Effects induced by BMPS in cultures of human articular chondrocytes: Comparative studies

Growth Factors

Volumn 26, Issue 5, 2008, Pages 275-283

  Chubinskaya, Susan ^a   Segalite, Diane ^a   Pikovsky, Dmitriy ^a   Hakimiyan, Arnavaz A ^a   Rueger, David C ^b  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b Stryker Orthopaedics   (United States)

Author keywords

Bone morphogenetic proteins; Cartilage metabolism; Cartilage derived morphogenetic proteins; Interleukin 1 ; Proteoglycans

Indexed keywords

ALGINIC ACID; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 6; DNA; GROWTH DIFFERENTIATION FACTOR 5; GROWTH FACTOR; INTERLEUKIN 1; INTERLEUKIN 1BETA; OSTEOGENIC PROTEIN 1; PROTEIN CDMP 2; PROTEOGLYCAN; UNCLASSIFIED DRUG;

ANKLE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL CULTURE; CELL METABOLISM; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA CONTENT; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; PROTEOGLYCAN SYNTHESIS;

AGED; AGED, 80 AND OVER; ALGINATES; BONE MORPHOGENETIC PROTEINS; CARTILAGE, ARTICULAR; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CHONDROCYTES; DRUG SYNERGISM; GLUCURONIC ACID; GROWTH DIFFERENTIATION FACTOR 5; HEXURONIC ACIDS; HUMANS; INTERLEUKIN-1BETA; MIDDLE AGED; PROTEOGLYCANS; RECOMBINANT PROTEINS; TIME FACTORS;

EID: 52649083250     PISSN: 08977194     EISSN: 10292292     Source Type: Journal    
DOI: 10.1080/08977190802291733     Document Type: Article

References (44)

1. Blanco, FJ, Geng, Y. and Lotz, M. (1995) Differentiation-dependent effects of IL-1 and TGF-beta on human articular chondrocyte proliferation are related to inducible nitric oxide synthase expression. J Immunol, 154:8, pp. 4018-4026.
2. Bobacz, K., Gruber, R., Soleiman, A., Erlacher, L., Smolen, JS and Graninger, WB (2003) Expression of Bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro. Arthritis Rheum, 48:9, pp. 2501-2508.
3. Chandrasekhar, S., Esterman, MA and Hoffman, HA (1987) Microdetermination of proteoglycans and glycosaminoglycans in the presence of guanidine hydrochloride. Anal Biochem, 161:1, pp. 103-108.
4. Chubinskaya, S., Frank, BS, Michalska, M., Kumar, B., Merrihew, CA, Thonar, EJ-MA, Lenz, ME, Otten, L., Rueger, DC and Block, JA (2006) Osteoarthritic protein-1 in synovial fluid from patients with rheumatoid arthritis or osteoarthritis: Relationship to disease and levels of hyaluronan and antigenic keratan sulfate. Arthritis Res Ther, 8:3, p. R73.
5. Chubinskaya, S., Hurtig, M. and Rueger, DC (2007) OP-1/BMP-7 in cartilage repair. Int Orthop, 31:6, pp. 773-781.
6. Chubinskaya, S., Kumar, B., Merrihew, C., Heretis, K., Rueger, D. and Kuettner, KE (2002) Age-related changes in cartilage endogenous BMP-7. Biochimica Biophysica Acta, 1588:2, pp. 126-134.
7. Del Carlo Jr, M and Loeser, RF (2002) Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species. Arthritis Rheum, 46, pp. 394-403.
8. Dingle, JT, Horner, A. and Shield, M. (1991) The sensitivity of synthesis of human cartilage matrix to inhibition by IL-1 suggests a mechanism for the development of osteoarthritis. Cell Biochem Funct, 9:2, pp. 99-102.
9. Elshaier, AM, Hakimiyan, A., Margulis, A., Rueger, DC and Chubinskaya, S. (2005) Effect of IL-1β on OP-1 signaling in human adult articular chondrocytes. Trans 51st ORS, 30, p. 4.
10. Flechtenmacher, J., Huch, K., Thonar, EJ-MA, Mollenhauer, JA, Davies, SR, Schmid, TM, Puhl, W., Sampath, TK, Aydelotte, MB and Kuettner, KE (1996) Recombinant human osteogenic protein 1 is a potent stimulator of the synthesis of cartilage proteoglycans and collagens by human articular chondrocytes. Arthritis Rheum, 39, pp. 1896-1904.
11. Glansbeek, HL, van Beuningen, HM, Vitters, EL, Morris, EA, van der Kraan, PM and van den Berg, WB (1997) Bone morphogenetic protein-2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin-1 alpha effects on proteoglycan synthesis and content. Arthritis Rheum, 40:6, pp. 1020-1028.
12. Goumans, MJ and Mummery, C. (2000) Functional analysis of the TGFβ receptor/Smad pathway through gene ablation in mice. Int J Dev Biol, 44, pp. 253-265.
13. Grunder, T., Gaissmaier, C., Fritz, J., Stoop, R., Hortschansky, P., Mollenhauer, J. and Aicher, WK (2004) Bone morphogenetic protein (BMP-2) enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads. Osteoarthritis Cartilage, 12, pp. 559-567.
14. Hogan, BLM (1996) Bone morphogenetic proteins: Multifunctional regulators of vertebrate development. Genes Dev, 10, pp. 1580-1594.
15. Huch, K., Wilbrink, B., Flechtenmacher, J., Koepp, HE, Aydelotte, MB, Sampath, TK, Kuettner, KE, Mollenhauer, JA and Thonar, EJ-MA (1997) Effects of recombinant human osteogenic protein 1 on the production of proteoglycan, prostaglandin E2, and interleukin-1 receptor antagonist by human articular chondrocytes cultured in the presence of interleukin-1β. Arthritis Rheum, 40, pp. 2157-2161.
16. Im, HJ, Pacione, C., Chubinskaya, S., Van Wijnen, AJ, Sun, Y. and Loeser, RF (2003) Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes. J Biol Chem, 278, pp. 25386-25394.
17. Itoh, S., Itoh, F., Gourmans, M-J and ten Dijke, P (2000) Signaling of transforming growth factor-β family members through Smad proteins. Eur J Biochem, 267, pp. 6954-6967.
18. Kim, YJ, Sah, RL, Doong, JY and Grodzinsky, AJ (1988) Fluorometric assay of DNA in cartilage explants using Hoechst 33258. Anal Biochem, 174:1, pp. 168-176.
19. Koepp, HE, Sampath, KT, Kuettner, KE and Homandberg, GA (1999) Osteogenic protein-1 (BMP-7) blocks cartilage damage caused by fibronectin fragments and promotes repair by enhancing proteoglycan synthesis. Inflamm Res, 47, pp. 1-6.
20. Loeser, RF, Pacione, CA and Chubinskaya, S. (2003) The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human chondrocytes. Arthritis Rheum, 48:8, pp. 2188-2196.
21. Lotz, M., Blanco, FJ, von Kempis, J., Dudler, J., Maier, R., Villiger, PM and Geng, Y. (1995) Cytokine regulation of chondrocyte functions. J Rheumatol Suppl, 43, pp. 104-108.
22. Luyten, FP, Chen, P., Paralkar, V. and Reddi, AH (1994) Recombinant bone morphogenetic protein-4, transforming growth factor-b, and activin A enhance the cartilage phenotype of articular chondrocytes in vitro. Exp Cell Res, 210, pp. 224-229.
23. Luyten, FP, Yu, YM, Yanagishita, M., Vukicevic, S., Hammonds, RG and Reddi, AH (1992) Natural bovine osteogenin and recombinant human bone morphogenetic protein-2B are equipotent in the maintenance of proteoglycans in bovine articular cartilage explant culture. J Biol Chem, 267, pp. 3691-3695.
24. Massague, J. and Chen, YG (2000) Controlling TGF-β signaling. Genes Dev, 14, pp. 627-644.
25. Masuda, K., Shirota, H. and Thonar, EJ (1994) Quantification of 35S-labeled proteoglycans complexed to alcian blue by rapid filtration in multiwell plates. Anal Biochem, 217:2, pp. 167-175.
26. Merrihew, C., Kumar, B., Heretis, K., Rueger, DC, Kuettner, KE and Chubinskaya, S. (2003) Alterations in endogenous osteogenic protein-1 (BMP-7) with degeneration of human articular cartilage. J Ortho Res, 21:5, pp. 899-907.
27. Merrihew, C., Soeder, S., Rueger, DC, Kuettner, KE and Chubinskaya, S. (2003) Differential response of endogenous osteogenic protein-1 to interleukin-1β. J Bone Joint Surg Am, 85, pp. 67-74.
28. Morris, E. (1996) Differential effects of TGF-beta superfamily members on articular cartilage metabolism: Stimulation by rhBMP-9 and rhBMP-2 and inhibition by TGF-beta. Trans Ortho Res Soc, 42, p. 175.
29. Nishida, Y., Knudson, CB and Knudson, W. (2004) Osteogenic protein-1 inhibits matrix depletion in a hyaluronan hexasaccharide-induced model of osteoarthritis. Osteoarthritis Cart, 12, pp. 374-382.
30. Petit, B., Masuda, K., D'Souza, AL, Otten, L., Pietryla, D., Hartmann, DJ, Morris, NP, Uebelhart, D., Schmid, TM and Thonar, EJ (1996) Characterization of crosslinked collagens synthesized by mature articular chondrocytes cultured in alginate beads: Comparison of two distinct matrix compartments. Exp Cell Res, 225:1, pp. 151-161.
31. Reddi, AH (2003) Cartilage morphogenetic proteins: Role in joint development, homeostasis, and regeneration. Ann Rheum Dis, 62, pp. 73-78.
32. Roberts, AB and Sporn, MB (1990) The transforming growth factor-βs. Peptide growth factors and their receptors part I, 95, pp. 419-472. Springer-Verlag, Berlin
33. Sailor, LZ, Hewick, RM and Morris, EA (1996) Recombinant human bone morphogenetic protein-2 maintains the articular chondrocyte phenotype in long-term culture. J Ortho Res, 14, pp. 937-945.
34. Sampath, TK and Reddi, AH (1981) Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation. Proc Natl Acad Sci USA, 78, pp. 7599-7603.
35. Schier, AF and Shen, MM (2000) Nodal signaling in vertebrate development. Nature, 403, pp. 385-389.
36. Soeder, S., Hakimiyan, A., Rueger, D., Kuettner, KE, Aigner, T. and Chubinskaya, S. (2005) Antisense inhibition of osteogenic protein-1 disturbs human articular cartilage integrity. Arthritis Rheum, 52:2, pp. 468-478.
37. Stewart, MC, Saunders, KM, Burton-Wurster, N. and Macleod, JN (2000) Phenotypic stability of articular chondrocytes in vitro: The effect of culture models, bone morphogenetic protein 2, and serum supplementation. J Bone Miner Res, 15, pp. 166-174.
38. Urist, MR (1997) Bone morphogenetic protein: The molecularization of skeletal system development. J Bone Miner Res, 12:3, pp. 343-346.
39. Urist, MR, Mikulski, A. and Lietze, A. (1979) Solubilized and insolubilized bone morphogenetic protein. Proc Natl Acad Sci USA, 76, pp. 1828-1832.
40. van der Kraan, PM, Vitters, EL, van Beuningen, HM, van de Loo, FAJ and van den Berg, WB (2000) Role of nitric oxide in the inhibition of BMP-2-mediated stimulation of proteoglycan synthesis in articular cartilage. Osteoarthritis Cartilage, 8, pp. 82-86.
41. van Susante, JLC, Buma, P., van Beuningen, HM, van den Berg, WB and Veth, RPH (2000) Responsiveness of bovine chondrocytes to growth factors in medium with different serum concentrations. J Ortho Res, 18, pp. 68-77.
42. Vukicevic, S., Luyten, FP and Reddi, AH (1989) Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitro by osteogenin. Proc Natl Acad Sci USA, 86, pp. 8793-8797.
43. Wozney, JM, Rosen, V., Celeste, AJ, Mitsock, LM, Whitters, MJ, Kriz, RW, Hewick, RM and Wang, EA (1988) Novel regulators of bone formation: Molecular clones and activities. Science, 242, pp. 1528-1534.
44. Yao, J., Cole, AA, Huch, K. and Kuettner, KE (1996) The effect of BMP-7 on IL-1beta induced gene expressions of matrix metalloproteinases and TIMP in human articular cartilage. Trans ORS, 42, p. 305.