Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing

Journal of Bone and Mineral Metabolism

Volumn 27, Issue 3, 2009, Pages 355-363

  Yano, Koichi ^a   Hoshino, Masatoshi ^a   Ohta, Yoichi ^a   Manaka, Tomoya ^a   Naka, Yoshifumi ^a   Imai, Yuuki ^a   Sebald, Walter ^b   Takaoka, Kunio ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

ALP activity; Bone induction; E. coli derived recombinant human bone morphogenetic protein 2; Ectopic bone formation; Heat stability

Indexed keywords

ALKALINE PHOSPHATASE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG ACTIVITY; ESCHERICHIA COLI; HEAT TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OSTEOBLAST; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; THERMOSTABILITY;

EID: 64949097323     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00774-009-0040-3     Document Type: Article

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