Rapid simultaneous quantification of immunosuppressants in transplant patients by turbulent flow chromatography combined with tandem mass spectrometry

Clinica Chimica Acta

Volumn 346, Issue 2, 2004, Pages 181-190

  Ceglarek, Uta ^a   Lembcke, Jan ^a   Fiedler, Georg Martin ^a   Werner, Maria ^a   Witzigmann, Helmut ^a   Hauss, Johann Peter ^a   Thiery, Joachim ^a  

^a UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

CsA; CsD; cyclosporin A; Cyclosporin A; cyclosporin D; FK 506; LC MS MS; liquid chromatography tandem mass spectrometry; MRM; multiple reaction monitoring; Sirolimus; Tacrolimus; tacrolimus; Tandem mass spectrometry; tandem MS; Therapeutic drug monitoring

Indexed keywords

CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; RAPAMYCIN; TACROLIMUS;

ARTICLE; BONE MARROW; CHROMATOGRAPHY; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE KIDNEY FUNCTION RELATION; DRUG LIVER LEVEL; HEMOLYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOASSAY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; TURBULENT FLOW;

BONE MARROW TRANSPLANTATION; CHEMISTRY, CLINICAL; CYCLOSPORINE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; PANCREAS TRANSPLANTATION; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SIROLIMUS; TACROLIMUS;

EID: 3142568414     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cccn.2004.03.017     Document Type: Article

References (28)

1. Hong J.C., Kahan B.D. Immunosuppressive agents in organ transplantation: past, present, and future. Semin. Nephrol. 20:2000;108-125
2. Armstrong V.W. Principles and practice of monitoring immunosuppressive drugs. J. Lab. Med. 26:2002;26-27
3. Flanagan W.M., Corthesy B., Bram R.J., Crabtree G.R. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature. 352:1991;803-807
4. Napoli K.L., Taylor P.J. From beach to bedside: history of the development of sirolimus. Ther. Drug Monit. 23:2001;559-586
5. Khanna A.K. Mechanism of the combination immunosuppressive effects of rapamycin with either cyclosporine or tacrolimus. Transplantation. 70:2000;690-694
6. McAlister V.C., Gao Z., Peltekian K., Domingues J., Mahalati K., MacDonald A.S. Sirolimus-tacrolimus combination immunosuppression. Lancet. 355:2000;376-377
7. Shaw L.M., Holt D.W., Keown P., Venkataramanan R., Yatscoff R.W. Current opinions on therapeutic drug monitoring of immunosuppressive drugs. Clin. Ther. 21:1999;1632-1652. [discussion 1631]
8. Kahan B.D., Napoli K.L., Kelly P.A., Podbielski J., Hussein I., Urbauer D.L., et al. Therapeutic drug monitoring of sirolimus: correlations with efficacy and toxicity. Clin. Transplant. 14:2000;97-109
9. Dusci L.J., Hackett L.P., Chiswell G.M., Ilett K.F. Comparison of cyclosporine measurement in whole blood by high-performance liquid chromatography, monoclonal fluorescence polarization immunoassay, and monoclonal enzyme-multiplied immunoassay. Ther. Drug Monit. 14:1992;327-332
10. Warty V., Zuckerman S., Venkataramanan R., Lever J., Chao J., McKaveney T., et al. Tacrolimus analysis: a comparison of different methods and matrices. Ther. Drug Monit. 17:1995;159-167
11. Oellerich M., Armstrong V.W., Kahan B., Shaw L., Holt D.W., Yatscoff R., et al. Lake Louise Consensus Conference on cyclosporin monitoring in organ transplantation: report of the consensus panel. Ther. Drug Monit. 17:1995;642-654
12. Murthy J.N., Davis D.L., Yatscoff R.W., Soldin S.J. Tacrolimus metabolite cross-reactivity in different tacrolimus assays. Clin. Biochem. 31:1998;613-617
13. Schütz E., Svinarov D., Shipkova M., Niedmann P.D., Armstrong V.W., Wieland E., et al. Cyclosporin whole blood immunoassays (AxSYM, CEDIA, and Emit): a critical overview of performance characteristics and comparison with HPLC. Clin. Chem. 44:1998;2158-2164
14. Volosov A., Napoli K.L., Soldin S.J. Simultaneous simple and fast quantification of three major immunosuppressants by liquid chromatography-tandem mass-spectrometry. Clin. Biochem. 34:2001;285-290
15. Streit F., Armstrong V.W., Oellerich M. Rapid liquid chromatography- tandem mass spectrometry routine method for simultaneous determination of sirolimus, everolimus, tacrolimus, and cyclosporin A in whole blood. Clin. Chem. 48:2002;955-958
16. Zimmer D., Pickard V., Czembor W., Muller C. Comparison of turbulent-flow chromatography with automated solid-phase extraction in 96-well plates and liquid-liquid extraction used as plasma sample preparation techniques for liquid chromatography-tandem mass spectrometry. J. Chromatogr. A. 854:1999;23-35
17. Grant R.P., Cameron C., Mackenzie-McMurter S. Generic serial and parallel on-line direct-injection using turbulent flow liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 16:2002;1785-1792
18. www.bioanalytics.co.uk. Analytical Services International. Proficiency testing.
19. Passing H., Bablok W. A new biometrical procedure for testing the equality of measurements from two different methods. J. Clin. Chem. Clin. Biochem. 19:1981;121-137
20. Bland J.M., Altman D.G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1:1986;307-310
21. Kirchner G.I., Vidal C., Jacobsen W., Franzke A., Hallensleben K., Christians U., et al. Simultaneous on-line extraction and analysis of sirolimus (rapamycin) and ciclosporin in blood by liquid chromatography-electrospray mass spectrometry. J. Chromatogr. B, Biomed. Sci. Appl. 721:1999;285-294
22. Hopfgartner G., Husser C., Zell M. High-throughput quantification of drugs and their metabolites in biosamples by LC-MS/MS and CE-MS/MS: possibilities and limitations. Ther. Drug Monit. 24:2002;134-143
23. Herman J.L. Generic method for on-line extraction of drug substances in the presence of biological matrices using turbulent flow chromatography. Rapid Commun. Mass Spectrom. 16:2002;421-426
24. Christians U., Jacobsen W., Serkova N., Benet L.Z., Vidal C., Sewing K.F., et al. Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants. J. Chromatogr. B, Biomed. Sci. Appl. 748:2000;41-53
25. Deters M., Kirchner G., Resch K., Kaever V. Simultaneous quantification of sirolimus, everolimus, tacrolimus and cyclosporine by liquid chromatography-mass spectrometry (LC-MS). Clin. Chem. Lab. Med. 40:2002;285-292
26. Brewer E., Henion J. Atmospheric pressure ionization LC/MS/MS techniques for drug disposition studies. J. Pharm. Sci. 87:1998;395-402
27. Jusko W.J., Thomson A.W., Fung J., McMaster P., Wong S.H., Zylber-Katz E., et al. Consensus document: therapeutic monitoring of tacrolimus (FK-506). Ther. Drug Monit. 17:1995;606-614
28. Staatz C.E., Taylor P.J., Tett S.E. Comparison of an ELISA and an LC/MS/MS method for measuring tacrolimus concentrations and making dosage decisions in transplant recipients. Ther. Drug Monit. 24:2002;607-615