HPLC-ESI-MS/MS validated method for simultaneous quantification of zopiclone and its metabolites, N-desmethyl zopiclone and zopiclone-N-oxide in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 864, Issue 1-2, 2008, Pages 137-148

  Mistri, Hiren N ^a,b   Jangid, Arvind G ^b   Pudage, Ashutosh ^b   Shrivastav, Pranav ^a  

^a GUJARAT UNIVERSITY   (India)

^b Accutest Research Laboratories I Pvt Ltd   (India)

Author keywords

LC MS MS; N desmethyl zopiclone; Solid phase extraction; Zopiclone; Zopiclone N oxide

Indexed keywords

N-DESMETHYL ZOPICLONE; SOLID PHASE EXTRACTION; ZOPICLONE; ZOPICLONE-N-OXIDE;

DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PHASE INTERFACES; PLASMA (HUMAN);

AROMATIC COMPOUNDS;

DRUG METABOLITE; METAXALONE; N DESMETHYL ZOPICLONE; UNCLASSIFIED DRUG; ZOPICLONE; ZOPICLONE N OXIDE;

ACCURACY; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DIET RESTRICTION; DILUTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PARTICLE SIZE; PRIORITY JOURNAL; QUALITY CONTROL; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

AZABICYCLO COMPOUNDS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; FASTING; HUMANS; HYPNOTICS AND SEDATIVES; MASS SPECTROMETRY; PIPERAZINES; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 40849147026     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.02.004     Document Type: Article

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