Development and validation of a liquid chromatography/tandem mass spectrometry assay for the quantification of methyl protodioscin in rat plasma: Application to a pharmacokinetic study

Biomedical Chromatography

Volumn 22, Issue 4, 2008, Pages 408-413

  Cao, Xiuzhen ^a   Yao, Zhihong ^b   Chen, Haifeng ^c   Dai, Yi ^b   Sun, Pinghua ^b   Ye, Wencai ^b   Yao, Xinsheng ^a,b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

^c TSINGHUA UNIVERSITY   (China)

Author keywords

HPLC MS MS; Methyl protodioscin; Pharmacokinetics; Rat plasma

Indexed keywords

BODY FLUIDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONS; MASS SPECTROMETRY; METHANOL; PRECIPITATION (CHEMICAL); RATS;

ANTITUMOUR ACTIVITY; ETHINYLESTRADIOL; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; HPLC-MS-MS; INTERNAL STANDARDS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY ASSAYS; METHYL PROTODIOSCIN; PHARMACOKINETIC STUDIES; PROTEIN PRECIPITATION; RAT PLASMA;

PHARMACOKINETICS;

ETHINYLESTRADIOL; METHANOL; METHYLPROTODIOSCIN; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STABILITY; ELUTION; ENVIRONMENTAL TEMPERATURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION MONITORING; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRECIPITATION; PROCESS DEVELOPMENT; QUANTITATIVE ASSAY; RAT; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

RATTUS;

EID: 42549166064     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.948     Document Type: Article

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