-
1
-
-
33646591352
-
-
Atlanta: American Cancer Society
-
American Cancer Society. Cancer Facts and Figures 2006. Atlanta: American Cancer Society; 2006.
-
(2006)
Cancer Facts and Figures 2006
-
-
-
2
-
-
0027256397
-
Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas
-
Edmonson JH, Ryan LM, Blum RH, et al. Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas. J Clin Oncol 1993; 11:1269-1275.
-
(1993)
J Clin Oncol
, vol.11
, pp. 1269-1275
-
-
Edmonson, J.H.1
Ryan, L.M.2
Blum, R.H.3
-
3
-
-
0142121411
-
Imatinib mesylate (STI-571 Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target. Results from an EORTC Soft Tissue and Bone Sarcoma Group phase II study
-
Verweij J, van Oosterom A, Blay JY. Imatinib mesylate (STI-571 Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target. Results from an EORTC Soft Tissue and Bone Sarcoma Group phase II study. Eur J Cancer 2003; 39:2006-2011.
-
(2003)
Eur J Cancer
, vol.39
, pp. 2006-2011
-
-
Verweij, J.1
Van Oosterom, A.2
Blay, J.Y.3
-
4
-
-
0035810148
-
Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor
-
Joensuu H, Roberts PJ, Sarlomo-Rikala M, et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med 2001; 344:1052-1056.
-
(2001)
N Engl J Med
, vol.344
, pp. 1052-1056
-
-
Joensuu, H.1
Roberts, P.J.2
Sarlomo-Rikala, M.3
-
5
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002; 347:472-480.
-
(2002)
N Engl J Med
, vol.347
, pp. 472-480
-
-
Demetri, G.D.1
Von Mehren, M.2
Blanke, C.D.3
-
6
-
-
0037096747
-
Gemcitabine and docetaxel in patients with unresectable leiomyosarcoma: Results of a phase II trial
-
Hensley ML, Maki R, Venkatraman E, et al. Gemcitabine and docetaxel in patients with unresectable leiomyosarcoma: results of a phase II trial. J Clin Oncol 2002; 20:2824-2831.
-
(2002)
J Clin Oncol
, vol.20
, pp. 2824-2831
-
-
Hensley, M.L.1
Maki, R.2
Venkatraman, E.3
-
7
-
-
26444442333
-
A phase II trial of temozolomide as a 6-week, continuous, oral schedule in patients with advanced soft tissue sarcoma: A study by the Spanish Group for Research on Sarcomas
-
Garcia del Muro X, Lopez-Pousa A, Martin J. A phase II trial of temozolomide as a 6-week, continuous, oral schedule in patients with advanced soft tissue sarcoma: a study by the Spanish Group for Research on Sarcomas. Cancer 2005; 104:1706-1712.
-
(2005)
Cancer
, vol.104
, pp. 1706-1712
-
-
Garcia Del Muro, X.1
Lopez-Pousa, A.2
Martin, J.3
-
8
-
-
7944223834
-
Targeting the mammalian target of rapamycin (mTOR): A new approach to treating cancer
-
Chan S. Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer. Br J Cancer 2004; 91:1420-1424.
-
(2004)
Br J Cancer
, vol.91
, pp. 1420-1424
-
-
Chan, S.1
-
9
-
-
27644447574
-
The mammalian target of the rapamycin (mTOR) kinase pathway: Its role in tumorigenesis and targeted antitumor therapy
-
Janus A, Robak T, Smolewski P. The mammalian target of the rapamycin (mTOR) kinase pathway: Its role in tumorigenesis and targeted antitumor therapy. Cell Mol Biol Lett 2005; 10:479-498. The authors present a succinct summary of the role of the mTOR pathway in tumorigenesis.
-
(2005)
Cell Mol Biol Lett
, vol.10
, pp. 479-498
-
-
Janus, A.1
Robak, T.2
Smolewski, P.3
-
10
-
-
0028950217
-
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
-
Sabers CJ, Martin MM, Brunn GJ, et al. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem 1995; 270:815-822.
-
(1995)
J Biol Chem
, vol.270
, pp. 815-822
-
-
Sabers, C.J.1
Martin, M.M.2
Brunn, G.J.3
-
11
-
-
17044411266
-
Phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of AP23573 an mTOR inhibitor administered IV daily x 5 every other week inpatients with refractory or advanced malignancies
-
Mita MM, Rowinsky EK, Goldston ML, et al. Phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of AP23573 an mTOR inhibitor administered IV daily x 5 every other week inpatients with refractory or advanced malignancies [abstract]. Proc Annu Meet Am Soc Clin Oncol 2005; 23:3076.
-
(2005)
Proc Annu Meet Am Soc Clin Oncol
, vol.23
, pp. 3076
-
-
Mita, M.M.1
Rowinsky, E.K.2
Goldston, M.L.3
-
13
-
-
2942735384
-
Safety and pharmacokinetic of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
-
Raymond E, Alexandre J, Faivre S, et al. Safety and pharmacokinetic of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol 2004; 22:2336-2347.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2336-2347
-
-
Raymond, E.1
Alexandre, J.2
Faivre, S.3
-
14
-
-
0036830256
-
Inhibitor of mTOR reverses doxorubicin resistance conferred by PTEN status in prostate cancer cells
-
Grunwald V, DeGrafenried L, Russel D. Inhibitor of mTOR reverses doxorubicin resistance conferred by PTEN status in prostate cancer cells. Cancer Res 2002; 62:6141-6145.
-
(2002)
Cancer Res
, vol.62
, pp. 6141-6145
-
-
Grunwald, V.1
DeGrafenried, L.2
Russel, D.3
-
15
-
-
26044479980
-
A phase I/II trial of the oral mTOR inhibitor everolimus (E) and imatinib mesylae (IM) in patients (pts) with gastrointestinal stromal tumor (GIST) refractory to IM: Study update
-
van Ooosterom A, Reichart P, Blay J, et al. A phase I/II trial of the oral mTOR inhibitor everolimus (E) and imatinib mesylae (IM) in patients (pts) with gastrointestinal stromal tumor (GIST) refractory to IM: Study update [abstract]. Proc Annu Meet Am Soc Clin Oncol 2005; 23:9033.
-
(2005)
Proc Annu Meet Am Soc Clin Oncol
, vol.23
, pp. 9033
-
-
Van Ooosterom, A.1
Reichart, P.2
Blay, J.3
-
16
-
-
0036189675
-
Progression-free rate as the principal end-point for phase II trials in soft-tissue sarcomas
-
Glabbeke M, Verweij J, Judson I, et al. Progression-free rate as the principal end-point for phase II trials in soft-tissue sarcomas. Eur J Cancer 2002; 38:543-549.
-
(2002)
Eur J Cancer
, vol.38
, pp. 543-549
-
-
Glabbeke, M.1
Verweij, J.2
Judson, I.3
-
17
-
-
23944453425
-
Phase II trial of Temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group Study
-
Galanis E, Buckner JC, Mauere MJ, et al. Phase II trial of Temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group Study. J Clin Oncol 2005; 23:5294-5304.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5294-5304
-
-
Galanis, E.1
Buckner, J.C.2
Mauere, M.J.3
-
18
-
-
0000183432
-
CCI-779, a rapamycin analog and multifaceted inhibitor of signal transduction: A phase I study
-
Hidalgo M, Rowinsky E, Erlichman E, et al. CCI-779, a rapamycin analog and multifaceted inhibitor of signal transduction: A phase I study [abstract]. Proc Annu Meet Am Soc Clin Oncol 2000; 726.
-
(2000)
Proc Annu Meet Am Soc Clin Oncol
, pp. 726
-
-
Hidalgo, M.1
Rowinsky, E.2
Erlichman, E.3
-
19
-
-
4344602002
-
The biology and clinical relevance of the PTEN tumor suppressor pathway
-
Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol 2004; 22:2954-2963.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2954-2963
-
-
Sansal, I.1
Sellers, W.R.2
-
20
-
-
1842426887
-
Role of PTEN in gastroinestinal stromal tumor progression
-
Ricci R, Maggian N, Castri F, et al. Role of PTEN in gastroinestinal stromal tumor progression. Arch Pathol Lab Med 2004; 128:421-425.
-
(2004)
Arch Pathol Lab Med
, vol.128
, pp. 421-425
-
-
Ricci, R.1
Maggian, N.2
Castri, F.3
-
21
-
-
0037457386
-
PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balance translocation
-
Saito T, Oda Y, Kawaguchi K, et al. PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balance translocation. Int J Cancer 2003; 104:175-178.
-
(2003)
Int J Cancer
, vol.104
, pp. 175-178
-
-
Saito, T.1
Oda, Y.2
Kawaguchi, K.3
-
22
-
-
0345687903
-
Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonin 308, in IGF-II-overexpressing rhabdomyosarcomas cells
-
Wan X, Helman LJ. Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonin 308, in IGF-II-overexpressing rhabdomyosarcomas cells. Oncogene 2003; 22:8205-8211.
-
(2003)
Oncogene
, vol.22
, pp. 8205-8211
-
-
Wan, X.1
Helman, L.J.2
-
23
-
-
33748075865
-
Updated interim results of phase 2 study of the mTOR inhibitor AP 23573 in patients with advanced sarcomas of soft tissue and bone
-
19-21 November 2005; Boca Raton. Alexandria: Connective Tissue Oncology Society; Abstract 447
-
Chawla SP, Tolcher AW, Sankhala KK, et al. Updated interim results of phase 2 study of the mTOR inhibitor AP 23573 in patients with advanced sarcomas of soft tissue and bone. In: Proceedings of the Connective Tissue Oncology Society Meeting; 19-21 November 2005; Boca Raton. Alexandria: Connective Tissue Oncology Society; 2005. Abstract 447.
-
(2005)
Proceedings of the Connective Tissue Oncology Society Meeting
-
-
Chawla, S.P.1
Tolcher, A.W.2
Sankhala, K.K.3
-
24
-
-
33748044025
-
FDA approves new treatment for gastrointestinal and kidney cancer
-
26 January 2006. Bethesda: Rockville: US Food and Drug Administration
-
FDA approves new treatment for gastrointestinal and kidney cancer. FDA News 26 January 2006. Bethesda: Rockville: US Food and Drug Administration; 2006.
-
(2006)
FDA News
-
-
-
25
-
-
12344324487
-
Use of positron emission tomography in localized extremity soft tissue sarcoma treated with neoadjuvant chemotherapy
-
Schuetze SM, Rubin BP, Vernon C, et al. Use of positron emission tomography in localized extremity soft tissue sarcoma treated with neoadjuvant chemotherapy. Cancer 2004; 103:339-348.
-
(2004)
Cancer
, vol.103
, pp. 339-348
-
-
Schuetze, S.M.1
Rubin, B.P.2
Vernon, C.3
-
26
-
-
19944432837
-
Prognostic significance of presoperative 18-F fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging in patients with resectable soft tissue sarcomas
-
Schwarzbach MH, Hinz U, Dimitrakopoulou-Strauss A, et al. Prognostic significance of presoperative 18-F fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging in patients with resectable soft tissue sarcomas. Ann Surg 2005; 241:286-294. The authors provide a good summary on the role of PET scanning in soft tissue sarcomas.
-
(2005)
Ann Surg
, vol.241
, pp. 286-294
-
-
Schwarzbach, M.H.1
Hinz, U.2
Dimitrakopoulou-Strauss, A.3
-
27
-
-
0041984595
-
18FDG-positron emission tomography for the early prediction of response in advanced soft tissue sarcoma treated with imatinib mesylate (Glivec)
-
Stroobants S, Goeminne J, Seegers M, et al. 18FDG-positron emission tomography for the early prediction of response in advanced soft tissue sarcoma treated with imatinib mesylate (Glivec). Eur J Cancer 2003; 29:2012-2020.
-
(2003)
Eur J Cancer
, vol.29
, pp. 2012-2020
-
-
Stroobants, S.1
Goeminne, J.2
Seegers, M.3
-
28
-
-
29444448360
-
Early response evaluation of therapy with AP23573 (an mTOR inhibitor) in sarcoma Fluoro-2-Dexoy-D-Glucose (FDG) positron emission tomography (PET) scan
-
Sankhala KK, Chawala SP, Lagaru A, et al. Early response evaluation of therapy with AP23573 (an mTOR inhibitor) in sarcoma Fluoro-2-Dexoy-D-Glucose (FDG) positron emission tomography (PET) scan. [abstract] Proc Annu Meet Am Soc Clin Oncol 2005; 23:9028.
-
(2005)
[Abstract] Proc Annu Meet Am Soc Clin Oncol
, vol.23
, pp. 9028
-
-
Sankhala, K.K.1
Chawala, S.P.2
Lagaru, A.3
-
29
-
-
0032757213
-
Measurement of clinical and subclinical tumour response using [18F]-fluorodeoxyglucose and positron emission tomography: Review and 1999 EORTC recommendations
-
European Organization for Research and Treatment of Cancer (EORTC) PET Study Group
-
Young H, Baum R, Cremerius U, et al. Measurement of clinical and subclinical tumour response using [18F]-fluorodeoxyglucose and positron emission tomography: review and 1999 EORTC recommendations. European Organization for Research and Treatment of Cancer (EORTC) PET Study Group. J Cancer 1999; 35:1773-1782.
-
(1999)
J Cancer
, vol.35
, pp. 1773-1782
-
-
Young, H.1
Baum, R.2
Cremerius, U.3
-
30
-
-
8344238409
-
A phase I trial of a novel mTOR inhibitor AP23573 administered weekly (wkly) in patients with refractory or advanced malignancies: A pharmacokinetic (PK) and pharmacoanalysis
-
Desai AA, Janisch L, Berk LR, et al. A phase I trial of a novel mTOR inhibitor AP23573 administered weekly (wkly) in patients with refractory or advanced malignancies: a pharmacokinetic (PK) and pharmacoanalysis [abstract]. Proc Annu Meet Am Soc Clin Oncol 2004; 3150.
-
(2004)
Proc Annu Meet Am Soc Clin Oncol
, pp. 3150
-
-
Desai, A.A.1
Janisch, L.2
Berk, L.R.3
-
31
-
-
28344456323
-
A phase I study with tumor molecular pharmacodynamic (MPD) evaluation of dose schedule of the oral mTOR inhibitor Everolimus (RAD001) in patients (PTS) with advanced tumors
-
Tabernero J, Rojo F, Burris H, et al. A phase I study with tumor molecular pharmacodynamic (MPD) evaluation of dose schedule of the oral mTOR inhibitor Everolimus (RAD001) in patients (PTS) with advanced tumors [abstract]. Proc Annu Meet Am Soc Clin Oncol 2005; 23:3007.
-
(2005)
Proc Annu Meet Am Soc Clin Oncol
, vol.23
, pp. 3007
-
-
Tabernero, J.1
Rojo, F.2
Burris, H.3
|