A simple and rapid determination of valproic acid in human plasma using a non-porous silica column and liquid chromatography with tandem mass spectrometric detection

Biomedical Chromatography

Volumn 22, Issue 4, 2008, Pages 387-393

  Matsuura, Katsuhiko ^a   Ohmori, Tomofumi ^b   Nakamura, Mitsuhiro ^b   Itoh, Yoshinori ^a   Hirano, Kazuyuki ^b  

^a GIFU UNIVERSITY HOSPITAL   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Multiple reaction monitoring; Non porous silica column; Tandem mass spectrometry; Valproic acid

Indexed keywords

ELECTROSPRAY IONIZATION; EXTRACTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; NEGATIVE IONS; PHASE SEPARATION; PLASMA (HUMAN); SILICA;

HUMAN PLASMAS; INTERNAL STANDARDS; LC-MS-MS; MULTIPLE REACTION MONITORING; NON-POROUS SILICUM COLUMN; NONPOROUS SILICA; SILICA COLUMN; TANDEM MASS SPECTROMETRY; TANDEM-MASS SPECTROMETRY; VALPROIC ACID;

COLUMN CHROMATOGRAPHY;

AMMONIUM ACETATE; BETAMETHASONE VALERATE; METHANOL; SILICON DIOXIDE; VALPROIC ACID;

ACCURACY; ADOLESCENT; ADULT; AGED; ARTICLE; CALIBRATION; CHILD; CONTROLLED STUDY; DRUG DETERMINATION; DRUG MONITORING; DRUG STRUCTURE; ELECTROSPRAY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; PLASMA; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

EID: 42549109552     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.944     Document Type: Article

References (20)

1. Amini H, Javan M and Ahmadiani A. Development and validation of a sensitive assay of valproic acid in human plasma by high-performance liquid chromatography without prior derivatization. Journal of Chromatography B 2006; 830: 368-371.
2. Burke JT and Thenot JP. Determination of antiepileptic drugs. Journal of Chromatography 1985; 340: 199-241.
3. de Collongue-Poyet B, Vidal-Madjar C, Sebille B and Unger KK. Study of conformational effects of recombinant interferon gamma adsorbed on a non-porous reversed-phase silica support. Journal of Chromatography B 1995; 664: 155-61.
4. Ehrenthal W and Rochel M. Drug monitoring for valproic acid with HPLC or EMIT and concomitant measurements of clinical-chemical parameters. Arzneimittelforschung 1982; 32: 449-452.
5. Ji QC, Gage EM, Rodila R, Chang MS and El-Shourbagy TA. Method development for the concentration determination of a protein in human plasma utilizing 96-well solid-phase extraction and liquid chromatography/tandem mass spectrometric detection. Rapid Communications in Mass Spectrometry 2003; 17: 794-799.
6. Jilge G, Janzen R, Giesche H, Unger KK, Kinkel JN and Hearn MT. Evaluation of advanced silica packings for the separation of biopolymers by high-performance liquid chromatography. III. Retention and selectivity of proteins and peptides in gradient elution on non-porous monodisperse 1.5-microns reversed-phase silicas. Journal of Chromatography 1987; 397: 71-80.
7. Kushida K and Ishizaki T. Concurrent determination of valproic acid with other antiepileptic drugs by high-performance liquid chromatography. Journal of Chromatography 1985; 338: 131-139.
8. Lin MC, Kou HS, Chen CC, Wu SM and Wu HL. Simple and sensitive fluorimetric liquid chromatography method for the determination of valproic acid in plasma. Journal of Chromatography B 2004; 810: 169-172.
9. Lingeman H and Underberg WJM. Detection Oriented Derivatization Techniques in Liquid Chromatograpy. Marcel Dekker: New York, 1990.
10. Macdonald RL and Kelly KM. Antiepileptic drug mechanisms of action. Epilepsia 1995; 36(suppl. 2): S2-12.
11. Mino T, Nakajima M, Wakabayashi H, Yamato S and Shimada K. Determination of valproic acid in serum by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. Analytical Science 2001; 17: 999-1001.
12. Nakamura M, Hirade K, Sugiyama T and Katagiri Y. High-performance liquid chromatographic assay of zonisamide in human plasma using a non-porous silica column. Journal of Chromatography B 2001; 755: 337-341.
13. Nakamura M, Fukawa K, Sugiyama T and Katagiri Y. High-performance liquid chromatographic assay of clonazepam in human plasma using a non-porous silica column. Biological Pharmaceutical Bulletin 2004; 27: 893-895.
14. Paasch BD, Lin YS, Porter S, Modi NB and Barder TJ. Determination of Ro 48-3656 in rat plasma by reversed-phase high-performance liquid chromatography. Comparison of 1.5-micron nonporous silica to 3.5-micron porous silica analytical columns. Journal of Chromatography B 1997; 704: 231-242.
15. Pucci V, Monteagudo E and Bonelli F. High sensitivity determination of valproic acid in mouse plasma using semi-automated sample preparation and liquid chromatography with tandem mass spectrometric detection. Rapid Communications in Mass Spectrometry 2005; 19: 3713-3718.
16. Ramakrishna NV, Vishwottam KN, Manoj S, Koteshwara M, Santosh M, Chidambara J and Kumar BR. Liquid chromatography/electrospray ionization mass spectrometry method for the quantification of valproic acid in human plasma. Rapid Communications in Mass Spectrometry 2005; 19: 1970-1978.
17. Spell JC and Stewart JT. Analysis of clonazepam in a tablet dosage form using smallbore HPLC. Journal of Pharmaceutical and Biomedical Analysis 1998; 18: 453-460.
18. TDxFLx package insert, Valproic Acid, Ref. 9514. Abbott Laboratories: IL, 2007.
19. Thomson PDR. Physicians' Desk Reference, 54th edn. Medical Economics: Montvale, NJ, 2000; 426.
20. Yu D, Gordon JD, Zheng J, Panesar SK, Riggs KW, Rurak DW and Abbott FS. Determination of valproic acid and its metabolites using gas chromatography with mass-selective detection: application to serum and urine samples from sheep. Journal of Chromatography B 1995; 666: 269-281.