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Volumn 20, Issue 4, 2008, Pages 400-406

New targets for therapy of sarcoma

Author keywords

Insulinlike growth factor 1 receptor; Mammalian target of rapamycin inhibitor; Sarcoma; Targeted therapy; Vascular endothelial growth factor receptor.

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; AMG 479; ANTHRACYCLINE; BEVACIZUMAB; CEDIRANIB; CETUXIMAB; CP 751871; DEFOROLIMUS; DOCETAXEL; DOXORUBICIN; ERLOTINIB; EVEROLIMUS; GEFITINIB; GEMCITABINE; IFOSFAMIDE; IMATINIB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; NVP AEW 541; PAZOPANIB; PLATELET DERIVED GROWTH FACTOR RECEPTOR; R 1507; RAPAMYCIN; SCH 717454; SEMAXANIB; SOMATOMEDIN C RECEPTOR; SORAFENIB; STEM CELL FACTOR RECEPTOR; TEMSIROLIMUS; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN RECEPTOR; ANTINEOPLASTIC AGENT; PROTEIN KINASE INHIBITOR;

EID: 47249110359     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/CCO.0b013e328303671d     Document Type: Review
Times cited : (21)

References (62)
  • 2
    • 34249723214 scopus 로고    scopus 로고
    • Opportunities for improving the therapeutic ratio for patients with sarcoma
    • An excellent comprehensive overview of past and future directions in sarcoma therapy
    • Wunder J, Nielsen TO, Maki R, et al. Opportunities for improving the therapeutic ratio for patients with sarcoma. Lancet Oncol 2007; 8:513-524. An excellent comprehensive overview of past and future directions in sarcoma therapy.
    • (2007) Lancet Oncol , vol.8 , pp. 513-524
    • Wunder, J.1    Nielsen, T.O.2    Maki, R.3
  • 3
    • 0029164860 scopus 로고
    • Results of single-agent and combination chemotherapy for advanced soft tissue sarcomas. Implications for decision making in the clinic
    • Demetri G, Elias A. Results of single-agent and combination chemotherapy for advanced soft tissue sarcomas. Implications for decision making in the clinic. Hematol Oncol Clin North Am 1995; 9:765-785.
    • (1995) Hematol Oncol Clin North Am , vol.9 , pp. 765-785
    • Demetri, G.1    Elias, A.2
  • 4
    • 33846705266 scopus 로고    scopus 로고
    • Systemic treatment options for patients with refractory adult-type sarcoma beyond anthracyclines
    • A comprehensive review exploring conventional, targeted, and experimental agents in treatment of advanced sarcoma
    • Hartmann J. Systemic treatment options for patients with refractory adult-type sarcoma beyond anthracyclines. Anticancer Drugs 2007; 18:245-254. A comprehensive review exploring conventional, targeted, and experimental agents in treatment of advanced sarcoma.
    • (2007) Anticancer Drugs , vol.18 , pp. 245-254
    • Hartmann, J.1
  • 5
    • 0027256397 scopus 로고
    • Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas
    • Edmonson J, Ryan L, Blum R, et al. Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas. J Clin Oncol 1993; 11:1269-1275.
    • (1993) J Clin Oncol , vol.11 , pp. 1269-1275
    • Edmonson, J.1    Ryan, L.2    Blum, R.3
  • 6
    • 0029005580 scopus 로고
    • Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: A randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
    • Santoro A, Tursz T, Mouridsen H, et al. Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: a randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. J Clin Oncol 1995; 13:1537-1545.
    • (1995) J Clin Oncol , vol.13 , pp. 1537-1545
    • Santoro, A.1    Tursz, T.2    Mouridsen, H.3
  • 7
    • 0031865087 scopus 로고    scopus 로고
    • Results of two consecutive trials of dose-intensive chemotherapy with doxorubicin and ifosfamide in patients with sarcomas
    • Patel S, Vadhan-Raj S, Burgess M, et al. Results of two consecutive trials of dose-intensive chemotherapy with doxorubicin and ifosfamide in patients with sarcomas. Am J Clin Oncol 1998; 21:317-321.
    • (1998) Am J Clin Oncol , vol.21 , pp. 317-321
    • Patel, S.1    Vadhan-Raj, S.2    Burgess, M.3
  • 8
    • 34447572873 scopus 로고    scopus 로고
    • Maki R, Wathen J, Patel S, et al. Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: results of Sarcoma Alliance for Research through Collaboration study 002. J Clin Oncol 2007; 25:2755-2763. Randomized study demonstrating superior progression-free and overall survival rates for patients treated with the combination compared to single-agent gemcitabine. The first study to demonstrate a survival advantage from combination chemotherapy in metastatic adult soft tissue sarcoma.
    • Maki R, Wathen J, Patel S, et al. Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: results of Sarcoma Alliance for Research through Collaboration study 002. J Clin Oncol 2007; 25:2755-2763. Randomized study demonstrating superior progression-free and overall survival rates for patients treated with the combination compared to single-agent gemcitabine. The first study to demonstrate a survival advantage from combination chemotherapy in metastatic adult soft tissue sarcoma.
  • 9
    • 0141799898 scopus 로고    scopus 로고
    • Mechanisms of sarcoma development
    • Helman L, Meltzer P. Mechanisms of sarcoma development. Nat Rev Cancer 2003; 3:685-694.
    • (2003) Nat Rev Cancer , vol.3 , pp. 685-694
    • Helman, L.1    Meltzer, P.2
  • 10
    • 33748194240 scopus 로고    scopus 로고
    • Recent developments in the targeting of the mammalian target of rapamycin (mTOR) kinase pathway
    • Smolewski P. Recent developments in the targeting of the mammalian target of rapamycin (mTOR) kinase pathway. Anticancer Drugs 2006; 17:487-549.
    • (2006) Anticancer Drugs , vol.17 , pp. 487-549
    • Smolewski, P.1
  • 11
    • 34548427415 scopus 로고    scopus 로고
    • The biology behind mTOR inhibition in sarcoma
    • The above study provides an in depth review of the mTOR pathway and mechanisms of inhibition. Future directions in mTOR inhibition are also reviewed
    • Wan X, Helman LJ. The biology behind mTOR inhibition in sarcoma. Oncologist 2007; 12:1007-1018. The above study provides an in depth review of the mTOR pathway and mechanisms of inhibition. Future directions in mTOR inhibition are also reviewed.
    • (2007) Oncologist , vol.12 , pp. 1007-1018
    • Wan, X.1    Helman, L.J.2
  • 12
    • 3142594193 scopus 로고    scopus 로고
    • The LKB1 tumor suppressor negatively regulates mTOR signaling
    • Shaw R, Bardeesy N, Manning B, et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 2004; 6:91-99.
    • (2004) Cancer Cell , vol.6 , pp. 91-99
    • Shaw, R.1    Bardeesy, N.2    Manning, B.3
  • 13
    • 0036195196 scopus 로고    scopus 로고
    • AKT proto-oncogene expression is an early event during sporadic colon carcinogenesis
    • Hemant K, Bola F, Dahn L, et al. AKT proto-oncogene expression is an early event during sporadic colon carcinogenesis. Carcinogenesis 2002; 23:201-205.
    • (2002) Carcinogenesis , vol.23 , pp. 201-205
    • Hemant, K.1    Bola, F.2    Dahn, L.3
  • 14
    • 0037096804 scopus 로고    scopus 로고
    • Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma
    • Nanami I, Shuho S, Masafumi I, et al. Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma. Cancer 2002; 94:3127-3134.
    • (2002) Cancer , vol.94 , pp. 3127-3134
    • Nanami, I.1    Shuho, S.2    Masafumi, I.3
  • 15
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I, Sawyers C. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2:489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.2
  • 16
    • 33748088144 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibitors in sarcomas
    • Okuno S. Mammalian target of rapamycin inhibitors in sarcomas. Curr Opin Oncol 2006; 18:360-362.
    • (2006) Curr Opin Oncol , vol.18 , pp. 360-362
    • Okuno, S.1
  • 17
    • 34250013899 scopus 로고    scopus 로고
    • The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas
    • The above article describes an important role of the mTOR pathway in the development of leiomyosarcoma in a mouse model and suggests that inhibition of mTOR in this model has substantial antisarcoma activity
    • Hernando E, Charytonowicz E, Dudas ME, et al. The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas. Nat Med 2007; 13:748-753. The above article describes an important role of the mTOR pathway in the development of leiomyosarcoma in a mouse model and suggests that inhibition of mTOR in this model has substantial antisarcoma activity.
    • (2007) Nat Med , vol.13 , pp. 748-753
    • Hernando, E.1    Charytonowicz, E.2    Dudas, M.E.3
  • 18
    • 0036174289 scopus 로고    scopus 로고
    • Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
    • Guba M, Von Breitenbuch P, Steinbauer M, et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 2002; 8:128-135.
    • (2002) Nat Med , vol.8 , pp. 128-135
    • Guba, M.1    Von Breitenbuch, P.2    Steinbauer, M.3
  • 19
    • 38649140450 scopus 로고    scopus 로고
    • Phase I trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with advanced malignancies
    • A clinical study demonstrating inhibition of target pathway and preliminary activity for novel mTOR inhibitor in solid tumors
    • Mita MM, Mita AC, Tolcher AW, et al. Phase I trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with advanced malignancies. J Clin Oncol 2008; 26:361-367. A clinical study demonstrating inhibition of target pathway and preliminary activity for novel mTOR inhibitor in solid tumors.
    • (2008) J Clin Oncol , vol.26 , pp. 361-367
    • Mita, M.M.1    Mita, A.C.2    Tolcher, A.W.3
  • 20
    • 33750238350 scopus 로고    scopus 로고
    • Updated results of a phase II trial of AP23573, a novel mTOR inhibitor, in patients with advanced soft tissue or bone sarcomas
    • abstract 9505
    • Chawla SP, Tolcher AW, Staddon AP, et al. Updated results of a phase II trial of AP23573, a novel mTOR inhibitor, in patients with advanced soft tissue or bone sarcomas. J Clin Oncol 2006; 24:521s. (abstract 9505).
    • (2006) J Clin Oncol , vol.24
    • Chawla, S.P.1    Tolcher, A.W.2    Staddon, A.P.3
  • 21
    • 33845938611 scopus 로고    scopus 로고
    • A multicenter phase 2 consortium (P2C) study of the mTOR inhibitor CCI-779 in advanced soft tissue sarcomas (STS)
    • abstract 9504
    • Okuno S, Mahoney M, Bailey H, et al. A multicenter phase 2 consortium (P2C) study of the mTOR inhibitor CCI-779 in advanced soft tissue sarcomas (STS). J Clin Oncol 2006; 24:521s. (abstract 9504).
    • (2006) J Clin Oncol , vol.24
    • Okuno, S.1    Mahoney, M.2    Bailey, H.3
  • 22
    • 39749126103 scopus 로고    scopus 로고
    • Phosph-S6 ribosomal protein: A potential new predictive sarcoma marker for targeted, mTOR, therapy
    • This study illustrates the potential for preselection to improve response rate of sarcomas to mTOR inhibitors, but findings need to be validated in prospective trials
    • Iwenofu OH, Lackman RD, Brooks JSJ, et al. Phosph-S6 ribosomal protein: a potential new predictive sarcoma marker for targeted, mTOR, therapy. Mod Pathol 2007; 21:231-237. This study illustrates the potential for preselection to improve response rate of sarcomas to mTOR inhibitors, but findings need to be validated in prospective trials.
    • (2007) Mod Pathol , vol.21 , pp. 231-237
    • Iwenofu, O.H.1    Lackman, R.D.2    Brooks, J.S.J.3
  • 23
    • 29444448360 scopus 로고    scopus 로고
    • Early response evaluation of therapy with AP23573 (an MTOR inhibitor) in sarcoma using (18F)2-fluoro-2deoxy-D-glucose (FDG) positron emission tomography (PET) scan
    • abstract 9028
    • Sankhala KK, Shawla SP, Lagaru A, et al. Early response evaluation of therapy with AP23573 (an MTOR inhibitor) in sarcoma using (18F)2-fluoro-2deoxy-D-glucose (FDG) positron emission tomography (PET) scan. J Clin Oncol 2005; 23:823s. (abstract 9028).
    • (2005) J Clin Oncol , vol.23
    • Sankhala, K.K.1    Shawla, S.P.2    Lagaru, A.3
  • 24
    • 34547523463 scopus 로고    scopus 로고
    • Small molecule signal transduction inhibitors for the treatment of solid tumors
    • Leary A, Johnston S. Small molecule signal transduction inhibitors for the treatment of solid tumors. Cancer Invest 2007; 25:347-365.
    • (2007) Cancer Invest , vol.25 , pp. 347-365
    • Leary, A.1    Johnston, S.2
  • 25
    • 4644312266 scopus 로고    scopus 로고
    • Biology of gastrointestinal stromal tumors
    • Corless C, Fletcher J, Heinrich M. Biology of gastrointestinal stromal tumors. J Clin Oncol 2004; 22:3813-3825.
    • (2004) J Clin Oncol , vol.22 , pp. 3813-3825
    • Corless, C.1    Fletcher, J.2    Heinrich, M.3
  • 26
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    • Demetri G, von Mehren M, Blanke C, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002; 347:472-480.
    • (2002) N Engl J Med , vol.347 , pp. 472-480
    • Demetri, G.1    von Mehren, M.2    Blanke, C.3
  • 27
    • 0037146220 scopus 로고    scopus 로고
    • Potential use of imatinib in Ewing's sarcoma: Evidence for in vitro and in vivo activity
    • Merchant M, Woo C-W, Mackall C, Thiele C. Potential use of imatinib in Ewing's sarcoma: evidence for in vitro and in vivo activity. J Natl Cancer Inst 2002; 94:1673-1679.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1673-1679
    • Merchant, M.1    Woo, C.-W.2    Mackall, C.3    Thiele, C.4
  • 28
    • 0038350031 scopus 로고    scopus 로고
    • C-KIT receptor expression in Ewing's sarcoma: Lack of prognostic value but therapeutic targeting opportunities in appropriate conditions
    • Scotlandi K, Marnara M, Strammiello R, et al. C-KIT receptor expression in Ewing's sarcoma: lack of prognostic value but therapeutic targeting opportunities in appropriate conditions. J Clin Oncol 2003; 21:1952-1960.
    • (2003) J Clin Oncol , vol.21 , pp. 1952-1960
    • Scotlandi, K.1    Marnara, M.2    Strammiello, R.3
  • 29
    • 0036352770 scopus 로고    scopus 로고
    • C-KIT-expressing tumor cells are insensitive to imatinib mesylate
    • Hotfilder M, Lanvers C, Jurgens H, et al. C-KIT-expressing tumor cells are insensitive to imatinib mesylate. Cancer Chemother Pharmacol 2002; 50:167-169.
    • (2002) Cancer Chemother Pharmacol , vol.50 , pp. 167-169
    • Hotfilder, M.1    Lanvers, C.2    Jurgens, H.3
  • 30
    • 34247098863 scopus 로고    scopus 로고
    • Evidence for activation of kit, PDFRα, and PDGFRβ receptors in the Ewing sarcoma family of tumors
    • Bozzi F, Tamborini E, Negri T, et al. Evidence for activation of kit, PDFRα, and PDGFRβ receptors in the Ewing sarcoma family of tumors. Cancer 2007; 109:1638-1645.
    • (2007) Cancer , vol.109 , pp. 1638-1645
    • Bozzi, F.1    Tamborini, E.2    Negri, T.3
  • 31
    • 33847348574 scopus 로고    scopus 로고
    • Do I, Araujo E, Kalil R, et al. Protein expression of KIT and gene mutation of c-kit and PDGFRs in Ewing sarcoma. Pathol Res Pract 2007; 203:127-134. Molecular analysis of c-kit and pdgfr genes in 71 Ewing's samples demonstrating that activating mutations are in c-kit at a very low frequency and are not present in pdgfr.
    • Do I, Araujo E, Kalil R, et al. Protein expression of KIT and gene mutation of c-kit and PDGFRs in Ewing sarcoma. Pathol Res Pract 2007; 203:127-134. Molecular analysis of c-kit and pdgfr genes in 71 Ewing's samples demonstrating that activating mutations are in c-kit at a very low frequency and are not present in pdgfr.
  • 32
    • 37549041711 scopus 로고    scopus 로고
    • A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: A Children's Oncology Group study
    • A controlled clinical trial demonstrating no significant activity of imatinib in Ewing's and other pediatric tumors
    • Bond M, Berstein ML, Pappo A, et al. A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: a Children's Oncology Group study. Pediatr Blood Cancer 2008; 50:254-258. A controlled clinical trial demonstrating no significant activity of imatinib in Ewing's and other pediatric tumors.
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 254-258
    • Bond, M.1    Berstein, M.L.2    Pappo, A.3
  • 33
    • 66749160581 scopus 로고    scopus 로고
    • Chugh R, Thomas D, Wathen P, et al. Imatinib mesylate in soft tissue and bone sarcomas: interim results of a Sarcoma Alliance for Research thru Collaboration (SARC) phase II trial. J Clin Oncol 2004; 22:818s. (abstract 9001). Maris J, Courtright J, Houghton P, et al. Initial testing of the VEGFR inhibitor AZD2171 by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer 2008; 50:581-587. Study describing the screening of small molecule VEGFR inhibitor in vitro and in xenograft model system against a panel of pediatric tumors.
    • Chugh R, Thomas D, Wathen P, et al. Imatinib mesylate in soft tissue and bone sarcomas: interim results of a Sarcoma Alliance for Research thru Collaboration (SARC) phase II trial. J Clin Oncol 2004; 22:818s. (abstract 9001). Maris J, Courtright J, Houghton P, et al. Initial testing of the VEGFR inhibitor AZD2171 by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer 2008; 50:581-587. Study describing the screening of small molecule VEGFR inhibitor in vitro and in xenograft model system against a panel of pediatric tumors.
  • 34
    • 0037402488 scopus 로고    scopus 로고
    • Genetics of dermatofibrosarcoma protuberans family of tumors: From ring chromosomes to tyrosine kinase inhibitor treatment
    • Servent N, Maire G, Pedeutour F, et al. Genetics of dermatofibrosarcoma protuberans family of tumors: from ring chromosomes to tyrosine kinase inhibitor treatment. Genes Chromosomes Cancer 2003; 37:1-19.
    • (2003) Genes Chromosomes Cancer , vol.37 , pp. 1-19
    • Servent, N.1    Maire, G.2    Pedeutour, F.3
  • 35
    • 0036727124 scopus 로고    scopus 로고
    • Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans
    • Rubin BP, Schuetze SM, Eary JF, et al. Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. J Clin Oncol 2002; 20:3586-3591.
    • (2002) J Clin Oncol , vol.20 , pp. 3586-3591
    • Rubin, B.P.1    Schuetze, S.M.2    Eary, J.F.3
  • 36
    • 14144256775 scopus 로고    scopus 로고
    • Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: Imatinib target exploration consortium study B2225
    • McArthur GA, Demetri GD, Van Oosterom A, et al. Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: imatinib target exploration consortium study B2225. J Clin Oncol 2005; 23:866-873.
    • (2005) J Clin Oncol , vol.23 , pp. 866-873
    • McArthur, G.A.1    Demetri, G.D.2    Van Oosterom, A.3
  • 37
    • 34247486113 scopus 로고    scopus 로고
    • A SARC phase II multicenter trial of imatinib mesylate (IM) in patients with aggressive fibromatosis
    • abstract 9515
    • Chugh R, Maki RG, Baker LH, et al. A SARC phase II multicenter trial of imatinib mesylate (IM) in patients with aggressive fibromatosis. J Clin Oncol 2006; 24:523s. (abstract 9515).
    • (2006) J Clin Oncol , vol.24
    • Chugh, R.1    Maki, R.G.2    Baker, L.H.3
  • 38
    • 66749184404 scopus 로고    scopus 로고
    • Fayette J, Dufresne A, Blay JY, et al. Imatinib for the treatment of aggressive fibromatosis/desmoid tumors (AF/DT) failing local treatment: updated outcome and predictive factors for progression free survival. A FNCLCC French Sarcoma Group-GETO study. J Clin Oncol 2007; 25:560s. (abstract 10062).
    • Fayette J, Dufresne A, Blay JY, et al. Imatinib for the treatment of aggressive fibromatosis/desmoid tumors (AF/DT) failing local treatment: updated outcome and predictive factors for progression free survival. A FNCLCC French Sarcoma Group-GETO study. J Clin Oncol 2007; 25:560s. (abstract 10062).
  • 39
    • 36849025758 scopus 로고    scopus 로고
    • Imatinib mesylate in advanced chordoma: A multicenter phase II study
    • abstract 10003
    • Stacchiotti S, Ferrari S, Gronchi A, et al. Imatinib mesylate in advanced chordoma: a multicenter phase II study. J Clin Oncol 2007; 25:545s. (abstract 10003).
    • (2007) J Clin Oncol , vol.25
    • Stacchiotti, S.1    Ferrari, S.2    Gronchi, A.3
  • 40
    • 33645231467 scopus 로고    scopus 로고
    • PDGFRα, PDGRFβ, and KIT expression/activation in conventional chondrosarcoma
    • Lagonigro MS, Tamboini E, Negri T, et al. PDGFRα, PDGRFβ, and KIT expression/activation in conventional chondrosarcoma. J Pathol 2006; 208: 615-623.
    • (2006) J Pathol , vol.208 , pp. 615-623
    • Lagonigro, M.S.1    Tamboini, E.2    Negri, T.3
  • 41
    • 33846900919 scopus 로고    scopus 로고
    • PDGFR-α as a potential therapeutic target in uterine sarcomas
    • Adams SF, Hickson JA, Yamad SD, et al. PDGFR-α as a potential therapeutic target in uterine sarcomas. Gynaecol Oncol 2007; 104:524-528.
    • (2007) Gynaecol Oncol , vol.104 , pp. 524-528
    • Adams, S.F.1    Hickson, J.A.2    Yamad, S.D.3
  • 42
    • 34548476964 scopus 로고    scopus 로고
    • Epidermal growth factor receptor is not amplified in schwannomas
    • Prayson RA, Yoder BJ, Barnett GH. Epidermal growth factor receptor is not amplified in schwannomas. Ann Diagn Pathol 2007; 11:326-329.
    • (2007) Ann Diagn Pathol , vol.11 , pp. 326-329
    • Prayson, R.A.1    Yoder, B.J.2    Barnett, G.H.3
  • 43
    • 0036682199 scopus 로고    scopus 로고
    • Epidermal growth factor signaling pathways are associated with tumorigenesis in the Nfl:p53 mouse tumor model
    • Li H, Velasco-Miguel S, Vass WC, et al. Epidermal growth factor signaling pathways are associated with tumorigenesis in the Nfl:p53 mouse tumor model. Cancer Res 2002; 62:4507-4513.
    • (2002) Cancer Res , vol.62 , pp. 4507-4513
    • Li, H.1    Velasco-Miguel, S.2    Vass, W.C.3
  • 44
    • 33846321419 scopus 로고    scopus 로고
    • Phase II study of erlotinib in metastatic or unresectable malignant peripheral nerve sheath tumors (MPNST)
    • abstract 9518
    • Albritton KH, Rankin C, Coffin CM, et al. Phase II study of erlotinib in metastatic or unresectable malignant peripheral nerve sheath tumors (MPNST). J Clin Oncol 2006; 24:524s. (abstract 9518).
    • (2006) J Clin Oncol , vol.24
    • Albritton, K.H.1    Rankin, C.2    Coffin, C.M.3
  • 45
    • 13444291031 scopus 로고    scopus 로고
    • Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma
    • Thomas D, Giordano TJ, Baker L, et al. Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma. Cancer 2005; 103:830-838.
    • (2005) Cancer , vol.103 , pp. 830-838
    • Thomas, D.1    Giordano, T.J.2    Baker, L.3
  • 46
    • 66749114598 scopus 로고    scopus 로고
    • Blay J, Le Cesne A, Whelan J, et al. Gefitinib in second line treatment of metastatic or locally advanced synovial sarcoma expressing HER1: a phase II trial of EORTC Soft Tissue and Bone Sarcoma Group. J Clin Oncol 2006; 24:524s. (abstract 9517).
    • Blay J, Le Cesne A, Whelan J, et al. Gefitinib in second line treatment of metastatic or locally advanced synovial sarcoma expressing HER1: a phase II trial of EORTC Soft Tissue and Bone Sarcoma Group. J Clin Oncol 2006; 24:524s. (abstract 9517).
  • 47
    • 32944463899 scopus 로고    scopus 로고
    • Angiogenesis
    • Folkman J. Angiogenesis. Annu Rev Med 2006; 57:1-18.
    • (2006) Annu Rev Med , vol.57 , pp. 1-18
    • Folkman, J.1
  • 48
    • 40749125333 scopus 로고    scopus 로고
    • Therapeutic potential for directed tyrosine kinase inhibitor therapy in sarcomas
    • A concise well organized review of TKIs in sarcoma
    • Shor A, Agresta S, Sondak V, et al. Therapeutic potential for directed tyrosine kinase inhibitor therapy in sarcomas. Cancer Control 2008; 15: 47-54. A concise well organized review of TKIs in sarcoma.
    • (2008) Cancer Control , vol.15 , pp. 47-54
    • Shor, A.1    Agresta, S.2    Sondak, V.3
  • 49
    • 16844366948 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: A therapeutic target for tumors of the Ewing's sarcoma family
    • Dalal S, Berry A, Cullinane C, et al. Vascular endothelial growth factor: a therapeutic target for tumors of the Ewing's sarcoma family. Clin Cancer Res 2005; 11:2364-2378.
    • (2005) Clin Cancer Res , vol.11 , pp. 2364-2378
    • Dalal, S.1    Berry, A.2    Cullinane, C.3
  • 50
    • 38549164180 scopus 로고    scopus 로고
    • Initial testing of the VEGFR inhibitor AZD2171 by the Pediatric Preclinical Testing Program
    • Study describing the screening of small molecule VEGFR inhibitor in vitro and in xenograft model system against a panel of pediatric tumors
    • Maris J, Courtright J, Houghton P, et al. Initial testing of the VEGFR inhibitor AZD2171 by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer 2008; 50:581-587. Study describing the screening of small molecule VEGFR inhibitor in vitro and in xenograft model system against a panel of pediatric tumors.
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 581-587
    • Maris, J.1    Courtright, J.2    Houghton, P.3
  • 51
    • 4444250452 scopus 로고    scopus 로고
    • Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas
    • Heymach JV, Desai J, Demetri GD. Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas. Clin Cancer Res 2004; 10:5732-5740.
    • (2004) Clin Cancer Res , vol.10 , pp. 5732-5740
    • Heymach, J.V.1    Desai, J.2    Demetri, G.D.3
  • 52
    • 66749134941 scopus 로고    scopus 로고
    • D'Adamo D, Keohan M, Schuetze S, et al. Clinical results of a phase II study of sorafenib in patients (pts) with non-GIST sarcomas (CTEP study #7060). J Clin Oncol 2007; 25:545s. (abstract 10001).
    • D'Adamo D, Keohan M, Schuetze S, et al. Clinical results of a phase II study of sorafenib in patients (pts) with non-GIST sarcomas (CTEP study #7060). J Clin Oncol 2007; 25:545s. (abstract 10001).
  • 53
    • 66749110938 scopus 로고    scopus 로고
    • Pazopanib (GW786034) in patients with relapsed or refractory soft tissue sarcoma, a phase II study for the EORTC STBSG (EORTC 62043)
    • 3 Nov, Seattle, WA abstract 875
    • Sleijfer S, Ray-Coquard I, Papai Z, et al. Pazopanib (GW786034) in patients with relapsed or refractory soft tissue sarcoma, a phase II study for the EORTC STBSG (EORTC 62043). CTOS 13th Annual Meeting 2007, 3 Nov 2007, Seattle, WA (abstract 875).
    • (2007) CTOS 13th Annual Meeting
    • Sleijfer, S.1    Ray-Coquard, I.2    Papai, Z.3
  • 54
    • 0001823035 scopus 로고    scopus 로고
    • Actions of IGF system proteins from studies of transgenic and gene knockout models
    • Rosenfeld RD, Roberts CT, editors, New Jersey: Humana press;
    • D'Ercole AJ. Actions of IGF system proteins from studies of transgenic and gene knockout models. In: Rosenfeld RD, Roberts CT, editors. The IFG system: molecular biology, physiology, and clinical applications. New Jersey: Humana press; 1999. pp. 545-574.
    • (1999) The IFG system: Molecular biology, physiology, and clinical applications , pp. 545-574
    • D'Ercole, A.J.1
  • 55
    • 0036018897 scopus 로고    scopus 로고
    • The insulin growth factor system as a therapeutic target in colorectal cancer
    • Hassan AB, Macaulay VM. The insulin growth factor system as a therapeutic target in colorectal cancer. Ann Oncol 2002; 13:349-356.
    • (2002) Ann Oncol , vol.13 , pp. 349-356
    • Hassan, A.B.1    Macaulay, V.M.2
  • 56
    • 0025166350 scopus 로고
    • Insulin-like growth factory receptor expression and function in human breast cancer
    • Cullen KJ, Yee D, Sly WS, et al. Insulin-like growth factory receptor expression and function in human breast cancer. Cancer Res 1990; 50:48-53.
    • (1990) Cancer Res , vol.50 , pp. 48-53
    • Cullen, K.J.1    Yee, D.2    Sly, W.S.3
  • 57
    • 0034667606 scopus 로고    scopus 로고
    • Insulin-like growth factor I is a dual effector of multiple myeloma cell growth
    • Ge NL, Rudikoff S. Insulin-like growth factor I is a dual effector of multiple myeloma cell growth. Blood 2000; 96:2856-2861.
    • (2000) Blood , vol.96 , pp. 2856-2861
    • Ge, N.L.1    Rudikoff, S.2
  • 58
    • 42349083307 scopus 로고    scopus 로고
    • Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the Pediatric Preclinical Testing Program
    • study demonstrating significant antitumor effect of humanized monoclonal antibody to IGF-1R in xenograft models of pediatric tumors, doi:10.1002. Preclinical
    • Kolb EA, Gorlick R, Houghton P, et al. Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer 2008; 50:1190-1197; doi:10.1002. Preclinical study demonstrating significant antitumor effect of humanized monoclonal antibody to IGF-1R in xenograft models of pediatric tumors.
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 1190-1197
    • Kolb, E.A.1    Gorlick, R.2    Houghton, P.3
  • 59
    • 20944447905 scopus 로고    scopus 로고
    • Antitumor activity and the insulinlike growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors
    • Scotlandi K, Manara MC, Nicoletti G, et al. Antitumor activity and the insulinlike growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors. Cancer Res 2005; 65:3868-3876.
    • (2005) Cancer Res , vol.65 , pp. 3868-3876
    • Scotlandi, K.1    Manara, M.C.2    Nicoletti, G.3
  • 60
    • 35348815620 scopus 로고    scopus 로고
    • Phase I dose escalation study of the antiinsulin-like growth factor-1 receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors
    • Haluska P, Shaw H, Batzel G, et al. Phase I dose escalation study of the antiinsulin-like growth factor-1 receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors. Clin Cancer Res 2007; 13:5834-5840.
    • (2007) Clin Cancer Res , vol.13 , pp. 5834-5840
    • Haluska, P.1    Shaw, H.2    Batzel, G.3
  • 61
    • 36148976199 scopus 로고    scopus 로고
    • A phase I pharmacokinetic and pharmacodynamic study of AMG 479, a fully human monoclonal antibody against insulin-like growth factor type 1 receptor (IGF-1R), in advanced solid tumors
    • abstract 3002
    • Tolcher AW, Rothenberg ML, Rodon J, et al. A phase I pharmacokinetic and pharmacodynamic study of AMG 479, a fully human monoclonal antibody against insulin-like growth factor type 1 receptor (IGF-1R), in advanced solid tumors. J Clin Oncol 2007; 25:118s. (abstract 3002).
    • (2007) J Clin Oncol , vol.25
    • Tolcher, A.W.1    Rothenberg, M.L.2    Rodon, J.3
  • 62
    • 66749152883 scopus 로고    scopus 로고
    • Activity of R1507, a fully humanized monoclonal antibody IGF-R (insulin-like growth factor receptor) antagonist
    • 3 Nov, Seattle, WA abstract 932
    • Benjamin R, Gore L, Dias C, et al. Activity of R1507, a fully humanized monoclonal antibody IGF-R (insulin-like growth factor receptor) antagonist, in patients with Ewing's sarcoma noted in a phase I study. CTOS 13th Annual Meeting 2007, 3 Nov 2007, Seattle, WA (abstract 932).
    • (2007) patients with Ewing's sarcoma noted in a phase I study. CTOS 13th Annual Meeting
    • Benjamin, R.1    Gore, L.2    Dias, C.3


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