CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 34, Issue 4, 2010, Pages 664-668

  Deng, Shumin ^a   Zhu, Gang ^a   Liu, Fang ^a   Zhang, Hui ^a   Qin, Xue ^a   Li, Lei ^a   Zhiyi, He ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

CYP4F2 V433M; Ischemic stroke; Polymorphism

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; ARACHIDONIC ACID; CYTOCHROME P450; CYTOCHROME P450 4F2; GUANINE; METHIONINE; RESTRICTION ENDONUCLEASE; UNCLASSIFIED DRUG; VALINE;

ADULT; ALLELE; AMINO ACID SUBSTITUTION; ARACHIDONIC ACID METABOLISM; ARTICLE; BLOOD VESSEL TONE; BRAIN BLOOD VESSEL; BRAIN ISCHEMIA; CASE CONTROL STUDY; CHINESE; CONTROLLED STUDY; CORONARY BLOOD VESSEL; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; KIDNEY BLOOD VESSEL; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; POPULATION GENETICS; SEX DIFFERENCE;

ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; BRAIN ISCHEMIA; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHINA; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; MALE; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; REGRESSION ANALYSIS; SEX FACTORS; STROKE;

EID: 77952673811     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2010.03.009     Document Type: Article

References (41)

1. Ariyaratnam R., Casas J.P., Whittaker J., Smeeth L., Hingorani A.D., Sharma P. Genetics of ischaemic stroke among persons of non-European descent: a meta-analysis of eight genes involving approximately 32,500 individuals. PloS Med 2007, 4:e131.
2. Cambj-Sapunar L., Yu M., Harder D.R., Roman R.J. Contribution of 5-hydroxytryptamine1B receptors and 20-hydroxyeiscosatetraenoic acid to fall in cerebral blood flow after subarachnoid hemorrhage. Stroke 2003, 34:1269-1275.
3. Casas J.P., Hingorani A.D., Bautisa L.E., Sharma P. Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls. Arch Neurol 2004, 61:1652-1661.
4. Catto A., Carter A.M., Barrett J.H., Stickland M., Bamford J., Davies J.A., et al. Angiotensin-converting enzyme insertion/deletion polymorphism and cerebrovascular disease. Stroke 1996, 27:435-440.
5. Domingues-Montanari S., Mendioroz M., del Rio-Espinola A., Fernández-Cadenas I., Montaner J. Genetics of stroke: a review of recent advances. Expert Rev Mol Diagn 2008, 8:495-513.
6. Dunn K.M., Renic M., Flasch A.K., Harder D.R., Falck J., Roman R.J. Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 2008, 295:H2455-H2465.
7. Fava C., Montagnana M., Almgren P., Rosberg L., Lippi G., Hedblad B., et al. The V433M variant of the CYP4F2 is associated with ischemic stroke in Male Swedes beyond its effect on blood pressure. Hypertension 2008, 52:373-380.
8. Fleming I. Cytochrome p450 and vascular homeostasis. Circ Res 2001, 89:753-762.
9. Fu Z., Nakayama T., Sato N., Izumi Y., Kasamaki Y., Shindo A., et al. A haplotype of the CYP4F2 gene is associated with cerebral infarction in Japanese men. Am J Hypertens 2008, 21:1216-1223.
10. Fu Z., Nakayama T., Sato N., Izumi Y., Kasamaki Y., Shindo A., et al. Haplotype-based case-control study of the human CYP4F2 gene and essential hypertension in Japanese subjects. Hypertens Res 2008, 31:1719-1726.
11. Fu Z., Nakayama T., Sato N., Izumi Y., Kasamaki Y., Shindo A., et al. A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men. Mol Genet Metab 2009, 96:145-147.
12. Gebremedhin D., Lange A.R., Lowry T.F., Taheri M.R., Birks E.K., Hudetz A.G., et al. Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circ Res 2000, 87:60-65.
13. + channel currents in rat cerebral arterial muscle cells. Am J Physiol Heart Circ Physiol 2008, 294:H107-H120.
14. Hademenos G.J., Alberts M.J., Awad I., Mayberg M., Shepard T., Jagoda A., et al. Advances in the genetics of cerebrovascular disease and stroke. Neurology 2001, 56:997-1008.
15. Harder D.R., Gebremedhin D., Narayanan J., Jefcoat C., Falck J.R., Campbell W.B., et al. Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels. Am J Physiol 1994, 5:H2098-H2107.
16. Hassan A., Markus H.S. Genetics and ischaemic stroke. Brain 2000, 123:1784-1812.
17. Helgadottir A., Manolescu A., Thorleifsson G., Gretarsdottir S., Jonsdottir H., Thorsteinsdottir U., et al. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet 2004, 36:233-239.
18. Holla V.R., Adas F., Imig J.D., Zhao X., Price E., Olsen N., et al. Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proc Natl Acad Sci USA 2001, 98:5211-5216.
19. Kehl F., Cambj-Sapunar L., Maier K.G., Miyata N., Kametani S., Okamoto H., et al. 20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat. Am J Physiol 2002, 282:H1556-H1565.
20. Lasker J.M., Chen W.B., Wolf I., Bloswick B.P., Wilson P.D., Powell P.K. Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11. J Biol Chem 2000, 275:4118-4126.
21. Liu H., Zhao Y.Y., Gong W., Shi J.P., Fu L.Y., Wang J., et al. Correlation analysis and identification of G421C in regulatory region of CYP4F2 gene with essential hypertension. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2006, 28:143-147.
22. Liu M., Wu B., Wang W.Z., Lee L.M., Zhang S.H., Kong L.Z. Stroke in China: epidemiology, prevention, and management strategies. Lancet Neurol 2007, 6:456-464.
23. Liu X., Zhao Y., Wang L., Yang X., Zheng Z., Zhang Y., et al. Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure. Kidney Int 2009, 75:1288-1296.
24. Ma A.J., Pan X.D., Zhang C.S., Xing Y., Zhang Y.N. A linkage between beta-fibrinogen gene-148C/T polymorphism and cerebral infarction. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006, 23:202-204.
25. McGiff J.C., Quilley J. 20-HETE and the kidney: resolution of old problems and new beginnings. Am J Physiol 1999, 277:R607-R623.
26. Miyata N., Roman R.J. Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular system. J Smooth Muscle Res 2005, 41:175-193.
27. Miyata N., Seki T., Tanaka Y., Omura T., Taniguchi K., Doi M., et al. Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl)phenyl-N′-hydroxyimido formamide], on hemorrhagic and ischemic stroke. J Pharmacol Exp Ther 2005, 1:77-85.
28. Nakagawa K., Marji J.S., Schwartzman M.L., Waterman M.R., Capdevila J.H. Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension. Am J Physiol Regul Integr Comp Physiol 2003, 284:R1055-R1062.
29. Needleman P., Turk J., Jakschik B.A., Morrison A.R., Lefkowith J.B. Arachidonic acid metabolism. Ann Rev Biochem 1986, 55:69-102.
30. Omura T., Tanaka Y., Miyata N., Koizumi C., Sakurai T., Fukasawa M., et al. Effect of a new inhibitor of the synthesis of 20-HETE on cerebral ischemia reperfusion injury. Stroke 2006, 37:1307-1313.
31. Poloyac S.M., Zhang Y., Biesl R.R., Kochanek P.M., Graham S.H. Protective effect of the 20-HETE inhibitor HET0016 on brain damage after temporary focal ischemia. J Cereb Blood Flow Metab 2006, 26:1551-1561.
32. Powell P.K., Wolf I., Jin R., Lasker J.M. Metabolism of arachidonic acid to 20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11. J Pharmacol Exp Ther 1998, 285:1327-1336.
33. Renic M., Klaus J.A., Omura T., Kawashima N., Onishi M., Miyata N., et al. Effect of 20-HETE inhibition on infarct volume and cerebral blood flow after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 2009, 29:629-639.
34. Roman R.J. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 2002, 82:131-185.
35. Singh H., Schwartzman M.L. Renal vascular cytochrome P450-derived eicosanoids in androgen-induced hypertension. Pharmacol Rep 2008, 60:29-37.
36. Singh H., Cheng J., Deng H., Kemp R., Ishizuka T., Nasjletti A., et al. Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension. Hypertension 2007, 50:123-129.
37. Staton J.M., Sayer M.S., Hankey G.J., Attia J., Thakkinstian A., Yi Q., et al. Association between phosphodiesterase 4D gene and ischaemic stroke. J Neurol Neurosurg Psychiatry 2006, 77:1067-1069.
38. Stec D.E., Roman R.J., Flasch A., Rieder M.J. Functional polymorphism in human CYP4F2 decreases 20-HETE production. Physiol Genomics 2007, 30:74-81.
39. Tanaka Y., Omura T., Fukasawa M., Horiuchi N., Miyata N., Minagawa T., et al. Continuous inhibition of 20-HETE synthesis by TS-011 improves neurological and functional outcomes after transient focal cerebral ischemia in rats. Neurosci Res 2007, 59:475-480.
40. Ward N.C., Tsai I.J., Barden A., van Bockxmeer F.M., Puddey I.B., Hodgson J.M., et al. A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure. Hypertension 2008, 51:1393-1398.
41. Yousif M.H., Benter I.F., Dunn K.M., Dahly-Vernon A.J., Akhtar S., Roman R.J. Role of 20-hydroxyeicosatetraenoic acid in altering vascular reactivity in diabetes. Auton Autacoid Pharmacol 2009, 29:1-12.