Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure

Kidney International

Volumn 75, Issue 12, 2009, Pages 1288-1296

  Liu, Xiaoliang ^a   Zhao, Yanyan ^a   Wang, Luzeng ^a   Yang, Xianghong ^a   Zheng, Zhihong ^a   Zhang, Yuanyuan ^a   Chen, Fangjie ^a   Liu, Hong ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

20 hydroxyeicosatetraenoic acid; Cytochrome P450 4F2; Hypertension; Transgenic mice

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; CYTOCHROME P450; CYTOCHROME P450 4F2; DNA BINDING PROTEIN; LUCIFERASE; POLYHISTIDINE TAG; PROTEIN KAP; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; HYPERTENSION; KIDNEY MICROSOME; KIDNEY PROXIMAL TUBULE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SYSTOLIC BLOOD PRESSURE; URINARY EXCRETION;

ANIMALS; BASE SEQUENCE; BLOOD PRESSURE; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE MODELS, ANIMAL; DNA, COMPLEMENTARY; GENE EXPRESSION; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; HYPERTENSION; KIDNEY TUBULES, PROXIMAL; MICE; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 67349175768     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2009.67     Document Type: Article

References (27)

1. Lasker JM, Chen WB, Wolf I et al. Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of CYP4F2 and CYP4A11. J. Biol Chem 2000; 275: 4118-4126.
2. McGiff JC, Quilley J. 20-HETE and the kidney: resolution of old problems and new beginnings. Am J Physiol 1999; 277: R607-R623.
3. Miyata N, Roman RJ. Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular system. J Smooth Muscle Res 2005; 41: 175-193.
4. Roman RJ. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 2002; 82: 131-185.
5. Sarkis A, Roman RJ. Role of cytochrome P450 metabolites of arachidonic acid in hypertension. Curr Drug Metab 2004; 5: 245-256.
6. Liu H, Zhao Y, Nie D et al. Association of a functional cytochrome P450 4F2 haplotype with urinary 20-HETE and hypertension. J Am Soc Nephrol 2008; 19: 714-721.
7. Ward NC, Tsai IJ, Barden A et al. A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure. Hypertension 2008; 51: 1393-1398.
8. Gainer JV, Bellamine A, Dawson EP et al. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation 2005; 111: 63-69.
9. Meseguer A, Catterall JF. Mouse kidney androgen-regulated protein messenger ribonucleic acid is expressed in the proximal convoluted tubules. Mol Endocrinol 1987; 1: 535-541.
10. Ding Y, Davisson RL, Hardy DO et al. The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. J Biol Chem 1997; 272: 28142-28148.
11. Ding Y, Sigmund CD. Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice. Am J Physiol Renal Physiol 2001; 280: F54-F60.
12. Lavoie JL, Lake-Bruse KD, Sigmund CD. Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule. Am J Physiol Renal Physiol 2004; 286: F965-F971.
13. Malstrom SE, Tornavaca O, Meseguer A et al. The characterization and hormonal regulation of kidney androgen-regulated protein (Kap)-luciferase transgenic mice. Toxicol Sci 2004; 79: 266-277.
14. Sachetelli S, Liu Q, Zhang SL et al. RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney. Kidney Int 2006; 69: 1016-1023.
15. Soler M, Tornavaca O, Solé E et al. Hormone-specific regulation of the kidney androgen-regulated gene promoter in cultured mouse renal proximal-tubule cells. Biochem J 2002; 366: 757-766.
16. Grates HE, McGowen RM, Gupta SV et al. Quantification of 20-hydroxyeicosatetraenoic acid by colorimetric competitive enzyme linked immunosorbent assay. J Biosci 2003; 28: 109-113.
17. Holla VR, Adas F, Imig JD et al. Alterations in the regulation of androgen-sensitive cyp 4a monooxygenase cause hypertension. Proc Natl Acad Sci USA 2001; 9: 5211-5216.
18. Maier KG, Henderson L, Narayanan J et al. Fluorescent HPLC assay for 20-HETE and other P-450 metabolites of arachidonic acid. Am J Physiol Heart Circ Physiol 2000; 279: H863-H871.
19. Laffer CL, Laniado-Schwartzman M, Wang MH et al. Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic Acid in human salt-sensitive versus salt-resistant hypertension. Circulation 2003; 107: 574-578.
20. Hoagland KM, Flasch AK, Roman RJ. Inhibitors of 20-HETE formation promote salt-sensitive hypertension in rats. Hypertension 2003; 42: 669-673.
21. Zhang F, Chen CL, Qian JQ et al. Long-term modifications of blood pressure in normotensive and spontaneously hypertensive rats by gene delivery of rAAV-mediated cytochrome P450 arachidonic acid hydroxylase. Cell Res 2005; 15: 717-724.
22. Iwai N, Inagami T. Isolation of preferentially expressed genes in the kidneys hypertensive rats. Hypertension 1991; 17: 161-169.
23. Su P, Kaushal KM, Kroetz DL. Inhibition of renal arachidonic acid omega-hydroxylase activity with ABT reduces blood pressure in the SHR. Am J Physiol 1998; 275: R426-R438.
24. Bianco RA, Keen HL, Lavoie JL et al. Untraditional methods for targeting the kidney in transgenic mice. Am J Physiol Renal Physiol 2003; 285: F1027-F1033.
25. Meseguer A, Catterall JF. Cell-specific expression of kidney androgen-regulated protein messenger RNA is under multihormonal control. Mol Endocrinol 1990; 4: 1240-1248.
26. Nakagawa K, Marji JS, Schwartzman ML et al. The androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension. Am J Physiol Regul Integr Comp Physiol 2003; 284: R1055-R1062.
27. Ward NC, Rivera J, Hodgson J et al. Urinary 20- hydroxyeicosatetraenoic acid is associated with endothelial dysfunction in humans. Circulation 2004; 110: 438-443.