-
1
-
-
77952855344
-
-
National Cancer Institute. Bethesda, MD. Available from: , based on November 2007 SEER data submission, posted to the SEER web site
-
Ries LAG, Melbert D, Krapcho M, et al. SEER cancer statistics review, 1975-2005, National Cancer Institute. Bethesda, MD. Available from: http://seer.cancer.gov/csr/ 1975-2005/, based on November 2007 SEER data submission, posted to the SEER web site, 2008
-
(2008)
-
-
Ries, L.A.G.1
Melbert, D.2
Krapcho, M.3
-
2
-
-
38749131631
-
Expression of MDR1 and GST-pi in osteosarcoma and soft tissue sarcoma and their correlation with chemotherapy resistance
-
Wei L, Song XR, Wang XW, et al. Expression of MDR1 and GST-pi in osteosarcoma and soft tissue sarcoma and their correlation with chemotherapy resistance. Zhonghua Zhong Liu Za Zhi 2006;28(6):445-448
-
(2006)
Zhonghua Zhong Liu Za Zhi
, vol.28
, Issue.6
, pp. 445-448
-
-
Wei, L.1
Song, X.R.2
Wang, X.W.3
-
3
-
-
53049088957
-
Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma
-
Pasello M, Michelacci F, Scionti I, et al. Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma. Cancer Res 2008;68(16):6661-6668
-
(2008)
Cancer Res
, vol.68
, Issue.16
, pp. 6661-6668
-
-
Pasello, M.1
Michelacci, F.2
Scionti, I.3
-
4
-
-
1942538016
-
Staging and prognosis
-
Pollock RE, editor. BC Decker, Inc., Hamiliton, Ontario
-
Pisters P. Staging and prognosis. In: Pollock RE, editor. American Cancer Society Atlas of Clinical Oncology: Soft tissue sarcomas. BC Decker, Inc., Hamiliton, Ontario; 2002. p. 80-88
-
(2002)
American Cancer Society Atlas of Clinical Oncology: Soft Tissue Sarcomas
, pp. 80-88
-
-
Pisters, P.1
-
5
-
-
0015436696
-
Chemotherapy of sarcomas with a combination of adriamycin and dimethyl triazeno imidazole carboxamide
-
Gottlieb JA, Baker LH, Quagliana JM, et al. Chemotherapy of sarcomas with a combination of adriamycin and dimethyl triazeno imidazole carboxamide. Cancer 1972;30:1632-1638
-
(1972)
Cancer
, vol.30
, pp. 1632-1638
-
-
Gottlieb, J.A.1
Baker, L.H.2
Quagliana, J.M.3
-
6
-
-
0020038042
-
Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion
-
Legha SS, Benjamin RS, Mackay B, et al. Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion. Ann Intern Med 1982;96:133-139
-
(1982)
Ann Intern Med
, vol.96
, pp. 133-139
-
-
Legha, S.S.1
Benjamin, R.S.2
MacKay, B.3
-
8
-
-
0025098002
-
Reduced cardiotoxicity of doxorubicin by a 6-hour infusion regimen: A prospective randomized evaluation
-
Shapira J, Gotfried M, Lishner M, Ravid M. Reduced cardiotoxicity of doxorubicin by a 6-hour infusion regimen: a prospective randomized evaluation. Cancer 1990;65:870-873
-
(1990)
Cancer
, vol.65
, pp. 870-873
-
-
Shapira, J.1
Gotfried, M.2
Lishner, M.3
Ravid, M.4
-
9
-
-
18844475615
-
Randomised phase II trial of pegylated liposomal doxorubicin (DOXIL(R)/ CAELYX(R)) versus doxorubicin in the treatment of advanced or metastatic soft tissue sarcoma
-
A study by the EORTC Soft Tissue and Bone Sarcoma Group
-
Judson I, Radford JA, Harris M, et al. Randomised phase II trial of pegylated liposomal doxorubicin (DOXIL(R)/ CAELYX(R)) versus doxorubicin in the treatment of advanced or metastatic soft tissue sarcoma: a study by the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer 2001;37:870-877
-
(2001)
Eur J Cancer
, vol.37
, pp. 870-877
-
-
Judson, I.1
Radford, J.A.2
Harris, M.3
-
10
-
-
0027533415
-
Cyclophosphamide versus ifosfamide: A randomized phase II trial in adult soft-tissue sarcomas
-
The European Organization for Research and Treatment of Cancer [EORTC] Soft Tissue and Bone Sarcoma Group
-
Bramwell VH, Mouridsen HT, Santoro A, et al. Cyclophosphamide versus ifosfamide: a randomized phase II trial in adult soft-tissue sarcomas. The European Organization for Research and Treatment of Cancer [EORTC], Soft Tissue and Bone Sarcoma Group. Cancer Chemother Pharmacol 1993;31(Suppl 2):S180-4
-
(1993)
Cancer Chemother Pharmacol
, vol.31
, Issue.SUPPL. 2
-
-
Bramwell, V.H.1
Mouridsen, H.T.2
Santoro, A.3
-
11
-
-
34547688913
-
Phase III trial of two investigational schedules of ifosfamide compared with standard-dose doxorubicin in advanced or metastatic soft tissue sarcoma
-
A European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study
-
Lorigan P, Verweij J, Papai Z, et al. Phase III trial of two investigational schedules of ifosfamide compared with standard-dose doxorubicin in advanced or metastatic soft tissue sarcoma: a European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study. J Clin Oncol 2007;25(21):3144-3150
-
(2007)
J Clin Oncol
, vol.25
, Issue.21
, pp. 3144-3150
-
-
Lorigan, P.1
Verweij, J.2
Papai, Z.3
-
12
-
-
0035003544
-
A randomised phase II study on neoadjuvant chemotherapy for 'high-risk' adult soft-tissue sarcoma
-
Gortzak E, Azzarelli A, Buesa J, et al. A randomised phase II study on neoadjuvant chemotherapy for 'high-risk' adult soft-tissue sarcoma. Eur J Cancer 2001;37:1096-1103
-
(2001)
Eur J Cancer
, vol.37
, pp. 1096-1103
-
-
Gortzak, E.1
Azzarelli, A.2
Buesa, J.3
-
13
-
-
49049089340
-
A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma
-
Peraiz N, Colterjohn N, Farrokhyar F, et al. A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma. Cancer 2008;113(3):573-581
-
(2008)
Cancer
, vol.113
, Issue.3
, pp. 573-581
-
-
Peraiz, N.1
Colterjohn, N.2
Farrokhyar, F.3
-
14
-
-
0033566150
-
Ecteinascidin 743: A minor groove alkylator that bends DNA toward the major groove
-
Zewail-Foote M, Hurley LH. Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove. J Med Chem 1999;42:2493-2497
-
(1999)
J Med Chem
, vol.42
, pp. 2493-2497
-
-
Zewail-Foote, M.1
Hurley, L.H.2
-
15
-
-
0032844806
-
Effect of ecteinascidin-743 on the interaction between DNA binding proteins and DNA
-
Bonfanti M, La Valle E, Fernandez Sousa Faro JM, et al. Effect of ecteinascidin-743 on the interaction between DNA binding proteins and DNA. Anticancer Drug Des 1999;14:179-186
-
(1999)
Anticancer Drug des
, vol.14
, pp. 179-186
-
-
Bonfanti, M.1
La Valle, E.2
Fernandez Sousa Faro, J.M.3
-
16
-
-
0034612352
-
Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation
-
Jin S, Gorfajn B, Faircloth G, et al. Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation. Proc Natl Acad Sci USA 2000;97:6775-6779
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 6775-6779
-
-
Jin, S.1
Gorfajn, B.2
Faircloth, G.3
-
17
-
-
0035874074
-
Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways
-
Damia G, Silvestri S, Carrassa L, et al. Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways. Int J Cancer 2001;92:583-588
-
(2001)
Int J Cancer
, vol.92
, pp. 583-588
-
-
Damia, G.1
Silvestri, S.2
Carrassa, L.3
-
18
-
-
0035146702
-
Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action
-
Erba E, Bergamaschi D, Bassano L, et al. Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action. Eur J Cancer 2001;37:97-105
-
(2001)
Eur J Cancer
, vol.37
, pp. 97-105
-
-
Erba, E.1
Bergamaschi, D.2
Bassano, L.3
-
19
-
-
17944374027
-
Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotideexcision repair
-
Takebayashi Y, Pourquier P, Zimonjic DB, et al. Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotideexcision repair. Nat Med 2001;7:961-966
-
(2001)
Nat Med
, vol.7
, pp. 961-966
-
-
Takebayashi, Y.1
Pourquier, P.2
Zimonjic, D.B.3
-
20
-
-
2342461682
-
Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy
-
Garcia-Carbonero R, Supko JG, Manola J, et al. Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy. J Clin Oncol 2004;22:1480-1490
-
(2004)
J Clin Oncol
, vol.22
, pp. 1480-1490
-
-
Garcia-Carbonero, R.1
Supko, J.G.2
Manola, J.3
-
21
-
-
20044372153
-
Phase II study of ET-743 in advanced soft tissue sarcomas
-
A European Organisation for the Research and Treatment of Cancer (EORTC) soft tissue and bone sarcoma group trial
-
Le Cesne A, Blay JY, Judson I, et al. Phase II study of ET-743 in advanced soft tissue sarcomas: a European Organisation for the Research and Treatment of Cancer (EORTC) soft tissue and bone sarcoma group trial. J Clin Oncol 2005;23:576-584
-
(2005)
J Clin Oncol
, vol.23
, pp. 576-584
-
-
Le Cesne, A.1
Blay, J.Y.2
Judson, I.3
-
22
-
-
1542398698
-
Phase II study of ecteinascidin-743 in advanced pretreated soft tissue sarcoma patients
-
Yovine A, Riofrio M, Blay JY, et al. Phase II study of ecteinascidin-743 in advanced pretreated soft tissue sarcoma patients. J Clin Oncol 2004;22:890-899
-
(2004)
J Clin Oncol
, vol.22
, pp. 890-899
-
-
Yovine, A.1
Riofrio, M.2
Blay, J.Y.3
-
23
-
-
70249101414
-
Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: Results of a randomized phase II study of two different schedules
-
Demetri GD, Chawla SP, von Mehren M, et al. Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules. J Clin Oncol 2009;27(25):4188-4196
-
(2009)
J Clin Oncol
, vol.27
, Issue.25
, pp. 4188-4196
-
-
Demetri, G.D.1
Chawla, S.P.2
Von Mehren, M.3
-
24
-
-
0033952086
-
Gemcitabine in soft tissue or bone sarcoma resistant to standard chemotherapy: A phase II study
-
Merimsky O, Meller I, Flusser G, et al. Gemcitabine in soft tissue or bone sarcoma resistant to standard chemotherapy: a phase II study. Cancer Chemother Pharmacol 2000;45:177-181
-
(2000)
Cancer Chemother Pharmacol
, vol.45
, pp. 177-181
-
-
Merimsky, O.1
Meller, I.2
Flusser, G.3
-
25
-
-
0344839034
-
Phase II trial of gemcitabine in patients with advanced sarcomas (E1797)
-
A trial of the Eastern Cooperative Oncology Group
-
Okuno S, Ryan LM, Edmonson JH, et al. Phase II trial of gemcitabine in patients with advanced sarcomas (E1797): a trial of the Eastern Cooperative Oncology Group. Cancer 2003;97:1969-1973
-
(2003)
Cancer
, vol.97
, pp. 1969-1973
-
-
Okuno, S.1
Ryan, L.M.2
Edmonson, J.H.3
-
26
-
-
0035424877
-
Phase II clinical investigation of gemcitabine in advanced soft tissue sarcomas and window evaluation of dose rate on gemcitabine triphosphate accumulation
-
Patel SR, Gandhi V, Jenkins J, et al. Phase II clinical investigation of gemcitabine in advanced soft tissue sarcomas and window evaluation of dose rate on gemcitabine triphosphate accumulation. J Clin Oncol 2001;19:3483-3489
-
(2001)
J Clin Oncol
, vol.19
, pp. 3483-3489
-
-
Patel, S.R.1
Gandhi, V.2
Jenkins, J.3
-
27
-
-
33745161449
-
Steroid premedication markedly reduces liver and bone marrow toxicity of trabectedin in advanced sarcoma
-
Grosso F, Dileo P, Sanfilippo R, et al. Steroid premedication markedly reduces liver and bone marrow toxicity of trabectedin in advanced sarcoma. Eur J Cancer 2006;42(10):1484-1490
-
(2006)
Eur J Cancer
, vol.42
, Issue.10
, pp. 1484-1490
-
-
Grosso, F.1
Dileo, P.2
Sanfilippo, R.3
-
28
-
-
34347214071
-
Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: A retrospective study
-
Grosso F, Jones RL, Demetri GD, et al. Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study. Lancet Oncol 2007;8:595-602
-
(2007)
Lancet Oncol
, vol.8
, pp. 595-602
-
-
Grosso, F.1
Jones, R.L.2
Demetri, G.D.3
-
29
-
-
50349083290
-
Sensitivity of myxoid-round cell liposarcoma (MRCL) to trabectedin (T) may be related to a direct effect on the fusion transcript
-
Grosso F, Forni C, Frapolli R, et al. Sensitivity of myxoid-round cell liposarcoma (MRCL) to trabectedin (T) may be related to a direct effect on the fusion transcript. ASCO Meeting Abstracts. 2007;25:10000
-
(2007)
ASCO Meeting Abstracts
, vol.25
, pp. 10000
-
-
Grosso, F.1
Forni, C.2
Frapolli, R.3
-
30
-
-
33748035692
-
Cross-talk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin
-
Herrero AB, Martin-Castellanos C, Marco E, et al. Cross-talk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin. Cancer Res 2006;66:8155-8162
-
(2006)
Cancer Res
, vol.66
, pp. 8155-8162
-
-
Herrero, A.B.1
Martin-Castellanos, C.2
Marco, E.3
-
31
-
-
47549083451
-
DNA repair functionality as a molecular signature for sensitivity(S)/resistance(R) in sarcoma patients (pts) treated with trabectedin (ET-743, Yondelis-)
-
14-18 April; Los Angeles, CA, USA
-
Schoffski P, Grosso F, Taron M. DNA repair functionality as a molecular signature for sensitivity(S)/resistance(R) in sarcoma patients (pts) treated with trabectedin (ET-743, Yondelis-). 98th AACR Annual Meeting; 14-18 April 2007; Los Angeles, CA, USA
-
(2007)
98th AACR Annual Meeting
-
-
Schoffski, P.1
Grosso, F.2
Taron, M.3
-
32
-
-
0028335697
-
Phase II study with docetaxel (Taxotere) in advanced soft tissue sarcomas of the adult
-
EORTC Soft Tissue and Bone Sarcoma Group
-
Van Hoesel QG, Verweij J, Catimel G, et al. Phase II study with docetaxel (Taxotere) in advanced soft tissue sarcomas of the adult. EORTC Soft Tissue and Bone Sarcoma Group. Ann Oncol 1994;5:539-542
-
(1994)
Ann Oncol
, vol.5
, pp. 539-542
-
-
Van Hoesel, Q.G.1
Verweij, J.2
Catimel, G.3
-
33
-
-
34447572873
-
Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: Results of sarcoma alliance for research through collaboration study 002
-
Maki RG, Wathen JK, Patel SR, et al. Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: results of sarcoma alliance for research through collaboration study 002. J Clin Oncol 2007;25(19):2755-2763
-
(2007)
J Clin Oncol
, vol.25
, Issue.19
, pp. 2755-2763
-
-
Maki, R.G.1
Wathen, J.K.2
Patel, S.R.3
-
34
-
-
33748088144
-
Mammalian target of rapamycin inhibitors in sarcomas
-
Okuno S. Mammalian target of rapamycin inhibitors in sarcomas. Curr Opin Oncol 2006;18:360-362
-
(2006)
Curr Opin Oncol
, vol.18
, pp. 360-362
-
-
Okuno, S.1
-
36
-
-
34250175840
-
Kaposi's sarcoma in renal transplant recipients-the impact of proliferation signal inhibitors
-
Campistol JM, Schena FP. Kaposi's sarcoma in renal transplant recipients-the impact of proliferation signal inhibitors. Nephrol Dial Transplant 2007;22(Suppl 1):i17-22
-
(2007)
Nephrol Dial Transplant
, vol.22
, Issue.SUPPL. 1
-
-
Campistol, J.M.1
Schena, F.P.2
-
37
-
-
33847779638
-
Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: Emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma
-
Montaner S. Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma. Cell Cycle 2007; 6:438-443
-
(2007)
Cell Cycle
, vol.6
, pp. 438-443
-
-
Montaner, S.1
-
38
-
-
44249102076
-
Classic mediterranean Kaposi's sarcoma regression with sirolimus treatment
-
Guenova E, Metzler G, Hoetzenecker W, et al. Classic mediterranean Kaposi's sarcoma regression with sirolimus treatment. Arch Dermatol 2008;144:692-693
-
(2008)
Arch Dermatol
, vol.144
, pp. 692-693
-
-
Guenova, E.1
Metzler, G.2
Hoetzenecker, W.3
-
39
-
-
45349095871
-
Targeting mTOR in HIV-negative classic Kaposi's sarcoma
-
Merimsky O, Jiveliouk I, Sagi-Eisenberg R. Targeting mTOR in HIV-negative classic Kaposi's sarcoma. Sarcoma 2008;2008:825093
-
(2008)
Sarcoma
, vol.2008
, pp. 825093
-
-
Merimsky, O.1
Jiveliouk, I.2
Sagi-Eisenberg, R.3
-
40
-
-
0029418483
-
Mechanism of action of sirolimus: New insights into the regulation of G1-phase progression in eukaryotic cells
-
Wiederrecht GJ, Sabers CJ, Brunn GJ, et al. Mechanism of action of sirolimus: new insights into the regulation of G1-phase progression in eukaryotic cells. Prog Cell Cycle Res 1995;1:53-71
-
(1995)
Prog Cell Cycle Res
, vol.1
, pp. 53-71
-
-
Wiederrecht, G.J.1
Sabers, C.J.2
Brunn, G.J.3
-
41
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1a expression and function by the mammalian target of rapamycin
-
Hudson CC, Liu M, Chiang GG, et al. Regulation of hypoxia-inducible factor 1a expression and function by the mammalian target of rapamycin. Mol Cell Biol 2002;22:7004-7014
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
-
42
-
-
0037111665
-
BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin
-
Mayerhofer M, Valent P, Sperr WR, et al. BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin. Blood 2002;100:3767-3775
-
(2002)
Blood
, vol.100
, pp. 3767-3775
-
-
Mayerhofer, M.1
Valent, P.2
Sperr, W.R.3
-
43
-
-
68149103024
-
The insulin-like growth factor-I receptor as an oncogene
-
Werner H, Bruchim I. The insulin-like growth factor-I receptor as an oncogene. Arch Physiol Biochem 2009;115(2):58-71
-
(2009)
Arch Physiol Biochem
, vol.115
, Issue.2
, pp. 58-71
-
-
Werner, H.1
Bruchim, I.2
-
44
-
-
47249106539
-
Targeting insulin-like growth factor 1 receptor in sarcomas
-
Scotlandi K, Picci P. Targeting insulin-like growth factor 1 receptor in sarcomas. Curr Opin Oncol 2008;20(4):419-427
-
(2008)
Curr Opin Oncol
, vol.20
, Issue.4
, pp. 419-427
-
-
Scotlandi, K.1
Picci, P.2
-
45
-
-
34447322566
-
Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
-
Kumar R, Knick VB, Rudolph SK, et al. Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. Mol Cancer Ther 2007;6(7):2012-2021
-
(2007)
Mol Cancer Ther
, vol.6
, Issue.7
, pp. 2012-2021
-
-
Kumar, R.1
Knick, V.B.2
Rudolph, S.K.3
-
46
-
-
27144502652
-
The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006
-
Yu C, Bruzek LM, MengXW, et al. The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006. Oncogene 2005;24:6861-6869
-
(2005)
Oncogene
, vol.24
, pp. 6861-6869
-
-
Yu, C.1
Mengxw, B.L.2
-
47
-
-
73449133782
-
The role of glutathione S-transferases in the mechanism of Brostallicin activation
-
Pezzola S, Antonini G, Geroni C, et al. The role of glutathione S-transferases in the mechanism of Brostallicin activation. Biochemistry 2010;49(1):226-235
-
(2010)
Biochemistry
, vol.49
, Issue.1
, pp. 226-235
-
-
Pezzola, S.1
Antonini, G.2
Geroni, C.3
-
48
-
-
67651158999
-
Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin
-
Guirouilh-Barbat J, Zhang YW, Pommier Y. Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin. Mol Cancer Ther 2009;8(7):1985-1994
-
(2009)
Mol Cancer Ther
, vol.8
, Issue.7
, pp. 1985-1994
-
-
Guirouilh-Barbat, J.1
Zhang, Y.W.2
Pommier, Y.3
-
49
-
-
5144220375
-
Structurally simplified macrolactone analogues of halichondrin B
-
Seletsky BM, Wang Y, Hawkins LD, et al. Structurally simplified macrolactone analogues of halichondrin B. Bioorg Med Chem Lett 2004;14:5547-5550
-
(2004)
Bioorg Med Chem Lett
, vol.14
, pp. 5547-5550
-
-
Seletsky, B.M.1
Wang, Y.2
Hawkins, L.D.3
-
50
-
-
23144433687
-
The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth
-
Jordan MA, Kamath K, Manna T, et al. The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth. Mol Cancer Ther 2005;4:1086-1095
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 1086-1095
-
-
Jordan, M.A.1
Kamath, K.2
Manna, T.3
-
51
-
-
0033817515
-
The mechanism of transport of the multitargeted antifolate. MTA-LY231514, and its cross-resistance pattern in cell with impaired transport of methotrexate
-
Zhao R, Babani S, Gao F, et al. The mechanism of transport of the multitargeted antifolate. MTA-LY231514, and its cross-resistance pattern in cell with impaired transport of methotrexate. Clin Cancer Res 2000;6:3687-3695
-
(2000)
Clin Cancer Res
, vol.6
, pp. 3687-3695
-
-
Zhao, R.1
Babani, S.2
Gao, F.3
-
52
-
-
0031852056
-
Multiple folate enzyme inhibition: Mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA)
-
Shih C, Mendelsohn LG, Chen VJ, Schultz RM. Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA). Adv Enzyme Regul 1998;38:135-152
-
(1998)
Adv Enzyme Regul
, vol.38
, pp. 135-152
-
-
Shih, C.1
Mendelsohn, L.G.2
Chen, V.J.3
Schultz, R.M.4
-
53
-
-
0032898580
-
Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514
-
Schultz RM, Patel VF, Worzalla JF, Shih CA. Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514. Anticancer Res 1999;19:437-443
-
(1999)
Anticancer Res
, vol.19
, pp. 437-443
-
-
Schultz, R.M.1
Patel, V.F.2
Worzalla, J.F.3
Shih, C.A.4
-
54
-
-
0030891198
-
LY231514, a pyrrolo(2,3-d) pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
-
Shih C, Chen VJ, Gossett LS, et al. LY231514, a pyrrolo(2,3-d) pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res 1997;57:1116-2011
-
(1997)
Cancer Res
, vol.57
, pp. 1116-2011
-
-
Shih, C.1
Chen, V.J.2
Gossett, L.S.3
-
55
-
-
38649140450
-
Phase i trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with advanced malignancies
-
Mita MM, Mita AC, Chu QS, et al. Phase I trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with advanced malignancies. J Clin Oncol 2008;26(3):361-367
-
(2008)
J Clin Oncol
, vol.26
, Issue.3
, pp. 361-367
-
-
Mita, M.M.1
Mita, A.C.2
Chu, Q.S.3
-
56
-
-
77952828631
-
Survival results with AP23573, a novel mTOR inhibitor, in patients (pts) with advanced soft tissue or bone sarcomas: Update of phase II trial [10076]
-
Chawla SP, Tolcher AW, Staddon AP, et al. Survival results with AP23573, a novel mTOR inhibitor, in patients (pts) with advanced soft tissue or bone sarcomas: update of phase II trial [10076]. 2007 ASCO Annual Meeting
-
(2007)
ASCO Annual Meeting
-
-
Chawla, S.P.1
Tolcher, A.W.2
Staddon, A.P.3
-
57
-
-
77952861402
-
-
Deforolimus (AP23573) in treatment of sarcoma; SUCCEED (Sarcoma Multi-Center Clinical Evaluation of the Efficacy of Deforolimus) study. Available from
-
Deforolimus (AP23573) in treatment of sarcoma; SUCCEED (Sarcoma Multi-Center Clinical Evaluation of the Efficacy of Deforolimus) study. Available from: http://www.clinicaltrials.gov/ct2/ show/NCT00538239
-
-
-
-
58
-
-
59449111147
-
Inhibition of mTOR radiosensitizes soft tissue sarcoma and tumor vasculature
-
Murphy JD, Spalding AC, Somnay YR, et al. Inhibition of mTOR radiosensitizes soft tissue sarcoma and tumor vasculature. Clin Cancer Res 2009;15(2):589-596
-
(2009)
Clin Cancer Res
, vol.15
, Issue.2
, pp. 589-596
-
-
Murphy, J.D.1
Spalding, A.C.2
Somnay, Y.R.3
-
59
-
-
0020962492
-
Monoclonal antibodies to receptors for insulin and somatomedin-c
-
Kull FC, Jacobs S, Su Y-F, et al. Monoclonal antibodies to receptors for insulin and somatomedin-c. J Biol Chem 1983;258:6561-6566
-
(1983)
J Biol Chem
, vol.258
, pp. 6561-6566
-
-
Kull, F.C.1
Jacobs, S.2
Su, Y.-F.3
-
60
-
-
0028053410
-
In vivo treatment with antibody against IGF-1 receptor suppresses growth of human rhabdomyosarcoma and down-regulates p34
-
Kalebic T, Tsokos M, Helman LJ. In vivo treatment with antibody against IGF-1 receptor suppresses growth of human rhabdomyosarcoma and down-regulates p34. Cancer Res 1994;54:5531-5534
-
(1994)
Cancer Res
, vol.54
, pp. 5531-5534
-
-
Kalebic, T.1
Tsokos, M.2
Helman, L.J.3
-
61
-
-
34548010576
-
Phase i trial involving the pharmacodynamic study of circulating tumour cells, of CP-751, 871 (C), a monoclonal antibody against the insulin-like growth factor-I receptor, with docetaxel in patients with advanced cancer
-
Fong PC, Molife RL, Spicer J, et al. Phase I trial involving the pharmacodynamic study of circulating tumour cells, of CP-751,871 (C), a monoclonal antibody against the insulin-like growth factor-I receptor, with docetaxel in patients with advanced cancer. EurJ Cancer Suppl 2006;4:61
-
(2006)
EurJ Cancer Suppl
, vol.4
, pp. 61
-
-
Fong, P.C.1
Molife, R.L.2
Spicer, J.3
-
62
-
-
33947262154
-
Preclinical in vivo study of new insulin-like growth factor-I receptor-specific inhibitor in Ewing's sarcoma
-
Manara MC, Landuzzi L, Nanni P, et al. Preclinical in vivo study of new insulin-like growth factor-I receptor-specific inhibitor in Ewing's sarcoma. Clin Cancer Res 2007;13:1322-1330
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1322-1330
-
-
Manara, M.C.1
Landuzzi, L.2
Nanni, P.3
-
63
-
-
67650337802
-
Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: A phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043)
-
Sleijfer S, Ray-Coquard I, Papai Z, et al. Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043). J Clin Oncol 2009;27(19):3126-3132
-
(2009)
J Clin Oncol
, vol.27
, Issue.19
, pp. 3126-3132
-
-
Sleijfer, S.1
Ray-Coquard, I.2
Papai, Z.3
-
64
-
-
4944249117
-
BAY43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L, et al. BAY43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64:7099-7109
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
-
65
-
-
33749263469
-
Analysis of transcription and protein expression changes in the 786-O human renal cell carcinoma tumor xenograft model in response to treatment with the multi-kinase inhibitor sorafenib (BAY 43-9006)
-
Levy AP, Pauloski N, Braun D, et al. Analysis of transcription and protein expression changes in the 786-O human renal cell carcinoma tumor xenograft model in response to treatment with the multi-kinase inhibitor sorafenib (BAY 43-9006). Proc Am Assoc Cancer Res 2006;47:213-214
-
(2006)
Proc Am Assoc Cancer Res
, vol.47
, pp. 213-214
-
-
Levy, A.P.1
Pauloski, N.2
Braun, D.3
-
66
-
-
67650293850
-
Phase II study of sorafenib in patients with metastatic or recurrent sarcomas
-
Maki RG, D'Adamo DR, Keohan ML, et al. Phase II study of sorafenib in patients with metastatic or recurrent sarcomas. J Clin Oncol 2009;27(19):3133-3140
-
(2009)
J Clin Oncol
, vol.27
, Issue.19
, pp. 3133-3140
-
-
Maki, R.G.1
D'Adamo, D.R.2
Keohan, M.L.3
-
67
-
-
77952826425
-
Early skin toxicity as a molecular marker of efficacy for tumor control in HCC patients treated with sorafenib
-
Vincenzi B, Santini D, Addeo R, et al. Early skin toxicity as a molecular marker of efficacy for tumor control in HCC patients treated with sorafenib. ESMO Annual Meeting 2009
-
(2009)
ESMO Annual Meeting
-
-
Vincenzi, B.1
Santini, D.2
Addeo, R.3
-
68
-
-
12444268322
-
Phase i and pharmacokinetic study of brostallicin (PNU-166196), a new DNA minor-groove binder, administered intravenously every 3 weeks to adult patients with metastatic cancer
-
Ten Tije AJ, Verweij J, Sparreboom A, et al. Phase I and pharmacokinetic study of brostallicin (PNU-166196), a new DNA minor-groove binder, administered intravenously every 3 weeks to adult patients with metastatic cancer. Clin Cancer Res 2003;9(8):2957-2964
-
(2003)
Clin Cancer Res
, vol.9
, Issue.8
, pp. 2957-2964
-
-
Ten Tije, A.J.1
Verweij, J.2
Sparreboom, A.3
-
69
-
-
33846410662
-
Brostallicin, an agent with potential activity in metastatic soft tissue sarcoma
-
European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. A phase II study from the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
-
Leahy M, Ray-Coquard I, Verweij J, et al. European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. Brostallicin, an agent with potential activity in metastatic soft tissue sarcoma: a phase II study from the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. Eur J Cancer. 2007;43(2):308-315
-
(2007)
Eur J Cancer
, vol.43
, Issue.2
, pp. 308-315
-
-
Leahy, M.1
Ray-Coquard, I.2
Verweij, J.3
-
70
-
-
67449123315
-
Phase i study of eribulin mesylate administered once every 21 days in patients with advanced solid tumors
-
Tan AR, Rubin EH, Walton DC, et al. Phase I study of eribulin mesylate administered once every 21 days in patients with advanced solid tumors. Clin Cancer Res 2009;15(12):4213-4219
-
(2009)
Clin Cancer Res
, vol.15
, Issue.12
, pp. 4213-4219
-
-
Tan, A.R.1
Rubin, E.H.2
Walton, D.C.3
-
71
-
-
67449147109
-
A phase i study of eribulin mesylate (E7389), a mechanistically novel inhibitor of microtubule dynamics, in patients with advanced solid malignancies
-
Goel S, Mita AC, Mita M, et al. A phase I study of eribulin mesylate (E7389), a mechanistically novel inhibitor of microtubule dynamics, in patients with advanced solid malignancies. Clin Cancer Res 2009;15(12):4207-4212
-
(2009)
Clin Cancer Res
, vol.15
, Issue.12
, pp. 4207-4212
-
-
Goel, S.1
Mita, A.C.2
Mita, M.3
-
72
-
-
34249106183
-
Phase i and pharmacokinetic study of pemetrexed with high-dose folic acid supplementation or multivitamin supplementation in patients with locally advanced or metastatic cancer
-
Takimoto CH, Hammond-Thelin LA, Latz JE, et al. Phase I and pharmacokinetic study of pemetrexed with high-dose folic acid supplementation or multivitamin supplementation in patients with locally advanced or metastatic cancer. Clin Cancer Res 2007;13(9):2675-2683
-
(2007)
Clin Cancer Res
, vol.13
, Issue.9
, pp. 2675-2683
-
-
Takimoto, C.H.1
Hammond-Thelin, L.A.2
Latz, J.E.3
-
73
-
-
67449164582
-
Phase i trial of pazopanib in patients with advanced cancer
-
Hurwitz HI, Dowlati A, Saini S, et al. Phase I trial of pazopanib in patients with advanced cancer. Clin Cancer Res 2009;15(12):4220-4227
-
(2009)
Clin Cancer Res
, vol.15
, Issue.12
, pp. 4220-4227
-
-
Hurwitz, H.I.1
Dowlati, A.2
Saini, S.3
-
74
-
-
23044510046
-
Safety and pharmacokinetics of the dual action Raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumors
-
Clark JW, Eder JP, Ryan D, et al. Safety and pharmacokinetics of the dual action Raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumors. Clin Cancer Res 2005;11:5472-5480
-
(2005)
Clin Cancer Res
, vol.11
, pp. 5472-5480
-
-
Clark, J.W.1
Eder, J.P.2
Ryan, D.3
-
75
-
-
20344362911
-
Phase i safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/ 7 days off in patients with advanced, refractory solid tumours
-
Awada A, Hendlisz A, Gil T, et al. Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/ 7 days off in patients with advanced, refractory solid tumours. Br J Cancer 2005;92:1855-1861
-
(2005)
Br J Cancer
, vol.92
, pp. 1855-1861
-
-
Awada, A.1
Hendlisz, A.2
Gil, T.3
-
76
-
-
27144527372
-
Phase i study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors
-
Moore M, Hirte HW, Siu L, et al. Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors. Ann Oncol 2005;16:1688-1694
-
(2005)
Ann Oncol
, vol.16
, pp. 1688-1694
-
-
Moore, M.1
Hirte, H.W.2
Siu, L.3
-
77
-
-
20044382799
-
Phase i clinical and pharmacokinetic study of the novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors
-
Strumberg D, Richly H, Hilger RA, et al. Phase I clinical and pharmacokinetic study of the novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. J Clin Oncol 2005;23:965-972
-
(2005)
J Clin Oncol
, vol.23
, pp. 965-972
-
-
Strumberg, D.1
Richly, H.2
Hilger, R.A.3
|