Erbitux®(cetuximab). Package Insert
  • 105
    • 46149098675 scopus 로고    scopus 로고
    • Managing premedications and the risk for reactions to infusional monoclonal antibody therapy
    • Chung CH: Managing premedications and the risk for reactions to infusional monoclonal antibody therapy. Oncologist 13(6), 725-732 (2008).
    • (2008) Oncologist , vol.13 , Issue.6 , pp. 725-732
    • Chung, C.H.1
  • 106
    • 40849142102 scopus 로고    scopus 로고
    • Cetuximab-induced anaphylaxis and IgE specific for galactose-α-1,3- galactose
    • Chung CH, Mirakhur B, Chan E et al.: Cetuximab-induced anaphylaxis and IgE specific for galactose-α-1,3-galactose. N. Engl. J. Med. 358(11), 1109-1117 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , Issue.11 , pp. 1109-1117
    • Chung, C.H.1    Mirakhur, B.2    Chan, E.3
  • 108
    • 34247224987 scopus 로고    scopus 로고
    • Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: A prospective study
    • DOI 10.1016/S1470-2045(07)70108-0, PII S1470204507701080
    • Tejpar S, Piessevaux H, Claes K et al.: Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: a prospective study. Lancet Oncol. 8(5), 387-394 (2007). (Pubitemid 46621761)
    • (2007) Lancet Oncology , vol.8 , Issue.5 , pp. 387-394
    • Tejpar, S.1    Piessevaux, H.2    Claes, K.3    Piront, P.4    Hoenderop, J.G.5    Verslype, C.6    Van Cutsem, E.7
  • 109
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • Demonstrating BRAF mutations also predicts for resistance to EGFR mAbs
    • Di Nicolantonio F, Martini M, Molinari F et al.: Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J. Clin. Oncol. 26(35), 5705-5712 (2008). • Demonstrating BRAF mutations also predicts for resistance to EGFR mAbs.
    • (2008) J. Clin. Oncol. , vol.26 , Issue.35 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3
  • 111
    • 40949135397 scopus 로고    scopus 로고
    • PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab
    • Jhawer M, Goel S, Wilson AJ et al.: PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. Cancer Res. 68(6), 1953-1961 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.6 , pp. 1953-1961
    • Jhawer, M.1    Goel, S.2    Wilson, A.J.3
  • 113
    • 66849140563 scopus 로고    scopus 로고
    • PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer
    • Loupakis F, Pollina L, Stasi I et al.: PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer. J. Clin. Oncol. 27(16), 2622-2629 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.16 , pp. 2622-2629
    • Loupakis, F.1    Pollina, L.2    Stasi, I.3
  • 114
    • 59049089201 scopus 로고    scopus 로고
    • PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients
    • Perrone F, Lampis A, Orsenigo M et al.: PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. Ann. Oncol. 20(1), 84-90 (2009).
    • (2009) Ann. Oncol. , vol.20 , Issue.1 , pp. 84-90
    • Perrone, F.1    Lampis, A.2    Orsenigo, M.3


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