mGlu3 metabotropic glutamate receptors modulate the differentiation of SVZ-derived neural stem cells towards the astrocytic lineage

GLIA

Volumn 58, Issue 7, 2010, Pages 813-822

  Ciceroni, C ^a   Mosillo, P ^b   Mastrantoni, E ^b   Sale, P ^a,b   Ricci Vitiani, L ^c   Biagioni, F ^d   Stocchi, F ^a   Nicoletti, F ^b,d   Melchiorri, D ^a,b  

^a IRCCS SAN RAFFAELE PISANA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d IRCCS NEUROMED   (Italy)

Author keywords

Astrocytes; Bone morphogenic protein; Progenitor cells

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; 4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; 8 BROMO CYCLIC AMP; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN RECEPTOR; COMPLEMENTARY DNA; CYCLIC AMP; FORSKOLIN; GENOMIC DNA; GLIAL FIBRILLARY ACIDIC PROTEIN; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR ANTAGONIST; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NESTIN; TRANSCRIPTION FACTOR SOX1; TUBULIN; UO 126;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FLUORESCENCE ACTIVATED CELL SORTER; IMMUNOCYTOCHEMISTRY; MOUSE; NEURAL STEM CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN RECEPTORS; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; INTERMEDIATE FILAMENT PROTEINS; MAP KINASE SIGNALING SYSTEM; MICE; NERVE TISSUE PROTEINS; RECEPTORS, METABOTROPIC GLUTAMATE; SMAD PROTEINS; SOXB1 TRANSCRIPTION FACTORS; SPHEROIDS, CELLULAR; STEM CELLS; TELENCEPHALON;

EID: 77952566968     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20965     Document Type: Article

References (63)

1. Arcella A, Carpinelli G, Battaglia G, D'Onofrio M, Santoro F, Ngomba RT Bruno V, Casolini P, Giangaspero F, Nicoletti F. 2005. Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro Oncol 7:236-245.
2. Arnold SE, Talbot K, Hahn CG. 2005. Neurodevelopment, neuroplasticity, and new genes for schizophrenia. Prog Brain Res 147:319-345.
3. Bailey JM, Singh PK, Hollingsworth MA. 2007. Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins J Cell Biochem 102:829-839.
4. Bishop JR, Wang K, Moline J, Ellingrod VL. 2007. Association analysis of the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia. Psychiatr Genet 17:358
5. Bonaguidi MA, McGuire T, Hu M, Kan L, Samanta J, Kessler JA. 2005. LIF and BMP signalling generate separate and discrete types of GFAP-expressing cells. Development 132:5503-5514.
6. Canudas AM, Di Giorgi-Gerevini V, Iacovelli L, Nano G, D'Onofrio M, Arcella A, Giangaspero F, Busceti C, Ricci-Vitiani L, Battaglia G, Nicoletti F, Melchiorri D. 2004. PHCCC, a specific enhancer of type 4 metabotropic glutamate receptors, reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors. J Neurosci 24:10343-10352.
7. Cao QL, Zhang YP, Howard RM, Walters WM, Tsoulfas P, Whittemore SR. 2001. Pluripotent stem cells engrafted into the normal or lesioned adult rat spinal cord are restricted to a glial lineage. Exp Neurol 167:48-58.
8. Cappuccio I, Spinsanti P, Porcellini A, Desiderati F, De Vita T, Storto M, Capobianco L, Battaglia G, Nicoletti F, Melchiorri D. 2005. Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells. Neuropharmacology 49:196-205. (Pubitemid 41115906)
9. Cappuccio I, Verani R, Spinsanti P, Niccolini C, Gradini R, Costantino S, Nicoletti F, Melchiorri D. 2006. Context-dependent regulation of embryonic stem cell differentiation by mGlu4 metabotropic glutamate receptors. Neuropharmacology 51:606-611.
10. Cartmell J, Monn JA, Schoepp DD. 1999. The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviours in rats. J Pharmacol Exp Ther 291:161-170. (Pubitemid 29451586)
11. Cartmell J, Monn JA, Schoepp DD. 2000. The mGlu2/3 receptor agonists LY379268 selectively blocks amphetamine ambulation and rearing. Eur J Pharmacol 361:39-46.
12. Charron F, Tessier-Lavigne M. 2005. Novel brain wiring functions for classical morphogens: A role as graded positional cues in axon guidance. Development 132:2251-2262.
13. Corti C, Battaglia G, Molinaro G, Riozzi B, Pittaluga A, Corsi M, Mugnaini M, Nicoletti F, Bruno V. 2007. The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection. J Neurosci 27:8297-8308.
14. D'Arcangelo G. 2006. Reelin mouse mutants as models of cortical development disorders. Epilepsy Behav 8:81-90.
15. Di Giorgi Gerevini VD, Caruso A, Cappuccio I, Ricci Vitiani L, Romeo S, Della Rocca C, Gradini R, Melchiorri D, Nicoletti F. 2004. The mGlu5 metabotropic glutamate receptor is expressed in zones of active neurogenesis of the embryonic and postnatal brain. Brain Res Dev Brain Res 150:17-22.
16. Di Giorgi Gerevini VD, Melchiorri D, Battaglia G, Ricci-Vitiani L, Ciceroni C, Busceti CL, Biagioni F, Iacovelli L, Canudas AM, Parati E, De Maria R, Nicoletti F. 2005. Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells. Cell death Differ 12:1124-1133. (Pubitemid 41065429)
17. D'Onofrio M, Cuomo L, Battaglia G, Ngomba RT, Storto M, Kingston AE, Orzi F, De Blasi A, Di Iorio P, Nicoletti F, Bruno V. 2001. Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol- 3-kinase pathways. J Neurochem 78:435-445.
18. Dumontheil I, Burgess PW, Blakemore SJ. 2008. Development of rostral prefrontal cortex and cognitive and behavioural disorders. Dev Med Child Neurol 50:168-181.
19. Fell MJ, Johnson BG, Svensson KA, Schoepp DD. 2008. Evidence for the role of mGlu2 not mGlu3 receptors in the pre-clinical antipsychotic pharmacology of the mGlu2/3 receptor agonist LY404039. J Pharmacol Exp Ther 326:209-217.
20. Ferraguti F, Baldani-Guerra B, Corsi M, Nakanishi S, Corti C. 1999. Activation of the extracellular signal-regulated kinase 2 by metabotropic glutamate receptors. Eur J Neurosci 11:2073-2082.
21. Franklin KBI, Paxinos G. 1997. The mouse brain in stereotaxic coordinates. London: Academic.
22. Fukuda S, Taga T. 2006. Roles of BMP in the development of the central nervous system. Clin Calcium 16:781-785.
23. Fusar-Poli P, Perez J, Broome M, Borgwardt S, Placentino A, Caverzasi E, Cortesi M, Veggiotti P, Politi P, Barale F, McGuire P. 2007. Neurofunctional correlates of vulnerability to psychosis: A systematic review and meta-analysis. Neurosci Biobehav Rev 31:465-484.
24. Gogtay N. 2008. Cortical brain development in schizophrenia: Insights from neuroimaging studies in childhood-onset schizophrenia. Schizophr Bull 34:30-36.
25. Gomes WA, Mehler MF, Kessler JA. 2003. Transgenic overexpression of BMP4 increases astroglial and decreases oligodendroglial lineage commitment. Dev Biol 255:164-177.
26. Ghosh S, Narla RK, Zheng Y, Liu XP, Jun X, Mao C, Sudbeck EA, Uckun FM. 1999. Structure-based design of potent inhibitors of EGFreceptor tyrosine kinase as anti-cancer agents. Anticancer Drug Des 14:403-410. (Pubitemid 30168572)
27. Haynes T, Gutierrez C, Aycinena JC, Tsonis PA, Del Rio-Tsonis K. 2007. BMP signalling mediates stem/progenitor cell-induced retina regeneration. Proc Natl Acad Sci USA 104:20380-20385.
28. Harrison PJ. 2008. Metabotropic glutamate receptor agonists for schizophrenia. Br J Psychiatry 192:86-87.
29. Herpin A, Cunningham C. 2007. Cross-talk between the bone morphogenetic protein pathway and other major signalling pathways results in tightly regulated cell-specific outcomes. FEBS J 274:2977-2985.
30. Horky LL, Galimi F, Gage FH, Horner PJ. 2006. Fate of endogenous stem/progenitor cells following spinal cord injury. J Comp Neurol 498:525-538.
31. Imre G. 2007. The preclinical properties of a novel group II metabotropic glutamate receptor agonist LY379268. CNS Drug Rev 13:444-464.
32. Lim SP, Garzino-Demo A. 2000. The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell line U-87 MG: Role of SP-1, AP-1, and NF-kappaB consensus sites J Virol 74:1632-1640.
33. Luyt K, Varadi A, Molnar E. 2003. Functional metabotropic glutamate receptors are expressed in oligodendrocyte progenitor cells. J Neurochem 84:1452-1464.
34. Luján R, Shigemoto R, Lopez-Bendito G. 2005. Glutamate and GABA receptor signalling in the developing brain. Neurosci 130:567-580.
35. McCabe BD, Marqués G, Haghighi AP, Fetter RD, Crotty ML, Haerry TE, Goodman CS, O'Connor MB. 2003. The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction. Neuron 39:241-254.
36. Catania MV, Landwehrmeyer GB, Testa CM, Standaert DG, Penney JB Jr, Young AB. 1994. Metabotropic glutamate receptors are differentially regulated during development. Neuroscience 61:481-495.
37. Mehler MF, Mabie PC, Zhang D, Kessler JA. 1997. Bone morphogenetic proteins in the nervous system. Trends Neurosci 20:309-317.
38. Mehler MF, Mattick JS. 2007. Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease. Physiol Rev 87:799-823.
39. Melchiorri D, Cappuccio I, Ciceroni C, Spinsanti P, Mosillo P, Sarichelou I, Sale P, Nicoletti F. 2007. Metabotropic glutamate receptors in stem/progenitor cells. Neuropharmacol 53:473-480.
40. Mi H, Barres BA. 1999. Purification and characterization of astrocyte precursor cells in the developing rat optic nerve. J Neurosci 19:1049-1061. (Pubitemid 29066167)
41. Moghaddam B, Adams B. 1998. Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonists in rats. Science 281:1349-1352. (Pubitemid 28406826)
42. Nordquist RE, Delenclos M, Ballard TM, Savignac H, Pauly-Evers M, Ozmen L, Spooren W. 2008. Cognitive performance in neurokinin 3 receptor knockout mice. Psychopharmacology 198:211-220.
43. Nunokawa A, Watanabe Y, Kitamura H, Kaneko N, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Ozaki N, Someya T. 2008. Large-scale case-control study of a functional polymorphism in the glutamate receptor, metabotropic 3 gene in patients with schizophrenia. Psychiatry Clin Neurosci 62:239-240.
44. Ohno M, Kohyama J, Namihira M, Sanosaka T, Takahashi JA, Hashimoto N, Nakashima K. 2006. Neuropoietin induces neuroepithelial cells to differentiate into astrocytes via activation of STAT3. Cytokine 36:17-22.
45. Otani H, Otsuka F, Inagaki K, Takeda M, Miyoshi T, Suzuki J, Mukai T, Ogura T, Makino H. 2007. Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation. Am J Physiol Renal Physiol 292:F1513-F1525.
46. Owen MJ, Craddock N, O'Donovan MC. 2005. Schizophrenia: Genes at last? Trends Genet 21:518-525.
47. Panchision DM, McKay RD. 2002. The control of neural stem cells by morphogenic signals. Curr Opin Genet Dev 12:478-487.
48. Patil S, Zhang L, Martenyi F, Lowe S, Jackson KA, Andreev BV, Avedisova AS, Bardenstein LM, Gurovich IY, Morozova MA, Mosolov SN, Nesnanov NG, Reznik AM, Smulevich AB, Tochilov VA, Johnson BG, Monn JA, Schoepp DD. 2007. Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: A randomized phase 2 clinical trial. Nat Med 13:1102-1107.
49. Piccirillo SG, Reynolds BA, Zanetti N, Lamorte G, Binda E, Broggi G, Brem H, Brem H, Olivi A, Dimeco F, Vescovi AL. 2006. Bone morphogenetic protein inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 444:761-765.
50. Pin JP, Duvoisin R,. 1995. The metabotropic glutamate receptors: Structure and functions. Neuropharmacology 34:1-26.
51. Rajan P, McKay RD. 1998. Multiple routes to astrocytic differentiation in the CNS. J Neurosci 18:3620-3629. (Pubitemid 28225670)
52. Roelen BA, Lin HY, Knezević V, Freund E, Mummery CL. 1994. Expression of TGF-b and their receptors during implantation and organogenesis of the mouse embryo. Dev Biol 166:716-728.
53. Sadlon TJ, Lewis ID, D'Andrea RJ. 2004. BMP4: Its role in development of the hematopoietic system and potential as a hematopoietic growth factor. Stem Cells 22:457-474. (Pubitemid 39014563)
54. Sartorius LJ, Weinberger DR, Hyde TM, Harrison PJ, Kleinman JE, Lipska BK. 2008. Expression of a GRM3 splice variant is increased in the dorsolateral prefrontal cortex of individuals carrying a schizophrenia risk SNP. Neuropsychopharmacology 33:2626-2634.
55. Schwab SG, Plummer C, Albus M, Borrmann-Hassenbach M, Lerer B, Trixler M, Maier W, Wildenauer DB. 2008. DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia: An association study. Psychiatr Genet 18:25-30.
56. Schoepp DD, Jane DE, Monn JA. 1999. Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 38:1431-1476.
57. Setoguchi T, Nakashima K, Takizawa T, Yanagisawa M, Ochiai W, Okabe M, Yone K, Komiya S, Taga T. 2004. Treatment of spinal cord injury by transplantation of fetal neural precursor cells engineered to express BMP inhibitor. Exp Neurol 189:33-44.
58. Spinsanti P, De Vita T, Di Castro S, Storto M, Formisano P, Nicoletti F, Melchiorri D. 2006. Endogenously activated mGlu5 metabotropic glutamate receptors sustain the increase in c-Myc expression induced by leukaemia inhibitory factor in cultured mouse embryonic stem cells. J Neurochem 99:299-307.
59. Swanson CJ, Bures M, Johnson MP, Linden AM, Monn JA, Schoepp DD. 2005. Metabotropic glutamate receptors as novel targets for anxiety and stress disorders. Nat Rev Drug Discov 4:131-144.
60. Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. 1992. A family of metabotropic glutamate receptors. Neuron 8:169-179.
61. Ten DijKe P. 2006. Bone morphogenetic protein signal transduction in bone. Curr Med Res Opin 22:S7-S11.
62. Vaibhav B, Nilesh P, Vikram S, Anshul C. 2007. Bone morphogenic protein and its application in trauma cases: A current concept update. Injury 38:1227-1235.
63. Weinberger DR. 2007. Schizophrenia drug says goodbye to dopamine. Nat Med 13:1018-1019.