Matrix Effects-A Challenge Toward Automation of Molecular Analysis

JALA - Journal of the Association for Laboratory Automation

Volumn 15, Issue 3, 2010, Pages 233-242

  Chiu, May L ^a   Lawi, Walson ^a   Snyder, Steven T ^a   Wong, Pak Kin ^b   Liao, Joseph C ^b,c   Gau, Vincent ^a  

^a GeneFluidics Inc   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Electrokinetics; Laboratory automation; Matrix effects; Microfluidics; Point of care; Saliva; Sample preparation; Urine; Whole blood

Indexed keywords

LABORATORY AUTOMATION; MATRIX EFFECTS; POINT OF CARE; SAMPLE PREPARATION; WHOLE BLOOD;

ASSAYS; AUTOMATION; BLOOD; COST REDUCTION; ELECTRODYNAMICS; ELECTROMAGNETIC FIELDS; ELECTROOSMOSIS; LABORATORIES; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; SOLVENT EXTRACTION;

MICROFLUIDICS;

ANALYTIC METHOD; ARTICLE; AUTOMATION; BLOOD ANALYSIS; CONDUCTANCE; IMMUNOASSAY; IONIC STRENGTH; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MICROFLUIDICS; MOLECULAR DYNAMICS; NUCLEIC ACID HYBRIDIZATION; PH; PRECIPITATION; PROCESS OPTIMIZATION; PURIFICATION; REPRODUCIBILITY; SENSITIVITY ANALYSIS; SOLID PHASE EXTRACTION; SURFACE PLASMON RESONANCE; TANDEM MASS SPECTROMETRY; URINALYSIS;

EID: 77952592278     PISSN: 15355535     EISSN: 15402452     Source Type: Journal    
DOI: 10.1016/j.jala.2010.02.001     Document Type: Article

References (110)

1. Viswanathan C.T., Bansal S., Booth B., DeStefano A.J., Rose M.J., Sailstad J., Shah V.P., Skelly S.P., Swann P.G., Weiner W. Workshop/conference report-Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays. AAPS J. 2007, 9:E30-E42.
2. " Guidance for Industry Bioanalytical Method Validation." U.S. Department of Health and Human Services Food and Drug Administration, Center for Drug Evaluation and Research (CDER), May 2001.
3. Eeckhaut A.V., Lanckmans K., Sarre S., Smolders I., Michotte Y. Validation of bioanalytical LC-MS/MS assays: evaluation of matrix effects. J. Chromatogr. B 2009, 877:2198-2207.
4. Xu R.N., Fan L., Rieser M.J., El-Shourbagy T.A. Recent advances in high-throughput quantitative bioanalysis by LC-MS/MS. J. Pharm. Biomed. 2007, 44:342-355.
5. Barrett Y.C., Akinsanya B., Chang S.-Y., Vesterqvist O. Automated on-line SPE LC-MS/MS method to quantitate 6beta-hydroxycortisol and cortisol in human urine: use of the 6beta-hydroxycortisol to cortisol ratio as an indicator of CYP3A4 activity. J. Chromatogr. B 2005, 821:159-165.
6. Zhou S., Zhou H., Larson M., Miller D.L., Mao D., Jiang X., Naidong W. High-throughput biological sample analysis using on-line turbulent flow extraction combined with monolithic column liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2005, 19:2144-2150.
7. Niederländer H.A.G., Koster E.H.M., Hilhorst M.J., Metting H.J., Eilders M., Ooms B., de Jong G.J. High throughput therapeutic drug monitoring of clozapine and metabolites in serum by on-line coupling of solid phase extraction with liquid chromatography-mass spectrometry. J. Chromatogr. B 2006, 834:98-107.
8. Ceglarek U., Lembcke J., Fiedler G.M., Helmut M.W., Witzigmann H., Hauss J.P., Thiery J. Rapid simultaneous quantification of immunosuppressants in transplant patients by turbulent flow chromatography combined with tandem mass spectrometry. Clin. Chim. Acta 2004, 346:181-190.
9. Kim J., Johnson M., Hill P., Gale B.K. Microfluidic sample preparation: cell lysis and nucleic acid purification. Integr. Biol. 2009, 1:574-586.
10. Antignac J.-P., de Wasch K., Monteau F., de Brabander H., Andre F., le Bizec B. The ion suppression phenomenon in liquid chromatography-mass spectrometry and its consequences in the field of residue analysis. Anal. Chim. Acta 2005, 29:129-136.
11. Kebarle P., Tang L. From ions in solution to ions in the gas phase-the mechanism of electrospray mass spectrometry. Anal. Chem. 1993, 65:972A-986A.
12. King R., Bonfiglio R., Fernandez-Metzler C., Miller-Stein C., Olah T. Mechanistic investigation of ionization suppression in electrospray ionization. J. Am. Soc. Mass Spectrom. 2000, 11:942-950.
13. Reilly P.T.A., Lazar A.C., Gieray R.A., Whitten W.B., Ramsey J.M. The elucidation of charge-transfer-induced matrix effects in environmental aerosols via real-time aerosol mass spectral analysis of individual airborne particles. Aerosol Sci. Tech. 2000, 33:135-152.
14. Bonfiglio R., King R.C., Olah T.V., Merkle K. The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds. Rapid Commun. Mass Spectrom. 1999, 13:1175-1185.
15. Matuszewski B.K., Constanzer M.L., Chavez-Eng C.M. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal. Chem. 2003, 75:3019-3030.
16. Schioler V., Thode J. Six direct radioimmunoassays of estradiol evaluated. Clin. Chem. 1988, 34:949-952.
17. Johansson M.A., Hellenas K.E. Matrix effects in immunobiosensor determination of clenbuterol in urine and serum. Analyst 2004, 129:438-442.
18. Sviridov D., Hortin G.L. Urine albumin measurement: effects of urine matrix constituents. Clin. Chim. Acta 2009, 404:140-143.
19. Chambers E., Wagrowski-Diehl D.M., Lu Z., Mazzeo J.R. Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses. J. Chromatogr. B 2007, 852:22-34.
20. Chin C., Zhang Z.P., Karnes H.T. A study of matrix effects on an LC/MS/MS assay for olanzapine and desmethyl olanzapine. J. Pharmaceut. Biomed 2004, 35:1149-1167.
21. Lac G. Saliva assays in clinical and research biology. Pathol. Biol. 2001, 49:660-667.
22. Kato K., Hillsgrove M., Weinhold L., Gorelick D.A., Darwin W.D., Cone E.J. Cocaine and metabolite excretion in saliva under stimulated and nonstimulated conditions. J. Anal. Toxicol. 1993, 17:338-341.
23. Jenkins A.J., Oyler J.M., Cone E.J. Comparison of heroin and cocaine concentrations in saliva with concentrations in blood and plasma. J. Anal. Toxicol. 1995, 19:359-374.
24. O'Neal C.L., Crouch D.J., Rollins D.E., Fatah A., Cheever M.L. Correlation of saliva codeine concentrations with plasma concentrations after oral codeine administration. J. Anal. Toxicol. 1999, 23:452-459.
25. Fulton A., Chan S., Coleman G. Effect of salivary proteins on binding curves of three radioimmunoassay kits: Amerlex-M Progesterone, Amerlex Cortisol, and Biodata Testosterone. Clin. Chem. 1989, 35:641-644.
26. Mitchell J.S., Lowe T.E. Matrix effects on an antigen immobilized format for competitive enzyme immunoassay of salivary testosterone. J. Immunol. Methods 2009, 349:61-66.
27. Eriksson E., Scrimgeour J., Granéli A., Ramser K., Wellander R., Enger J., Hanstorp D., Goksör M. Optical manipulation and microfluidics for studies of single cell dynamics. J. Opt. A Pure Appl. Opt. 2007, 9:S113-S121.
28. Oroszi László, Dér András, Kirei H. Manipulation of microfluidic flow pattern by optically controlled electroosmosis. Microfluid Nanofluid 2009, 6:565-569.
29. Bu M., Christensen T.B., Smistrup K., Wolff A., Hansen M.F. Characterization of a microfluidic magnetic bead separator for high-throughput applications. Sensors Actuators A Physical 2008, 145-146:430-436.
30. Yi C., Li C.-W., Ji S., Yang M. Microfluidics technology for manipulation and analysis of biological cells. Anal. Chim. Acta 2006, 560(1-2, 23):1-23.
31. Lin R., Burke D.T., Burns M.A. Addressable electric fields for size-fractioned sample extraction in microfluidic devices. Anal. Chem. 2005, 77(14):4338-4347.
32. Dams R., Huestis M.A., Lambert W.E., Murphy C.M. Matrix effect in bio-analysis of illicit drugs with LC-MS/MS: influence of ionization type, sample preparation, and biofluid. J. Am. Soc. Mass Spectrom. 2003, 14:1290-1294.
33. Meyer M., Armbruster F.P., Maier I., Schwing J., Haller C., Missbichler A., Knut A., Forssmann W.-G., Woloszczuk W. Urinary and plasma urodilatin measured by a direct RIA using a highly specific antiserum. Clin. Chem. 1998, 44:2524-2529.
34. Cooke D.G., Binnie J.E., Blackwell L.F. Validation of a reference ELISA for estrone glucuronide using urine samples normalized by dilution to a constant rate of urine production. Steroids 2007, 72:580-591.
35. Fang W., Wang J., Liao W., Zimmermann B.G., Wong D., Ho C.-H. Electrochemical detection of low-copy number salivary RNA based on specific signal amplification with a hairpin probe. Nucleic Acids Res. 2008, 36:e65.
36. Gau V., Wong D. Oral fluid nanosensor test (OFNASET) with advanced electrochemical-based molecular analysis platform. Ann. N.Y. Acad. Sci. 2007, 1098:401-410.
37. Belter P.A., Cussler E.L., Hu W.-S. Bioseparations: Downstream Processing for Biotechnology 1988, John Wiley & Sons, New York, NY.
38. Yuan M., Carmichael W.W., Hilborn E.D. Microcystin analysis in human sera and liver from human fatalities in Caruaru, Brazil 1996. Toxicon 2006, 48:627-640.
39. Yang Y., Li H., Gao K., Liu M., Sun Y., Yan T., Fawcett J.P., Cui Y., Gu J. Simultaneous quantitation of dexamethasone palmitate and dexamethasone in human plasma by liquid chromatography/tandem mass spectrometry. J. Chromatogr. B 2007, 862:119-124.
40. Le Saux T., Chhun S., Rey E., Launay O., Weiss L., Viard J.-P., Pons G., Jullien V. Quantification of seven nucleoside/nucleotide reverse transcriptase inhibitors in human plasma by high-performance liquid chromatography with tandem mass-spectrometry. J. Chromatogr. B 2008, 865:81-90.
41. Cao X., Yao Z., Chen H., Dai Y., Sun P., Ye W., Yao X. Development and validation of a liquid chromatography tandem mass spectrometry assay for the quantification of methyl protodioscin in rat plasma: application to a pharmacokinetic study. Biomed. Chromatogr. 2007, 22:408-413.
42. Flarakos J., Luo W., Aman M., Svinarov S., Gerber N., Vouros P. Quantification of risperidone and 9-hydroxyrisperidone in plasma and saliva from adult and pediatric patients by liquid chromatography-mass spectrometry. J. Chromatogr. A 2004, 1026:175-183.
43. Walter R.E., Cramer J.A., Tse F.L.S. Comparison of manual protein precipitation (PPT) versus a new small volume PPT 96-well filter plate to decrease sample preparation time. J. Pharmaceut. Biomed. 2001, 25:331-337.
44. Xue Y.J., Akinsanya J.B., Liu J., Unger S.E. A simplified protein precipitation/mixed-mode cation-exchange solid-phase extraction, followed by high-speed liquid chromatography/mass spectrometry, for the determination of a basic drug in human plasma. Rapid Commun. Mass Spectrom. 2006, 20:2660-2668.
45. Ji H.Y., Park E.J., Lee K.C., Lee H.S. Quantification of doxazosin in human plasma using hydrophilic interaction liquid chromatography with tandem mass spectrometry. J. Sep. Sci. 2008, 31:1628-1633.
46. Buhrman D.L., Price P.I., Rudewicz P.J. Quantitation of SR 27417 in human plasma using electrospray liquid chromatography-tandem mass spectrometry: a study of ion suppression. J. Am. Soc. Mass. Spectrom. 1996, 7:1099-1105.
47. Lee H.-S., Kang I.-M., Lee H.-W., Seo J.-H., Ryu J.-H., Choi S.-J., Lee M.-J., Jeong S.Y., Cho Y.-W., Lee K.-T. Development and validation of high performance liquid chromatography-tandem mass spectrometry for the determination of etodolac in human plasma. J. Chromatogr. B 2008, 863:158-162.
48. Nirogi R.V.S., Kandikere V.N., Shukla M., Mudigonda K., Maurya S., Boosi R., Anjaneyulu Y. Development and validation of a sensitive liquid chromatography/electrospray tandem mass spectrometry assay for the quantification of olanzapine in human plasma. J. Pharmaceut. Biomed 2006, 41:935-942.
49. Chen K.-B., Cai M.-Q., Chen X.-H., Jin M.-C. Quantitative analysis of triptolide in human whole blood by LC-APCI-IT-MS-MS. Chromatographia 2008, 67:225-230.
50. Dighe A.S., Sluss P.M. Improved detection of serum estradiol after sample extraction procedure. Clin. Chem. 2003, 50:764-766.
51. Sarmento M.J., Pires M.J., Cabral J.M.S., Aires-Barros M.R. Liquid-liquid extraction of a recombinant protein, cytochrome b5, from an impure extract using aqueous two-phase systems. Bioproc. Biosyst. Eng 1997, 16:295-297.
52. Pawlizyn J. Sampling and Sample Preparation for Field and Laboratory 2002, Vol. 37:727. Elsevier, Amsterdam, The Netherlands.
53. Wang P.G., Wei J.S., Kim G., Chang M., El-Shourbagy T. Validation and application of a high-performance liquid chromatography-tandem mass spectrometric method for simultaneous quantification of lopinavir and ritonavir in human plasma using semi-automated 96-well liquid-liquid extraction. J. Chromatogr. A 2006, 1130:302-307.
54. Xu X.S., Yan K.X., Song H., Lo M.W. Quantitative determination of a novel dual PPAR α/γ agonist using on-line turbulent flow extraction with liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 2005, 814:29-36.
55. Berrueta L.A., Gallo B., Vicente F. A review of solid phase extraction: basic principles and new developments. Chromatographia 1995, 40:474-483.
56. Matsuura K., Ohmori T., Nakamura M., Itoh Y., Hirano K. A simple and rapid determination of valproic acid in human plasma using a non-porous silica column and liquid chromatography with tandem mass spectrometric detection. Biomed. Chromatogr. 2008, 22:387-393.
57. Tranfo G., Paci E., Sisto R., Pigini D. Validation of an HPLC/MS/MS method with isotopic dilution for quantitative determination of trans, trans-muconic acid in urine samples of workers exposed to low benzene concentrations. J. Chromatogr. B 2008, 867:26-31.
58. Mistri H.N., Jangid A.G., Pudage A., Shrivastav P. HPLC-ESI-MS/MS validated method for simultaneous quantification of zopiclone and its metabolites, N-desmethyl zopiclone and zopiclone-N-oxide in human plasma. J. Chromatogr. B 2008, 862:137-148.
59. Lindegardh N., Annerberg A., White N.J., Day N.P.J. Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of piperaquine in plasma stable isotope labeled internal standard does not always compensate for matrix effects. J. Chromatogr. B 2007, 862:227-236.
60. Naik G.O., Moe G.W. Use of a solid-phase extraction with radioimmunoassay to identify the proportional bias of clinical B-type natriuretic peptide immunoassay: the impact of plasma matrix and antibody multispecificity. Clin. Chem. Lab. Med. 2007, 45:1353-1359.
61. Jiang H., Li Y., Pelzer M., Cannon M.J., Randlett C., Junga H., Jiang X., Ji Q.J. Determination of molindone enantiomers in human plasma by high-performance liquid chromatography-tandem mass spectrometry using macrocyclic antibiotic chiral stationary phases. J. Chromatogr. A 2008, 119:230-238.
62. Stevenson D. Immuno-affinity solid-phase extraction. J. Chromatogr. B 2000, 745:39-48.
63. Haasnoot W., Kemmers-Voncken A. Immunofiltration as sample cleanup for the immunochemical detection of β-agonist in urine. Analyst 2002, 127:87-92.
64. Hansel T.T., De Vries I.J., Iff T., Rihs S., Wandzilak M., Betz S., Blaser K., Walker C. An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils. J. Immunol. Methods 1991, 145:105-110.
65. Hayashi Y., Shono F., Yamamoto S., Takasaki W., Nakagawa A., Watanabe K., Yamashita K., Miyazaki H. Immunoaffinity purification of 11-dehydro-thromboxane B2 from human urine and plasma for quantitative analysis by radioimmunoassay. Anal. Biochem. 1990, 187:151-159.
66. Rashid B.A., Kwasowski P., Stevenson D. Solid phase extraction of clenbuterol from plasma using immunoaffinity followed by HPLC. J. Pharm. Biomed. 1999, 21:635-639.
67. Degan P., Shigenaga M.K., Park E.-M., Alperin P.E., Ames B.N. Immunoaffinity isolation of urinary 8-hydroxy-2'-deoxygunosine and 8-hydroxyguanine and quantitation of 8-hydroxy-2'deoxyguanosine in DNA by polyclonal antibodies. Carcinogenesis 1991, 12:865-871.
68. Rashid B.A., Aherne G.W., Katmeh M.F., Kwasowski P., Stevensonm D. Determination of morphine in urine by solid-phase immunoextraction and high-performance liquid chromatography with electrochemical detection. J. Chromatogr. A 1998, 797:245-250.
69. Kawatus K., Shibata T., Hamano Y. Application of immunoaffinity chromatography for detection of tetrodotoxin from urine samples of poisoned patients. Toxicon 1999, 37:325-333.
70. Pohl H.A. Dielectrophoresis: The Behavior of Neutral Matter in Nonuniform Electric Fields 1978, Cambridge University Press, Cambridge, NY.
71. Asbury C.L., van den Engh G. Trapping of DNA in nonuniform oscillating electric fields. Biophys. J. 1998, 74:1024-1030.
72. Ramos A., Morgan H., Green N.G., Castellanos A. AC electrokinetics: a review of forces in microelectrode structures. J. Phys. D Appl. Phys. 1999, 31:2338-2353.
73. Hughes M.P. AC electrokinetics: applications for nanotechnology. Nanotechnology 2000, 11:124-132.
74. Wong P.K., Wang T.-H., Deval J.H., Ho C.-M. Electrokinetics in micro devices for biotechnology applications. IEEE-ASME Trans. Mechatronics 2004, 9:366-376.
75. Jones T.B. Electromechanics of Particles 1995, Cambridge University Press, Cambridge, NY.
76. Gimsa J. A comprehensive approach to electro-orientation, electrodeformation, dielectrophoresis, and electrorotation of ellipsoidal particles and biological cells. Bioelectrochemistry 2001, 54:23-31.
77. Chou C.F., et al. Electrodeless dielectrophoresis of single- and double-stranded DNA. Biophys. J. 2002, 83:2170-2179.
78. Huang Y., et al. Dielectrophoretic cell separation and gene expression profiling on microelectronic chip arrays. Anal. Chem. 2002, 74:3362-3371.
79. Chiou P.Y., Ohta A.T., Wu M.C. Massively parallel manipulation of single cells and microparticles using optical images. Nature 2005, 436:370-372.
80. Green N.G., Ramos A., Gonzalez A., Morgan H., Castellanos A. Fluid flow induced by nonuniform AC electric fields in electrolytes on microelectrodes. I. Experimental measurements. Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics 2000, 61:4011-4018.
81. Gonzalez A., Ramos A., Green N.G., Castellanos A., Morgan H. Fluid flow induced by nonuniform AC electric fields in electrolytes on microelectrodes. II. A linear double-layer analysis. Phys. Rev. E 2000, 61:4019-4028.
82. Green N.G., Ramos A., Gonzalez A., Morgan H., Castellanos A. A fluid flow induced by nonuniform AC electric fields in electrolytes on microelectrodes. III. Observation of streamlines and numerical simulation. Phys. Rev. E 2002, 66:305-316.
83. Wong P.K., Chen C.Y., Wang T.H., Ho C.M. Electrokinetic bioprocessor for concentrating cells and molecules. Anal. Chem. 2004, 76:6908-6914.
84. Sin, M. L. Y.; Constantino, V. U.; Gau, V., Haake, D. A.; Wong, P. K. Scaling analysis of a universal electrode for molecular biosensors. IEEE Rev. Adv. Micro Nano Mol. Syst. (accepted 2007).
85. Sin M.L.Y., Gau V., Liao J.C., Haake D.A., Wong P.K. Active manipulation of quantum dots using AC electrokinetics. J. Phys. Chem. C 2009, 113:6561-6565.
86. Souverain S., Rudaz S., Veuthey J.-L. Matrix effect in LC-ESI-MS and LC-APCI-MS with off-line and online extraction procedures. J. Chromatogr. A 2004, 1058:61-66.
87. Mei H., Hsieh Y., Nardo C., Xu X., Wang S., Ng K., Korfmacher W.A. Investigation of matrix effects in bioanalytical high-performance liquid chromatography/tandem mass spectrometric assays: application to drug discovery. Rapid Commun. Mass Spectrom. 2009, 17:97-103.
88. Taylor A.W., Bruno R.S., Frei B., Traber M.G. Benefits of prolonged gradient separation for high-performance liquid chromatography-tandem mass spectrometry quantitation of plasma. Anal. Biochem. 2006, 350:41-51.
89. Andrews C.L., et al. Improved liquid chromatography-mass spectrometry performance in quantitative analysis using a nanosplitter interface. J. Chromatogr. A 2004, 1053:1-2.
90. Andrews C.L., Feng L., Yang E., Yu C.-P., Vouros P. Incorporation of a nanosplitter interface into an LC-MS-RD system to facilitate drug metabolism studies. J. Mass Spectrom. 2006, 41:43-49.
91. Juraschek R., Dülcks T., Karas M. Nanoelectrospray-more than just a minimized-flow electrospray ionization source. J. Am. Soc. Mass Spectrom. 1999, 10:300-308.
92. Hong M. Using Mass Spectrometry for Drug Metabolism Studies 2005, 103-150. CRC Press, Boca Raton, FL. W.A. Korfmacher (Ed.).
93. Wang S., Cyronak M., Yang E. Does a stable isotopically labeled internal standard always correct analyte response? A matrix effect study on a LC/MS/MS method for the determination of carvedilol enantiomers in human plasma. J. Pharm. Biomed. Anal. 2007, 43:701-707.
94. Sojo L.E., Lum G., Chee P. Internal standard signal suppression by co-eluting analyte in isotope dilution LC-ESI-MS. Analyst 2003, 128:51-54.
95. Liang H.R., Foltz R.L., Meng M., Bennett P. Ionization enhancement in atmospheric pressure chemical ionization and suppression in electrospray ionization between target drugs and stable-isotope-labeled internal standards in quantitative liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2003, 17:2815-2821.
96. Matuszewski B.K., Constanzer M.L., Chavez-Eng C.M. Matrix effect in quantitative LC/MS/MS analyses of biological fluids: a method for determination of finasteride in human plasma at pictogram per milliliter concentrations. Anal. Chem. 1998, 70:882-889.
97. Hsieh Y. Potential of HILIC-MS in quantitative bioanalysis of drugs and drug metabolites. J. Sep. Sci. 2008, 31:1481-1491.
98. Situ C., Wylie A.R.G., Douglas A., Elliott C.T. Reduction of severe bovine serum associated matrix effects on carboxymethylated dextran coated biosensor surfaces. Talanta 2008, 76(4, 15):832-836.
99. Ratcliffe W.A., Corrie J.E., Dalziel A.H., Macpherson J.S. Direct 125I-Radioligand assays for serum progesterone compared with assays involving extraction of serum. Clin. Chem. 1982, 28:1314-1318.
100. Basu A., Shrivastav T.G., Maitra S.K. A direct antigen heterologous enzyme immunoassay for measuring progesterone in serum without using displacer. Steroids 2006, 71:222-230.
101. Wild D. Immunoassay Handbook 2005, 141. Elsevier, Oxford, UK. 3rd ed. D. Wild (Ed.).
102. Ullman E. Homogeneous immunoassays: historical perspective and future promise. J. Chem. Ed. 1999, 76:781-788.
103. Marchi I., Rudaz S., Veuthey J.-L. Sample preparation development and matrix effects evaluation for multianalyte determination in urine. J. Pharm. Biomed. Anal. 2009, 49(2, 20):459-467.
104. Möller K., Nilsson U., Crescenzi C. Investigation of matrix effects of urine on a molecularly imprinted solid-phase extraction. J. Chromatogr. B 2004, 811(2, 25):171-176.
105. Mach K.E., Du C.B., Phull H., Haake D.A., Shih M.C., Baron E.J., Liao J.C. Multiplex pathogen identification for polymicrobial urinary tract infections using biosensor technology: a prospective clinical study. J. Urol. 2009, 182(6):2735-2741.
106. Damsa R., Huestis M.A., Lambert W.E., Murphy C.M. Matrix effect in bio-analysis of illicit drugs with LC-MS/MS: influence of ionization type, sample preparation, and biofluid. J. Am. Soc. Mass Spectrom. 2003, 14(11):1290-1294.
107. Saar E., Gerostamoulos D., Drummer O.H., Beyer J. Comparison of extraction efficiencies and LC-MS-MS, matrix effects using LLE and SPE methods for 19 antipsychotics in human blood. Anal Bioanal Chem 2009, 393:727-734.
108. Mitchell J.S., Lowe T.E. Matrix effects on an antigen immobilized format for competitive enzyme immunoassay of salivary testosterone. J. Immunol. Methods 2009, 349(1-2, 30):61-66.
109. Mitchell J.S., Lowe T.E., Ingram J.R. Rapid ultrasensitive measurement of salivary cortisol using nano-linker chemistry coupled with surface plasmon resonance detection. Analyst 2009, 134(2):380-386. Epub November 13, 2008.
110. Gaster R.S., Hall D.A., Nielsen C.H., Osterfeld S.J., Yu H., Mach K.E., Wilson R.J., Murmann B., Liao J.C., Gambhir S.S., Wang S.X. Matrix-insensitive protein assays push the limits of biosensors in medicine. Nat. Med 2009, 15(11):1327-1332.