Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension

Hypertension

Volumn 50, Issue 1, 2007, Pages 123-129

  Singh, Harpreet ^a   Cheng, Jennifer ^a   Deng, Huan ^a   Kemp, Rowena ^a   Ishizuka, Tsuneo ^a   Nasjletti, Alberto ^a   Schwartzman, Michal Laniado ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

20 HETE; Cytochrome P450; Endothelial dysfunction; Hypertension; NO; Superoxide anion

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; ACETYLCHOLINE; ANDROSTANOLONE; CYTOCHROME P450 4A; CYTOCHROME P450 INHIBITOR; HET 0016; N HYDROXY N' (4 BUTYL 2 METHYLPHENYL)FORMAMIDINE; PHENYLEPHRINE; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; ENDOTHELIAL DYSFUNCTION; FATTY ACID SYNTHESIS; KIDNEY ARTERY; MALE; NITROSYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; WESTERN BLOTTING;

ACETYLCHOLINE; ALKANE 1-MONOOXYGENASE; AMIDINES; ANIMALS; BLOOD PRESSURE; DIHYDROTESTOSTERONE; DRUG SYNERGISM; ENDOTHELIUM, VASCULAR; HYDROXYEICOSATETRAENOIC ACIDS; HYPERTENSION; MALE; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; RENAL ARTERY; SUPEROXIDES; VASODILATION; VASODILATOR AGENTS;

EID: 34250847145     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.107.089599     Document Type: Article

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