Transcriptionally mediated inhibition of telomerase of fungal immunomodulatory protein from Ganoderma tsugae in A549 human lung adenocarcinoma cell line

Molecular Carcinogenesis

Volumn 45, Issue 4, 2006, Pages 220-229

  Liao, Chien Huang ^a   Hsiao, Yi Min ^b   Hsu, Chung Ping ^c,d   Lin, Meei Yn ^e   Wang, James Chun Huan ^a   Huang, Yu Lu ^a   Ko, Jiunn Liang ^a  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

^e NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Fungal immunomodulatory protein; Ganoderma tsugae; Telomerase

Indexed keywords

FUNGAL PROTEIN; LUCIFERASE; MESSENGER RNA; RECOMBINANT FUNGAL IMMUNOMODULATORY PROTEIN GTS; RECOMBINANT PROTEIN; RIBONUCLEOPROTEIN; TELOMERASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL IMMORTALIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; E BOX ELEMENT; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME REPRESSION; ESCHERICHIA COLI; FIBROBLAST; GANODERMA; GANODERMA TSUGAE; GEL MOBILITY SHIFT ASSAY; GENE DELETION; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG CARCINOGENESIS; MOLECULAR CLONING; NONHUMAN; ONCOGENE C MYC; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN ISOLATION; REPORTER GENE; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ADENOCARCINOMA; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; DNA-BINDING PROTEINS; E-BOX ELEMENTS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FIBROBLASTS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LECTINS; LUCIFERASES; LUNG; LUNG NEOPLASMS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-MYC; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TELOMERASE; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

ESCHERICHIA COLI; GANODERMA; GANODERMA TSUGAE;

EID: 33645457460     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20161     Document Type: Article

References (54)

1. Eisenberg DM, Davis RB, Ettner SL, et al. Trends in alternative medicine use in the United States, 1990-1997: Results of a follow-up national survey. Jama 1998;280:1569-1575.
2. Risberg T, Lund E, Wist E, Kaasa S, Wilsgaard T. Cancer patients use of nonproven therapy: A 5-year follow-up study. J Clin Oncol 1998;16:6-12.
3. Wang SY, Hsu ML, Hsu HC, et al. The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T-lymphocytes. Int J Cancer 1997;70:699-705.
4. Zhu M, Chang Q, Wong LK, Chong FS, Li RC. Triterpene antioxidantsfrom Ganoderma lucidum. Phytother Res 1999; 13:529-531.
5. Kim DH, Shim SB, Kim NJ, Jang IS. Beta-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum. Biol Pharm Bull 1999;22:162-164.
6. Kabir Y, Kimura S, Tamura T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1988;34:433-438.
7. Gan KH, Fann YF, Hsu SH, Kuo KW, Lin CN. Mediation of the cytotoxicity of lanostanoids and steroids of Ganoderma tsugae through apoptosis and cell cycle. J Nat Prod 1998; 61:485-487.
8. Ko JL, Hsu CI, Lin RH, Kao CL, Lin JY. A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina velutipes and its complete amino acid sequence. Eur J Biochem 1995;228:244-249.
9. Hsu HC, Hsu CI, Lin RH, Kao CL, Lin JY. Fip-wo, a new fungal immunomodulatory protein isolated from Volvariella volvacea. Biochem J 1997;323:557-565.
10. Wang PH, Hsu CI, Tang SC, Huang YL, Lin JY, Ko JL. Fungal immunomodulatory protein from Flammulina velutipes induces interferon-gamma production through p38 mitogen-activated protein kinase signaling pathway. J Agric Food Chem 2004;52:2721-2725.
11. Greider CW, Blackburn EH. A telomericsequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 1989;337:331-337.
12. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266:2011-2015.
13. Harley CB, Villeponteau B. Telomeres and telomerase in aging and cancer. Curr Opin Genet Dev 1995;5:249-255.
14. Wu TC, Lin P, Hsu CP, et al. Loss of telomerase activity may be a potential favorable prognostic marker in lung carcinomas. Lung Cancer 2003;41:163-169.
15. Counter CM, Meyerson M, Eaton EN, et al. Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. Oncogene 1998;16:1217-1222.
16. Horikawa I, Cable PL, Afshari C, Barrett JC. Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene. Cancer Res 1999;59:826-830.
17. Wick M, Zubov D, Hagen G. Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT). Gene 1999;232:97-106.
18. Kyo S, Takakura M, Kanaya T, et al. Estrogen activates telomerase. Cancer Res 1999;59:5917-5921.
19. Xu D, Popov N, Hou M, et al. Switch from myc/Max to Mad1/ Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. Proc Natl Acad Sci USA 2001;98:3826-3831.
20. Won J, Yim J, Kim TK. Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells. J Biol Chem 2002;277:38230-38238.
21. Budiyanto A, Bito T, Kunisada M, Ashida M, Ichihashi M, Ueda M. Inhibition of the epidermal growth factor receptor suppresses telomerase activity in HSC-1 human cutaneous squamous cell carcinoma cells. J Invest Dermatol 2003;121:1088-1094.
22. Goueli BS, Janknecht R. Upregulation of the Catalytic Telomerase Subunit by the Transcription Factor ER81 and Oncogenic HER2/Neu, Ras, or Raf. Mol Cell Biol 2004;24:25-35.
23. Ikeda N, Uemura H, Ishiguro H, et al. Combination treatment with 1 alpha,25-dihydroxyvitamin D3 and 9-cis-retinoic acid directly inhibits human telomerase reverse transcriptase transcription in prostate cancer cells. Mol Cancer Ther 2003;2:739-746.
24. Kawagoe J, Ohmichi M, Takahashi T, et al. Raloxifene inhibits estrogen-induced upregulation of telomerase activity in a human breast cancer cell line. J Biol Chem 2003;278:43363-43372.
25. Hung CH, Lee MC, Lin MT, Lin JY. Cloning and expression of the gene encoding Acacia confusa trypsin inhibitor that is active without post-translational proteolysis. Gene 1993; 127:215-219.
26. Falchetti ML, Levi A, Molinari P, Verna R, D'Ambrosio E. Increased sensitivity and reproducibility of TRAP assay by avoiding direct primers interaction. Nucleic Acids Res 1998; 26:862-863.
27. Naasani I, Oh-Hashi F, Oh-Hara T, et al. Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo. Cancer Res 2003;63:824-830.
28. Ito H, Kyo S, Kanaya T, Takakura M, Inoue M, Namiki M. Expression of human telomerase subunits and correlation with telomerase activity in urothelial cancer. Clin Cancer Res 1998;4:1603-1608.
29. Liu WJ, Jiang JF, Xiao D, Ding J. Downregulation of telomerase activity via protein phosphatase 2A activation in salvicine-induced human leukemia HL-60 cell apoptosis. Biochem Pharmacol 2002;64:1677-1687.
30. Lopata MA, Cleveland DW, Sollner-Webb B. High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran-mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment. Nucleic Acids Res 1984;12:5707-5717.
31. Weng MW, Hsiao YM, Chen CJ, Wang JP, Chen WC, Ko JL. Benzo[a]pyrene diol epoxide upregulates COX-2 expression through NF-kappaB in rat astrocytes. Toxicol Lett 2004;151:345-355.
32. Haak-Frendscho M, Kino K, Sone T, Jardieu P. Ling Zhi-8: A novel T cell mitogen induces cytokine production and up-regulation of ICAM-1 expression. Cell Immunol 1993;150:101-113.
33. van der Hem LG, van der Vliet JA, Bocken CF, Kino K, Hoitsma AJ, Tax WJ. Ling Zhi-8: Studies of a new immunomodulating agent. Transplantation 1995;60:438-443.
34. Lee JC, Jong HS, Yoo CG, Han SK, Shim YS, Kim YW. Telomerase activity in lung cancer cell lines and tissues. Lung Cancer 1998;21:99-103.
35. Cong YS, Wright WE, Shay JW. Human telomerase and its regulation. Microbiol Mol Biol Rev 2002;66:407-425, table of contents.
36. Kao ST, Yen CC, Hsieh CC, et al. The Chinese medicine Bu-Zhong-Yi-Qi-Tang inhibited proliferation of hepatoma cell lines by inducing apoptosis via G0/G1 arrest. Life Sci 2001; 69:1485-1496.
37. Lee SM, Li ML, Tse YC, et al. Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. Life Sci 2002;71:2267-2277.
38. Hu H, Ahn NS, Yang X, Lee YS, Kang KS. Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. Int J Cancer 2002;102:250-253.
39. Liu JP. Studies of the molecular mechanisms in the regulation of telomerase activity. Faseb J 1999;13:2091-2104.
40. Kondo S, Kondo Y, Li G, Silverman RH, Cowell JK. Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA. Oncogene 1998;16:3323-3330.
41. Hahn WC, Stewart SA, Brooks MW, et al. Inhibition of telomerase limits the growth of human cancer cells. Nat Med 1999;5:1164-1170.
42. Rezler EM, Bearss DJ, Hurley LH. Telomeres and telomerases as drug targets. Curr Opin Pharmacol 2002;2:415-423.
43. Zhang RG, Zhang RP, Wang XW, Xie H. Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells. Cell Res 2002;12:55-62.
44. Lyu SY, Choi SH, Park WB. Korean mistletoe lectin-induced apoptosis in hepatocarcinoma cells is associated with inhibition of telomerase via mitochondrial controlled pathway independent of p53. Arch Pharm Res 2002;25:93-101.
45. Naasani I, Seimiya H, Tsuruo T. Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins. Biochem Biophys Res Commun 1998;249:391-396.
46. Mittal A, Pate MS, Wylie RC, Tollefsbol TO, Katiyar SK. EGCG downregulates telomerase in human breast carcinoma MCF 7 cells, leading to suppression of cell viability and induction of apoptosis. Int J Oncol 2004;24:703-710.
47. Wu KJ, Grandori C, Amacker M, et al. Direct activation of TERT transcription byc-myc. Nat Genet 1999;21:220-224.
48. Ogretmen B, Kraveka JM, Schady D, Usta J, Hannun YA, Obeid LM. Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line. J Biol Chem 2001;276:32506-32514.
49. Gunes C, Lichtsteiner S, Vasserot AP, Englert C. Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1. Cancer Res 2000;60:2116-2121.
50. Veldman T, Liu X, Yuan H, Schlegel R. Human papillomavirus E6 and myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter. Proc Natl Acad Sci USA 2003;100:8211-8216.
51. Takakura M, Kyo S, Kanaya T, et al. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res 1999;59:551-557.
52. Lin SY, Elledge SJ. Multiple tumor suppressor pathways negatively regulate telomerase. Cell 2003;113:881-889.
53. Wang S, Zhu J. Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoter. J Biol Chem 2003;278:18842-18850.
54. Kelland LR. Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics-Current status and future prospects. Eur J Cancer 2005;41:971-979.