Role of benzo[α]pyrene in generation of clustered DNA damage in human breast tissue

Free Radical Biology and Medicine

Volumn 49, Issue 1, 2010, Pages 77-87

  Sigounas, George ^a,b   Hairr, Jonathan W ^a   Cooke, Charles D ^a   Owen, Jennifer R ^a   Asch, Adam S ^a,b   Weidner, Douglas A ^a   Wiley, John E ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Benzo pyrene; Carcinogens; Clustered DNA damage; Human breast cells; Primary mammary cells; Reactive oxygen species; Total antioxidant capacity

Indexed keywords

AP ENDONUCLEUS 1; BENZO[A]PYRENE; DEOXYRIBONUCLEASE I; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; APEX1 PROTEIN, HUMAN; BENZO[A]PYRENE DERIVATIVE; CARCINOGEN; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE;

APOPTOSIS; ARTICLE; BREAST CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL SURVIVAL; CELL TRANSFORMATION; CHROMOSOME ABERRATION; CHROMOSOME NUMBER; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; ENZYME METABOLISM; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; OXIDATIVE STRESS; PRIORITY JOURNAL; BREAST TUMOR; CELL CULTURE; CHEMICALLY INDUCED; DRUG EFFECTS; FEMALE; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; TISSUE CULTURE TECHNIQUE;

APOPTOSIS; BENZOPYRENES; BREAST NEOPLASMS; CARCINOGENS; CELL PROLIFERATION; CELLS, CULTURED; CHROMOSOME ABERRATIONS; DNA DAMAGE; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; FEMALE; HUMANS; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; TISSUE CULTURE TECHNIQUES;

EID: 77953022695     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.03.018     Document Type: Article

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